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Fusion gene ID: 11156 |
FusionGeneSummary for EHD4_GPR176 |
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Fusion gene information | Fusion gene name: EHD4_GPR176 | Fusion gene ID: 11156 | Hgene | Tgene | Gene symbol | EHD4 | GPR176 | Gene ID | 30844 | 11245 |
Gene name | EH domain containing 4 | G protein-coupled receptor 176 | |
Synonyms | PAST4 | HB-954 | |
Cytomap | 15q15.1 | 15q14-q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | EH domain-containing protein 4PAST homolog 4hepatocellular carcinoma-associated protein 10/11hepatocellular carcinoma-associated protein HCA11ortholog of rat pincher | G-protein coupled receptor 176probable G-protein coupled receptor 176 | |
Modification date | 20180522 | 20180517 | |
UniProtAcc | Q9H223 | Q14439 | |
Ensembl transtripts involved in fusion gene | ENST00000220325, | ENST00000299092, ENST00000561100, ENST00000543580, ENST00000560729, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 1 X 4=16 |
# samples | 5 | 4 | |
** MAII score | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EHD4 [Title/Abstract] AND GPR176 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EB-A550-01A | EHD4 | chr15 | 42264457 | - | GPR176 | chr15 | 40099459 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000220325 | ENST00000299092 | EHD4 | chr15 | 42264457 | - | GPR176 | chr15 | 40099459 | - |
5CDS-intron | ENST00000220325 | ENST00000561100 | EHD4 | chr15 | 42264457 | - | GPR176 | chr15 | 40099459 | - |
5CDS-intron | ENST00000220325 | ENST00000543580 | EHD4 | chr15 | 42264457 | - | GPR176 | chr15 | 40099459 | - |
5CDS-5UTR | ENST00000220325 | ENST00000560729 | EHD4 | chr15 | 42264457 | - | GPR176 | chr15 | 40099459 | - |
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FusionProtFeatures for EHD4_GPR176 |
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Hgene | Tgene |
EHD4 | GPR176 |
ATP- and membrane-binding protein that probably controlsmembrane reorganization/tubulation upon ATP hydrolysis. Plays arole in early endosomal transport. {ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:18331452}. | Orphan receptor involved in normal circadian rhythmbehavior. Acts through the G-protein subclass G(z)-alpha and hasan agonist-independent basal activity to repress cAMP production.{ECO:0000250|UniProtKB:Q80WT4}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EHD4_GPR176 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EHD4_GPR176 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EHD4 | STYXL1, DGKQ, EHD1, RASGRF1, AFP, ADSL, SZRD1, CTPS2, AASDHPPT, GTF3C4, HIST1H2AB, NOL3, PLCG1, PSMG1, RPL38, ZC3HC1, LRSAM1, MTMR2, NT5C2, UBA2, CCDC8, EGFR, TGFBR2, FSD1, DDX19B, HEPACAM2, C19orf54, DDOST, STX7, UQCRC2, WARS, NTRK1, CLTC, MCM2, SNW1, CDC5L, CDH1, PTPRM, RBSN, EXOC8, VWA5A, IQCF1, TNFRSF13B, OLFM3, TPCN2, TRIM11, NTRK3, PCDHB16, TMEM52B | GPR176 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EHD4_GPR176 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EHD4_GPR176 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |