|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 11190 |
FusionGeneSummary for EIF1_MED28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EIF1_MED28 | Fusion gene ID: 11190 | Hgene | Tgene | Gene symbol | EIF1 | MED28 | Gene ID | 10209 | 80306 |
| Gene name | eukaryotic translation initiation factor 1 | mediator complex subunit 28 | |
| Synonyms | A121|EIF-1|EIF1A|ISO1|SUI1 | 1500003D12Rik|EG1|magicin | |
| Cytomap | 17q21.2 | 4p15.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | eukaryotic translation initiation factor 1protein translation factor SUI1 homologsui1iso1 | mediator of RNA polymerase II transcription subunit 28endothelial-derived gene 1endothelial-derived protein 1mediator of RNA polymerase II transcription, subunit 28 homologmerlin and Grb2-interacting cytoskeletal proteintumor angiogenesis marker EG-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41567 | Q9H204 | |
| Ensembl transtripts involved in fusion gene | ENST00000591776, ENST00000469257, ENST00000310837, | ENST00000237380, ENST00000499786, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: EIF1 [Title/Abstract] AND MED28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EIF1 | GO:0006446 | regulation of translational initiation | 22156057 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A1X5-01A | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000591776 | ENST00000237380 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| 5CDS-intron | ENST00000591776 | ENST00000499786 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| In-frame | ENST00000469257 | ENST00000237380 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| 5CDS-intron | ENST00000469257 | ENST00000499786 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| intron-3CDS | ENST00000310837 | ENST00000237380 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
| intron-intron | ENST00000310837 | ENST00000499786 | EIF1 | chr17 | 39846193 | + | MED28 | chr4 | 17621524 | + |
Top |
FusionProtFeatures for EIF1_MED28 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EIF1 | MED28 |
| Necessary for scanning and involved in initiation siteselection. Promotes the assembly of 48S ribosomal complexes at theauthentic initiation codon of a conventional capped mRNA. | Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. May be part of a complex containingNF2/merlin that participates in cellular signaling to the actincytoskeleton downstream of tyrosine kinase signaling pathways.{ECO:0000269|PubMed:15467741}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >MED28 | chr17:39846193 | chr4:17621524 | ENST00000237380 | + | 0 | 4 | 109_145 | 53 | 179 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for EIF1_MED28 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_191aa MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKACFASLVSQDYVNGTDQEEIRTGVD QCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQAS >In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_191aa MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKACFASLVSQDYVNGTDQEEIRTGVD QCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQAS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_573nt ATGTCCGCTATCCAGAACCTCCACTCTTTCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTAT ATCCATATAAGAATTCAACAGAGAAACGGCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTG AAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGAT CAGTGTATCCAGAAGTTTCTGGATATTGCAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAG CAAGTTATCAAAGAGGATGTGTCAGAACTAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCAT TGGCAGCAGGTGCTGGAGGACATCAACGTGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCT >In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_573nt ATGTCCGCTATCCAGAACCTCCACTCTTTCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTAT ATCCATATAAGAATTCAACAGAGAAACGGCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTG AAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGAT CAGTGTATCCAGAAGTTTCTGGATATTGCAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAG CAAGTTATCAAAGAGGATGTGTCAGAACTAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCAT TGGCAGCAGGTGCTGGAGGACATCAACGTGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EIF1_ENST00000591776_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_11032nt CCCAGTCACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCT CCCGCCACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTT TCGACCCCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTATATCCATATAAGAATTCAACAGAGAAACG GCAGGAAGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTGAAGGCGTTTAAGAAAGCTTGCTTTGCAT CTCTGGTGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGATCAGTGTATCCAGAAGTTTCTGGATATTG CAAGACAGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAGCAAGTTATCAAAGAGGATGTGTCAGAAC TAAGGAATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCATTGGCAGCAGGTGCTGGAGGACATCAACG TGCAGCACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCTGCCAACATCCCTGCACCTCTGAAGCCAA CGTGAGCAAAGGGCAGAGGCAGTTGGCCTATGAGTGGGCTGATGCGTGAGGTTGGCCACACATTCCTTCCTGTGGACTTGACATTTTGGA AGAACTCTTTGCCAGATAATGAGTTCATTTTAGTTTTATGCTCCCATTGAAAAATTTTCCACTATTTTTATAAGCTGTTAATTTCTTGAG TACTTTATAACATGTCTGTAGCTTGGATAAACCAAGTAAGTATTTTTTTTTTGTCTTTAGCAAAGTTTAGACTGTGAATATGATGACACA GATTCTTTTTTATGGTGGCTTTGCTTGTTTTAAATTTTTGCATGACTTTTCATCTTTTTATGTGTGTTTCCTGTAGTTTGATCCGAAGGA AAAGAGTATAGTAGCCTGAGAATCAGGAGATGGGAGTTTTAGTCGTAGGCCTTATGATAATTACCCCGCGGTGGTGTGTAGAAAAGTATG TAAATTTGCTCTGTTTTAAGACTTTGAACTACCTCAAGAAGAGGAATCTAATACAATATTTGTAATGTTTCCAGAGCTCTCAGAATGAGG ATTTTTTTGTAAATAGGTCAGAAGACGATGGAACTGTCCTGGGTTAGTATAGTAATCTTACAGTAGGATCCTTAGGTTGATGCTGACTTC TGTTTGGGGTATGTTTATATTTTATGTGGTGTTTACTTTTTTTTTTTGACATAGAAGGATATAGTGGGAGCAGTGATACGCTAACATTCA TTACATTCTGCAGTAATGAATCTGTTTAATGGGTCAGTCACTGTTTTCAGTAGCATGACAGTGGGGTCATAGGTGAGCTGTGAGGGGCTA AATCTTGCTCTGATTGTCTCTTTCTGTTTTGAGTTTTGTTTGCGTGTATCATTTTTGTTCTACATTTTGGGAGGGGAAACATTTTCCGTT AAGGAAGGTTGTTGCCAGTGGATTTGACTCCAAGGGACTAGAGTGTCGTGGTGGGGGTGGGGAGGGGCTGCAGGGTGATCATTGGCTACT GAGCCTCCACAGAGAGCATGTGGTGCCCTGCCTTTGGGAGGGTATTTTGCTCTCGTTAGTTTTGTGGGCAGCCTCAGATTCCCTGTTGAG TTGCTGTTAAGAAATGGAGATTTCTGGCTCTCATTGGGTAAGGTTTTCTGAGTTTTATATCTTATTAGATCACATCCCTTTACCCAGAAC AAATGCTTCACTGTCTTCTGATTGGCAGTACTCCTGTGGCTTTGTGCCTTGACTCATTTTGTTGTCTTCAGCCTTGAAGGCCCCTTCCCA CATGGACTGACATCCACTCATGTGCCTGATCCCTGAAGCCTCCCAGCACCCATTCAGTTGCATCCCCAGGGCACAGGACTTTGATCTCTT CTGTTGCCCTCGCTAGGTTCTCCCTGGTGGGTTAGTGCTTTGTATCTGTCTCTCTGCCCCTCACTAATTCTACACCCATGAGAATTAGAC ATTATTCTCCTTAAATATATAAGGACCATATAATCTGTATCTTTTTGGTGTGTGTATATGGTATCTGGCACATGGATCTCTGATTACCAG CCTGACATCAACAAATCCCCTCAGTTACAACGTATAGGTTAAACAAAGCTTTTAAAAGCTCATGTGGTATGACCTCAAGGTTGCTAACCT GGTCACTCATGGTAATTAGAAACTCTGATTGGCAGCTTTGTATTTCTTGACTAAAAACCTAAATAAACTGATTAGGTTTTAGGCGTTCTT TCAAAGAGGTTCTTGAGAAGATTGAGAACTATCCTATTTGGTGCTTAGTGAAAAGATTTTGAATTACTGTACGTACCAGTTGTTGCCATT TCTTTATTAAATTCAGAAGTTTTTTTGCCAAATAACAATTTTTCAATCTTCTCTGTTTGTAGACATCTTACTGGGTGATGAATAATCCTC TAAGAAACCCTCTGAGCTGCTAACTTTTTCAGGGAGAAAATCACAAGCCATCTTCTCAAGTTCCCCTAGAAACCTGTGGAATGCCCTCTG CCAAGCACTGCTCTGGTACTGGGGAGTGGAGTATTATGTCTTGGAAGAGACTCCTGCTGTGATTGTCCAGGGGTACGTTCTGGTCTGGCT TGGTGCTTGACCTTAGGTCTGCCCACAGGCTTCAGGCTTTCAACTTTGAAACAAACATCTGTGCCACACACATTTTGTAAATGATCCCAT TCAGTCTTCTAGAAGCCTTATAACAGAATCAATATTGTTTTTCCCATTTTCACAGATGGATAATAAATCTGTAAAATAGGGATAAGACTA GGACCTATTCCCCAGGATTACTTCTGCAGATTAAAGGAGATGTTGAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGG GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTGATGAGCCAAGATCGTGCCATTGCACTCCATCCTGGGCTACAAGAG TGAAACTCCGTCTCAAAAAAGAAAAAGGAGATGTTGAATGGGAAGTCAGCAAGGGTGCTAGAATGTAGCAAGTATTCTTCAGGTGTTAGT GATTTCTGTTGTTCGGGAAGAGGAGGGTTATGGAGGAAGAGTATGGGATTTAGGTGGGTTAAGTGATTTGCCCAAAGTCAAGAGGTTAGT CTTTAACCTTTGGCAGAAGCAGGATTTGAAGTGAGTTTTCACACCCCTCTTCCCTGGTCAGTGTGTTGATAACAGCCCACCCACCTGTGG TTCCAGGGTGTTCTTAAGAAGCCAAGGTTGTCTTGGGTGTGGTAGCTCTTTGAAAGGTAGAAAGTTCCACCAAGAAGGCCTTTTTTCTTG AATACTGCTTAGCTTCCTTGTCAGGCTCCAAGATGCAGATTGCCTGTGGGCTATCTCTCTCCACAGATAAACCTACTCACATCTTCAGGA CAGCCTTTTTTTTTTGAGACAGGAGTCTTGCTCTGTTGCCCAGGCTGTAGTGCAGTGGCACAACGGGGTCCCACAGGCAAGTGCTGGGGA AAGGCCCACCCAGCCATCAGGTAGCCTGTGTGTTCTACAAACAGCAGCTGGCAGCACTGTCTCCTGCCGGACATTCCTGCCACCCGACAT CAAAGCTGGTGGGTGACCTTTTCAGCCATTTGACATTCCTCCCAGAAGAACCTCTGCCTCCCAGAGGTTTAAGCAGTTCTCCTGCCTCAG CCTCCCAAGTAGCTGGGCTATTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCGGTTAGAGTGCAGTGGTGCAATCTCG GCTCACTGCAACCTCTGCCTCCCGGGTTCAAGTAATTTTCCTACGTCAGCCTCCCGAGTAGCTGTCAGGTGCACACCACTACACCCAGAT AATTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGATGGTCTCAATCTGACCTCGTGATCCGCCTGCCTCTGCCTCCCA AAGGGCTGGGATTACAGGCATGAGCCACCGCGCCCAGCCTTAATTTTTGTATTTTTAATGGAGATGGGGTTTTGCCATGTTGGCCAGGCT GGTCTTGAACTCCTGACCTCAAGTGATCTGTCCGCCTCAGCCTCCCAAAGTACTGAGATTACAGGCATGAGCCACCGTGCCCAGCCCATC TTCATCTTCTTTACTTGAACTTAATTCTTTTTCATGCATCTTCCCTTCTTTCCTCTTTTCTCCTCCACCCAAATGTCTTAACTGTTAACA TTCCCAGGTGTTTGGTCCTGGGCCTCTGGAGGTTGTGAAGGAGCACTGCTCAGTCCTCCCTTCAAGAAAGCAGCTTCAAGGAGTTCAATT ACAAAAGCTCCTGGCATTGGGGACCTGCCGCCATGTTCCTGCCCAGGGCATGCTGGTCCTGGCTGTCACCAAGCACAGTGGAGGTCAGGT GCTAGGCCATTTCTGCCCGACACAGGCCTCCTCTAATGAGCAGTCTGAGGCCAGGCACAGGAGGCTGAGGCAGGAGAATCGCTTGAACCC AGGAGGTGGACGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGACAGAGTAAGACTTCGTCTCAAAAAATAAAAAATA AAAAAATACTGAGCAGTCTGCTTGGGCGCTTCCATCAGCCTGGCCATGACATCTTTGGAGCTGTCCTGCCCTCTTTTGCCCCGGTGTTCC TTGGCCCACCTGTCAGACCTACATCATAGGCTCTTCCTGTCTTCTGTTTCCTCTCCCCTTTCTCTAACATAGGTGTTTCTCCTGAGAAAG AAAAAAACCACCTGTCCCTGACATTCAGAAGCTGACAACACTGTTCGGTCATGCCATTCTCCTGTTGGACATAAACAGTCTCTGAATGCC AACCCCAAAGTTGCTCTCAGGCCATGATAAAATAAACCACTTAATAATTTTGTCTAAGCACGTACAAAGAAAATTCAAGGTCAGTTTACC ACTCACAAAATACCAAACATCCTTCTGCTGGTTAAAACGAGTGACAGCTGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAT GTGTATATGCGTATATATGTGTATGTATGTGTGTATATATATATGTGTGTGTGTATATATATATATGCAATTATACCTTTATCCCTACTC TAGTCCACCTTCCTATAAATAAGATGTATTGAGATGCTCAGTGCCCCCATTCTGACAGCATCCAATCGAGTGAATCCTCACTTCCTTGAA ATCACCCAACCAGGGCCAGAATCCTAAAAGAGGTTCTTTGTGACACCCTCTGTCTGAGAAGTCCTATGGTTCTCTGTGATGAATAGACCC AACTTGTTCAAATACAGGCATTTCTGGTGGGCTTTGGCTGAAGGCATTCACACCCCCCAGTGAATGTCTTGCACTTCTAATTGTGTCTCG GGGCATGCCTGGTGGAGGACCTGACTGAGACAATTGTGACTGGATGTGGTCTGAGAGCAGGCAGTAGGATGAGGCTTGGGGACTGGCTCA CTCACTGCCCAACTGGTAGCAAAACCCATCTGGAGCAGCGTGTGAGGTATGGACACTCACTCACACGAGGGGGTGGCCCAGTTGCTGAGG ATTCCACCAGTGGTACCCTGGGAAAATATCCCTGTGGAGGGGAATGGGAGGAGTCAAACTGTGGAAGATAAGAGGAGTACTGCACACAAG GACAGTAGAGTGTCTGTTCCCTGCAGAGGGATAGTGAGGAACTGATGAGGTGACTGTGAGTGCCCGGGGCCTCTGTCGTTATCTTGGAGG ATCACTTTGAGGTCAGGAGTTCATGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACATTAATTAGCATGGTGGCGG GTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCCGAGGTTGCAGTGAGCTGAGATGGCGCCA CTGCACCCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAACAAACACACAGTACTGCATCCTGGGGGTGGAGGTGAGGTGACGGTA GAGATCAGTGCTACCCTTGGAAATCTGACAGATACAGTAAGATGGTCCCTATCATAGTTCCATTTAATTTGCCAGCCTCATCTGCAGAAT CCAGATGGATCCTGGAGAAAAATTAACCAAGTAGCCTCAATCACAAATGTTGGGTTGGATATTACATCAGTGTTAGAGCAGTTAAGGGCT CAGGTATGTGGTGTGCAGCCATTGACTGGGTGAATCCATTTTTACCTACCCCAATTACAAAACAGTTTGCTTTCATGTGGAACAGATAGT ATTCCTTTCAGTTTTGCTGCAGGAACATATTAACTCTTCCACCCCTGTCATAATACAGCCTGAAGAGATTTACCATTAAATACTGTTTTT TTCTCTCTCTTAACTTAATCCCGAATTGGATAATTTCTCTTCATCTTCACTGTCACCTCTACGCCATCACTGTCATCTCTAGACCGCTCT GCTGTTGAGAGATTGATGGAATCATTATGCAAACTAAAATAGAATGTTTTATCTATCAAATTGTATTTCTTTGTCAATAGTGTTAGGGCA CAGTAGGTTCATTTACTGCTGGTAAGGGTGTAAATTGTTAGAAACTTTCTGAATGGCAGTTTGGTAATAACAAACAAAAAGCTTAAGTTT GTGTCCTTAAATGCCTTACTTCAATACCCAAGGCATATGGCCTCAATAAAAAATTATGGAAGCATGCAAAGATTTTGTTAACAAAGATAT AATCATTGCAGGGTAGAATTTAGAAATTTAAGACTGAAAGATCTTTTCAGTCACCTGCAGCAAGAAAGGAGTCAAAACCTATGTACGATC TCAACTAGTAAAATTTTCTCCTTGCCCAGGGATCATGCTGAGTTTAAGGACAGAAATGCAAAGTGCAGCCTGGGAAAGTGTTTCAACACA CAAAAATAGAACCACCTGTATGTAGTCTTTTTGAAAGCACAAAATAAAGAGCAGTCCTACAGGGTTCACTGCTATGTCCTGAATGTTGAT GTCCCTTCCAAAATTCATATGTTGGAACCTAATGTCAATGTAATAGTATTAAGAGGTGGGGCTTTTGGGAAGCAATGGAGTCATGAGGGC TTCACCCTCATGAGTAGGATAAGTACCCTTACAAAAGAGGCTCAGGGAGGCGCTCTTGCCTCTTCCACCATGTAAGGACACGTAGCAGGC ACCCATTTCTGAAGAATGGGCCCTCCCCAGACTCCATATCTGCTGGTGCCTTGATCTTGGACTTAGCCTCTAGGACTGTGAGTGACATAT TTCTATTGTTTATAAATTATCCAGTATAAGTAAGATATTTTGTTAGAGCAGCCTGAACGAACTAAGACACTCTAAGCGGGAAACTCACAA AAAATATTTGGTAGTGAAAAACAGTATGGTGTGTTAATGTATGGTGACAAGTGTTTGTTTGCATTTAAAAATGCATTGGAGCCTCGTTTT GATTAGGCAGTAAATTTACCTTTAATACGTAAGTTTGACAGTTATATGTAATCAGCTTTTTTTTTTTTAAGATGGTGTGATTGAGGTTAA TGTGAACTGAACTTTCTATTTCTAAGCTGTCTTCATCTAATTTTACCTTTCTGTGGAAAATCAATACAAGTCAACCATTTTTATTGCCCA GTTATTCAAAGTTTTATTCAAAGAGCAAAGATTTGACAATGCATAGAATTAACATTGGTTTGTGGGCCACCTTCTGGGCCAGCACCAAAG ACTGAAAAAATATTTTGCCCCCTAAAAGTTGTTATTGAGTCTTGTCAAATCACATTGCTCTGTCAGAAGGTAAGACAAATCAGTGTGGAC TGAGAGCAAGGTCAGCACCGTGAACAGCCATTGCGGTTCCTTTAACCCACTGGGAATTCATGCAGTGAAGAAGCAACACACCATGAGGCA AATGGCTCAAACCCAAAGACCAGAGGTTCAGGGGATATATATATATATTTTTTTAATCTGTAGAGATGGGATCTCACTATCTTGCCCAGG CTGGTCTCGAACTCTTGGGCTCATGCTGTCCTACCTCAGACTTCCAAGTAGCTGGGTTTTCTTTGGGCTAATTATTTTTTTGTAGAGATG GAGGTCTCGCTGTGTTGCCCAGGCTGGTCTCAAATTCCTGGCCTCAAGCTCTCCTCCCATCTCAGCCTCCCAAAGTGTTGGGATTACAGG CATGAGCCATGTGCCCAGTCTAGAAGATCTTTGACTTCAAAGAACAGATAATCTAGAGACCTTCACAAGTGATCATGTTGGCACTATGGT CATTACACTGAGACCTATAACTGGGCTAGGATTGGTTATTTACAGAAAAACCTTGTGGTACTTAATTCCAATTCATGTTAATTTATGTTA TCTTGCTTAATCCTTGCAAAGCCCTTTTAGAGGTGGGTGTTATCCCATCTATAATCTGCTGCTTGTCTTAGACCAAGGAAGTGAAAGTAT TCAGTCCAAGCATGCTACCATCCATTTCTGGTAGGTTTGGTTTGTTTTTAGTTGGCTTTCCTGTTTAACTGTTATTTGTCTTCCTATTGA GGTTAGATGTGCATTTTGGAATTGCATCATTTTACATAGAAACAGCTTTCCAGTGGAGTTGACTAGCATCCTAAGGACAAGTACAACCAC TTTTGAAATAGATCATGGAAATCACAAAGTCTGATGTTCCACAAAATGGAGTATGATGTTATGGACACTAGAAATACAAGGTATGGGTCA TTAGTAACGCTAATAACATTTTCCTATAGATGACTTTTAATAACACTGGTTTAATGTCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTGGAGACAGGGTCTCCCTCTGTCACCCAGGCTGGTTGGAATGCAGGAGTTCGAACTTGGCTCACTGCAACCTCTGCC TCCTAGGTTCAAGTGATCCTCCCGCCTCAGTCCCCCAAGTACCTGGGACCACAGGCACACGCCACCATGCCTGGCTAATTTTTGTATATT TTGTAGAGATGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAATTCCTGGACTCAAGCAGTCCATCTGCCTCAGCCTCCCAAAGTGATG GGATTACAGGCGTGAGCTGCTGTGCCTGGCAGAACAGTATGAAGTGTTAACGCCAAAATTTGTTTTAGCTATCATATATAAATCATAAGC ATATTATTTGGTTGGTTGGTGTTAGTTCATTCCTTCAATCGGATGATTTAAAATAAATGTTTTTCAAGTATCCTCTGTGATGTATCCCAA