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Fusion gene ID: 11204 |
FusionGeneSummary for EIF2AK3_UGT2B4 |
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Fusion gene information | Fusion gene name: EIF2AK3_UGT2B4 | Fusion gene ID: 11204 | Hgene | Tgene | Gene symbol | EIF2AK3 | UGT2B4 | Gene ID | 9451 | 7363 |
Gene name | eukaryotic translation initiation factor 2 alpha kinase 3 | UDP glucuronosyltransferase family 2 member B4 | |
Synonyms | PEK|PERK|WRS | HLUG25|UDPGT2B4|UDPGTH1|UDPGTh-1|UGT2B11 | |
Cytomap | 2p11.2 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation initiation factor 2-alpha kinase 3PRKR-like endoplasmic reticulum kinasepancreatic EIF2-alpha kinase | UDP-glucuronosyltransferase 2B4UDP glucuronosyltransferase 2 family, polypeptide B4UDP-glucuronyltransferase, family 2, beta-4UDPGT 2B4hyodeoxycholic acidhyodeoxycholic acid-specific UDPGT | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NZJ5 | P06133 | |
Ensembl transtripts involved in fusion gene | ENST00000419748, ENST00000303236, ENST00000470706, | ENST00000381096, ENST00000512583, ENST00000305107, ENST00000506580, | |
Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: EIF2AK3 [Title/Abstract] AND UGT2B4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EIF2AK3 | GO:0006983 | ER overload response | 10677345|11907036 |
Hgene | EIF2AK3 | GO:0030968 | endoplasmic reticulum unfolded protein response | 10677345|11907036|22169477 |
Hgene | EIF2AK3 | GO:0046777 | protein autophosphorylation | 10026192|11907036 |
Tgene | UGT2B4 | GO:0052695 | cellular glucuronidation | 20056724 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI114505 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000419748 | ENST00000381096 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000419748 | ENST00000512583 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000419748 | ENST00000305107 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-5UTR | ENST00000419748 | ENST00000506580 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3CDS | ENST00000303236 | ENST00000381096 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000303236 | ENST00000512583 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000303236 | ENST00000305107 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-5UTR | ENST00000303236 | ENST00000506580 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3CDS | ENST00000470706 | ENST00000381096 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000470706 | ENST00000512583 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-3UTR | ENST00000470706 | ENST00000305107 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
intron-5UTR | ENST00000470706 | ENST00000506580 | EIF2AK3 | chr2 | 88922517 | + | UGT2B4 | chr4 | 70346360 | - |
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FusionProtFeatures for EIF2AK3_UGT2B4 |
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Hgene | Tgene |
EIF2AK3 | UGT2B4 |
Metabolic-stress sensing protein kinase thatphosphorylates the alpha subunit of eukaryotic translationinitiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during theunfolded protein response (UPR) and in response to low amino acidavailability. Converts phosphorylated eIF-2-alpha/EIF2S1 either ina global protein synthesis inhibitor, leading to a reduced overallutilization of amino acids, or to a translation initiationactivator of specific mRNAs, such as the transcriptional activatorATF4, and hence allowing ATF4-mediated reprogramming of amino acidbiosynthetic gene expression to alleviate nutrient depletion.Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1).Involved in control of mitochondrial morphology and function.{ECO:0000250|UniProtKB:Q9Z2B5}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EIF2AK3_UGT2B4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EIF2AK3_UGT2B4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EIF2AK3_UGT2B4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EIF2AK3_UGT2B4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EIF2AK3 | C0038220 | Status Epilepticus | 1 | CTD_human |
Hgene | EIF2AK3 | C0038868 | Progressive supranuclear palsy | 1 | CTD_human |
Hgene | EIF2AK3 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | EIF2AK3 | C0432217 | Wolcott-Rallison syndrome | 1 | CTD_human;ORPHANET;UNIPROT |