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Fusion gene ID: 11210 |
FusionGeneSummary for EIF2AK4_FEM1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF2AK4_FEM1B | Fusion gene ID: 11210 | Hgene | Tgene | Gene symbol | EIF2AK4 | FEM1B | Gene ID | 440275 | 10116 |
| Gene name | eukaryotic translation initiation factor 2 alpha kinase 4 | fem-1 homolog B | |
| Synonyms | GCN2|PVOD2 | F1A-ALPHA|F1AA|FEM1-beta | |
| Cytomap | 15q15.1 | 15q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eIF-2-alpha kinase GCN2GCN2 eIF2alpha kinaseGCN2-like proteingeneral control nonderepressible 2 | protein fem-1 homolog BFEM-1-like death receptor binding proteinfem-1-like death receptor-binding protein alphafem-1-like in apoptotic pathway protein alpha | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9P2K8 | Q9UK73 | |
| Ensembl transtripts involved in fusion gene | ENST00000559624, ENST00000382727, ENST00000263791, ENST00000560648, ENST00000559311, | ENST00000306917, | |
| Fusion gene scores | * DoF score | 10 X 10 X 9=900 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/900*10)=-3.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: EIF2AK4 [Title/Abstract] AND FEM1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-43-8116-01A | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000559624 | ENST00000306917 | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
| In-frame | ENST00000382727 | ENST00000306917 | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
| In-frame | ENST00000263791 | ENST00000306917 | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
| intron-3CDS | ENST00000560648 | ENST00000306917 | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
| intron-3CDS | ENST00000559311 | ENST00000306917 | EIF2AK4 | chr15 | 40314806 | + | FEM1B | chr15 | 68581945 | + |
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FusionProtFeatures for EIF2AK4_FEM1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF2AK4 | FEM1B |
| Component of an E3 ubiquitin-protein ligase complex, inwhich it may act as a substrate recognition subunit. Involved inapoptosis by acting as a death receptor-associated protein thatmediates apoptosis. Also involved in glucose homeostasis inpancreatic islet. Functions as an adapter/mediator in replicationstress-induced signaling that leads to the activation of CHEK1.{ECO:0000269|PubMed:10542291, ECO:0000269|PubMed:19330022}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF2AK4_FEM1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EIF2AK4_ENST00000382727_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_1980aa MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYPDVVPEI ELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYF NMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRL ADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQF RRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAY IHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFS LGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHT LTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHS GMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSI YLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLMPTINSLIKQKTGIAQLV KYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAI DKISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSHVKVCHXW CHCSLVCSWSRTFXSCXTSSQPWSQREPYHSNXFNPPAGSMLXWQTGHCEILGXKXCQHQHCQQIXQHLPNDCGIXGTHXCGQIPFRTTC XSQCQSTLWSHSIALCSXSWAHRYCERADKMACCYSSEWPWDDAIESSCRKLXSXCRRTVTLSCXLRPKKSDXSFGTLGCLLCKXPXELX HHKDIPLSIFSHVREVPRWXXHSRKRGSSTNPCLWEXNXMXKSSGTGVHSARQRCSSYGRPYSSGTDFRCXQYXCFSSHHLQRSCLCGXY GIXAVYQVVASCPAPQTKRXQEHPQGSSSICSSFLTNDTFEXNCEGPRHRMCFEMQCFGNRTKYEQSEKYFRCXCPQCYGQLXMXSLYLS VFSVHLYQNTVQRRRSVQNXQADLQPDSPXSQNSXRFHLAASGCQFQYSSXXFPHQXRLQLSKCTCHKAPAGLWCXGECRGQXGKQCPSY YRSVQQAHQXFFDLALHHHXPSXSRSSHXHDEXTEXDSARQKYNWGIXNTAXNSNEDESQVPGCPSSSGXXHXLPRPDPQNSXRVCWISL >In-frame_EIF2AK4_ENST00000263791_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_2008aa MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCPPTYPDVVPEI ELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHRANSSGRSRRERQYSVCNSEDSPGSCEILYF NMGSPDQLMVHKGKCIGSDEQLGKLVYNALETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRL ADICKEDVFEQTRVRFSDNALPYKTGKKGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQF RRIKGEVTLLSRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTL RDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRP TATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNS FLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEILAAGG RYDLLIPQFRGPQALGPVPTAIGVSIAIDKISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ EYCRHHEITYVALVSDKEGSHVKVCHXWCHCSLVCSWSRTFXSCXTSSQPWSQREPYHSNXFNPPAGSMLXWQTGHCEILGXKXCQHQHC QQIXQHLPNDCGIXGTHXCGQIPFRTTCXSQCQSTLWSHSIALCSXSWAHRYCERADKMACCYSSEWPWDDAIESSCRKLXSXCRRTVTL SCXLRPKKSDXSFGTLGCLLCKXPXELXHHKDIPLSIFSHVREVPRWXXHSRKRGSSTNPCLWEXNXMXKSSGTGVHSARQRCSSYGRPY SSGTDFRCXQYXCFSSHHLQRSCLCGXYGIXAVYQVVASCPAPQTKRXQEHPQGSSSICSSFLTNDTFEXNCEGPRHRMCFEMQCFGNRT KYEQSEKYFRCXCPQCYGQLXMXSLYLSVFSVHLYQNTVQRRRSVQNXQADLQPDSPXSQNSXRFHLAASGCQFQYSSXXFPHQXRLQLS KCTCHKAPAGLWCXGECRGQXGKQCPSYYRSVQQAHQXFFDLALHHHXPSXSRSSHXHDEXTEXDSARQKYNWGIXNTAXNSNEDESQVP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EIF2AK4_ENST00000382727_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_5941nt ATGGCTGGGGGCCGTGGGGCCCCCGGGCGCGGCCGGGACGAGCCTCCGGAGAGCTACCCGCAACGACAGGACCACGAGCTACAGGCCCTG GAGGCCATTTACGGCGCGGACTTCCAAGACCTGCGGCCGGACGCTTGCGGACCGGTCAAAGAGCCCCCTGAAATCAATTTAGTTTTGTAC CCTCAAGGCCTAACTGGTGAAGAAGTATATGTAAAAGTGGATTTGAGGGTTAAATGCCCACCTACCTATCCAGATGTAGTTCCTGAAATA GAGTTAAAAAATGCCAAAGGTCTATCAAATGAAAGTGTCAATTTGTTAAAATCTCGCCTAGAAGAACTGGCCAAGAAACACTGTGGGGAG GTGATGATCTTTGAACTGGCTTACCACGTGCAGTCATTTCTCAGCGAGCATAACAAGCCCCCTCCCAAGTCTTTTCATGAAGAAATGCTG GAAAGGCGGGCTCAGGAGGAGCAGCAGAGGCTGTTGGAGGCCAAGCGGAAAGAAGAGCAGGAGCAACGTGAAATCCTGCATGAGATTCAG AGAAGGAAAGAAGAGATAAAAGAAGAGAAAAAAAGGAAAGAAATGGCTAAGCAGGAACGTTTGGAAATTGCTAGTTTGTCAAACCAAGAT CATACCTCTAAGAAGGACCCAGGAGGACACAGAACGGCTGCCATTCTACATGGAGGCTCTCCTGACTTTGTAGGAAATGGTAAACATCGG GCAAACTCCTCAGGAAGGTCTAGGCGAGAACGTCAGTATTCTGTATGTAATAGTGAAGATTCTCCTGGCTCTTGTGAAATTCTGTATTTC AATATGGGGAGTCCTGATCAGCTCATGGTGCACAAAGGGAAATGTATTGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTG GAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGGTCCTTCAGTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAA GAGAAGATTGATAAGTGCAAAAAGCAGATTCAAGGAACAGAAACAGAATTCAACTCACTGGTAAAATTGAGCCATCCAAATGTAGTACGC TACCTTGCAATGAATCTCAAAGAGCAAGACGACTCCATCGTGGTGGACATTTTAGTGGAGCACATTAGTGGGGTCTCTCTTGCTGCACAC CTGAGCCACTCAGGCCCCATCCCTGTGCATCAGCTTCGCAGGTACACAGCTCAGCTCCTGTCAGGCCTTGATTATCTGCACAGCAATTCT GTGGTGCATAAGGTCCTGAGTGCATCTAATGTCTTGGTGGATGCAGAAGGCACCGTCAAGATTACGGACTATAGCATTTCTAAGCGCCTC GCAGACATTTGCAAGGAGGATGTGTTTGAGCAAACCCGAGTTCGTTTTAGTGACAATGCTCTGCCTTATAAAACGGGGAAGAAAGGAGAT GTTTGGCGTCTTGGCCTTCTGCTGCTGTCCCTCAGCCAAGGACAGGAATGTGGAGAGTACCCTGTGACCATCCCTAGTGACTTACCAGCT GACTTTCAAGATTTTCTAAAGAAATGTGTGTGCTTGGATGACAAGGAAAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAAT CCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAGATTCTGAAGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTA CCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTTCCCGATACTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCT TTTGGAGCTGTCATCAAGGTGCAGAACAAGTTGGACGGCTGCTGCTACGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTC CGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCTGCACCATGAGAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAG CGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGCCCCTGGCCAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACA GACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCATCCTCAGCAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGT GCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACGAGGACGACGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTG CCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATGAAGATGAGAACAGTAAAAGTCAGAATCAGATGGAGTACTGTGAGAAGAGC ACTTTACGAGACACCATTGACCAGGGACTGTATCGAGACACCGTCAGACTCTGGAGGCTTTTTCGAGAGATTCTGGATGGATTAGCTTAT ATCCATGAGAAAGGAATGATTCACCGGGATTTGAAGCCTGTCAACATTTTTTTGGATTCTGATGACCATGTGAAAATAGGTGATTTTGGT TTGGCGACAGACCATCTAGCCTTTTCTGCTGACAGCAAACAAGACGATCAGACAGGAGACTTGATTAAGTCAGACCCTTCAGGTCACTTA ACTGGGATGGTTGGCACTGCTCTCTATGTAAGCCCAGAGGTCCAAGGAAGCACCAAATCTGCATACAACCAGAAAGTGGATCTCTTCAGC CTGGGAATTATCTTCTTTGAGATGTCCTATCACCCCATGGTCACGGCTTCAGAAAGGATCTTTGTTCTCAACCAACTCAGAGATCCCACT TCGCCTAAGTTTCCAGAAGACTTTGACGATGGAGAGCATGCAAAGCAGAAATCAGTCATCTCCTGGCTGTTGAACCACGATCCAGCAAAA CGGCCCACAGCCACAGAACTGCTCAAGAGTGAGCTGCTGCCCCCACCCCAGATGGAGGAGTCAGAGCTGCATGAAGTGCTGCACCACACG CTGACCAACGTGGATGGGAAGGCCTACCGCACCATGATGGCCCAGATCTTCTCGCAGCGCATCTCCCCTGCCATCGATTACACCTATGAC AGCGACATACTGAAGGGCAACTTCTCAATCCGTACAGCCAAGATGCAGCAGCATGTGTGTGAAACCATCATCCGCATCTTTAAAAGACAT GGAGCTGTTCAGTTGTGTACTCCACTACTGCTTCCCCGAAACAGACAAATATATGAGCACAACGAAGCTGCCCTATTCATGGACCACAGC GGGATGCTGGTGATGCTTCCTTTTGACCTGCGGATCCCTTTTGCAAGATATGTGGCAAGAAATAATATATTGAATTTAAAACGATACTGC ATAGAACGTGTGTTCAGGCCGCGCAAGTTAGATCGATTTCATCCCAAAGAACTTCTGGAGTGTGCATTTGATATTGTCACTTCTACCACC AACAGCTTTCTGCCCACTGCTGAAATTATCTACACTATCTATGAAATCATCCAAGAGTTTCCAGCACTTCAGGAAAGAAATTACAGTATT TATTTGAACCATACCATGTTATTGAAAGCAATACTCTTACACTGTGGGATCCCAGAAGATAAACTCAGTCAAGTCTACATTATTCTGTAT GATGCTGTGACAGAGAAGCTGACGAGGAGAGAAGTGGAAGCTAAATTTTGTAATCTGTCTTTGTCTTCTAATAGTCTGTGTCGACTCTAC AAGTTTATTGAACAGAAGGGAGATTTGCAAGATCTTATGCCAACAATAAATTCATTAATAAAACAGAAAACAGGTATTGCACAGTTGGTG AAGTATGGCTTAAAAGACCTAGAGGAGGTTGTTGGACTGTTGAAGAAACTCGGCATCAAGTTACAGGTCTTGATCAATTTGGGCTTGGTT TACAAGGTGCAGCAGCACAATGGAATCATCTTCCAGTTTGTGGCTTTCATCAAACGAAGGCAAAGGGCTGTACCTGAAATCCTCGCAGCT GGAGGCAGATATGACCTGCTGATTCCCCAGTTTAGAGGGCCACAAGCTCTGGGGCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATA GACAAGATATCTGCTGCTGTCCTCAACATGGAGGAATCTGTTACAATAAGCTCTTGTGACCTCCTGGTTGTAAGTGTTGGCCAGATGTCT ATGTCCAGGGCCATCAACCTAACCCAGAAACTCTGGACAGCAGGCATCACAGCAGAAATCATGTACGACTGGTCACAGTCCCAAGAGGAA TTACAAGAGTACTGCAGACATCATGAAATCACCTATGTGGCCCTTGTCTCGGATAAAGAAGGAAGCCATGTCAAGGTATGTCATTGATGG TGCCACTGCTCTTTGGTGTGCAGCTGGAGCAGGACATTTTGAAGTTGTTAAACTTCTAGTCAGCCATGGAGCCAACGTGAACCATACCAC AGTAACTAATTCAACCCCCCTGCGGGCAGCATGCTTTGATGGCAGACTGGACATTGTGAAATACTTGGTTGAAAATAATGCCAACATCAG CATTGCCAACAAATATGACAACACCTGCCTAATGATTGCGGCATATAAGGGACACACTGATGTGGTCAGATACCTTTTAGAACAACGTGC TGATCCCAATGCCAAAGCACATTGTGGAGCCACAGCATTGCACTTTGCAGCTGAAGCTGGGCACATAGATATTGTGAAAGAGCTGATAAA