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Fusion gene ID: 11214 |
FusionGeneSummary for EIF2AK4_TMOD3 |
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Fusion gene information | Fusion gene name: EIF2AK4_TMOD3 | Fusion gene ID: 11214 | Hgene | Tgene | Gene symbol | EIF2AK4 | TMOD3 | Gene ID | 440275 | 29766 |
Gene name | eukaryotic translation initiation factor 2 alpha kinase 4 | tropomodulin 3 | |
Synonyms | GCN2|PVOD2 | UTMOD | |
Cytomap | 15q15.1 | 15q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2 | tropomodulin-3tropomodulin 3 (ubiquitous)ubiquitous tropomodulin | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9P2K8 | Q9NYL9 | |
Ensembl transtripts involved in fusion gene | ENST00000559624, ENST00000382727, ENST00000263791, ENST00000560648, ENST00000559311, | ENST00000308580, ENST00000544199, ENST00000561136, | |
Fusion gene scores | * DoF score | 10 X 10 X 9=900 | 2 X 3 X 3=18 |
# samples | 11 | 3 | |
** MAII score | log2(11/900*10)=-3.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EIF2AK4 [Title/Abstract] AND TMOD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-2H-A9GN-01A | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000559624 | ENST00000308580 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000559624 | ENST00000544199 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000559624 | ENST00000561136 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000382727 | ENST00000308580 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000382727 | ENST00000544199 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000382727 | ENST00000561136 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000263791 | ENST00000308580 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000263791 | ENST00000544199 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
5CDS-intron | ENST00000263791 | ENST00000561136 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000560648 | ENST00000308580 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000560648 | ENST00000544199 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000560648 | ENST00000561136 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000559311 | ENST00000308580 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000559311 | ENST00000544199 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
intron-intron | ENST00000559311 | ENST00000561136 | EIF2AK4 | chr15 | 40247969 | + | TMOD3 | chr15 | 52223228 | + |
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FusionProtFeatures for EIF2AK4_TMOD3 |
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Hgene | Tgene |
EIF2AK4 | TMOD3 |
Blocks the elongation and depolymerization of the actinfilaments at the pointed end. The Tmod/TM complex contributes tothe formation of the short actin protofilament, which in turndefines the geometry of the membrane skeleton (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF2AK4_TMOD3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF2AK4_TMOD3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EIF2AK4 | USP46, GGNBP1, ARRB2, TRAP1, FAM153B, PPP1CC, PPP1CA, CROT, TARS, MATR3, LRPPRC, DEF8, TKT, PALM2, PSMC3, MDM4, C6orf141, CRYL1 | TMOD3 | USP45, NR4A1, TNFSF11, DUSP23, MAP1LC3B, ELAVL1, ARRB1, ARRB2, ISG15, FBXO25, LRRK2, ATP6V1B1, AHCYL1, PPIL3, NPC1, PSMC4, SULT1A1, HNRNPUL2, PSMB7, CSNK2A1, PAN2, PSMD9, DHX15, PABPC1, PPP1CA, YWHAE, CUL7, CCDC8, DAPK1, ATP6V1B2, MCFD2, PAM16, RUVBL2, SMARCC1, SMARCC2, SNRPD1, CAPZB, DHX9, HSPA5, PSMA1, PSMD3, RAD23A, USP5, XRCC6, HIST1H3E, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, LIMA1, ANLN, MYO5C, MYO19, MYO18A, ZSCAN26, FBXW7, ESR1, CDC5L, CDH1, DUSP19, SCIN, LRRFIP1, POTEI, MYO5B, INF2, ALAS1, SVIL, FLII, LRRFIP2, ACTA2, GSN, LONP2, LRCH3, MEIS2, SPIRE2, COBL, PRPF3, FECH, PHACTR2, ACTBL2, ACTB, TBC1D4, DOCK7, MYO5A, TWF2, ACTC1, SPIRE1, PBX2, PRPF4, ENAH, CSRP2BP, PBX3, FBXO34, SSH1, BDH2, COX15, PARK7, TRIM25, G3BP1, CCND2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF2AK4_TMOD3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF2AK4_TMOD3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF2AK4 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Hgene | EIF2AK4 | C0018500 | Hair Diseases | 1 | CTD_human |
Hgene | EIF2AK4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Hgene | EIF2AK4 | C0021053 | Immune System Diseases | 1 | CTD_human |
Hgene | EIF2AK4 | C0026848 | Myopathy | 1 | CTD_human |
Hgene | EIF2AK4 | C0034091 | Pulmonary Veno-Occlusive Disease (disorder) | 1 | CTD_human;ORPHANET |
Hgene | EIF2AK4 | C0340848 | PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE | 1 | UNIPROT |