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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 11190

FusionGeneSummary for EIF1_MED28

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF1_MED28
Fusion gene ID: 11190
HgeneTgene
Gene symbol

EIF1

MED28

Gene ID

10209

80306

Gene nameeukaryotic translation initiation factor 1mediator complex subunit 28
SynonymsA121|EIF-1|EIF1A|ISO1|SUI11500003D12Rik|EG1|magicin
Cytomap

17q21.2

4p15.32

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 1protein translation factor SUI1 homologsui1iso1mediator of RNA polymerase II transcription subunit 28endothelial-derived gene 1endothelial-derived protein 1mediator of RNA polymerase II transcription, subunit 28 homologmerlin and Grb2-interacting cytoskeletal proteintumor angiogenesis marker EG-1
Modification date2018052320180523
UniProtAcc

P41567

Q9H204

Ensembl transtripts involved in fusion geneENST00000591776, ENST00000469257, 
ENST00000310837, 
ENST00000237380, 
ENST00000499786, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: EIF1 [Title/Abstract] AND MED28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF1

GO:0006446

regulation of translational initiation

22156057


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-D8-A1X5-01AEIF1chr17

39846193

+MED28chr4

17621524

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000591776ENST00000237380EIF1chr17

39846193

+MED28chr4

17621524

+
5CDS-intronENST00000591776ENST00000499786EIF1chr17

39846193

+MED28chr4

17621524

+
In-frameENST00000469257ENST00000237380EIF1chr17

39846193

+MED28chr4

17621524

+
5CDS-intronENST00000469257ENST00000499786EIF1chr17

39846193

+MED28chr4

17621524

+
intron-3CDSENST00000310837ENST00000237380EIF1chr17

39846193

+MED28chr4

17621524

+
intron-intronENST00000310837ENST00000499786EIF1chr17

39846193

+MED28chr4

17621524

+

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FusionProtFeatures for EIF1_MED28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF1

P41567

MED28

Q9H204

Necessary for scanning and involved in initiation siteselection. Promotes the assembly of 48S ribosomal complexes at theauthentic initiation codon of a conventional capped mRNA. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. May be part of a complex containingNF2/merlin that participates in cellular signaling to the actincytoskeleton downstream of tyrosine kinase signaling pathways.{ECO:0000269|PubMed:15467741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMED28chr17:39846193chr4:17621524ENST00000237380+04109_14553179Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for EIF1_MED28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_191aa
MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKACFASLVSQDYVNGTDQEEIRTGVD
QCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQAS

>In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_191aa
MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKACFASLVSQDYVNGTDQEEIRTGVD
QCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQAS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_573nt
ATGTCCGCTATCCAGAACCTCCACTCTTTCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTAT
ATCCATATAAGAATTCAACAGAGAAACGGCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTG
AAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGAT
CAGTGTATCCAGAAGTTTCTGGATATTGCAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAG
CAAGTTATCAAAGAGGATGTGTCAGAACTAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCAT
TGGCAGCAGGTGCTGGAGGACATCAACGTGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCT

>In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_573nt
ATGTCCGCTATCCAGAACCTCCACTCTTTCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTAT
ATCCATATAAGAATTCAACAGAGAAACGGCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTG
AAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGAT
CAGTGTATCCAGAAGTTTCTGGATATTGCAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAG
CAAGTTATCAAAGAGGATGTGTCAGAACTAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCAT
TGGCAGCAGGTGCTGGAGGACATCAACGTGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_11032nt
CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT
CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT
TCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTATATCCATATAAGAATTCAACAGAGAAACG
GCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTGAAGGCGTTTAAGAAAGCTTGCTTTGCAT
CTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGATCAGTGTATCCAGAAGTTTCTGGATATTG
CAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAGCAAGTTATCAAAGAGGATGTGTCAGAAC
TAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCATTGGCAGCAGGTGCTGGAGGACATCAACG
TGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCTGCCAACATCCCTGCACCTCTGAAGCCAA
CGTGAGCAAAGGGCAGAGGCAGTTGGCCTATGAGTGGGCTGATGCGTGAGGTTGGCCACACATTCCTTCCTGTGGACTTGACATTTTGGA
AGAACTCTTTGCCAGATAATGAGTTCATTTTAGTTTTATGCTCCCATTGAAAAATTTTCCACTATTTTTATAAGCTGTTAATTTCTTGAG
TACTTTATAACATGTCTGTAGCTTGGATAAACCAAGTAAGTATTTTTTTTTTGTCTTTAGCAAAGTTTAGACTGTGAATATGATGACACA
GATTCTTTTTTATGGTGGCTTTGCTTGTTTTAAATTTTTGCATGACTTTTCATCTTTTTATGTGTGTTTCCTGTAGTTTGATCCGAAGGA
AAAGAGTATAGTAGCCTGAGAATCAGGAGATGGGAGTTTTAGTCGTAGGCCTTATGATAATTACCCCGCGGTGGTGTGTAGAAAAGTATG
TAAATTTGCTCTGTTTTAAGACTTTGAACTACCTCAAGAAGAGGAATCTAATACAATATTTGTAATGTTTCCAGAGCTCTCAGAATGAGG
ATTTTTTTGTAAATAGGTCAGAAGACGATGGAACTGTCCTGGGTTAGTATAGTAATCTTACAGTAGGATCCTTAGGTTGATGCTGACTTC
TGTTTGGGGTATGTTTATATTTTATGTGGTGTTTACTTTTTTTTTTTGACATAGAAGGATATAGTGGGAGCAGTGATACGCTAACATTCA
TTACATTCTGCAGTAATGAATCTGTTTAATGGGTCAGTCACTGTTTTCAGTAGCATGACAGTGGGGTCATAGGTGAGCTGTGAGGGGCTA
AATCTTGCTCTGATTGTCTCTTTCTGTTTTGAGTTTTGTTTGCGTGTATCATTTTTGTTCTACATTTTGGGAGGGGAAACATTTTCCGTT
AAGGAAGGTTGTTGCCAGTGGATTTGACTCCAAGGGACTAGAGTGTCGTGGTGGGGGTGGGGAGGGGCTGCAGGGTGATCATTGGCTACT
GAGCCTCCACAGAGAGCATGTGGTGCCCTGCCTTTGGGAGGGTATTTTGCTCTCGTTAGTTTTGTGGGCAGCCTCAGATTCCCTGTTGAG
TTGCTGTTAAGAAATGGAGATTTCTGGCTCTCATTGGGTAAGGTTTTCTGAGTTTTATATCTTATTAGATCACATCCCTTTACCCAGAAC
AAATGCTTCACTGTCTTCTGATTGGCAGTACTCCTGTGGCTTTGTGCCTTGACTCATTTTGTTGTCTTCAGCCTTGAAGGCCCCTTCCCA
CATGGACTGACATCCACTCATGTGCCTGATCCCTGAAGCCTCCCAGCACCCATTCAGTTGCATCCCCAGGGCACAGGACTTTGATCTCTT
CTGTTGCCCTCGCTAGGTTCTCCCTGGTGGGTTAGTGCTTTGTATCTGTCTCTCTGCCCCTCACTAATTCTACACCCATGAGAATTAGAC
ATTATTCTCCTTAAATATATAAGGACCATATAATCTGTATCTTTTTGGTGTGTGTATATGGTATCTGGCACATGGATCTCTGATTACCAG
CCTGACATCAACAAATCCCCTCAGTTACAACGTATAGGTTAAACAAAGCTTTTAAAAGCTCATGTGGTATGACCTCAAGGTTGCTAACCT
GGTCACTCATGGTAATTAGAAACTCTGATTGGCAGCTTTGTATTTCTTGACTAAAAACCTAAATAAACTGATTAGGTTTTAGGCGTTCTT
TCAAAGAGGTTCTTGAGAAGATTGAGAACTATCCTATTTGGTGCTTAGTGAAAAGATTTTGAATTACTGTACGTACCAGTTGTTGCCATT
TCTTTATTAAATTCAGAAGTTTTTTTGCCAAATAACAATTTTTCAATCTTCTCTGTTTGTAGACATCTTACTGGGTGATGAATAATCCTC
TAAGAAACCCTCTGAGCTGCTAACTTTTTCAGGGAGAAAATCACAAGCCATCTTCTCAAGTTCCCCTAGAAACCTGTGGAATGCCCTCTG
CCAAGCACTGCTCTGGTACTGGGGAGTGGAGTATTATGTCTTGGAAGAGACTCCTGCTGTGATTGTCCAGGGGTACGTTCTGGTCTGGCT
TGGTGCTTGACCTTAGGTCTGCCCACAGGCTTCAGGCTTTCAACTTTGAAACAAACATCTGTGCCACACACATTTTGTAAATGATCCCAT
TCAGTCTTCTAGAAGCCTTATAACAGAATCAATATTGTTTTTCCCATTTTCACAGATGGATAATAAATCTGTAAAATAGGGATAAGACTA
GGACCTATTCCCCAGGATTACTTCTGCAGATTAAAGGAGATGTTGAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGG
GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTGATGAGCCAAGATCGTGCCATTGCACTCCATCCTGGGCTACAAGAG
TGAAACTCCGTCTCAAAAAAGAAAAAGGAGATGTTGAATGGGAAGTCAGCAAGGGTGCTAGAATGTAGCAAGTATTCTTCAGGTGTTAGT
GATTTCTGTTGTTCGGGAAGAGGAGGGTTATGGAGGAAGAGTATGGGATTTAGGTGGGTTAAGTGATTTGCCCAAAGTCAAGAGGTTAGT
CTTTAACCTTTGGCAGAAGCAGGATTTGAAGTGAGTTTTCACACCCCTCTTCCCTGGTCAGTGTGTTGATAACAGCCCACCCACCTGTGG
TTCCAGGGTGTTCTTAAGAAGCCAAGGTTGTCTTGGGTGTGGTAGCTCTTTGAAAGGTAGAAAGTTCCACCAAGAAGGCCTTTTTTCTTG
AATACTGCTTAGCTTCCTTGTCAGGCTCCAAGATGCAGATTGCCTGTGGGCTATCTCTCTCCACAGATAAACCTACTCACATCTTCAGGA
CAGCCTTTTTTTTTTGAGACAGGAGTCTTGCTCTGTTGCCCAGGCTGTAGTGCAGTGGCACAACGGGGTCCCACAGGCAAGTGCTGGGGA
AAGGCCCACCCAGCCATCAGGTAGCCTGTGTGTTCTACAAACAGCAGCTGGCAGCACTGTCTCCTGCCGGACATTCCTGCCACCCGACAT
CAAAGCTGGTGGGTGACCTTTTCAGCCATTTGACATTCCTCCCAGAAGAACCTCTGCCTCCCAGAGGTTTAAGCAGTTCTCCTGCCTCAG
CCTCCCAAGTAGCTGGGCTATTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCGGTTAGAGTGCAGTGGTGCAATCTCG
GCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTAATTTTCCTACGTCAGCCTCCCGAGTAGCTGTCAGGTGCACACCACTACACCCAGAT
AATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGATGGTCTCAATCTGACCTCGTGATCCGCCTGCCTCTGCCTCCCA
AAGGGCTGGGATTACAGGCATGAGCCACCGCGCCCAGCCTTAATTTTTGTATTTTTAATGGAGATGGGGTTTTGCCATGTTGGCCAGGCT
GGTCTTGAACTCCTGACCTCAAGTGATCTGTCCGCCTCAGCCTCCCAAAGTACTGAGATTACAGGCATGAGCCACCGTGCCCAGCCCATC
TTCATCTTCTTTACTTGAACTTAATTCTTTTTCATGCATCTTCCCTTCTTTCCTCTTTTCTCCTCCACCCAAATGTCTTAACTGTTAACA
TTCCCAGGTGTTTGGTCCTGGGCCTCTGGAGGTTGTGAAGGAGCACTGCTCAGTCCTCCCTTCAAGAAAGCAGCTTCAAGGAGTTCAATT
ACAAAAGCTCCTGGCATTGGGGACCTGCCGCCATGTTCCTGCCCAGGGCATGCTGGTCCTGGCTGTCACCAAGCACAGTGGAGGTCAGGT
GCTAGGCCATTTCTGCCCGACACAGGCCTCCTCTAATGAGCAGTCTGAGGCCAGGCACAGGAGGCTGAGGCAGGAGAATCGCTTGAACCC
AGGAGGTGGACGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGACAGAGTAAGACTTCGTCTCAAAAAATAAAAAATA
AAAAAATACTGAGCAGTCTGCTTGGGCGCTTCCATCAGCCTGGCCATGACATCTTTGGAGCTGTCCTGCCCTCTTTTGCCCCGGTGTTCC
TTGGCCCACCTGTCAGACCTACATCATAGGCTCTTCCTGTCTTCTGTTTCCTCTCCCCTTTCTCTAACATAGGTGTTTCTCCTGAGAAAG
AAAAAAACCACCTGTCCCTGACATTCAGAAGCTGACAACACTGTTCGGTCATGCCATTCTCCTGTTGGACATAAACAGTCTCTGAATGCC
AACCCCAAAGTTGCTCTCAGGCCATGATAAAATAAACCACTTAATAATTTTGTCTAAGCACGTACAAAGAAAATTCAAGGTCAGTTTACC
ACTCACAAAATACCAAACATCCTTCTGCTGGTTAAAACGAGTGACAGCTGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAT
GTGTATATGCGTATATATGTGTATGTATGTGTGTATATATATATGTGTGTGTGTATATATATATATGCAATTATACCTTTATCCCTACTC
TAGTCCACCTTCCTATAAATAAGATGTATTGAGATGCTCAGTGCCCCCATTCTGACAGCATCCAATCGAGTGAATCCTCACTTCCTTGAA
ATCACCCAACCAGGGCCAGAATCCTAAAAGAGGTTCTTTGTGACACCCTCTGTCTGAGAAGTCCTATGGTTCTCTGTGATGAATAGACCC
AACTTGTTCAAATACAGGCATTTCTGGTGGGCTTTGGCTGAAGGCATTCACACCCCCCAGTGAATGTCTTGCACTTCTAATTGTGTCTCG
GGGCATGCCTGGTGGAGGACCTGACTGAGACAATTGTGACTGGATGTGGTCTGAGAGCAGGCAGTAGGATGAGGCTTGGGGACTGGCTCA
CTCACTGCCCAACTGGTAGCAAAACCCATCTGGAGCAGCGTGTGAGGTATGGACACTCACTCACACGAGGGGGTGGCCCAGTTGCTGAGG
ATTCCACCAGTGGTACCCTGGGAAAATATCCCTGTGGAGGGGAATGGGAGGAGTCAAACTGTGGAAGATAAGAGGAGTACTGCACACAAG
GACAGTAGAGTGTCTGTTCCCTGCAGAGGGATAGTGAGGAACTGATGAGGTGACTGTGAGTGCCCGGGGCCTCTGTCGTTATCTTGGAGG
ATCACTTTGAGGTCAGGAGTTCATGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACATTAATTAGCATGGTGGCGG
GTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCCGAGGTTGCAGTGAGCTGAGATGGCGCCA
CTGCACCCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAACAAACACACAGTACTGCATCCTGGGGGTGGAGGTGAGGTGACGGTA
GAGATCAGTGCTACCCTTGGAAATCTGACAGATACAGTAAGATGGTCCCTATCATAGTTCCATTTAATTTGCCAGCCTCATCTGCAGAAT
CCAGATGGATCCTGGAGAAAAATTAACCAAGTAGCCTCAATCACAAATGTTGGGTTGGATATTACATCAGTGTTAGAGCAGTTAAGGGCT
CAGGTATGTGGTGTGCAGCCATTGACTGGGTGAATCCATTTTTACCTACCCCAATTACAAAACAGTTTGCTTTCATGTGGAACAGATAGT
ATTCCTTTCAGTTTTGCTGCAGGAACATATTAACTCTTCCACCCCTGTCATAATACAGCCTGAAGAGATTTACCATTAAATACTGTTTTT
TTCTCTCTCTTAACTTAATCCCGAATTGGATAATTTCTCTTCATCTTCACTGTCACCTCTACGCCATCACTGTCATCTCTAGACCGCTCT
GCTGTTGAGAGATTGATGGAATCATTATGCAAACTAAAATAGAATGTTTTATCTATCAAATTGTATTTCTTTGTCAATAGTGTTAGGGCA
CAGTAGGTTCATTTACTGCTGGTAAGGGTGTAAATTGTTAGAAACTTTCTGAATGGCAGTTTGGTAATAACAAACAAAAAGCTTAAGTTT
GTGTCCTTAAATGCCTTACTTCAATACCCAAGGCATATGGCCTCAATAAAAAATTATGGAAGCATGCAAAGATTTTGTTAACAAAGATAT
AATCATTGCAGGGTAGAATTTAGAAATTTAAGACTGAAAGATCTTTTCAGTCACCTGCAGCAAGAAAGGAGTCAAAACCTATGTACGATC
TCAACTAGTAAAATTTTCTCCTTGCCCAGGGATCATGCTGAGTTTAAGGACAGAAATGCAAAGTGCAGCCTGGGAAAGTGTTTCAACACA