ATGGCGTGCTGCTATAGTAGTGAATGGCCATGGGATGACGCCATTGAAAGTAGCTGCCGAAAGCTGTAAAGCTGATGTCGTAGAACTGTT ACTCTCTCATGCTGATTGCGACCGAAGAAGTCGGATTGAAGCTTTGGAACTCTTGGGTGCCTCCTTTGCAAATGACCGTGAGAACTATGA CATCATAAAGACATACCACTATCTATATTTAGCCATGTTAGAGAGGTTCCAAGATGGTGATAACATTCTCGAAAAAGAGGTTCTTCCACC AATCCATGCTTATGGGAATAGAACTGAATGTAGAAATCCTCAGGAACTGGAGTCCATTCGGCAAGACAGAGATGCTCTTCATATGGAAGG CCTTATAGTTCGGGAACGGATTTTAGGTGCTGACAATATTGATGTTTCTCATCCCATCATTTACAGAGGAGCTGTTTATGCGGATAATAT GGAATTTGAGCAGTGTATCAAGTTGTGGCTTCATGCCCTGCACCTCAGACAAAAAGGTAACAGGAACACCCACAAGGATCTTCTTCGATT TGCTCAAGTTTTCTCACAAATGATACATTTGAATGAAACTGTGAAGGCCCCAGACATAGAATGTGTTTTGAGATGCAGTGTTTTGGAAAT AGAACAAAGTATGAACAGAGTGAAAAATATTTCAGATGCTGATGTCCACAATGCTATGGACAATTATGAATGTAATCTCTATACCTTTCT GTATTTAGTGTGCATCTCTACCAAAACACAGTGCAGCGAAGAAGATCAGTGCAAAATTAACAAGCAGATCTACAACCTGATTCACCTTGA TCCCAGAACTCGTGAAGGTTTCACCTTGCTGCATCTGGCTGTCAATTCCAATACTCCAGTTGATGATTTCCACACCAATGACGTCTGCAG CTTTCCAAATGCACTTGTCACAAAGCTCCTGCTGGACTGTGGTGCTGAGGTGAATGCCGTGGACAATGAGGGAAACAGTGCCCTTCATAT TATCGTTCAGTACAACAGGCCCATCAGTGATTTTTTGACCTTGCACTCCATCATCATTAGCCTAGTTGAAGCCGGAGCTCACACTGACAT GACGAATAAACAGAATAAGACTCCGCTAGACAAAAGTACAACTGGGGTATCTGAAATACTGCTTAAAACTCAAATGAAGATGAGTCTCAA GTGCCTGGCTGCCCGAGCAGTTCGGGCTAATGACATTAACTACCAAGACCAGATCCCCAGAACTCTTGAAGAGTTTGTTGGATTTCATTA >In-frame_EIF2AK4_ENST00000263791_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_6025nt ATGGCTGGGGGCCGTGGGGCCCCCGGGCGCGGCCGGGACGAGCCTCCGGAGAGCTACCCGCAACGACAGGACCACGAGCTACAGGCCCTG GAGGCCATTTACGGCGCGGACTTCCAAGACCTGCGGCCGGACGCTTGCGGACCGGTCAAAGAGCCCCCTGAAATCAATTTAGTTTTGTAC CCTCAAGGCCTAACTGGTGAAGAAGTATATGTAAAAGTGGATTTGAGGGTTAAATGCCCACCTACCTATCCAGATGTAGTTCCTGAAATA GAGTTAAAAAATGCCAAAGGTCTATCAAATGAAAGTGTCAATTTGTTAAAATCTCGCCTAGAAGAACTGGCCAAGAAACACTGTGGGGAG GTGATGATCTTTGAACTGGCTTACCACGTGCAGTCATTTCTCAGCGAGCATAACAAGCCCCCTCCCAAGTCTTTTCATGAAGAAATGCTG GAAAGGCGGGCTCAGGAGGAGCAGCAGAGGCTGTTGGAGGCCAAGCGGAAAGAAGAGCAGGAGCAACGTGAAATCCTGCATGAGATTCAG AGAAGGAAAGAAGAGATAAAAGAAGAGAAAAAAAGGAAAGAAATGGCTAAGCAGGAACGTTTGGAAATTGCTAGTTTGTCAAACCAAGAT CATACCTCTAAGAAGGACCCAGGAGGACACAGAACGGCTGCCATTCTACATGGAGGCTCTCCTGACTTTGTAGGAAATGGTAAACATCGG GCAAACTCCTCAGGAAGGTCTAGGCGAGAACGTCAGTATTCTGTATGTAATAGTGAAGATTCTCCTGGCTCTTGTGAAATTCTGTATTTC AATATGGGGAGTCCTGATCAGCTCATGGTGCACAAAGGGAAATGTATTGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTG GAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGGTCCTTCAGTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAA GAGAAGATTGATAAGTGCAAAAAGCAGATTCAAGGAACAGAAACAGAATTCAACTCACTGGTAAAATTGAGCCATCCAAATGTAGTACGC TACCTTGCAATGAATCTCAAAGAGCAAGACGACTCCATCGTGGTGGACATTTTAGTGGAGCACATTAGTGGGGTCTCTCTTGCTGCACAC CTGAGCCACTCAGGCCCCATCCCTGTGCATCAGCTTCGCAGGTACACAGCTCAGCTCCTGTCAGGCCTTGATTATCTGCACAGCAATTCT GTGGTGCATAAGGTCCTGAGTGCATCTAATGTCTTGGTGGATGCAGAAGGCACCGTCAAGATTACGGACTATAGCATTTCTAAGCGCCTC GCAGACATTTGCAAGGAGGATGTGTTTGAGCAAACCCGAGTTCGTTTTAGTGACAATGCTCTGCCTTATAAAACGGGGAAGAAAGGAGAT GTTTGGCGTCTTGGCCTTCTGCTGCTGTCCCTCAGCCAAGGACAGGAATGTGGAGAGTACCCTGTGACCATCCCTAGTGACTTACCAGCT GACTTTCAAGATTTTCTAAAGAAATGTGTGTGCTTGGATGACAAGGAAAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAAT CCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAGATTCTGAAGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTA CCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTTCCCGATACTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCT TTTGGAGCTGTCATCAAGGTGCAGAACAAGTTGGACGGCTGCTGCTACGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTC CGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCTGCACCATGAGAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAG CGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGCCCCTGGCCAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACA GACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCATCCTCAGCAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGT GCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACGAGGACGACGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTG CCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATGAAGATGAGAACAGTAAAAGTCAGAATCAGGATGAAGATTGCAATGAAAAG AATGGCTGCCATGAAAGTGAGCCATCAGTGACGACTGAGGCTGTGCACTACCTATACATCCAGATGGAGTACTGTGAGAAGAGCACTTTA CGAGACACCATTGACCAGGGACTGTATCGAGACACCGTCAGACTCTGGAGGCTTTTTCGAGAGATTCTGGATGGATTAGCTTATATCCAT GAGAAAGGAATGATTCACCGGGATTTGAAGCCTGTCAACATTTTTTTGGATTCTGATGACCATGTGAAAATAGGTGATTTTGGTTTGGCG ACAGACCATCTAGCCTTTTCTGCTGACAGCAAACAAGACGATCAGACAGGAGACTTGATTAAGTCAGACCCTTCAGGTCACTTAACTGGG ATGGTTGGCACTGCTCTCTATGTAAGCCCAGAGGTCCAAGGAAGCACCAAATCTGCATACAACCAGAAAGTGGATCTCTTCAGCCTGGGA ATTATCTTCTTTGAGATGTCCTATCACCCCATGGTCACGGCTTCAGAAAGGATCTTTGTTCTCAACCAACTCAGAGATCCCACTTCGCCT AAGTTTCCAGAAGACTTTGACGATGGAGAGCATGCAAAGCAGAAATCAGTCATCTCCTGGCTGTTGAACCACGATCCAGCAAAACGGCCC ACAGCCACAGAACTGCTCAAGAGTGAGCTGCTGCCCCCACCCCAGATGGAGGAGTCAGAGCTGCATGAAGTGCTGCACCACACGCTGACC AACGTGGATGGGAAGGCCTACCGCACCATGATGGCCCAGATCTTCTCGCAGCGCATCTCCCCTGCCATCGATTACACCTATGACAGCGAC ATACTGAAGGGCAACTTCTCAATCCGTACAGCCAAGATGCAGCAGCATGTGTGTGAAACCATCATCCGCATCTTTAAAAGACATGGAGCT GTTCAGTTGTGTACTCCACTACTGCTTCCCCGAAACAGACAAATATATGAGCACAACGAAGCTGCCCTATTCATGGACCACAGCGGGATG CTGGTGATGCTTCCTTTTGACCTGCGGATCCCTTTTGCAAGATATGTGGCAAGAAATAATATATTGAATTTAAAACGATACTGCATAGAA CGTGTGTTCAGGCCGCGCAAGTTAGATCGATTTCATCCCAAAGAACTTCTGGAGTGTGCATTTGATATTGTCACTTCTACCACCAACAGC