AGGTTAGCTTAGAAAGAAAAGTACTTGGTGAACCATTCCTGGTGCGGAGAGCCCTGTTTCTGCTGGACTTCTTTGGCTTGGGCCGTTTCA CCATCTGGGGTCCTAAAAGCAAAAAAAGGTTTTTTTATATGGTTTTGAAAACTATGCAAGAAGCAGCTTAATACCCACCATCTTTTCAGG GAAAGATAACTGCTTGTTTACTCTTCAAAAACACCCAAATGGGACTGGCCAACATTAGTAGTGGGAAACAAATTGTAAAGGATGGGGCTG GGGAGGGAGTACCTAATCCTCATTTGGAAAACAGAAGGTTCACCATTGTTTGGTTCTCCATTGTTCCTTTGAGACTTAGTGGTTGTAGCT CTAATAATGCAGGATTAACCAAACCTACAGATCAAGAGACTTTGTTTTTATTTTTTGTGACAGAGTCTCCCTCTGTCACCCAGGCTGGAG TGCAGTGGCATGATCTCGGCTCACTGCAACCTCCAGCCTCCTGCGTTCAAGCGATCATTGTGCCTCAGCCTCCCGGGGAGCTGGAATTAC AGGCGCATACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGACC TTAGGTGATCCACCCACCTCCATCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCCGATTAAGAGACTTTAGAATTC CAAGGTGATAGAGTAAATCTTGAGGAATAATGTTAGTAATAATACTGAAACTATATTGAAGATTTTTGTGCCAAGTCCTGTGCTAAGCAC ATCCTATGGATTAATTCCTTTAGTCTCACGTCAGTCTGATGAGATAGGTGCTGTATTATCTTAATTTTAAAGGCAAGGTATATGGAGACC TGGAGAGGTCAAGTGACCTGTCCAAGGCCACAGAGCTAAGAATGAGGAAGACTGTAATTTGAATTCAGACCTCCAGGCCAGATGGAGTCC ACCTTTTGTATAACCCATGCTGAAGTTTTCAGGTAAGTGATTCAGTGTCCCTTGTCTAATCATCCATGAAAAAAGGCCTTCTGGAATTTG GTACCAGGTGCTAGAAAGAATCCTACTTCCCCTCTTATCTACAGGGAAATAGAATAAGGGCCCCTGTCCCCAACATCCCCCAAACCTTGT GGCAGTTTTTGCATCTGTAGACTGGTTGGGTTTGTAGGTCCGGCCACAGCTGGGGCTTGGGTCCAAGCTGGGTGATGTAGTTATTGGAGG GGCATTAATCCTGGAACTCAGATCGCCACTCAGAAAGTTCTTTGCATAGGAGGCGAGGTTCGGCACGCTGACCACGCGGCTGGGCACGTC CTCCACCTTCTTTTTCTGTTTGTATTAATGGACAGGTTAGTGCAATGCAATGCAAAAAACAAAATAAAGCATTATTGTAAAAGCAAATAA TGCTCACCCAATCAAAATTGTATCGGAGAAGAAGCAACAATTTCATTTATACACTTACATGCTATTTTTTAAAGCACTTTTCCCTCCAAT >In-frame_EIF1_ENST00000469257_chr17_39846193_+_MED28_ENST00000237380_chr4_17621524_+_11026nt CACTGAGCCGCCGCCGAGGATTCAGCAGCCTCCCCCTTGAGCCCCCTCGCTTCCCGACGTTCCGTTCCCCCCTGCCCGCCTTCTCCCGCC ACCGCCGCCGCCGCCTTCCGCAGGCCGTTTCCACCGAGGAAAAGGAATCGTATCGTATGTCCGCTATCCAGAACCTCCACTCTTTCGACC CCTTTGCTGATGCAAGTAAGGGTGATGACCTGCTTCCTGCTGGCACTGAGGATTATATCCATATAAGAATTCAACAGAGAAACGGCAGGA AGACCCTTACTACTGTCCAAGGGATCGCTGATGATTACGATAAAAAGAAACTAGTGAAGGCGTTTAAGAAAGCTTGCTTTGCATCTCTGG TGAGTCAGGACTATGTCAATGGCACCGATCAGGAAGAAATTCGAACCGGTGTTGATCAGTGTATCCAGAAGTTTCTGGATATTGCAAGAC AGACAGAATGTTTTTTCTTACAAAAAAGATTGCAGTTATCTGTCCAGAAACCAGAGCAAGTTATCAAAGAGGATGTGTCAGAACTAAGGA ATGAATTACAGCGGAAAGATGCACTAGTCCAGAAGCACTTGACAAAGCTGAGGCATTGGCAGCAGGTGCTGGAGGACATCAACGTGCAGC ACAAAAAGCCCGCCGACATCCCTCAGGGCTCCTTGGCCTACCTGGAGCAGGCATCTGCCAACATCCCTGCACCTCTGAAGCCAACGTGAG CAAAGGGCAGAGGCAGTTGGCCTATGAGTGGGCTGATGCGTGAGGTTGGCCACACATTCCTTCCTGTGGACTTGACATTTTGGAAGAACT CTTTGCCAGATAATGAGTTCATTTTAGTTTTATGCTCCCATTGAAAAATTTTCCACTATTTTTATAAGCTGTTAATTTCTTGAGTACTTT ATAACATGTCTGTAGCTTGGATAAACCAAGTAAGTATTTTTTTTTTGTCTTTAGCAAAGTTTAGACTGTGAATATGATGACACAGATTCT TTTTTATGGTGGCTTTGCTTGTTTTAAATTTTTGCATGACTTTTCATCTTTTTATGTGTGTTTCCTGTAGTTTGATCCGAAGGAAAAGAG TATAGTAGCCTGAGAATCAGGAGATGGGAGTTTTAGTCGTAGGCCTTATGATAATTACCCCGCGGTGGTGTGTAGAAAAGTATGTAAATT TGCTCTGTTTTAAGACTTTGAACTACCTCAAGAAGAGGAATCTAATACAATATTTGTAATGTTTCCAGAGCTCTCAGAATGAGGATTTTT TTGTAAATAGGTCAGAAGACGATGGAACTGTCCTGGGTTAGTATAGTAATCTTACAGTAGGATCCTTAGGTTGATGCTGACTTCTGTTTG GGGTATGTTTATATTTTATGTGGTGTTTACTTTTTTTTTTTGACATAGAAGGATATAGTGGGAGCAGTGATACGCTAACATTCATTACAT TCTGCAGTAATGAATCTGTTTAATGGGTCAGTCACTGTTTTCAGTAGCATGACAGTGGGGTCATAGGTGAGCTGTGAGGGGCTAAATCTT GCTCTGATTGTCTCTTTCTGTTTTGAGTTTTGTTTGCGTGTATCATTTTTGTTCTACATTTTGGGAGGGGAAACATTTTCCGTTAAGGAA GGTTGTTGCCAGTGGATTTGACTCCAAGGGACTAGAGTGTCGTGGTGGGGGTGGGGAGGGGCTGCAGGGTGATCATTGGCTACTGAGCCT CCACAGAGAGCATGTGGTGCCCTGCCTTTGGGAGGGTATTTTGCTCTCGTTAGTTTTGTGGGCAGCCTCAGATTCCCTGTTGAGTTGCTG TTAAGAAATGGAGATTTCTGGCTCTCATTGGGTAAGGTTTTCTGAGTTTTATATCTTATTAGATCACATCCCTTTACCCAGAACAAATGC TTCACTGTCTTCTGATTGGCAGTACTCCTGTGGCTTTGTGCCTTGACTCATTTTGTTGTCTTCAGCCTTGAAGGCCCCTTCCCACATGGA CTGACATCCACTCATGTGCCTGATCCCTGAAGCCTCCCAGCACCCATTCAGTTGCATCCCCAGGGCACAGGACTTTGATCTCTTCTGTTG CCCTCGCTAGGTTCTCCCTGGTGGGTTAGTGCTTTGTATCTGTCTCTCTGCCCCTCACTAATTCTACACCCATGAGAATTAGACATTATT CTCCTTAAATATATAAGGACCATATAATCTGTATCTTTTTGGTGTGTGTATATGGTATCTGGCACATGGATCTCTGATTACCAGCCTGAC ATCAACAAATCCCCTCAGTTACAACGTATAGGTTAAACAAAGCTTTTAAAAGCTCATGTGGTATGACCTCAAGGTTGCTAACCTGGTCAC TCATGGTAATTAGAAACTCTGATTGGCAGCTTTGTATTTCTTGACTAAAAACCTAAATAAACTGATTAGGTTTTAGGCGTTCTTTCAAAG AGGTTCTTGAGAAGATTGAGAACTATCCTATTTGGTGCTTAGTGAAAAGATTTTGAATTACTGTACGTACCAGTTGTTGCCATTTCTTTA TTAAATTCAGAAGTTTTTTTGCCAAATAACAATTTTTCAATCTTCTCTGTTTGTAGACATCTTACTGGGTGATGAATAATCCTCTAAGAA ACCCTCTGAGCTGCTAACTTTTTCAGGGAGAAAATCACAAGCCATCTTCTCAAGTTCCCCTAGAAACCTGTGGAATGCCCTCTGCCAAGC ACTGCTCTGGTACTGGGGAGTGGAGTATTATGTCTTGGAAGAGACTCCTGCTGTGATTGTCCAGGGGTACGTTCTGGTCTGGCTTGGTGC TTGACCTTAGGTCTGCCCACAGGCTTCAGGCTTTCAACTTTGAAACAAACATCTGTGCCACACACATTTTGTAAATGATCCCATTCAGTC TTCTAGAAGCCTTATAACAGAATCAATATTGTTTTTCCCATTTTCACAGATGGATAATAAATCTGTAAAATAGGGATAAGACTAGGACCT ATTCCCCAGGATTACTTCTGCAGATTAAAGGAGATGTTGAGGCCAGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGGGGCTGA GGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGTGATGAGCCAAGATCGTGCCATTGCACTCCATCCTGGGCTACAAGAGTGAAAC TCCGTCTCAAAAAAGAAAAAGGAGATGTTGAATGGGAAGTCAGCAAGGGTGCTAGAATGTAGCAAGTATTCTTCAGGTGTTAGTGATTTC TGTTGTTCGGGAAGAGGAGGGTTATGGAGGAAGAGTATGGGATTTAGGTGGGTTAAGTGATTTGCCCAAAGTCAAGAGGTTAGTCTTTAA CCTTTGGCAGAAGCAGGATTTGAAGTGAGTTTTCACACCCCTCTTCCCTGGTCAGTGTGTTGATAACAGCCCACCCACCTGTGGTTCCAG GGTGTTCTTAAGAAGCCAAGGTTGTCTTGGGTGTGGTAGCTCTTTGAAAGGTAGAAAGTTCCACCAAGAAGGCCTTTTTTCTTGAATACT GCTTAGCTTCCTTGTCAGGCTCCAAGATGCAGATTGCCTGTGGGCTATCTCTCTCCACAGATAAACCTACTCACATCTTCAGGACAGCCT TTTTTTTTTGAGACAGGAGTCTTGCTCTGTTGCCCAGGCTGTAGTGCAGTGGCACAACGGGGTCCCACAGGCAAGTGCTGGGGAAAGGCC CACCCAGCCATCAGGTAGCCTGTGTGTTCTACAAACAGCAGCTGGCAGCACTGTCTCCTGCCGGACATTCCTGCCACCCGACATCAAAGC TGGTGGGTGACCTTTTCAGCCATTTGACATTCCTCCCAGAAGAACCTCTGCCTCCCAGAGGTTTAAGCAGTTCTCCTGCCTCAGCCTCCC AAGTAGCTGGGCTATTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGTCGCCCGGTTAGAGTGCAGTGGTGCAATCTCGGCTCAC TGCAACCTCTGCCTCCCGGGTTCAAGTAATTTTCCTACGTCAGCCTCCCGAGTAGCTGTCAGGTGCACACCACTACACCCAGATAATTTT GTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGTCAGGATGGTCTCAATCTGACCTCGTGATCCGCCTGCCTCTGCCTCCCAAAGGGC TGGGATTACAGGCATGAGCCACCGCGCCCAGCCTTAATTTTTGTATTTTTAATGGAGATGGGGTTTTGCCATGTTGGCCAGGCTGGTCTT GAACTCCTGACCTCAAGTGATCTGTCCGCCTCAGCCTCCCAAAGTACTGAGATTACAGGCATGAGCCACCGTGCCCAGCCCATCTTCATC TTCTTTACTTGAACTTAATTCTTTTTCATGCATCTTCCCTTCTTTCCTCTTTTCTCCTCCACCCAAATGTCTTAACTGTTAACATTCCCA GGTGTTTGGTCCTGGGCCTCTGGAGGTTGTGAAGGAGCACTGCTCAGTCCTCCCTTCAAGAAAGCAGCTTCAAGGAGTTCAATTACAAAA GCTCCTGGCATTGGGGACCTGCCGCCATGTTCCTGCCCAGGGCATGCTGGTCCTGGCTGTCACCAAGCACAGTGGAGGTCAGGTGCTAGG CCATTTCTGCCCGACACAGGCCTCCTCTAATGAGCAGTCTGAGGCCAGGCACAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGG TGGACGTTGCAGTGAGCCGAGATCGAGCCACTGCACTCCAGCCTGGGTGACAGAGTAAGACTTCGTCTCAAAAAATAAAAAATAAAAAAA TACTGAGCAGTCTGCTTGGGCGCTTCCATCAGCCTGGCCATGACATCTTTGGAGCTGTCCTGCCCTCTTTTGCCCCGGTGTTCCTTGGCC CACCTGTCAGACCTACATCATAGGCTCTTCCTGTCTTCTGTTTCCTCTCCCCTTTCTCTAACATAGGTGTTTCTCCTGAGAAAGAAAAAA ACCACCTGTCCCTGACATTCAGAAGCTGACAACACTGTTCGGTCATGCCATTCTCCTGTTGGACATAAACAGTCTCTGAATGCCAACCCC AAAGTTGCTCTCAGGCCATGATAAAATAAACCACTTAATAATTTTGTCTAAGCACGTACAAAGAAAATTCAAGGTCAGTTTACCACTCAC