CAAAAATAGAACCACCTGTATGTAGTCTTTTTGAAAGCACAAAATAAAGAGCAGTCCTACAGGGTTCACTGCTATGTCCTGAATGTTGAT
GTCCCTTCCAAAATTCATATGTTGGAACCTAATGTCAATGTAATAGTATTAAGAGGTGGGGCTTTTGGGAAGCAATGGAGTCATGAGGGC
TTCACCCTCATGAGTAGGATAAGTACCCTTACAAAAGAGGCTCAGGGAGGCGCTCTTGCCTCTTCCACCATGTAAGGACACGTAGCAGGC
ACCCATTTCTGAAGAATGGGCCCTCCCCAGACTCCATATCTGCTGGTGCCTTGATCTTGGACTTAGCCTCTAGGACTGTGAGTGACATAT
TTCTATTGTTTATAAATTATCCAGTATAAGTAAGATATTTTGTTAGAGCAGCCTGAACGAACTAAGACACTCTAAGCGGGAAACTCACAA
AAAATATTTGGTAGTGAAAAACAGTATGGTGTGTTAATGTATGGTGACAAGTGTTTGTTTGCATTTAAAAATGCATTGGAGCCTCGTTTT
GATTAGGCAGTAAATTTACCTTTAATACGTAAGTTTGACAGTTATATGTAATCAGCTTTTTTTTTTTTAAGATGGTGTGATTGAGGTTAA
TGTGAACTGAACTTTCTATTTCTAAGCTGTCTTCATCTAATTTTACCTTTCTGTGGAAAATCAATACAAGTCAACCATTTTTATTGCCCA
GTTATTCAAAGTTTTATTCAAAGAGCAAAGATTTGACAATGCATAGAATTAACATTGGTTTGTGGGCCACCTTCTGGGCCAGCACCAAAG
ACTGAAAAAATATTTTGCCCCCTAAAAGTTGTTATTGAGTCTTGTCAAATCACATTGCTCTGTCAGAAGGTAAGACAAATCAGTGTGGAC
TGAGAGCAAGGTCAGCACCGTGAACAGCCATTGCGGTTCCTTTAACCCACTGGGAATTCATGCAGTGAAGAAGCAACACACCATGAGGCA
AATGGCTCAAACCCAAAGACCAGAGGTTCAGGGGATATATATATATATTTTTTTAATCTGTAGAGATGGGATCTCACTATCTTGCCCAGG
CTGGTCTCGAACTCTTGGGCTCATGCTGTCCTACCTCAGACTTCCAAGTAGCTGGGTTTTCTTTGGGCTAATTATTTTTTTGTAGAGATG
GAGGTCTCGCTGTGTTGCCCAGGCTGGTCTCAAATTCCTGGCCTCAAGCTCTCCTCCCATCTCAGCCTCCCAAAGTGTTGGGATTACAGG
CATGAGCCATGTGCCCAGTCTAGAAGATCTTTGACTTCAAAGAACAGATAATCTAGAGACCTTCACAAGTGATCATGTTGGCACTATGGT
CATTACACTGAGACCTATAACTGGGCTAGGATTGGTTATTTACAGAAAAACCTTGTGGTACTTAATTCCAATTCATGTTAATTTATGTTA
TCTTGCTTAATCCTTGCAAAGCCCTTTTAGAGGTGGGTGTTATCCCATCTATAATCTGCTGCTTGTCTTAGACCAAGGAAGTGAAAGTAT
TCAGTCCAAGCATGCTACCATCCATTTCTGGTAGGTTTGGTTTGTTTTTAGTTGGCTTTCCTGTTTAACTGTTATTTGTCTTCCTATTGA
GGTTAGATGTGCATTTTGGAATTGCATCATTTTACATAGAAACAGCTTTCCAGTGGAGTTGACTAGCATCCTAAGGACAAGTACAACCAC
TTTTGAAATAGATCATGGAAATCACAAAGTCTGATGTTCCACAAAATGGAGTATGATGTTATGGACACTAGAAATACAAGGTATGGGTCA
TTAGTAACGCTAATAACATTTTCCTATAGATGACTTTTAATAACACTGGTTTAATGTCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTGGAGACAGGGTCTCCCTCTGTCACCCAGGCTGGTTGGAATGCAGGAGTTCGAACTTGGCTCACTGCAACCTCTGCC
TCCTAGGTTCAAGTGATCCTCCCGCCTCAGTCCCCCAAGTACCTGGGACCACAGGCACACGCCACCATGCCTGGCTAATTTTTGTATATT
TTGTAGAGATGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAATTCCTGGACTCAAGCAGTCCATCTGCCTCAGCCTCCCAAAGTGATG
GGATTACAGGCGTGAGCTGCTGTGCCTGGCAGAACAGTATGAAGTGTTAACGCCAAAATTTGTTTTAGCTATCATATATAAATCATAAGC
ATATTATTTGGTTGGTTGGTGTTAGTTCATTCCTTCAATCGGATGATTTAAAATAAATGTTTTTCAAGTATCCTCTGTGATGTATCCCAA
AGGTTAGCTTAGAAAGAAAAGTACTTGGTGAACCATTCCTGGTGCGGAGAGCCCTGTTTCTGCTGGACTTCTTTGGCTTGGGCCGTTTCA
CCATCTGGGGTCCTAAAAGCAAAAAAAGGTTTTTTTATATGGTTTTGAAAACTATGCAAGAAGCAGCTTAATACCCACCATCTTTTCAGG
GAAAGATAACTGCTTGTTTACTCTTCAAAAACACCCAAATGGGACTGGCCAACATTAGTAGTGGGAAACAAATTGTAAAGGATGGGGCTG
GGGAGGGAGTACCTAATCCTCATTTGGAAAACAGAAGGTTCACCATTGTTTGGTTCTCCATTGTTCCTTTGAGACTTAGTGGTTGTAGCT
CTAATAATGCAGGATTAACCAAACCTACAGATCAAGAGACTTTGTTTTTATTTTTTGTGACAGAGTCTCCCTCTGTCACCCAGGCTGGAG
TGCAGTGGCATGATCTCGGCTCACTGCAACCTCCAGCCTCCTGCGTTCAAGCGATCATTGTGCCTCAGCCTCCCGGGGAGCTGGAATTAC
AGGCGCATACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGACC
TTAGGTGATCCACCCACCTCCATCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCCGATTAAGAGACTTTAGAATTC
CAAGGTGATAGAGTAAATCTTGAGGAATAATGTTAGTAATAATACTGAAACTATATTGAAGATTTTTGTGCCAAGTCCTGTGCTAAGCAC
ATCCTATGGATTAATTCCTTTAGTCTCACGTCAGTCTGATGAGATAGGTGCTGTATTATCTTAATTTTAAAGGCAAGGTATATGGAGACC
TGGAGAGGTCAAGTGACCTGTCCAAGGCCACAGAGCTAAGAATGAGGAAGACTGTAATTTGAATTCAGACCTCCAGGCCAGATGGAGTCC
ACCTTTTGTATAACCCATGCTGAAGTTTTCAGGTAAGTGATTCAGTGTCCCTTGTCTAATCATCCATGAAAAAAGGCCTTCTGGAATTTG
GTACCAGGTGCTAGAAAGAATCCTACTTCCCCTCTTATCTACAGGGAAATAGAATAAGGGCCCCTGTCCCCAACATCCCCCAAACCTTGT
GGCAGTTTTTGCATCTGTAGACTGGTTGGGTTTGTAGGTCCGGCCACAGCTGGGGCTTGGGTCCAAGCTGGGTGATGTAGTTATTGGAGG
GGCATTAATCCTGGAACTCAGATCGCCACTCAGAAAGTTCTTTGCATAGGAGGCGAGGTTCGGCACGCTGACCACGCGGCTGGGCACGTC
CTCCACCTTCTTTTTCTGTTTGTATTAATGGACAGGTTAGTGCAATGCAATGCAAAAAACAAAATAAAGCATTATTGTAAAAGCAAATAA
TGCTCACCCAATCAAAATTGTATCGGAGAAGAAGCAACAATTTCATTTATACACTTACATGCTATTTTTTAAAGCACTTTTCCCTCCAAT

>In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_11026nt
CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC
ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGACC
CCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTATATCCATATAAGAATTCAACAGAGAAACGGCAGGA
AGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTGAAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGG
TGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGATCAGTGTATCCAGAAGTTTCTGGATATTGCAAGAC
AGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAGCAAGTTATCAAAGAGGATGTGTCAGAACTAAGGA
ATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCATTGGCAGCAGGTGCTGGAGGACATCAACGTGCAGC
ACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCTGCCAACATCCCTGCACCTCTGAAGCCAACGTGAG
CAAAGGGCAGAGGCAGTTGGCCTATGAGTGGGCTGATGCGTGAGGTTGGCCACACATTCCTTCCTGTGGACTTGACATTTTGGAAGAACT
CTTTGCCAGATAATGAGTTCATTTTAGTTTTATGCTCCCATTGAAAAATTTTCCACTATTTTTATAAGCTGTTAATTTCTTGAGTACTTT
ATAACATGTCTGTAGCTTGGATAAACCAAGTAAGTATTTTTTTTTTGTCTTTAGCAAAGTTTAGACTGTGAATATGATGACACAGATTCT
TTTTTATGGTGGCTTTGCTTGTTTTAAATTTTTGCATGACTTTTCATCTTTTTATGTGTGTTTCCTGTAGTTTGATCCGAAGGAAAAGAG
TATAGTAGCCTGAGAATCAGGAGATGGGAGTTTTAGTCGTAGGCCTTATGATAATTACCCCGCGGTGGTGTGTAGAAAAGTATGTAAATT
TGCTCTGTTTTAAGACTTTGAACTACCTCAAGAAGAGGAATCTAATACAATATTTGTAATGTTTCCAGAGCTCTCAGAATGAGGATTTTT
TTGTAAATAGGTCAGAAGACGATGGAACTGTCCTGGGTTAGTATAGTAATCTTACAGTAGGATCCTTAGGTTGATGCTGACTTCTGTTTG
GGGTATGTTTATATTTTATGTGGTGTTTACTTTTTTTTTTTGACATAGAAGGATATAGTGGGAGCAGTGATACGCTAACATTCATTACAT
TCTGCAGTAATGAATCTGTTTAATGGGTCAGTCACTGTTTTCAGTAGCATGACAGTGGGGTCATAGGTGAGCTGTGAGGGGCTAAATCTT
GCTCTGATTGTCTCTTTCTGTTTTGAGTTTTGTTTGCGTGTATCATTTTTGTTCTACATTTTGGGAGGGGAAACATTTTCCGTTAAGGAA
GGTTGTTGCCAGTGGATTTGACTCCAAGGGACTAGAGTGTCGTGGTGGGGGTGGGGAGGGGCTGCAGGGTGATCATTGGCTACTGAGCCT
CCACAGAGAGCATGTGGTGCCCTGCCTTTGGGAGGGTATTTTGCTCTCGTTAGTTTTGTGGGCAGCCTCAGATTCCCTGTTGAGTTGCTG
TTAAGAAATGGAGATTTCTGGCTCTCATTGGGTAAGGTTTTCTGAGTTTTATATCTTATTAGATCACATCCCTTTACCCAGAACAAATGC
TTCACTGTCTTCTGATTGGCAGTACTCCTGTGGCTTTGTGCCTTGACTCATTTTGTTGTCTTCAGCCTTGAAGGCCCCTTCCCACATGGA
CTGACATCCACTCATGTGCCTGATCCCTGAAGCCTCCCAGCACCCATTCAGTTGCATCCCCAGGGCACAGGACTTTGATCTCTTCTGTTG
CCCTCGCTAGGTTCTCCCTGGTGGGTTAGTGCTTTGTATCTGTCTCTCTGCCCCTCACTAATTCTACACCCATGAGAATTAGACATTATT
CTCCTTAAATATATAAGGACCATATAATCTGTATCTTTTTGGTGTGTGTATATGGTATCTGGCACATGGATCTCTGATTACCAGCCTGAC
ATCAACAAATCCCCTCAGTTACAACGTATAGGTTAAACAAAGCTTTTAAAAGCTCATGTGGTATGACCTCAAGGTTGCTAACCTGGTCAC
TCATGGTAATTAGAAACTCTGATTGGCAGCTTTGTATTTCTTGACTAAAAACCTAAATAAACTGATTAGGTTTTAGGCGTTCTTTCAAAG
AGGTTCTTGAGAAGATTGAGAACTATCCTATTTGGTGCTTAGTGAAAAGATTTTGAATTACTGTACGTACCAGTTGTTGCCATTTCTTTA
TTAAATTCAGAAGTTTTTTTGCCAAATAACAATTTTTCAATCTTCTCTGTTTGTAGACATCTTACTGGGTGATGAATAATCCTCTAAGAA
ACCCTCTGAGCTGCTAACTTTTTCAGGGAGAAAATCACAAGCCATCTTCTCAAGTTCCCCTAGAAACCTGTGGAATGCCCTCTGCCAAGC
ACTGCTCTGGTACTGGGGAGTGGAGTATTATGTCTTGGAAGAGACTCCTGCTGTGATTGTCCAGGGGTACGTTCTGGTCTGGCTTGGTGC
TTGACCTTAGGTCTGCCCACAGGCTTCAGGCTTTCAACTTTGAAACAAACATCTGTGCCACACACATTTTGTAAATGATCCCATTCAGTC
TTCTAGAAGCCTTATAACAGAATCAATATTGTTTTTCCCATTTTCACAGATGGATAATAAATCTGTAAAATAGGGATAAGACTAGGACCT
ATTCCCCAGGATTACTTCTGCAGATTAAAGGAGATGTTGAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGGGGCTGA
GGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTGATGAGCCAAGATCGTGCCATTGCACTCCATCCTGGGCTACAAGAGTGAAAC
TCCGTCTCAAAAAAGAAAAAGGAGATGTTGAATGGGAAGTCAGCAAGGGTGCTAGAATGTAGCAAGTATTCTTCAGGTGTTAGTGATTTC
TGTTGTTCGGGAAGAGGAGGGTTATGGAGGAAGAGTATGGGATTTAGGTGGGTTAAGTGATTTGCCCAAAGTCAAGAGGTTAGTCTTTAA
CCTTTGGCAGAAGCAGGATTTGAAGTGAGTTTTCACACCCCTCTTCCCTGGTCAGTGTGTTGATAACAGCCCACCCACCTGTGGTTCCAG
GGTGTTCTTAAGAAGCCAAGGTTGTCTTGGGTGTGGTAGCTCTTTGAAAGGTAGAAAGTTCCACCAAGAAGGCCTTTTTTCTTGAATACT
GCTTAGCTTCCTTGTCAGGCTCCAAGATGCAGATTGCCTGTGGGCTATCTCTCTCCACAGATAAACCTACTCACATCTTCAGGACAGCCT
TTTTTTTTTGAGACAGGAGTCTTGCTCTGTTGCCCAGGCTGTAGTGCAGTGGCACAACGGGGTCCCACAGGCAAGTGCTGGGGAAAGGCC
CACCCAGCCATCAGGTAGCCTGTGTGTTCTACAAACAGCAGCTGGCAGCACTGTCTCCTGCCGGACATTCCTGCCACCCGACATCAAAGC
TGGTGGGTGACCTTTTCAGCCATTTGACATTCCTCCCAGAAGAACCTCTGCCTCCCAGAGGTTTAAGCAGTTCTCCTGCCTCAGCCTCCC
AAGTAGCTGGGCTATTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCGGTTAGAGTGCAGTGGTGCAATCTCGGCTCAC
TGCAACCTCTGCCTCCCGGGTTCAAGTAATTTTCCTACGTCAGCCTCCCGAGTAGCTGTCAGGTGCACACCACTACACCCAGATAATTTT
GTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGATGGTCTCAATCTGACCTCGTGATCCGCCTGCCTCTGCCTCCCAAAGGGC
TGGGATTACAGGCATGAGCCACCGCGCCCAGCCTTAATTTTTGTATTTTTAATGGAGATGGGGTTTTGCCATGTTGGCCAGGCTGGTCTT
GAACTCCTGACCTCAAGTGATCTGTCCGCCTCAGCCTCCCAAAGTACTGAGATTACAGGCATGAGCCACCGTGCCCAGCCCATCTTCATC
TTCTTTACTTGAACTTAATTCTTTTTCATGCATCTTCCCTTCTTTCCTCTTTTCTCCTCCACCCAAATGTCTTAACTGTTAACATTCCCA
GGTGTTTGGTCCTGGGCCTCTGGAGGTTGTGAAGGAGCACTGCTCAGTCCTCCCTTCAAGAAAGCAGCTTCAAGGAGTTCAATTACAAAA
GCTCCTGGCATTGGGGACCTGCCGCCATGTTCCTGCCCAGGGCATGCTGGTCCTGGCTGTCACCAAGCACAGTGGAGGTCAGGTGCTAGG
CCATTTCTGCCCGACACAGGCCTCCTCTAATGAGCAGTCTGAGGCCAGGCACAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGG
TGGACGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGACAGAGTAAGACTTCGTCTCAAAAAATAAAAAATAAAAAAA
TACTGAGCAGTCTGCTTGGGCGCTTCCATCAGCCTGGCCATGACATCTTTGGAGCTGTCCTGCCCTCTTTTGCCCCGGTGTTCCTTGGCC
CACCTGTCAGACCTACATCATAGGCTCTTCCTGTCTTCTGTTTCCTCTCCCCTTTCTCTAACATAGGTGTTTCTCCTGAGAAAGAAAAAA
ACCACCTGTCCCTGACATTCAGAAGCTGACAACACTGTTCGGTCATGCCATTCTCCTGTTGGACATAAACAGTCTCTGAATGCCAACCCC
AAAGTTGCTCTCAGGCCATGATAAAATAAACCACTTAATAATTTTGTCTAAGCACGTACAAAGAAAATTCAAGGTCAGTTTACCACTCAC
AAAATACCAAACATCCTTCTGCTGGTTAAAACGAGTGACAGCTGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTAT
ATGCGTATATATGTGTATGTATGTGTGTATATATATATGTGTGTGTGTATATATATATATGCAATTATACCTTTATCCCTACTCTAGTCC
ACCTTCCTATAAATAAGATGTATTGAGATGCTCAGTGCCCCCATTCTGACAGCATCCAATCGAGTGAATCCTCACTTCCTTGAAATCACC
CAACCAGGGCCAGAATCCTAAAAGAGGTTCTTTGTGACACCCTCTGTCTGAGAAGTCCTATGGTTCTCTGTGATGAATAGACCCAACTTG
TTCAAATACAGGCATTTCTGGTGGGCTTTGGCTGAAGGCATTCACACCCCCCAGTGAATGTCTTGCACTTCTAATTGTGTCTCGGGGCAT
GCCTGGTGGAGGACCTGACTGAGACAATTGTGACTGGATGTGGTCTGAGAGCAGGCAGTAGGATGAGGCTTGGGGACTGGCTCACTCACT
GCCCAACTGGTAGCAAAACCCATCTGGAGCAGCGTGTGAGGTATGGACACTCACTCACACGAGGGGGTGGCCCAGTTGCTGAGGATTCCA
CCAGTGGTACCCTGGGAAAATATCCCTGTGGAGGGGAATGGGAGGAGTCAAACTGTGGAAGATAAGAGGAGTACTGCACACAAGGACAGT
AGAGTGTCTGTTCCCTGCAGAGGGATAGTGAGGAACTGATGAGGTGACTGTGAGTGCCCGGGGCCTCTGTCGTTATCTTGGAGGATCACT
TTGAGGTCAGGAGTTCATGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACATTAATTAGCATGGTGGCGGGTGCCT
GTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCCGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCAC
CCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAACAAACACACAGTACTGCATCCTGGGGGTGGAGGTGAGGTGACGGTAGAGATC
AGTGCTACCCTTGGAAATCTGACAGATACAGTAAGATGGTCCCTATCATAGTTCCATTTAATTTGCCAGCCTCATCTGCAGAATCCAGAT
GGATCCTGGAGAAAAATTAACCAAGTAGCCTCAATCACAAATGTTGGGTTGGATATTACATCAGTGTTAGAGCAGTTAAGGGCTCAGGTA
TGTGGTGTGCAGCCATTGACTGGGTGAATCCATTTTTACCTACCCCAATTACAAAACAGTTTGCTTTCATGTGGAACAGATAGTATTCCT
TTCAGTTTTGCTGCAGGAACATATTAACTCTTCCACCCCTGTCATAATACAGCCTGAAGAGATTTACCATTAAATACTGTTTTTTTCTCT
CTCTTAACTTAATCCCGAATTGGATAATTTCTCTTCATCTTCACTGTCACCTCTACGCCATCACTGTCATCTCTAGACCGCTCTGCTGTT
GAGAGATTGATGGAATCATTATGCAAACTAAAATAGAATGTTTTATCTATCAAATTGTATTTCTTTGTCAATAGTGTTAGGGCACAGTAG
GTTCATTTACTGCTGGTAAGGGTGTAAATTGTTAGAAACTTTCTGAATGGCAGTTTGGTAATAACAAACAAAAAGCTTAAGTTTGTGTCC
TTAAATGCCTTACTTCAATACCCAAGGCATATGGCCTCAATAAAAAATTATGGAAGCATGCAAAGATTTTGTTAACAAAGATATAATCAT
TGCAGGGTAGAATTTAGAAATTTAAGACTGAAAGATCTTTTCAGTCACCTGCAGCAAGAAAGGAGTCAAAACCTATGTACGATCTCAACT
AGTAAAATTTTCTCCTTGCCCAGGGATCATGCTGAGTTTAAGGACAGAAATGCAAAGTGCAGCCTGGGAAAGTGTTTCAACACACAAAAA
TAGAACCACCTGTATGTAGTCTTTTTGAAAGCACAAAATAAAGAGCAGTCCTACAGGGTTCACTGCTATGTCCTGAATGTTGATGTCCCT
TCCAAAATTCATATGTTGGAACCTAATGTCAATGTAATAGTATTAAGAGGTGGGGCTTTTGGGAAGCAATGGAGTCATGAGGGCTTCACC
CTCATGAGTAGGATAAGTACCCTTACAAAAGAGGCTCAGGGAGGCGCTCTTGCCTCTTCCACCATGTAAGGACACGTAGCAGGCACCCAT
TTCTGAAGAATGGGCCCTCCCCAGACTCCATATCTGCTGGTGCCTTGATCTTGGACTTAGCCTCTAGGACTGTGAGTGACATATTTCTAT
TGTTTATAAATTATCCAGTATAAGTAAGATATTTTGTTAGAGCAGCCTGAACGAACTAAGACACTCTAAGCGGGAAACTCACAAAAAATA
TTTGGTAGTGAAAAACAGTATGGTGTGTTAATGTATGGTGACAAGTGTTTGTTTGCATTTAAAAATGCATTGGAGCCTCGTTTTGATTAG
GCAGTAAATTTACCTTTAATACGTAAGTTTGACAGTTATATGTAATCAGCTTTTTTTTTTTTAAGATGGTGTGATTGAGGTTAATGTGAA
CTGAACTTTCTATTTCTAAGCTGTCTTCATCTAATTTTACCTTTCTGTGGAAAATCAATACAAGTCAACCATTTTTATTGCCCAGTTATT
CAAAGTTTTATTCAAAGAGCAAAGATTTGACAATGCATAGAATTAACATTGGTTTGTGGGCCACCTTCTGGGCCAGCACCAAAGACTGAA
AAAATATTTTGCCCCCTAAAAGTTGTTATTGAGTCTTGTCAAATCACATTGCTCTGTCAGAAGGTAAGACAAATCAGTGTGGACTGAGAG
CAAGGTCAGCACCGTGAACAGCCATTGCGGTTCCTTTAACCCACTGGGAATTCATGCAGTGAAGAAGCAACACACCATGAGGCAAATGGC
TCAAACCCAAAGACCAGAGGTTCAGGGGATATATATATATATTTTTTTAATCTGTAGAGATGGGATCTCACTATCTTGCCCAGGCTGGTC
TCGAACTCTTGGGCTCATGCTGTCCTACCTCAGACTTCCAAGTAGCTGGGTTTTCTTTGGGCTAATTATTTTTTTGTAGAGATGGAGGTC
TCGCTGTGTTGCCCAGGCTGGTCTCAAATTCCTGGCCTCAAGCTCTCCTCCCATCTCAGCCTCCCAAAGTGTTGGGATTACAGGCATGAG
CCATGTGCCCAGTCTAGAAGATCTTTGACTTCAAAGAACAGATAATCTAGAGACCTTCACAAGTGATCATGTTGGCACTATGGTCATTAC
ACTGAGACCTATAACTGGGCTAGGATTGGTTATTTACAGAAAAACCTTGTGGTACTTAATTCCAATTCATGTTAATTTATGTTATCTTGC
TTAATCCTTGCAAAGCCCTTTTAGAGGTGGGTGTTATCCCATCTATAATCTGCTGCTTGTCTTAGACCAAGGAAGTGAAAGTATTCAGTC
CAAGCATGCTACCATCCATTTCTGGTAGGTTTGGTTTGTTTTTAGTTGGCTTTCCTGTTTAACTGTTATTTGTCTTCCTATTGAGGTTAG
ATGTGCATTTTGGAATTGCATCATTTTACATAGAAACAGCTTTCCAGTGGAGTTGACTAGCATCCTAAGGACAAGTACAACCACTTTTGA
AATAGATCATGGAAATCACAAAGTCTGATGTTCCACAAAATGGAGTATGATGTTATGGACACTAGAAATACAAGGTATGGGTCATTAGTA
ACGCTAATAACATTTTCCTATAGATGACTTTTAATAACACTGGTTTAATGTCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTGGAGACAGGGTCTCCCTCTGTCACCCAGGCTGGTTGGAATGCAGGAGTTCGAACTTGGCTCACTGCAACCTCTGCCTCCTAG
GTTCAAGTGATCCTCCCGCCTCAGTCCCCCAAGTACCTGGGACCACAGGCACACGCCACCATGCCTGGCTAATTTTTGTATATTTTGTAG
AGATGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAATTCCTGGACTCAAGCAGTCCATCTGCCTCAGCCTCCCAAAGTGATGGGATTA
CAGGCGTGAGCTGCTGTGCCTGGCAGAACAGTATGAAGTGTTAACGCCAAAATTTGTTTTAGCTATCATATATAAATCATAAGCATATTA
TTTGGTTGGTTGGTGTTAGTTCATTCCTTCAATCGGATGATTTAAAATAAATGTTTTTCAAGTATCCTCTGTGATGTATCCCAAAGGTTA
GCTTAGAAAGAAAAGTACTTGGTGAACCATTCCTGGTGCGGAGAGCCCTGTTTCTGCTGGACTTCTTTGGCTTGGGCCGTTTCACCATCT
GGGGTCCTAAAAGCAAAAAAAGGTTTTTTTATATGGTTTTGAAAACTATGCAAGAAGCAGCTTAATACCCACCATCTTTTCAGGGAAAGA
TAACTGCTTGTTTACTCTTCAAAAACACCCAAATGGGACTGGCCAACATTAGTAGTGGGAAACAAATTGTAAAGGATGGGGCTGGGGAGG
GAGTACCTAATCCTCATTTGGAAAACAGAAGGTTCACCATTGTTTGGTTCTCCATTGTTCCTTTGAGACTTAGTGGTTGTAGCTCTAATA
ATGCAGGATTAACCAAACCTACAGATCAAGAGACTTTGTTTTTATTTTTTGTGACAGAGTCTCCCTCTGTCACCCAGGCTGGAGTGCAGT
GGCATGATCTCGGCTCACTGCAACCTCCAGCCTCCTGCGTTCAAGCGATCATTGTGCCTCAGCCTCCCGGGGAGCTGGAATTACAGGCGC
ATACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGACCTTAGGT
GATCCACCCACCTCCATCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCCGATTAAGAGACTTTAGAATTCCAAGGT
GATAGAGTAAATCTTGAGGAATAATGTTAGTAATAATACTGAAACTATATTGAAGATTTTTGTGCCAAGTCCTGTGCTAAGCACATCCTA
TGGATTAATTCCTTTAGTCTCACGTCAGTCTGATGAGATAGGTGCTGTATTATCTTAATTTTAAAGGCAAGGTATATGGAGACCTGGAGA
GGTCAAGTGACCTGTCCAAGGCCACAGAGCTAAGAATGAGGAAGACTGTAATTTGAATTCAGACCTCCAGGCCAGATGGAGTCCACCTTT
TGTATAACCCATGCTGAAGTTTTCAGGTAAGTGATTCAGTGTCCCTTGTCTAATCATCCATGAAAAAAGGCCTTCTGGAATTTGGTACCA
GGTGCTAGAAAGAATCCTACTTCCCCTCTTATCTACAGGGAAATAGAATAAGGGCCCCTGTCCCCAACATCCCCCAAACCTTGTGGCAGT
TTTTGCATCTGTAGACTGGTTGGGTTTGTAGGTCCGGCCACAGCTGGGGCTTGGGTCCAAGCTGGGTGATGTAGTTATTGGAGGGGCATT
AATCCTGGAACTCAGATCGCCACTCAGAAAGTTCTTTGCATAGGAGGCGAGGTTCGGCACGCTGACCACGCGGCTGGGCACGTCCTCCAC
CTTCTTTTTCTGTTTGTATTAATGGACAGGTTAGTGCAATGCAATGCAAAAAACAAAATAAAGCATTATTGTAAAAGCAAATAATGCTCA
CCCAATCAAAATTGTATCGGAGAAGAAGCAACAATTTCATTTATACACTTACATGCTATTTTTTAAAGCACTTTTCCCTCCAATCTTCAT


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FusionGenePPI for EIF1_MED28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EIF1RASA1, MAPK6, APP, EIF2D, DHX9, EIF5, EIF3GMED28KLHL12, USHBP1, MAGEA11, NF2, GRB2, MED10, MED9, MED29, MED19, MED13L, MED13, MED12, MED14, MED23, MED15, MED24, MED16, MED25, MED17, MED26, CCNC, CDK8, CDK19, MED27, MED4, MED6, MED7, MED8, MED18, MED20, MED30, MED28, MED21, MED22, MED11, MED31, MED1, POLR2J, POLR2D, POLR2A, POLR2B, POLR2C, POLR2G, POLR2L, ZC3H13, RCOR1, POLR2E, CDK9, TRIP4, TADA2A, ELAVL1, FBXW7, TEC, YES1, SRC, OSTF1, BTK, FYN, ABL2, SNX9, NPHP1, PSTPIP1, STAM, PIK3R2, PIK3R1, ARHGEF5, DLG4, HCK, NEBL, MAGI3, WWTR1, NEDD4L, PRMT6, PUF60, SPERT, SHMT2, MOV10, TCL1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EIF1_MED28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EIF1_MED28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMED28C0027627Neoplasm Metastasis1CTD_human
TgeneMED28C1458155Mammary Neoplasms1CTD_human