TTTCTGCCCACTGCTGAAATTATCTACACTATCTATGAAATCATCCAAGAGTTTCCAGCACTTCAGGAAAGAAATTACAGTATTTATTTG AACCATACCATGTTATTGAAAGCAATACTCTTACACTGTGGGATCCCAGAAGATAAACTCAGTCAAGTCTACATTATTCTGTATGATGCT GTGACAGAGAAGCTGACGAGGAGAGAAGTGGAAGCTAAATTTTGTAATCTGTCTTTGTCTTCTAATAGTCTGTGTCGACTCTACAAGTTT ATTGAACAGAAGGGAGATTTGCAAGATCTTATGCCAACAATAAATTCATTAATAAAACAGAAAACAGGTATTGCACAGTTGGTGAAGTAT GGCTTAAAAGACCTAGAGGAGGTTGTTGGACTGTTGAAGAAACTCGGCATCAAGTTACAGGTCTTGATCAATTTGGGCTTGGTTTACAAG GTGCAGCAGCACAATGGAATCATCTTCCAGTTTGTGGCTTTCATCAAACGAAGGCAAAGGGCTGTACCTGAAATCCTCGCAGCTGGAGGC AGATATGACCTGCTGATTCCCCAGTTTAGAGGGCCACAAGCTCTGGGGCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATAGACAAG ATATCTGCTGCTGTCCTCAACATGGAGGAATCTGTTACAATAAGCTCTTGTGACCTCCTGGTTGTAAGTGTTGGCCAGATGTCTATGTCC AGGGCCATCAACCTAACCCAGAAACTCTGGACAGCAGGCATCACAGCAGAAATCATGTACGACTGGTCACAGTCCCAAGAGGAATTACAA GAGTACTGCAGACATCATGAAATCACCTATGTGGCCCTTGTCTCGGATAAAGAAGGAAGCCATGTCAAGGTATGTCATTGATGGTGCCAC TGCTCTTTGGTGTGCAGCTGGAGCAGGACATTTTGAAGTTGTTAAACTTCTAGTCAGCCATGGAGCCAACGTGAACCATACCACAGTAAC TAATTCAACCCCCCTGCGGGCAGCATGCTTTGATGGCAGACTGGACATTGTGAAATACTTGGTTGAAAATAATGCCAACATCAGCATTGC CAACAAATATGACAACACCTGCCTAATGATTGCGGCATATAAGGGACACACTGATGTGGTCAGATACCTTTTAGAACAACGTGCTGATCC CAATGCCAAAGCACATTGTGGAGCCACAGCATTGCACTTTGCAGCTGAAGCTGGGCACATAGATATTGTGAAAGAGCTGATAAAATGGCG TGCTGCTATAGTAGTGAATGGCCATGGGATGACGCCATTGAAAGTAGCTGCCGAAAGCTGTAAAGCTGATGTCGTAGAACTGTTACTCTC TCATGCTGATTGCGACCGAAGAAGTCGGATTGAAGCTTTGGAACTCTTGGGTGCCTCCTTTGCAAATGACCGTGAGAACTATGACATCAT AAAGACATACCACTATCTATATTTAGCCATGTTAGAGAGGTTCCAAGATGGTGATAACATTCTCGAAAAAGAGGTTCTTCCACCAATCCA TGCTTATGGGAATAGAACTGAATGTAGAAATCCTCAGGAACTGGAGTCCATTCGGCAAGACAGAGATGCTCTTCATATGGAAGGCCTTAT AGTTCGGGAACGGATTTTAGGTGCTGACAATATTGATGTTTCTCATCCCATCATTTACAGAGGAGCTGTTTATGCGGATAATATGGAATT TGAGCAGTGTATCAAGTTGTGGCTTCATGCCCTGCACCTCAGACAAAAAGGTAACAGGAACACCCACAAGGATCTTCTTCGATTTGCTCA AGTTTTCTCACAAATGATACATTTGAATGAAACTGTGAAGGCCCCAGACATAGAATGTGTTTTGAGATGCAGTGTTTTGGAAATAGAACA AAGTATGAACAGAGTGAAAAATATTTCAGATGCTGATGTCCACAATGCTATGGACAATTATGAATGTAATCTCTATACCTTTCTGTATTT AGTGTGCATCTCTACCAAAACACAGTGCAGCGAAGAAGATCAGTGCAAAATTAACAAGCAGATCTACAACCTGATTCACCTTGATCCCAG AACTCGTGAAGGTTTCACCTTGCTGCATCTGGCTGTCAATTCCAATACTCCAGTTGATGATTTCCACACCAATGACGTCTGCAGCTTTCC AAATGCACTTGTCACAAAGCTCCTGCTGGACTGTGGTGCTGAGGTGAATGCCGTGGACAATGAGGGAAACAGTGCCCTTCATATTATCGT TCAGTACAACAGGCCCATCAGTGATTTTTTGACCTTGCACTCCATCATCATTAGCCTAGTTGAAGCCGGAGCTCACACTGACATGACGAA TAAACAGAATAAGACTCCGCTAGACAAAAGTACAACTGGGGTATCTGAAATACTGCTTAAAACTCAAATGAAGATGAGTCTCAAGTGCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EIF2AK4_ENST00000382727_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_10614nt GGCCCACCGCCGCCCAGGCAAGGCCGCCCTGCCTTGGGCGCAGCGCTGCCATGGCTGGGGGCCGTGGGGCCCCCGGGCGCGGCCGGGACG AGCCTCCGGAGAGCTACCCGCAACGACAGGACCACGAGCTACAGGCCCTGGAGGCCATTTACGGCGCGGACTTCCAAGACCTGCGGCCGG ACGCTTGCGGACCGGTCAAAGAGCCCCCTGAAATCAATTTAGTTTTGTACCCTCAAGGCCTAACTGGTGAAGAAGTATATGTAAAAGTGG ATTTGAGGGTTAAATGCCCACCTACCTATCCAGATGTAGTTCCTGAAATAGAGTTAAAAAATGCCAAAGGTCTATCAAATGAAAGTGTCA ATTTGTTAAAATCTCGCCTAGAAGAACTGGCCAAGAAACACTGTGGGGAGGTGATGATCTTTGAACTGGCTTACCACGTGCAGTCATTTC TCAGCGAGCATAACAAGCCCCCTCCCAAGTCTTTTCATGAAGAAATGCTGGAAAGGCGGGCTCAGGAGGAGCAGCAGAGGCTGTTGGAGG CCAAGCGGAAAGAAGAGCAGGAGCAACGTGAAATCCTGCATGAGATTCAGAGAAGGAAAGAAGAGATAAAAGAAGAGAAAAAAAGGAAAG AAATGGCTAAGCAGGAACGTTTGGAAATTGCTAGTTTGTCAAACCAAGATCATACCTCTAAGAAGGACCCAGGAGGACACAGAACGGCTG CCATTCTACATGGAGGCTCTCCTGACTTTGTAGGAAATGGTAAACATCGGGCAAACTCCTCAGGAAGGTCTAGGCGAGAACGTCAGTATT CTGTATGTAATAGTGAAGATTCTCCTGGCTCTTGTGAAATTCTGTATTTCAATATGGGGAGTCCTGATCAGCTCATGGTGCACAAAGGGA AATGTATTGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTGGAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGG TCCTTCAGTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAAGAGAAGATTGATAAGTGCAAAAAGCAGATTCAAGGAACAG AAACAGAATTCAACTCACTGGTAAAATTGAGCCATCCAAATGTAGTACGCTACCTTGCAATGAATCTCAAAGAGCAAGACGACTCCATCG TGGTGGACATTTTAGTGGAGCACATTAGTGGGGTCTCTCTTGCTGCACACCTGAGCCACTCAGGCCCCATCCCTGTGCATCAGCTTCGCA GGTACACAGCTCAGCTCCTGTCAGGCCTTGATTATCTGCACAGCAATTCTGTGGTGCATAAGGTCCTGAGTGCATCTAATGTCTTGGTGG ATGCAGAAGGCACCGTCAAGATTACGGACTATAGCATTTCTAAGCGCCTCGCAGACATTTGCAAGGAGGATGTGTTTGAGCAAACCCGAG TTCGTTTTAGTGACAATGCTCTGCCTTATAAAACGGGGAAGAAAGGAGATGTTTGGCGTCTTGGCCTTCTGCTGCTGTCCCTCAGCCAAG GACAGGAATGTGGAGAGTACCCTGTGACCATCCCTAGTGACTTACCAGCTGACTTTCAAGATTTTCTAAAGAAATGTGTGTGCTTGGATG ACAAGGAAAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAATCCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAG ATTCTGAAGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTACCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTT CCCGATACTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCTTTTGGAGCTGTCATCAAGGTGCAGAACAAGTTGGACGGCT GCTGCTACGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTCCGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCTGC ACCATGAGAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAGCGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGC CCCTGGCCAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACAGACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCA TCCTCAGCAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGTGCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACG AGGACGACGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTGCCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATG AAGATGAGAACAGTAAAAGTCAGAATCAGATGGAGTACTGTGAGAAGAGCACTTTACGAGACACCATTGACCAGGGACTGTATCGAGACA CCGTCAGACTCTGGAGGCTTTTTCGAGAGATTCTGGATGGATTAGCTTATATCCATGAGAAAGGAATGATTCACCGGGATTTGAAGCCTG TCAACATTTTTTTGGATTCTGATGACCATGTGAAAATAGGTGATTTTGGTTTGGCGACAGACCATCTAGCCTTTTCTGCTGACAGCAAAC AAGACGATCAGACAGGAGACTTGATTAAGTCAGACCCTTCAGGTCACTTAACTGGGATGGTTGGCACTGCTCTCTATGTAAGCCCAGAGG TCCAAGGAAGCACCAAATCTGCATACAACCAGAAAGTGGATCTCTTCAGCCTGGGAATTATCTTCTTTGAGATGTCCTATCACCCCATGG TCACGGCTTCAGAAAGGATCTTTGTTCTCAACCAACTCAGAGATCCCACTTCGCCTAAGTTTCCAGAAGACTTTGACGATGGAGAGCATG CAAAGCAGAAATCAGTCATCTCCTGGCTGTTGAACCACGATCCAGCAAAACGGCCCACAGCCACAGAACTGCTCAAGAGTGAGCTGCTGC CCCCACCCCAGATGGAGGAGTCAGAGCTGCATGAAGTGCTGCACCACACGCTGACCAACGTGGATGGGAAGGCCTACCGCACCATGATGG CCCAGATCTTCTCGCAGCGCATCTCCCCTGCCATCGATTACACCTATGACAGCGACATACTGAAGGGCAACTTCTCAATCCGTACAGCCA AGATGCAGCAGCATGTGTGTGAAACCATCATCCGCATCTTTAAAAGACATGGAGCTGTTCAGTTGTGTACTCCACTACTGCTTCCCCGAA ACAGACAAATATATGAGCACAACGAAGCTGCCCTATTCATGGACCACAGCGGGATGCTGGTGATGCTTCCTTTTGACCTGCGGATCCCTT TTGCAAGATATGTGGCAAGAAATAATATATTGAATTTAAAACGATACTGCATAGAACGTGTGTTCAGGCCGCGCAAGTTAGATCGATTTC ATCCCAAAGAACTTCTGGAGTGTGCATTTGATATTGTCACTTCTACCACCAACAGCTTTCTGCCCACTGCTGAAATTATCTACACTATCT ATGAAATCATCCAAGAGTTTCCAGCACTTCAGGAAAGAAATTACAGTATTTATTTGAACCATACCATGTTATTGAAAGCAATACTCTTAC ACTGTGGGATCCCAGAAGATAAACTCAGTCAAGTCTACATTATTCTGTATGATGCTGTGACAGAGAAGCTGACGAGGAGAGAAGTGGAAG CTAAATTTTGTAATCTGTCTTTGTCTTCTAATAGTCTGTGTCGACTCTACAAGTTTATTGAACAGAAGGGAGATTTGCAAGATCTTATGC CAACAATAAATTCATTAATAAAACAGAAAACAGGTATTGCACAGTTGGTGAAGTATGGCTTAAAAGACCTAGAGGAGGTTGTTGGACTGT TGAAGAAACTCGGCATCAAGTTACAGGTCTTGATCAATTTGGGCTTGGTTTACAAGGTGCAGCAGCACAATGGAATCATCTTCCAGTTTG TGGCTTTCATCAAACGAAGGCAAAGGGCTGTACCTGAAATCCTCGCAGCTGGAGGCAGATATGACCTGCTGATTCCCCAGTTTAGAGGGC CACAAGCTCTGGGGCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATAGACAAGATATCTGCTGCTGTCCTCAACATGGAGGAATCTG TTACAATAAGCTCTTGTGACCTCCTGGTTGTAAGTGTTGGCCAGATGTCTATGTCCAGGGCCATCAACCTAACCCAGAAACTCTGGACAG CAGGCATCACAGCAGAAATCATGTACGACTGGTCACAGTCCCAAGAGGAATTACAAGAGTACTGCAGACATCATGAAATCACCTATGTGG CCCTTGTCTCGGATAAAGAAGGAAGCCATGTCAAGGTATGTCATTGATGGTGCCACTGCTCTTTGGTGTGCAGCTGGAGCAGGACATTTT GAAGTTGTTAAACTTCTAGTCAGCCATGGAGCCAACGTGAACCATACCACAGTAACTAATTCAACCCCCCTGCGGGCAGCATGCTTTGAT GGCAGACTGGACATTGTGAAATACTTGGTTGAAAATAATGCCAACATCAGCATTGCCAACAAATATGACAACACCTGCCTAATGATTGCG GCATATAAGGGACACACTGATGTGGTCAGATACCTTTTAGAACAACGTGCTGATCCCAATGCCAAAGCACATTGTGGAGCCACAGCATTG CACTTTGCAGCTGAAGCTGGGCACATAGATATTGTGAAAGAGCTGATAAAATGGCGTGCTGCTATAGTAGTGAATGGCCATGGGATGACG CCATTGAAAGTAGCTGCCGAAAGCTGTAAAGCTGATGTCGTAGAACTGTTACTCTCTCATGCTGATTGCGACCGAAGAAGTCGGATTGAA GCTTTGGAACTCTTGGGTGCCTCCTTTGCAAATGACCGTGAGAACTATGACATCATAAAGACATACCACTATCTATATTTAGCCATGTTA GAGAGGTTCCAAGATGGTGATAACATTCTCGAAAAAGAGGTTCTTCCACCAATCCATGCTTATGGGAATAGAACTGAATGTAGAAATCCT CAGGAACTGGAGTCCATTCGGCAAGACAGAGATGCTCTTCATATGGAAGGCCTTATAGTTCGGGAACGGATTTTAGGTGCTGACAATATT GATGTTTCTCATCCCATCATTTACAGAGGAGCTGTTTATGCGGATAATATGGAATTTGAGCAGTGTATCAAGTTGTGGCTTCATGCCCTG CACCTCAGACAAAAAGGTAACAGGAACACCCACAAGGATCTTCTTCGATTTGCTCAAGTTTTCTCACAAATGATACATTTGAATGAAACT GTGAAGGCCCCAGACATAGAATGTGTTTTGAGATGCAGTGTTTTGGAAATAGAACAAAGTATGAACAGAGTGAAAAATATTTCAGATGCT GATGTCCACAATGCTATGGACAATTATGAATGTAATCTCTATACCTTTCTGTATTTAGTGTGCATCTCTACCAAAACACAGTGCAGCGAA GAAGATCAGTGCAAAATTAACAAGCAGATCTACAACCTGATTCACCTTGATCCCAGAACTCGTGAAGGTTTCACCTTGCTGCATCTGGCT GTCAATTCCAATACTCCAGTTGATGATTTCCACACCAATGACGTCTGCAGCTTTCCAAATGCACTTGTCACAAAGCTCCTGCTGGACTGT GGTGCTGAGGTGAATGCCGTGGACAATGAGGGAAACAGTGCCCTTCATATTATCGTTCAGTACAACAGGCCCATCAGTGATTTTTTGACC TTGCACTCCATCATCATTAGCCTAGTTGAAGCCGGAGCTCACACTGACATGACGAATAAACAGAATAAGACTCCGCTAGACAAAAGTACA ACTGGGGTATCTGAAATACTGCTTAAAACTCAAATGAAGATGAGTCTCAAGTGCCTGGCTGCCCGAGCAGTTCGGGCTAATGACATTAAC TACCAAGACCAGATCCCCAGAACTCTTGAAGAGTTTGTTGGATTTCATTAAGTGACTGGATATGTAAAGTCGTTTAATGTGGTGCTAAAA AGTAAAGGACTTTTAATCACAGACAGTAGAATTATGTGTTCATAAATTCTGCTTTTCTTTCCACTACCCTTCCTCCCATCCCATCCTTCC TTAGTTCTGTATTTGTTTTTCTTGCCTCATGGTAATTGATTTCAGACAGACTTTAACAAAACCACATTGTTTTGGTGTAACTATAAGGTA TTTGCATATTGGTTACCTATTTGTCTTTCTTTTTTTTAAAGGAACAGATATAAAATGTTTTGTTTATGTAACAAGGGACATTTATAATTT CAAGTTGATAATGTTTTAAACAGCTGCTTACAAAAGTATTTCTGTTAAGCCTATGTCAGCATGTTATCCATGCAGCAGTTTTGAGGATTT TATGAAGAAAAAGAGCTAAAAAGGAACATTAAGAGGAATGGGATATCCAGGTGTTCTGCACATGCCAAACTGCTGTAGATAGTTTACACT CTTCCATTATTTATACGGAGTGATGCAGCACATTTTAGCATTCAGGAGGATTTTTAAAAAATAGCTGCAGATTAATCTGGAAAATGTGCT AATTTAATAATAGTTACAAATTTATAAATTTAAATCCATTTGAAATTGTTGCATTATGCTGGGTAGTATATACAAAATGGTTATCATCTT AAACCAACTTTTCAGAGAATCTTGATGGACTCTGCCTTTAGGCTTGAATTCTTCAAAGTCTATTTTAATGAAATTTATCTAAATTGCAGC AGTCTATTTGATTCAGCTCATAGACATGTAAAAATTATGAATGCTGTTTTCTTATGAAACAAATTGTCACAGTGTAGTTATACATTCTAT TTTTGTCCCCTTTTCCCTTTTTCTCCTGTATCTTTTAAAATTTGGAAACTACTTTTCCAGAAGGCATTATTTATGCCTCCCTAATAAGGT ATTTTACTTATGACAGATGAAAAGGAACCAGGATATGTTTGAATTTTTTCACTTTCTTAGTCTGTGACAAGAAGTAGAAATATCACTAGT GTGGTATAGGAACTTACATGTTTTTTATGATGAAAATAATTCTCAATGCCACTTGAAAGGTAATTGTGTCTGAGAGCTGCAAATTTTTCA ACCACAAAATGTCACTTATTCCTACAGGCTATACAGAGGTCTTTATGGTTTTTTTGTTTTGTTTTAATGGCAACATTGTAACTGTCAAAC TAAAAGGGTATTCTGTGATTATCTTTTAAGCATTACAGAAATTCAAGTGAAAGTTATATGCTTATTTCTATTGATGTTAAAAATGATAAT GAAAGCAAAATTAGCTGTATCTGTAATTTTCTCTCTAGTGCCAAATGAATGCCTTAGCTACTCATAGTGCATGGTACTGTAAGTGAAGAC