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Fusion gene ID: 11211 |
FusionGeneSummary for EIF2AK4_HMGN2P46 |
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Fusion gene information | Fusion gene name: EIF2AK4_HMGN2P46 | Fusion gene ID: 11211 | Hgene | Tgene | Gene symbol | EIF2AK4 | HMGN2P46 | Gene ID | 440275 | 283651 |
Gene name | eukaryotic translation initiation factor 2 alpha kinase 4 | high mobility group nucleosomal binding domain 2 pseudogene 46 | |
Synonyms | GCN2|PVOD2 | C15orf21|D-PCa-2 | |
Cytomap | 15q15.1 | 15q21.1 | |
Type of gene | protein-coding | pseudo | |
Description | eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2 | Dresden prostate cancer 2Dresden prostate carcinoma 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9P2K8 | ||
Ensembl transtripts involved in fusion gene | ENST00000559624, ENST00000382727, ENST00000263791, ENST00000560648, ENST00000559311, | ENST00000409454, | |
Fusion gene scores | * DoF score | 10 X 10 X 9=900 | 1 X 1 X 1=1 |
# samples | 11 | 1 | |
** MAII score | log2(11/900*10)=-3.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: EIF2AK4 [Title/Abstract] AND HMGN2P46 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | THCA | TCGA-FE-A239-01A | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000559624 | ENST00000409454 | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
5CDS-3UTR | ENST00000382727 | ENST00000409454 | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
5CDS-3UTR | ENST00000263791 | ENST00000409454 | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
intron-3UTR | ENST00000560648 | ENST00000409454 | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
intron-3UTR | ENST00000559311 | ENST00000409454 | EIF2AK4 | chr15 | 40241469 | + | HMGN2P46 | chr15 | 45847688 | + |
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FusionProtFeatures for EIF2AK4_HMGN2P46 |
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Hgene | Tgene |
EIF2AK4 | HMGN2P46 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF2AK4_HMGN2P46 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF2AK4_HMGN2P46 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EIF2AK4 | USP46, GGNBP1, ARRB2, TRAP1, FAM153B, PPP1CC, PPP1CA, CROT, TARS, MATR3, LRPPRC, DEF8, TKT, PALM2, PSMC3, MDM4, C6orf141, CRYL1 | HMGN2P46 | ELAVL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF2AK4_HMGN2P46 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF2AK4_HMGN2P46 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF2AK4 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Hgene | EIF2AK4 | C0018500 | Hair Diseases | 1 | CTD_human |
Hgene | EIF2AK4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
Hgene | EIF2AK4 | C0021053 | Immune System Diseases | 1 | CTD_human |
Hgene | EIF2AK4 | C0026848 | Myopathy | 1 | CTD_human |
Hgene | EIF2AK4 | C0034091 | Pulmonary Veno-Occlusive Disease (disorder) | 1 | CTD_human;ORPHANET |
Hgene | EIF2AK4 | C0340848 | PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE | 1 | UNIPROT |