AAAATACCAAACATCCTTCTGCTGGTTAAAACGAGTGACAGCTGCCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTAT ATGCGTATATATGTGTATGTATGTGTGTATATATATATGTGTGTGTGTATATATATATATGCAATTATACCTTTATCCCTACTCTAGTCC ACCTTCCTATAAATAAGATGTATTGAGATGCTCAGTGCCCCCATTCTGACAGCATCCAATCGAGTGAATCCTCACTTCCTTGAAATCACC CAACCAGGGCCAGAATCCTAAAAGAGGTTCTTTGTGACACCCTCTGTCTGAGAAGTCCTATGGTTCTCTGTGATGAATAGACCCAACTTG TTCAAATACAGGCATTTCTGGTGGGCTTTGGCTGAAGGCATTCACACCCCCCAGTGAATGTCTTGCACTTCTAATTGTGTCTCGGGGCAT GCCTGGTGGAGGACCTGACTGAGACAATTGTGACTGGATGTGGTCTGAGAGCAGGCAGTAGGATGAGGCTTGGGGACTGGCTCACTCACT GCCCAACTGGTAGCAAAACCCATCTGGAGCAGCGTGTGAGGTATGGACACTCACTCACACGAGGGGGTGGCCCAGTTGCTGAGGATTCCA CCAGTGGTACCCTGGGAAAATATCCCTGTGGAGGGGAATGGGAGGAGTCAAACTGTGGAAGATAAGAGGAGTACTGCACACAAGGACAGT AGAGTGTCTGTTCCCTGCAGAGGGATAGTGAGGAACTGATGAGGTGACTGTGAGTGCCCGGGGCCTCTGTCGTTATCTTGGAGGATCACT TTGAGGTCAGGAGTTCATGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACATTAATTAGCATGGTGGCGGGTGCCT GTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCCGAGGTTGCAGTGAGCTGAGATGGCGCCACTGCAC CCCAGCTTGGGTGACAGAGCAAGACTCCGTCTCAAAAACAAACACACAGTACTGCATCCTGGGGGTGGAGGTGAGGTGACGGTAGAGATC AGTGCTACCCTTGGAAATCTGACAGATACAGTAAGATGGTCCCTATCATAGTTCCATTTAATTTGCCAGCCTCATCTGCAGAATCCAGAT GGATCCTGGAGAAAAATTAACCAAGTAGCCTCAATCACAAATGTTGGGTTGGATATTACATCAGTGTTAGAGCAGTTAAGGGCTCAGGTA TGTGGTGTGCAGCCATTGACTGGGTGAATCCATTTTTACCTACCCCAATTACAAAACAGTTTGCTTTCATGTGGAACAGATAGTATTCCT TTCAGTTTTGCTGCAGGAACATATTAACTCTTCCACCCCTGTCATAATACAGCCTGAAGAGATTTACCATTAAATACTGTTTTTTTCTCT CTCTTAACTTAATCCCGAATTGGATAATTTCTCTTCATCTTCACTGTCACCTCTACGCCATCACTGTCATCTCTAGACCGCTCTGCTGTT GAGAGATTGATGGAATCATTATGCAAACTAAAATAGAATGTTTTATCTATCAAATTGTATTTCTTTGTCAATAGTGTTAGGGCACAGTAG GTTCATTTACTGCTGGTAAGGGTGTAAATTGTTAGAAACTTTCTGAATGGCAGTTTGGTAATAACAAACAAAAAGCTTAAGTTTGTGTCC TTAAATGCCTTACTTCAATACCCAAGGCATATGGCCTCAATAAAAAATTATGGAAGCATGCAAAGATTTTGTTAACAAAGATATAATCAT TGCAGGGTAGAATTTAGAAATTTAAGACTGAAAGATCTTTTCAGTCACCTGCAGCAAGAAAGGAGTCAAAACCTATGTACGATCTCAACT AGTAAAATTTTCTCCTTGCCCAGGGATCATGCTGAGTTTAAGGACAGAAATGCAAAGTGCAGCCTGGGAAAGTGTTTCAACACACAAAAA TAGAACCACCTGTATGTAGTCTTTTTGAAAGCACAAAATAAAGAGCAGTCCTACAGGGTTCACTGCTATGTCCTGAATGTTGATGTCCCT TCCAAAATTCATATGTTGGAACCTAATGTCAATGTAATAGTATTAAGAGGTGGGGCTTTTGGGAAGCAATGGAGTCATGAGGGCTTCACC CTCATGAGTAGGATAAGTACCCTTACAAAAGAGGCTCAGGGAGGCGCTCTTGCCTCTTCCACCATGTAAGGACACGTAGCAGGCACCCAT TTCTGAAGAATGGGCCCTCCCCAGACTCCATATCTGCTGGTGCCTTGATCTTGGACTTAGCCTCTAGGACTGTGAGTGACATATTTCTAT TGTTTATAAATTATCCAGTATAAGTAAGATATTTTGTTAGAGCAGCCTGAACGAACTAAGACACTCTAAGCGGGAAACTCACAAAAAATA TTTGGTAGTGAAAAACAGTATGGTGTGTTAATGTATGGTGACAAGTGTTTGTTTGCATTTAAAAATGCATTGGAGCCTCGTTTTGATTAG GCAGTAAATTTACCTTTAATACGTAAGTTTGACAGTTATATGTAATCAGCTTTTTTTTTTTTAAGATGGTGTGATTGAGGTTAATGTGAA CTGAACTTTCTATTTCTAAGCTGTCTTCATCTAATTTTACCTTTCTGTGGAAAATCAATACAAGTCAACCATTTTTATTGCCCAGTTATT CAAAGTTTTATTCAAAGAGCAAAGATTTGACAATGCATAGAATTAACATTGGTTTGTGGGCCACCTTCTGGGCCAGCACCAAAGACTGAA AAAATATTTTGCCCCCTAAAAGTTGTTATTGAGTCTTGTCAAATCACATTGCTCTGTCAGAAGGTAAGACAAATCAGTGTGGACTGAGAG CAAGGTCAGCACCGTGAACAGCCATTGCGGTTCCTTTAACCCACTGGGAATTCATGCAGTGAAGAAGCAACACACCATGAGGCAAATGGC TCAAACCCAAAGACCAGAGGTTCAGGGGATATATATATATATTTTTTTAATCTGTAGAGATGGGATCTCACTATCTTGCCCAGGCTGGTC TCGAACTCTTGGGCTCATGCTGTCCTACCTCAGACTTCCAAGTAGCTGGGTTTTCTTTGGGCTAATTATTTTTTTGTAGAGATGGAGGTC TCGCTGTGTTGCCCAGGCTGGTCTCAAATTCCTGGCCTCAAGCTCTCCTCCCATCTCAGCCTCCCAAAGTGTTGGGATTACAGGCATGAG CCATGTGCCCAGTCTAGAAGATCTTTGACTTCAAAGAACAGATAATCTAGAGACCTTCACAAGTGATCATGTTGGCACTATGGTCATTAC ACTGAGACCTATAACTGGGCTAGGATTGGTTATTTACAGAAAAACCTTGTGGTACTTAATTCCAATTCATGTTAATTTATGTTATCTTGC