CTGTAGCTTTTTTTTTTTCTTTAATGAAAAGCATTATAATGATGTAGCAGCATCAGATATAAACTTAAAAAAAAAGGTTTCAATTAACAT TTTATATATGGATAATGCTTTGTAAAGTGTAAGAGAAAGGTTGCAGTTGGATCAGTATAAAACAATGACCAAGCCAAAATCAGCACCCTA GGGCCTTAAATAAAATAGAGATACCCCACAAAATGAAATATTTTGAAGGATGGGAGGGGACAGAAGGGGGGACTATCCCCCAAGGATGCA AGATACTTTTTACAGTTGCTATCATTATACTTTGTCTTCTTGCTTCAGTTAGGAAGGTTTTGATGGTAAATTCTGTCATGGTAATAGATA CCTATTTTCCTAACCTGAGATTTTACAAGGAAGGTTTTTAGGTTGGCTTAAATGGAGGTATTTATTTGAGTGAGCCCTAATTTGAAAATT ACCAGACTTGATCCTCCTGGTATGAATCAAGGAAATACTGTACCTTGCTCTTAGCAACTCTCAGTGGCCTGAAAGAGAAAATGCACTTCT TCAAGGTGAGTGAATCATGCTTTTTCCACAGTTCAGATCAGACCCTTTATTTTTCAAACTACAAGGCCTGCTTATTGGACAGTCTAAGGA ATAGCTTTGATACTTGGTATTCAGTTGGTTCCATTATTAATGTATATTATTTTTATTTAAACATCAAAACTTAAAATATCAGATAATGTT GCATGTTTTAAAAACACATTTCATCCCTTTGGCTACCCAGGACCAGCACTATTTAAGACACTGCTTATTTATAAAATGAGAATAATGATT ATATGTACATATTCAGACATCAAAATTTAATGACATTCTATTTTGAGAAGGGAAGACAATGCTGAAGAAAGTAAAACTGTTGATTGAAAT GCTGACAGGGTGGAGAACGAATTTGAAGACAGTGGAATAAACTATGAACTATGCTAATGGTAATTAGATTTTTTGTTTGTTTAGTATAGT GGTAAATTGTGTAGTATCTTGCTGAGAATCTAATTCTATCTTGTAAAATCAATCCAAATGTGTATTGTGAAACACCTGTATAAAATCATT TTTGAAATAAGTGATCTACATGCCTGTTTTTTTAAAATGTTTTTGGTAGAATTGTTTGAAAATATGTTTAGCCAGACCCTTCCCCAACTT AATTTTTTTTTAAAAAAGGAAAATAGGTAAGAAAATGATAGTTCTATATCTCAGCCCTCTGTGAACTCTAGGCTGTCTCCATTTTGCAGC CACTTTGGTCATTTGATGTTTACTATTGGTATACTTATGCTTTGAATTGTAAATCTTCATTGATGGTATTACAGATTCAACCAAAACTTC TCTGTCCTGTTCAGTAATTGTTATATAAATCTGGATGAGCTAGGGAGGCCCAGGTGGATGTTTTCATTCGCAAATCATGAGAAACTTAAG TGGGTTTTATGCACTTGATAGAGTTGGCAAAATTGAACTATGAAGTTAACTATTTAACTCAAGGAATGGGCGGCAAACCCATCCCCTCGA TTGATAAAGAAGGGGAACATTTTTACATTAGAACTGACACTGAAAACATAGCTTTTTCAGTCCACCCTGGTTGCTCTAGTAGCCCACAGC CCAATCACGTTAAGGTTCTTTGCTGTGGGAATTTTAAATAAACCAAACCCCAAAGCAGACCATCTGTAAGCTTTGGTCTGCTTGTTTCTG AGAAGGGTTTTATTTCATTATACTAATAGTGGACTAATAATTGGTAATTGTGAGAACTTAGGTATGATAACATTGTTTGAAGTAAAATAT GATTTGGGGGCAGCAGCTTTCTAAATACCAACTCTGTTTGACAAATGTTTTGAAAATTAAAATTTCAAGTGAGCAACACCCTGTTAAGAG TTTTCACTATAGTTGAGGCAGCTACTTTATGAATAAGACCACTTTGGGTTATTTAAGCAGAAGCGTTTCTTTTTTTTTTTTGGAATGGGG TGGGATGAGGAGTGAGTTGCCAGACCTTTGATTAGTTTGCTGGTTTAGAAACAGCCAGTGGCTGAATTAGTGAGTAAATGAATGAAAGTA TAAAGGACTTGTTTTTTATGATAGATTTTCTGTAAGAATCTTAAATGTTCCTTTTCAAATTAGATGTGTTGATGCACACATGACTATTCT GTTTTTCTCACTGACTATATAACATTAAAAAGGGGTTAAAGAAAACAAAACTCTGCCTTTTGTGCTATGAAATATTTTTAGTCCAGAGGT TTTAAGCTGTGTGTCCATTCCTACTCTGAAAATGCATAGCTTTGTTCTGGATGTCATCTCTTGAAAGTAGAAAACTCCTATGTGTTTATC ACATTGCAGGGCTTTCTTATGTATTTCTGGCAGACTTGCCCAAATCTTTAGATGGGCTGGGTTATACAGCATGCCCTCCCCCAAATAAGG GATCTGAAATAAATACTACACTATTGATAGTGGAGATATATTAATTTTTAAAACTGTAAAGTAAATGTGGTCTCTAGGTTTGTGGTGTGT ACCTTTGTGTTAATGTGTAGGGAAGAGACAGTGACTTGATGGTTATGGGGAGTGTATCTTGATGTGTGTATAGGGGTAAGTATTGCTAAA TTATTTACAGCTTTTATTCAGGGTGAGTCATGTGATGAATGGCCTAATCAGAAAAGTGAAGGAGCGAAGATGCAAGCTTGCCAAATGATG AAATGAACAAGATTTTGTATCTATTTTTTATCAGGTGTTGTAAAATTTGTGCATGGCTTTTTGTTGTTGTTGCTTAGTAACTGGTAGAGG AGAAAAGATGAGGAAAGAAACTCAGCTTTCCTCACAGTCTTTTCAAAGGTACACAGTTGGGGAGTAAAATCTGACTGGCCTAATCGATGG AAAAGACCCTGTCCTTTTCACCCCATCCTGCAATCCTCCGTGCAGAGGAACTACACTGTTGTATTCTAGTAATTCACTGTGATTTATAAC AAACCGGTGATGTCATTCTATTGTGCACTTTTGTCAAACCATTTATGTGACTTTAATAAACATAGTAAACTTGCTGACTGCACCAGAGGT CCATTAGTGATTTATATATTGCATGACATTTTCTATTTGAGTTTGACATGTAGAGTCATTTTTAGTTTCATGGCAATTGACAGTCCTAAT >In-frame_EIF2AK4_ENST00000263791_chr15_40314806_+_FEM1B_ENST00000306917_chr15_68581945_+_10691nt CGCCGCCCAGGCAAGGCCGCCCTGCCTTGGGCGCAGCGCTGCCATGGCTGGGGGCCGTGGGGCCCCCGGGCGCGGCCGGGACGAGCCTCC GGAGAGCTACCCGCAACGACAGGACCACGAGCTACAGGCCCTGGAGGCCATTTACGGCGCGGACTTCCAAGACCTGCGGCCGGACGCTTG CGGACCGGTCAAAGAGCCCCCTGAAATCAATTTAGTTTTGTACCCTCAAGGCCTAACTGGTGAAGAAGTATATGTAAAAGTGGATTTGAG GGTTAAATGCCCACCTACCTATCCAGATGTAGTTCCTGAAATAGAGTTAAAAAATGCCAAAGGTCTATCAAATGAAAGTGTCAATTTGTT AAAATCTCGCCTAGAAGAACTGGCCAAGAAACACTGTGGGGAGGTGATGATCTTTGAACTGGCTTACCACGTGCAGTCATTTCTCAGCGA GCATAACAAGCCCCCTCCCAAGTCTTTTCATGAAGAAATGCTGGAAAGGCGGGCTCAGGAGGAGCAGCAGAGGCTGTTGGAGGCCAAGCG GAAAGAAGAGCAGGAGCAACGTGAAATCCTGCATGAGATTCAGAGAAGGAAAGAAGAGATAAAAGAAGAGAAAAAAAGGAAAGAAATGGC TAAGCAGGAACGTTTGGAAATTGCTAGTTTGTCAAACCAAGATCATACCTCTAAGAAGGACCCAGGAGGACACAGAACGGCTGCCATTCT ACATGGAGGCTCTCCTGACTTTGTAGGAAATGGTAAACATCGGGCAAACTCCTCAGGAAGGTCTAGGCGAGAACGTCAGTATTCTGTATG TAATAGTGAAGATTCTCCTGGCTCTTGTGAAATTCTGTATTTCAATATGGGGAGTCCTGATCAGCTCATGGTGCACAAAGGGAAATGTAT TGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTGGAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGGTCCTTCA GTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAAGAGAAGATTGATAAGTGCAAAAAGCAGATTCAAGGAACAGAAACAGA ATTCAACTCACTGGTAAAATTGAGCCATCCAAATGTAGTACGCTACCTTGCAATGAATCTCAAAGAGCAAGACGACTCCATCGTGGTGGA CATTTTAGTGGAGCACATTAGTGGGGTCTCTCTTGCTGCACACCTGAGCCACTCAGGCCCCATCCCTGTGCATCAGCTTCGCAGGTACAC AGCTCAGCTCCTGTCAGGCCTTGATTATCTGCACAGCAATTCTGTGGTGCATAAGGTCCTGAGTGCATCTAATGTCTTGGTGGATGCAGA AGGCACCGTCAAGATTACGGACTATAGCATTTCTAAGCGCCTCGCAGACATTTGCAAGGAGGATGTGTTTGAGCAAACCCGAGTTCGTTT TAGTGACAATGCTCTGCCTTATAAAACGGGGAAGAAAGGAGATGTTTGGCGTCTTGGCCTTCTGCTGCTGTCCCTCAGCCAAGGACAGGA ATGTGGAGAGTACCCTGTGACCATCCCTAGTGACTTACCAGCTGACTTTCAAGATTTTCTAAAGAAATGTGTGTGCTTGGATGACAAGGA AAGATGGAGTCCCCAGCAGTTGTTGAAACACAGCTTTATAAATCCCCAGCCAAAAATGCCTCTAGTGGAACAAAGTCCTGAAGATTCTGA AGGACAAGATTATGTTGAGACTGTTATTCCTAGCAACCGGCTACCCAGTGCTGCCTTCTTTAGTGAGACACAGAGACAGTTTTCCCGATA