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Fusion gene ID: 11258 |
FusionGeneSummary for EIF3D_MYH9 |
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Fusion gene information | Fusion gene name: EIF3D_MYH9 | Fusion gene ID: 11258 | Hgene | Tgene | Gene symbol | EIF3D | MYH9 | Gene ID | 8664 | 4627 |
Gene name | eukaryotic translation initiation factor 3 subunit D | myosin heavy chain 9 | |
Synonyms | EIF3S7|eIF3-p66|eIF3-zeta | BDPLT6|DFNA17|EPSTS|FTNS|MHA|NMHC-II-A|NMMHC-IIA|NMMHCA | |
Cytomap | 22q12.3 | 22q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 3 subunit DeIF3 p66eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDatranslation initiation factor eIF3 p66 subunit | myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O15371 | P35579 | |
Ensembl transtripts involved in fusion gene | ENST00000216190, ENST00000478547, ENST00000541106, ENST00000405442, | ENST00000216181, ENST00000475726, ENST00000401701, | |
Fusion gene scores | * DoF score | 9 X 10 X 4=360 | 23 X 25 X 7=4025 |
# samples | 11 | 28 | |
** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/4025*10)=-3.84549005094438 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EIF3D [Title/Abstract] AND MYH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF3D | GO:0002191 | cap-dependent translational initiation | 27462815 |
Hgene | EIF3D | GO:0006413 | translational initiation | 17581632 |
Hgene | EIF3D | GO:0075522 | IRES-dependent viral translational initiation | 9573242 |
Hgene | EIF3D | GO:0075525 | viral translational termination-reinitiation | 21347434 |
Tgene | MYH9 | GO:0001525 | angiogenesis | 16403913 |
Tgene | MYH9 | GO:0006509 | membrane protein ectodomain proteolysis | 16186248 |
Tgene | MYH9 | GO:0030048 | actin filament-based movement | 12237319|15845534 |
Tgene | MYH9 | GO:0031032 | actomyosin structure organization | 24072716 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-85-7696-01A | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000216190 | ENST00000216181 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
5UTR-intron | ENST00000216190 | ENST00000475726 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
5UTR-intron | ENST00000216190 | ENST00000401701 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-3CDS | ENST00000478547 | ENST00000216181 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-intron | ENST00000478547 | ENST00000475726 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-intron | ENST00000478547 | ENST00000401701 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
5UTR-3CDS | ENST00000541106 | ENST00000216181 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
5UTR-intron | ENST00000541106 | ENST00000475726 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
5UTR-intron | ENST00000541106 | ENST00000401701 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-3CDS | ENST00000405442 | ENST00000216181 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-intron | ENST00000405442 | ENST00000475726 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
intron-intron | ENST00000405442 | ENST00000401701 | EIF3D | chr22 | 36925123 | - | MYH9 | chr22 | 36682892 | - |
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FusionProtFeatures for EIF3D_MYH9 |
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Hgene | Tgene |
EIF3D | MYH9 |
mRNA cap-binding component of the eukaryotic translationinitiation factor 3 (eIF-3) complex, a complex required forseveral steps in the initiation of protein synthesis of aspecialized repertoire of mRNAs (PubMed:27462815). The eIF-3complex associates with the 40S ribosome and facilitates therecruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5to form the 43S pre-initiation complex (43S PIC). The eIF-3complex stimulates mRNA recruitment to the 43S PIC and scanning ofthe mRNA for AUG recognition. The eIF-3 complex is also requiredfor disassembly and recycling of post-termination ribosomalcomplexes and subsequently prevents premature joining of the 40Sand 60S ribosomal subunits prior to initiation (PubMed:18599441,PubMed:25849773). The eIF-3 complex specifically targets andinitiates translation of a subset of mRNAs involved in cellproliferation, including cell cycling, differentiation andapoptosis, and uses different modes of RNA stem-loop binding toexert either translational activation or repression(PubMed:25849773). In the eIF-3 complex, EIF3D specificallyrecognizes and binds the 7-methylguanosine cap of a subset ofmRNAs (PubMed:27462815). {ECO:0000269|PubMed:18599441,ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}. (Microbial infection) In case of FCV infection, plays arole in the ribosomal termination-reinitiation event leading tothe translation of VP2 (PubMed:18056426).