TTAATCCTTGCAAAGCCCTTTTAGAGGTGGGTGTTATCCCATCTATAATCTGCTGCTTGTCTTAGACCAAGGAAGTGAAAGTATTCAGTC CAAGCATGCTACCATCCATTTCTGGTAGGTTTGGTTTGTTTTTAGTTGGCTTTCCTGTTTAACTGTTATTTGTCTTCCTATTGAGGTTAG ATGTGCATTTTGGAATTGCATCATTTTACATAGAAACAGCTTTCCAGTGGAGTTGACTAGCATCCTAAGGACAAGTACAACCACTTTTGA AATAGATCATGGAAATCACAAAGTCTGATGTTCCACAAAATGGAGTATGATGTTATGGACACTAGAAATACAAGGTATGGGTCATTAGTA ACGCTAATAACATTTTCCTATAGATGACTTTTAATAACACTGGTTTAATGTCAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT TTTTTTTTGGAGACAGGGTCTCCCTCTGTCACCCAGGCTGGTTGGAATGCAGGAGTTCGAACTTGGCTCACTGCAACCTCTGCCTCCTAG GTTCAAGTGATCCTCCCGCCTCAGTCCCCCAAGTACCTGGGACCACAGGCACACGCCACCATGCCTGGCTAATTTTTGTATATTTTGTAG AGATGGGGTTTCACCATATTGGCCAGGCTGGTCTCAAATTCCTGGACTCAAGCAGTCCATCTGCCTCAGCCTCCCAAAGTGATGGGATTA CAGGCGTGAGCTGCTGTGCCTGGCAGAACAGTATGAAGTGTTAACGCCAAAATTTGTTTTAGCTATCATATATAAATCATAAGCATATTA TTTGGTTGGTTGGTGTTAGTTCATTCCTTCAATCGGATGATTTAAAATAAATGTTTTTCAAGTATCCTCTGTGATGTATCCCAAAGGTTA GCTTAGAAAGAAAAGTACTTGGTGAACCATTCCTGGTGCGGAGAGCCCTGTTTCTGCTGGACTTCTTTGGCTTGGGCCGTTTCACCATCT GGGGTCCTAAAAGCAAAAAAAGGTTTTTTTATATGGTTTTGAAAACTATGCAAGAAGCAGCTTAATACCCACCATCTTTTCAGGGAAAGA TAACTGCTTGTTTACTCTTCAAAAACACCCAAATGGGACTGGCCAACATTAGTAGTGGGAAACAAATTGTAAAGGATGGGGCTGGGGAGG GAGTACCTAATCCTCATTTGGAAAACAGAAGGTTCACCATTGTTTGGTTCTCCATTGTTCCTTTGAGACTTAGTGGTTGTAGCTCTAATA ATGCAGGATTAACCAAACCTACAGATCAAGAGACTTTGTTTTTATTTTTTGTGACAGAGTCTCCCTCTGTCACCCAGGCTGGAGTGCAGT GGCATGATCTCGGCTCACTGCAACCTCCAGCCTCCTGCGTTCAAGCGATCATTGTGCCTCAGCCTCCCGGGGAGCTGGAATTACAGGCGC ATACCACCACACCTGGCTAATTTTTGTATTTTTTGTAGAGATGGGTTTCACCATGTTGCCCAGGCTGGTCTCGAACTCCTGACCTTAGGT GATCCACCCACCTCCATCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCAAGCCCGGCCCGATTAAGAGACTTTAGAATTCCAAGGT GATAGAGTAAATCTTGAGGAATAATGTTAGTAATAATACTGAAACTATATTGAAGATTTTTGTGCCAAGTCCTGTGCTAAGCACATCCTA TGGATTAATTCCTTTAGTCTCACGTCAGTCTGATGAGATAGGTGCTGTATTATCTTAATTTTAAAGGCAAGGTATATGGAGACCTGGAGA GGTCAAGTGACCTGTCCAAGGCCACAGAGCTAAGAATGAGGAAGACTGTAATTTGAATTCAGACCTCCAGGCCAGATGGAGTCCACCTTT TGTATAACCCATGCTGAAGTTTTCAGGTAAGTGATTCAGTGTCCCTTGTCTAATCATCCATGAAAAAAGGCCTTCTGGAATTTGGTACCA GGTGCTAGAAAGAATCCTACTTCCCCTCTTATCTACAGGGAAATAGAATAAGGGCCCCTGTCCCCAACATCCCCCAAACCTTGTGGCAGT TTTTGCATCTGTAGACTGGTTGGGTTTGTAGGTCCGGCCACAGCTGGGGCTTGGGTCCAAGCTGGGTGATGTAGTTATTGGAGGGGCATT AATCCTGGAACTCAGATCGCCACTCAGAAAGTTCTTTGCATAGGAGGCGAGGTTCGGCACGCTGACCACGCGGCTGGGCACGTCCTCCAC CTTCTTTTTCTGTTTGTATTAATGGACAGGTTAGTGCAATGCAATGCAAAAAACAAAATAAAGCATTATTGTAAAAGCAAATAATGCTCA CCCAATCAAAATTGTATCGGAGAAGAAGCAACAATTTCATTTATACACTTACATGCTATTTTTTAAAGCACTTTTCCCTCCAATCTTCAT |
Top |
FusionGenePPI for EIF1_MED28 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EIF1 | RASA1, MAPK6, APP, EIF2D, DHX9, EIF5, EIF3G | MED28 | KLHL12, USHBP1, MAGEA11, NF2, GRB2, MED10, MED9, MED29, MED19, MED13L, MED13, MED12, MED14, MED23, MED15, MED24, MED16, MED25, MED17, MED26, CCNC, CDK8, CDK19, MED27, MED4, MED6, MED7, MED8, MED18, MED20, MED30, MED28, MED21, MED22, MED11, MED31, MED1, POLR2J, POLR2D, POLR2A, POLR2B, POLR2C, POLR2G, POLR2L, ZC3H13, RCOR1, POLR2E, CDK9, TRIP4, TADA2A, ELAVL1, FBXW7, TEC, YES1, SRC, OSTF1, BTK, FYN, ABL2, SNX9, NPHP1, PSTPIP1, STAM, PIK3R2, PIK3R1, ARHGEF5, DLG4, HCK, NEBL, MAGI3, WWTR1, NEDD4L, PRMT6, PUF60, SPERT, SHMT2, MOV10, TCL1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for EIF1_MED28 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for EIF1_MED28 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MED28 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | MED28 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|