CTTCATTGAGTTTGAAGAATTACAACTTCTTGGTAAAGGAGCTTTTGGAGCTGTCATCAAGGTGCAGAACAAGTTGGACGGCTGCTGCTA CGCAGTGAAGCGCATCCCCATCAACCCGGCCAGCCGGCAGTTCCGCAGGATCAAGGGCGAAGTGACACTGCTGTCACGGCTGCACCATGA GAACATTGTGCGCTACTACAACGCCTGGATCGAGCGGCACGAGCGGCCGGCGGGACCGGGGACGCCGCCCCCGGACTCCGGGCCCCTGGC CAAGGATGACCGAGCTGCACGCGGGCAGCCGGCGAGCGACACAGACGGCCTGGACAGCGTAGAGGCCGCCGCGCCGCCACCCATCCTCAG CAGCTCGGTGGAGTGGAGCACTTCGGGCGAGCGCTCGGCCAGTGCCCGTTTCCCCGCCACCGGCCCGGGCTCCAGCGATGACGAGGACGA CGACGAGGACGAGCACGGTGGCGTCTTCTCCCAGTCCTTCCTGCCTGCTTCAGATTCTGAAAGTGATATTATCTTTGACAATGAAGATGA GAACAGTAAAAGTCAGAATCAGGATGAAGATTGCAATGAAAAGAATGGCTGCCATGAAAGTGAGCCATCAGTGACGACTGAGGCTGTGCA CTACCTATACATCCAGATGGAGTACTGTGAGAAGAGCACTTTACGAGACACCATTGACCAGGGACTGTATCGAGACACCGTCAGACTCTG GAGGCTTTTTCGAGAGATTCTGGATGGATTAGCTTATATCCATGAGAAAGGAATGATTCACCGGGATTTGAAGCCTGTCAACATTTTTTT GGATTCTGATGACCATGTGAAAATAGGTGATTTTGGTTTGGCGACAGACCATCTAGCCTTTTCTGCTGACAGCAAACAAGACGATCAGAC AGGAGACTTGATTAAGTCAGACCCTTCAGGTCACTTAACTGGGATGGTTGGCACTGCTCTCTATGTAAGCCCAGAGGTCCAAGGAAGCAC CAAATCTGCATACAACCAGAAAGTGGATCTCTTCAGCCTGGGAATTATCTTCTTTGAGATGTCCTATCACCCCATGGTCACGGCTTCAGA AAGGATCTTTGTTCTCAACCAACTCAGAGATCCCACTTCGCCTAAGTTTCCAGAAGACTTTGACGATGGAGAGCATGCAAAGCAGAAATC AGTCATCTCCTGGCTGTTGAACCACGATCCAGCAAAACGGCCCACAGCCACAGAACTGCTCAAGAGTGAGCTGCTGCCCCCACCCCAGAT GGAGGAGTCAGAGCTGCATGAAGTGCTGCACCACACGCTGACCAACGTGGATGGGAAGGCCTACCGCACCATGATGGCCCAGATCTTCTC GCAGCGCATCTCCCCTGCCATCGATTACACCTATGACAGCGACATACTGAAGGGCAACTTCTCAATCCGTACAGCCAAGATGCAGCAGCA TGTGTGTGAAACCATCATCCGCATCTTTAAAAGACATGGAGCTGTTCAGTTGTGTACTCCACTACTGCTTCCCCGAAACAGACAAATATA TGAGCACAACGAAGCTGCCCTATTCATGGACCACAGCGGGATGCTGGTGATGCTTCCTTTTGACCTGCGGATCCCTTTTGCAAGATATGT GGCAAGAAATAATATATTGAATTTAAAACGATACTGCATAGAACGTGTGTTCAGGCCGCGCAAGTTAGATCGATTTCATCCCAAAGAACT TCTGGAGTGTGCATTTGATATTGTCACTTCTACCACCAACAGCTTTCTGCCCACTGCTGAAATTATCTACACTATCTATGAAATCATCCA AGAGTTTCCAGCACTTCAGGAAAGAAATTACAGTATTTATTTGAACCATACCATGTTATTGAAAGCAATACTCTTACACTGTGGGATCCC AGAAGATAAACTCAGTCAAGTCTACATTATTCTGTATGATGCTGTGACAGAGAAGCTGACGAGGAGAGAAGTGGAAGCTAAATTTTGTAA TCTGTCTTTGTCTTCTAATAGTCTGTGTCGACTCTACAAGTTTATTGAACAGAAGGGAGATTTGCAAGATCTTATGCCAACAATAAATTC ATTAATAAAACAGAAAACAGGTATTGCACAGTTGGTGAAGTATGGCTTAAAAGACCTAGAGGAGGTTGTTGGACTGTTGAAGAAACTCGG CATCAAGTTACAGGTCTTGATCAATTTGGGCTTGGTTTACAAGGTGCAGCAGCACAATGGAATCATCTTCCAGTTTGTGGCTTTCATCAA ACGAAGGCAAAGGGCTGTACCTGAAATCCTCGCAGCTGGAGGCAGATATGACCTGCTGATTCCCCAGTTTAGAGGGCCACAAGCTCTGGG GCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATAGACAAGATATCTGCTGCTGTCCTCAACATGGAGGAATCTGTTACAATAAGCTC TTGTGACCTCCTGGTTGTAAGTGTTGGCCAGATGTCTATGTCCAGGGCCATCAACCTAACCCAGAAACTCTGGACAGCAGGCATCACAGC AGAAATCATGTACGACTGGTCACAGTCCCAAGAGGAATTACAAGAGTACTGCAGACATCATGAAATCACCTATGTGGCCCTTGTCTCGGA TAAAGAAGGAAGCCATGTCAAGGTATGTCATTGATGGTGCCACTGCTCTTTGGTGTGCAGCTGGAGCAGGACATTTTGAAGTTGTTAAAC TTCTAGTCAGCCATGGAGCCAACGTGAACCATACCACAGTAACTAATTCAACCCCCCTGCGGGCAGCATGCTTTGATGGCAGACTGGACA TTGTGAAATACTTGGTTGAAAATAATGCCAACATCAGCATTGCCAACAAATATGACAACACCTGCCTAATGATTGCGGCATATAAGGGAC ACACTGATGTGGTCAGATACCTTTTAGAACAACGTGCTGATCCCAATGCCAAAGCACATTGTGGAGCCACAGCATTGCACTTTGCAGCTG AAGCTGGGCACATAGATATTGTGAAAGAGCTGATAAAATGGCGTGCTGCTATAGTAGTGAATGGCCATGGGATGACGCCATTGAAAGTAG CTGCCGAAAGCTGTAAAGCTGATGTCGTAGAACTGTTACTCTCTCATGCTGATTGCGACCGAAGAAGTCGGATTGAAGCTTTGGAACTCT TGGGTGCCTCCTTTGCAAATGACCGTGAGAACTATGACATCATAAAGACATACCACTATCTATATTTAGCCATGTTAGAGAGGTTCCAAG ATGGTGATAACATTCTCGAAAAAGAGGTTCTTCCACCAATCCATGCTTATGGGAATAGAACTGAATGTAGAAATCCTCAGGAACTGGAGT CCATTCGGCAAGACAGAGATGCTCTTCATATGGAAGGCCTTATAGTTCGGGAACGGATTTTAGGTGCTGACAATATTGATGTTTCTCATC CCATCATTTACAGAGGAGCTGTTTATGCGGATAATATGGAATTTGAGCAGTGTATCAAGTTGTGGCTTCATGCCCTGCACCTCAGACAAA AAGGTAACAGGAACACCCACAAGGATCTTCTTCGATTTGCTCAAGTTTTCTCACAAATGATACATTTGAATGAAACTGTGAAGGCCCCAG ACATAGAATGTGTTTTGAGATGCAGTGTTTTGGAAATAGAACAAAGTATGAACAGAGTGAAAAATATTTCAGATGCTGATGTCCACAATG CTATGGACAATTATGAATGTAATCTCTATACCTTTCTGTATTTAGTGTGCATCTCTACCAAAACACAGTGCAGCGAAGAAGATCAGTGCA AAATTAACAAGCAGATCTACAACCTGATTCACCTTGATCCCAGAACTCGTGAAGGTTTCACCTTGCTGCATCTGGCTGTCAATTCCAATA CTCCAGTTGATGATTTCCACACCAATGACGTCTGCAGCTTTCCAAATGCACTTGTCACAAAGCTCCTGCTGGACTGTGGTGCTGAGGTGA ATGCCGTGGACAATGAGGGAAACAGTGCCCTTCATATTATCGTTCAGTACAACAGGCCCATCAGTGATTTTTTGACCTTGCACTCCATCA TCATTAGCCTAGTTGAAGCCGGAGCTCACACTGACATGACGAATAAACAGAATAAGACTCCGCTAGACAAAAGTACAACTGGGGTATCTG AAATACTGCTTAAAACTCAAATGAAGATGAGTCTCAAGTGCCTGGCTGCCCGAGCAGTTCGGGCTAATGACATTAACTACCAAGACCAGA TCCCCAGAACTCTTGAAGAGTTTGTTGGATTTCATTAAGTGACTGGATATGTAAAGTCGTTTAATGTGGTGCTAAAAAGTAAAGGACTTT TAATCACAGACAGTAGAATTATGTGTTCATAAATTCTGCTTTTCTTTCCACTACCCTTCCTCCCATCCCATCCTTCCTTAGTTCTGTATT TGTTTTTCTTGCCTCATGGTAATTGATTTCAGACAGACTTTAACAAAACCACATTGTTTTGGTGTAACTATAAGGTATTTGCATATTGGT TACCTATTTGTCTTTCTTTTTTTTAAAGGAACAGATATAAAATGTTTTGTTTATGTAACAAGGGACATTTATAATTTCAAGTTGATAATG TTTTAAACAGCTGCTTACAAAAGTATTTCTGTTAAGCCTATGTCAGCATGTTATCCATGCAGCAGTTTTGAGGATTTTATGAAGAAAAAG AGCTAAAAAGGAACATTAAGAGGAATGGGATATCCAGGTGTTCTGCACATGCCAAACTGCTGTAGATAGTTTACACTCTTCCATTATTTA TACGGAGTGATGCAGCACATTTTAGCATTCAGGAGGATTTTTAAAAAATAGCTGCAGATTAATCTGGAAAATGTGCTAATTTAATAATAG TTACAAATTTATAAATTTAAATCCATTTGAAATTGTTGCATTATGCTGGGTAGTATATACAAAATGGTTATCATCTTAAACCAACTTTTC AGAGAATCTTGATGGACTCTGCCTTTAGGCTTGAATTCTTCAAAGTCTATTTTAATGAAATTTATCTAAATTGCAGCAGTCTATTTGATT CAGCTCATAGACATGTAAAAATTATGAATGCTGTTTTCTTATGAAACAAATTGTCACAGTGTAGTTATACATTCTATTTTTGTCCCCTTT