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Fusion gene ID: 11162 |
FusionGeneSummary for EHF_CSN2 |
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Fusion gene information | Fusion gene name: EHF_CSN2 | Fusion gene ID: 11162 | Hgene | Tgene | Gene symbol | EHF | CSN2 | Gene ID | 26298 | 9318 |
Gene name | ETS homologous factor | COP9 signalosome subunit 2 | |
Synonyms | ESE3|ESE3B|ESEJ | ALIEN|CSN2|SGN2|TRIP15 | |
Cytomap | 11p13 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ETS homologous factorESE3 transcription factorETS domain-containing transcription factorepithelium-specific Ets transcription factor 3hEHF | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9NZC4 | P05814 | |
Ensembl transtripts involved in fusion gene | ENST00000527001, ENST00000257831, ENST00000450654, ENST00000530286, ENST00000533754, ENST00000531728, ENST00000531794, ENST00000527935, | ENST00000353151, | |
Fusion gene scores | * DoF score | 8 X 9 X 4=288 | 14 X 11 X 2=308 |
# samples | 9 | 3 | |
** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/308*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EHF [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EHF | GO:0045893 | positive regulation of transcription, DNA-templated | 10644770 |
Hgene | EHF | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17027647 |
Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A1KO-01A | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000527001 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
Frame-shift | ENST00000257831 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
intron-3CDS | ENST00000450654 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
Frame-shift | ENST00000530286 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
Frame-shift | ENST00000533754 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
intron-3CDS | ENST00000531728 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
Frame-shift | ENST00000531794 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
intron-3CDS | ENST00000527935 | ENST00000353151 | EHF | chr11 | 34673342 | + | CSN2 | chr4 | 70823498 | - |
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FusionProtFeatures for EHF_CSN2 |
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Hgene | Tgene |
EHF | CSN2 |
Transcriptional activator that may play a role inregulating epithelial cell differentiation and proliferation. Mayact as a repressor for a specific subset of ETS/AP-1-responsivegenes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNAsequences containing the consensus nucleotide core sequence GGAA.Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute todevelopment and carcinogenesis by acting as a tumor suppressorgene or anti-oncogene. {ECO:0000269|PubMed:10527851,ECO:0000269|PubMed:10644770, ECO:0000269|PubMed:11259407,ECO:0000269|PubMed:12444029, ECO:0000269|PubMed:17027647}. | Important role in determination of the surfaceproperties of the casein micelles. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EHF_CSN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EHF_CSN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EHF | ELF3, FRZB, XRCC6, XRCC5, CST6, KPRP, APP, ARG1 | CSN2 | CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EHF_CSN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EHF_CSN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EHF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |