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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 11170

FusionGeneSummary for EHMT1_EHMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: EHMT1_EHMT1
Fusion gene ID: 11170
HgeneTgene
Gene symbol

EHMT1

EHMT1

Gene ID

79813

79813

Gene nameeuchromatic histone lysine methyltransferase 1euchromatic histone lysine methyltransferase 1
SynonymsEHMT1-IT1|EUHMTASE1|Eu-HMTase1|FP13812|GLP|GLP1|KLEFS1|KMT1DEHMT1-IT1|EUHMTASE1|Eu-HMTase1|FP13812|GLP|GLP1|KLEFS1|KMT1D
Cytomap

9q34.3

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-mhistone-lysine N-methyltransferase EHMT1EHMT1 intronic transcript 1G9a-like protein 1H3-K9-HMTase 5euchromatic histone-lysine N-methyltransferase 1histone H3-K9 methyltransferase 5histone-lysine N-methyltransferase, H3 lysine-9 specific 5lysine N-m
Modification date2018052220180522
UniProtAcc

Q9H9B1

Q9H9B1

Ensembl transtripts involved in fusion geneENST00000462484, ENST00000334856, 
ENST00000460843, ENST00000371394, 
ENST00000462484, ENST00000334856, 
ENST00000460843, ENST00000371394, 
Fusion gene scores* DoF score10 X 9 X 7=6305 X 7 X 2=70
# samples 138
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/70*10)=0.192645077942396
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EHMT1 [Title/Abstract] AND EHMT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEHMT1

GO:0006325

chromatin organization

12004135

HgeneEHMT1

GO:0016571

histone methylation

12004135

HgeneEHMT1

GO:0018027

peptidyl-lysine dimethylation

20118233

TgeneEHMT1

GO:0006325

chromatin organization

12004135

TgeneEHMT1

GO:0016571

histone methylation

12004135

TgeneEHMT1

GO:0018027

peptidyl-lysine dimethylation

20118233


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ370417EHMT1chr9

140611429

+EHMT1chr9

140622837

-
ChiTaRS3.1BF997880EHMT1chr9

140611295

-EHMT1chr9

140622838

-
ChiTaRS3.1CV420354EHMT1chr9

140721748

-EHMT1chr9

140721670

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000462484ENST00000462484EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000462484ENST00000334856EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000462484ENST00000460843EHMT1chr9

140611429

+EHMT1chr9

140622837

-
5CDS-3UTRENST00000462484ENST00000371394EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000334856ENST00000462484EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000334856ENST00000334856EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000334856ENST00000460843EHMT1chr9

140611429

+EHMT1chr9

140622837

-
5CDS-3UTRENST00000334856ENST00000371394EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000460843ENST00000462484EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000460843ENST00000334856EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000460843ENST00000460843EHMT1chr9

140611429

+EHMT1chr9

140622837

-
5CDS-3UTRENST00000460843ENST00000371394EHMT1chr9

140611429

+EHMT1chr9

140622837

-
3UTR-3CDSENST00000371394ENST00000462484EHMT1chr9

140611429

+EHMT1chr9

140622837

-
3UTR-3CDSENST00000371394ENST00000334856EHMT1chr9

140611429

+EHMT1chr9

140622837

-
3UTR-3CDSENST00000371394ENST00000460843EHMT1chr9

140611429

+EHMT1chr9

140622837

-
3UTR-3UTRENST00000371394ENST00000371394EHMT1chr9

140611429

+EHMT1chr9

140622837

-
In-frameENST00000462484ENST00000462484EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000462484ENST00000334856EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000462484ENST00000460843EHMT1chr9

140611295

-EHMT1chr9

140622838

-
5CDS-3UTRENST00000462484ENST00000371394EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000334856ENST00000462484EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000334856ENST00000334856EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000334856ENST00000460843EHMT1chr9

140611295

-EHMT1chr9

140622838

-
5CDS-3UTRENST00000334856ENST00000371394EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000460843ENST00000462484EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000460843ENST00000334856EHMT1chr9

140611295

-EHMT1chr9

140622838

-
In-frameENST00000460843ENST00000460843EHMT1chr9

140611295

-EHMT1chr9

140622838

-
5CDS-3UTRENST00000460843ENST00000371394EHMT1chr9

140611295

-EHMT1chr9

140622838

-
3UTR-3CDSENST00000371394ENST00000462484EHMT1chr9

140611295

-EHMT1chr9

140622838

-
3UTR-3CDSENST00000371394ENST00000334856EHMT1chr9

140611295

-EHMT1chr9

140622838

-
3UTR-3CDSENST00000371394ENST00000460843EHMT1chr9

140611295

-EHMT1chr9

140622838

-
3UTR-3UTRENST00000371394ENST00000371394EHMT1chr9

140611295

-EHMT1chr9

140622838

-
intron-intronENST00000462484ENST00000462484EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000462484ENST00000334856EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000462484ENST00000460843EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000462484ENST00000371394EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000334856ENST00000462484EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000334856ENST00000334856EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000334856ENST00000460843EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000334856ENST00000371394EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000460843ENST00000462484EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000460843ENST00000334856EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000460843ENST00000460843EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000460843ENST00000371394EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000371394ENST00000462484EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000371394ENST00000334856EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000371394ENST00000460843EHMT1chr9

140721748

-EHMT1chr9

140721670

+
intron-intronENST00000371394ENST00000371394EHMT1chr9

140721748

-EHMT1chr9

140721670

+

Top

FusionProtFeatures for EHMT1_EHMT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHMT1

Q9H9B1

EHMT1

Q9H9B1

Histone methyltransferase that specifically mono- anddimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2,respectively) in euchromatin. H3K9me represents a specific tag forepigenetic transcriptional repression by recruiting HP1 proteinsto methylated histones. Also weakly methylates 'Lys-27' of histoneH3 (H3K27me). Also required for DNA methylation, the histonemethyltransferase activity is not required for DNA methylation,suggesting that these 2 activities function independently.Probably targeted to histone H3 by different DNA-binding proteinslike E2F6, MGA, MAX and/or DP1. During G0 phase, it probablycontributes to silencing of MYC- and E2F-responsive genes,suggesting a role in G0/G1 transition in cell cycle. In additionto the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.{ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}. Histone methyltransferase that specifically mono- anddimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2,respectively) in euchromatin. H3K9me represents a specific tag forepigenetic transcriptional repression by recruiting HP1 proteinsto methylated histones. Also weakly methylates 'Lys-27' of histoneH3 (H3K27me). Also required for DNA methylation, the histonemethyltransferase activity is not required for DNA methylation,suggesting that these 2 activities function independently.Probably targeted to histone H3 by different DNA-binding proteinslike E2F6, MGA, MAX and/or DP1. During G0 phase, it probablycontributes to silencing of MYC- and E2F-responsive genes,suggesting a role in G0/G1 transition in cell cycle. In additionto the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.{ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171292_1295-44826Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017406_409-44826Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017442_449-44826Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271292_1295-91299Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027406_409-91299Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027442_449-91299Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161292_1295-13809Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016406_409-13809Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016442_449-13809Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171292_1295-44826Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017406_409-44826Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017442_449-44826Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271292_1295-91299Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027406_409-91299Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027442_449-91299Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161292_1295-13809Compositional biasNote=Poly-Ala
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016406_409-13809Compositional biasNote=Poly-Glu
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016442_449-13809Compositional biasNote=Poly-Arg
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171060_1123-44826DomainPre-SET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171126_1243-44826DomainSET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271060_1123-91299DomainPre-SET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271126_1243-91299DomainSET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161060_1123-13809DomainPre-SET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161126_1243-13809DomainSET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171060_1123-44826DomainPre-SET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171126_1243-44826DomainSET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271060_1123-91299DomainPre-SET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271126_1243-91299DomainSET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161060_1123-13809DomainPre-SET
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161126_1243-13809DomainSET
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171136_1138-44826RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171200_1201-44826RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017905_907-44826RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271136_1138-91299RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271200_1201-91299RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027905_907-91299RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161136_1138-13809RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161200_1201-13809RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016905_907-13809RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171136_1138-44826RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171200_1201-44826RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017905_907-44826RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271136_1138-91299RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271200_1201-91299RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027905_907-91299RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161136_1138-13809RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161200_1201-13809RegionNote=S-adenosyl-L-methionine binding
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016905_907-13809RegionNote=Histone H3K9me binding
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017737_766-44826RepeatNote=ANK 1
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017772_801-44826RepeatNote=ANK 2
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017805_834-44826RepeatNote=ANK 3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017838_868-44826RepeatNote=ANK 4
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017872_901-44826RepeatNote=ANK 5
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017905_934-44826RepeatNote=ANK 6
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017938_967-44826RepeatNote=ANK 7
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+017971_1004-44826RepeatNote=ANK 8
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027737_766-91299RepeatNote=ANK 1
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027772_801-91299RepeatNote=ANK 2
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027805_834-91299RepeatNote=ANK 3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027838_868-91299RepeatNote=ANK 4
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027872_901-91299RepeatNote=ANK 5
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027905_934-91299RepeatNote=ANK 6
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027938_967-91299RepeatNote=ANK 7
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+027971_1004-91299RepeatNote=ANK 8
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016737_766-13809RepeatNote=ANK 1
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016772_801-13809RepeatNote=ANK 2
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016805_834-13809RepeatNote=ANK 3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016838_868-13809RepeatNote=ANK 4
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016872_901-13809RepeatNote=ANK 5
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016905_934-13809RepeatNote=ANK 6
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016938_967-13809RepeatNote=ANK 7
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+016971_1004-13809RepeatNote=ANK 8
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017737_766-44826RepeatNote=ANK 1
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017772_801-44826RepeatNote=ANK 2
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017805_834-44826RepeatNote=ANK 3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017838_868-44826RepeatNote=ANK 4
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017872_901-44826RepeatNote=ANK 5
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017905_934-44826RepeatNote=ANK 6
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017938_967-44826RepeatNote=ANK 7
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+017971_1004-44826RepeatNote=ANK 8
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027737_766-91299RepeatNote=ANK 1
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027772_801-91299RepeatNote=ANK 2
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027805_834-91299RepeatNote=ANK 3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027838_868-91299RepeatNote=ANK 4
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027872_901-91299RepeatNote=ANK 5
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027905_934-91299RepeatNote=ANK 6
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027938_967-91299RepeatNote=ANK 7
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+027971_1004-91299RepeatNote=ANK 8
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016737_766-13809RepeatNote=ANK 1
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016772_801-13809RepeatNote=ANK 2
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016805_834-13809RepeatNote=ANK 3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016838_868-13809RepeatNote=ANK 4
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016872_901-13809RepeatNote=ANK 5
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016905_934-13809RepeatNote=ANK 6
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016938_967-13809RepeatNote=ANK 7
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+016971_1004-13809RepeatNote=ANK 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EHMT1_EHMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EHMT1_EHMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171162_1181-44826histone H3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000334856+0171242_1245-44826histone H3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271162_1181-91299histone H3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000460843+0271242_1245-91299histone H3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161162_1181-13809histone H3
TgeneEHMT1chr9:140611295chr9:140622838ENST00000462484+0161242_1245-13809histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171162_1181-44826histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000334856+0171242_1245-44826histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271162_1181-91299histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000460843+0271242_1245-91299histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161162_1181-13809histone H3
TgeneEHMT1chr9:140611429chr9:140622837ENST00000462484+0161242_1245-13809histone H3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EHMT1_EHMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EHMT1_EHMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEHMT1C0025149Medulloblastoma1CTD_human
HgeneEHMT1C0795833Kleefstra Syndrome1CTD_human;UNIPROT
TgeneEHMT1C0025149Medulloblastoma1CTD_human
TgeneEHMT1C0795833Kleefstra Syndrome1CTD_human;UNIPROT