TCCCTTTTTCTCCTGTATCTTTTAAAATTTGGAAACTACTTTTCCAGAAGGCATTATTTATGCCTCCCTAATAAGGTATTTTACTTATGA CAGATGAAAAGGAACCAGGATATGTTTGAATTTTTTCACTTTCTTAGTCTGTGACAAGAAGTAGAAATATCACTAGTGTGGTATAGGAAC TTACATGTTTTTTATGATGAAAATAATTCTCAATGCCACTTGAAAGGTAATTGTGTCTGAGAGCTGCAAATTTTTCAACCACAAAATGTC ACTTATTCCTACAGGCTATACAGAGGTCTTTATGGTTTTTTTGTTTTGTTTTAATGGCAACATTGTAACTGTCAAACTAAAAGGGTATTC TGTGATTATCTTTTAAGCATTACAGAAATTCAAGTGAAAGTTATATGCTTATTTCTATTGATGTTAAAAATGATAATGAAAGCAAAATTA GCTGTATCTGTAATTTTCTCTCTAGTGCCAAATGAATGCCTTAGCTACTCATAGTGCATGGTACTGTAAGTGAAGACCTGTAGCTTTTTT TTTTTCTTTAATGAAAAGCATTATAATGATGTAGCAGCATCAGATATAAACTTAAAAAAAAAGGTTTCAATTAACATTTTATATATGGAT AATGCTTTGTAAAGTGTAAGAGAAAGGTTGCAGTTGGATCAGTATAAAACAATGACCAAGCCAAAATCAGCACCCTAGGGCCTTAAATAA AATAGAGATACCCCACAAAATGAAATATTTTGAAGGATGGGAGGGGACAGAAGGGGGGACTATCCCCCAAGGATGCAAGATACTTTTTAC AGTTGCTATCATTATACTTTGTCTTCTTGCTTCAGTTAGGAAGGTTTTGATGGTAAATTCTGTCATGGTAATAGATACCTATTTTCCTAA CCTGAGATTTTACAAGGAAGGTTTTTAGGTTGGCTTAAATGGAGGTATTTATTTGAGTGAGCCCTAATTTGAAAATTACCAGACTTGATC CTCCTGGTATGAATCAAGGAAATACTGTACCTTGCTCTTAGCAACTCTCAGTGGCCTGAAAGAGAAAATGCACTTCTTCAAGGTGAGTGA ATCATGCTTTTTCCACAGTTCAGATCAGACCCTTTATTTTTCAAACTACAAGGCCTGCTTATTGGACAGTCTAAGGAATAGCTTTGATAC TTGGTATTCAGTTGGTTCCATTATTAATGTATATTATTTTTATTTAAACATCAAAACTTAAAATATCAGATAATGTTGCATGTTTTAAAA ACACATTTCATCCCTTTGGCTACCCAGGACCAGCACTATTTAAGACACTGCTTATTTATAAAATGAGAATAATGATTATATGTACATATT CAGACATCAAAATTTAATGACATTCTATTTTGAGAAGGGAAGACAATGCTGAAGAAAGTAAAACTGTTGATTGAAATGCTGACAGGGTGG AGAACGAATTTGAAGACAGTGGAATAAACTATGAACTATGCTAATGGTAATTAGATTTTTTGTTTGTTTAGTATAGTGGTAAATTGTGTA GTATCTTGCTGAGAATCTAATTCTATCTTGTAAAATCAATCCAAATGTGTATTGTGAAACACCTGTATAAAATCATTTTTGAAATAAGTG ATCTACATGCCTGTTTTTTTAAAATGTTTTTGGTAGAATTGTTTGAAAATATGTTTAGCCAGACCCTTCCCCAACTTAATTTTTTTTTAA AAAAGGAAAATAGGTAAGAAAATGATAGTTCTATATCTCAGCCCTCTGTGAACTCTAGGCTGTCTCCATTTTGCAGCCACTTTGGTCATT TGATGTTTACTATTGGTATACTTATGCTTTGAATTGTAAATCTTCATTGATGGTATTACAGATTCAACCAAAACTTCTCTGTCCTGTTCA GTAATTGTTATATAAATCTGGATGAGCTAGGGAGGCCCAGGTGGATGTTTTCATTCGCAAATCATGAGAAACTTAAGTGGGTTTTATGCA CTTGATAGAGTTGGCAAAATTGAACTATGAAGTTAACTATTTAACTCAAGGAATGGGCGGCAAACCCATCCCCTCGATTGATAAAGAAGG GGAACATTTTTACATTAGAACTGACACTGAAAACATAGCTTTTTCAGTCCACCCTGGTTGCTCTAGTAGCCCACAGCCCAATCACGTTAA GGTTCTTTGCTGTGGGAATTTTAAATAAACCAAACCCCAAAGCAGACCATCTGTAAGCTTTGGTCTGCTTGTTTCTGAGAAGGGTTTTAT TTCATTATACTAATAGTGGACTAATAATTGGTAATTGTGAGAACTTAGGTATGATAACATTGTTTGAAGTAAAATATGATTTGGGGGCAG CAGCTTTCTAAATACCAACTCTGTTTGACAAATGTTTTGAAAATTAAAATTTCAAGTGAGCAACACCCTGTTAAGAGTTTTCACTATAGT TGAGGCAGCTACTTTATGAATAAGACCACTTTGGGTTATTTAAGCAGAAGCGTTTCTTTTTTTTTTTTGGAATGGGGTGGGATGAGGAGT GAGTTGCCAGACCTTTGATTAGTTTGCTGGTTTAGAAACAGCCAGTGGCTGAATTAGTGAGTAAATGAATGAAAGTATAAAGGACTTGTT TTTTATGATAGATTTTCTGTAAGAATCTTAAATGTTCCTTTTCAAATTAGATGTGTTGATGCACACATGACTATTCTGTTTTTCTCACTG ACTATATAACATTAAAAAGGGGTTAAAGAAAACAAAACTCTGCCTTTTGTGCTATGAAATATTTTTAGTCCAGAGGTTTTAAGCTGTGTG TCCATTCCTACTCTGAAAATGCATAGCTTTGTTCTGGATGTCATCTCTTGAAAGTAGAAAACTCCTATGTGTTTATCACATTGCAGGGCT TTCTTATGTATTTCTGGCAGACTTGCCCAAATCTTTAGATGGGCTGGGTTATACAGCATGCCCTCCCCCAAATAAGGGATCTGAAATAAA TACTACACTATTGATAGTGGAGATATATTAATTTTTAAAACTGTAAAGTAAATGTGGTCTCTAGGTTTGTGGTGTGTACCTTTGTGTTAA TGTGTAGGGAAGAGACAGTGACTTGATGGTTATGGGGAGTGTATCTTGATGTGTGTATAGGGGTAAGTATTGCTAAATTATTTACAGCTT TTATTCAGGGTGAGTCATGTGATGAATGGCCTAATCAGAAAAGTGAAGGAGCGAAGATGCAAGCTTGCCAAATGATGAAATGAACAAGAT TTTGTATCTATTTTTTATCAGGTGTTGTAAAATTTGTGCATGGCTTTTTGTTGTTGTTGCTTAGTAACTGGTAGAGGAGAAAAGATGAGG AAAGAAACTCAGCTTTCCTCACAGTCTTTTCAAAGGTACACAGTTGGGGAGTAAAATCTGACTGGCCTAATCGATGGAAAAGACCCTGTC CTTTTCACCCCATCCTGCAATCCTCCGTGCAGAGGAACTACACTGTTGTATTCTAGTAATTCACTGTGATTTATAACAAACCGGTGATGT CATTCTATTGTGCACTTTTGTCAAACCATTTATGTGACTTTAATAAACATAGTAAACTTGCTGACTGCACCAGAGGTCCATTAGTGATTT ATATATTGCATGACATTTTCTATTTGAGTTTGACATGTAGAGTCATTTTTAGTTTCATGGCAATTGACAGTCCTAATAACTCAGCTAATT |
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FusionGenePPI for EIF2AK4_FEM1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF2AK4 | USP46, GGNBP1, ARRB2, TRAP1, FAM153B, PPP1CC, PPP1CA, CROT, TARS, MATR3, LRPPRC, DEF8, TKT, PALM2, PSMC3, MDM4, C6orf141, CRYL1 | FEM1B | COPS6, TCEB1, GNB2L1, KIAA0319, TCEB2, CUL2, CUL5, COPS5, DCUN1D1, NEDD8, CHEK1, RAD9A, COPS4, RBX1, PPM1F, NKX3-1, HIF1AN, GLI1, MVB12B, DMWD, EPN3, TGFB1, COPS2, COPS3, WNT3A, CAMKMT, ALDH1B1, GAK, SLBP, TRIM44, GLMN, SYCE3, MAPK8IP1, BPNT1, COPS8, FOXRED2, OLFM2, BSPRY, COPS7B, GORASP1, SHKBP1, DLC1, KIF2B, RAB41, TOMM22, CNTF, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF2AK4_FEM1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF2AK4_FEM1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EIF2AK4 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
| Hgene | EIF2AK4 | C0018500 | Hair Diseases | 1 | CTD_human |
| Hgene | EIF2AK4 | C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| Hgene | EIF2AK4 | C0021053 | Immune System Diseases | 1 | CTD_human |
| Hgene | EIF2AK4 | C0026848 | Myopathy | 1 | CTD_human |
| Hgene | EIF2AK4 | C0034091 | Pulmonary Veno-Occlusive Disease (disorder) | 1 | CTD_human;ORPHANET |
| Hgene | EIF2AK4 | C0340848 | PULMONARY VENOOCCLUSIVE DISEASE 2, AUTOSOMAL RECESSIVE | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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