{ECO:0000269|PubMed:18056426}. | Cellular myosin that appears to play a role incytokinesis, cell shape, and specialized functions such assecretion and capping. During cell spreading, plays an importantrole in cytoskeleton reorganization, focal contacts formation (inthe margins but not the central part of spreading cells), andlamellipodial retraction; this function is mechanicallyantagonized by MYH10. {ECO:0000269|PubMed:20052411}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF3D_MYH9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF3D_MYH9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EIF3D | EIF1B, EIF4A2, EIF3A, EIF3L, PHLDA1, EIF3G, EIF3H, EIF3F, USP3, HAX1, CD4, EIF3E, PSMD12, DNAJB11, RAD21, SIRT7, CAND1, EIF3C, EIF3K, EIF3B, EIF3I, EIF3M, NCL, DDX3X, FN1, VCAM1, EIF3J, HNRNPU, RPL23A, RPL35, RPS11, RPS12, RPS18, RPS20, RPS27, RPS28, RPS4X, RPS9, STAU1, REL, TRIM27, SAT1, HOMER3, BEND5, LZTS2, CCDC8, RNF2, ABCE1, FBXW11, EIF3CL, SRSF7, SRSF5, SUPT4H1, NTRK1, HERC2, XPO1, MATR3, GAN, MCM2, BCOR, NANOG, POU5F1, ZNF746, EIF4A1, RAF1, CYLD, DLD, DNM1L, HSD17B10, SOD1, TRIM25, G3BP1, UBE2A | MYH9 | EPB41, MARK4, ASCC2, MYL9, PRKCE, USP1, USP45, GRB2, RAC1, YWHAZ, EMD, TERF1, TERF2, CBL, PPP2R4, AGO3, YWHAQ, MME, HDAC5, NCOA3, CREBBP, UBE3A, ARRB1, ARRB2, SIRT7, TRAF4, SP1, ISG15, FBXO25, CDK2, CUL1, TRIM72, GRK5, UBASH3B, PIK3R2, SHC1, MYL6, SPTAN1, HSP90AB1, ACTA2, MYH10, HNRNPU, FLNA, ACTR1A, RAB11A, EIF4B, SEL1L, ATP5A1, SEPT7, RALA, HSPA5, TUBA4A, EIF3A, EIF3C, TPM4, MRPS18B, PSME3, HSPA1A, ESR1, TSGA10, EIF4A3, MAGOH, TRAF3IP1, MEN1, HSP90AA1, VCAM1, FN1, IQCB1, ITGA4, PAN2, ACE, ACTB, CSNK2A1, PIK3C3, PPP2CA, CASP4, TARDBP, AKAP10, CDC73, MYH14, OTUD6B, MYL12A, RPA1, RPA2, RPA3, LGR4, IVNS1ABP, TP53, HUWE1, ALK, UBE2I, EED, AMFR, OS9, SYVN1, ATG9A, USP7, HNRNPA1, ATP5L, MYO1E, SRSF5, SSB, NTRK1, ACTA1, ACTG1, ACTN4, ACTN1, AP2A1, AP2B1, ANXA2, APOB, DST, CALD1, CALM1, CALML3, CAPZA1, CAPZA2, CAPZB, CD44, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DAPK3, DBN1, DSG2, CTTN, STOM, EPS15, FLII, FLNB, FYN, GNAI1, GNAI2, GNAS, GNB2, GSN, HIP1, ITPR2, ITPR3, JUP, LGALS1, ABLIM1, LMO7, LSS, LYN, MYO1B, MSN, PDLIM7, ANLN, MYO19, MYO18A, MYLK, MYO1C, MYO5A, MYO5B, MYO6, PPP1R12A, PPP1R12B, NAP1L1, PAWR, PIK3C2A, PLEC, PLS1, PPIA, PPP1CA, PPP1CB, PPP1CC, PSMB10, TWF1, PEX5, RPL22, SIPA1, SORD, SPTBN1, SPTBN2, SSFA2, ST5, SVIL, TCEA2, TMOD1, TNFAIP1, TPM1, TPM2, TPM3, CORO2A, YES1, LUZP1, PICALM, PIP5K1A, SORBS2, IQGAP1, HIP1R, GPRC5A, LRRFIP2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, ARPC2, BCAP31, FLOT1, BASP1, IMMT, RBPMS, DSTN, TRIOBP, CEP250, AKAP2, TWF2, SYNPO, CEP162, LIMCH1, PALLD, SIPA1L3, MPRIP, COBL, KIF13B, SPECC1L, ATP13A2, MACF1, CORO1C, STX12, GCA, PLEKHG3, RAI14, ZBTB20, AHDC1, PACSIN3, TMOD3, PNMA3, FCF1, CEP83, LIMA1, GTSE1, KDM3B, UACA, CDCA8, BMP2K, UNC45A, MYO5C, GNG12, MUC13, CORO1B, MICAL3, ARHGAP21, SHROOM3, AFAP1, INF2, NARFL, METTL17, AHNAK, EFHD2, CYBRD1, WDR76, DSN1, RNF170, TRIM56, ARPC5L, ANTXR1, LZTS2, PPP1R9B, CEP89, STON2, DOCK7, DIXDC1, SSH2, NEXN, ELMSAN1, SPECC1, CCDC102A, FCHO2, MISP, JMY, CD109, ACTRT1, MYL6B, CCDC50, OARD1, GAS2L3, TTLL6, TPRN, ACTBL2, MCM2, MCM5, SNW1, CDC5L, BOP1, PES1, EGFR, CDH1, C9orf156, MYL3, H2AFY, CYLD, TRIM25, BRCA1, HDAC6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF3D_MYH9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MYH9 | P35579 | DB11638 | Artenimol | Myosin-9 | small molecule | approved|investigational |
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RelatedDiseases for EIF3D_MYH9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MYH9 | C0403445 | Fechtner syndrome (disorder) | 9 | UNIPROT |
Tgene | MYH9 | C0398641 | Epstein syndrome (disorder) | 7 | UNIPROT |
Tgene | MYH9 | C0340978 | May-Hegglin anomaly | 6 | UNIPROT |
Tgene | MYH9 | C0022661 | Kidney Failure, Chronic | 2 | CTD_human |
Tgene | MYH9 | C1854520 | SEBASTIAN SYNDROME | 2 | CTD_human;ORPHANET;UNIPROT |
Tgene | MYH9 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Tgene | MYH9 | C0020544 | Renal hypertension | 1 | CTD_human |
Tgene | MYH9 | C0027706 | Hereditary nephritis | 1 | CTD_human |
Tgene | MYH9 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MYH9 | C1863659 | DEAFNESS, AUTOSOMAL DOMINANT 17 | 1 | UNIPROT |
Tgene | MYH9 | C2673482 | Increased susceptibility to schizophrenia | 1 | PSYGENET |