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Fusion gene ID: 11155 |
FusionGeneSummary for EHD4_FSIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EHD4_FSIP1 | Fusion gene ID: 11155 | Hgene | Tgene | Gene symbol | EHD4 | FSIP1 | Gene ID | 30844 | 161835 |
| Gene name | EH domain containing 4 | fibrous sheath interacting protein 1 | |
| Synonyms | PAST4 | HSD10 | |
| Cytomap | 15q15.1 | 15q14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | EH domain-containing protein 4PAST homolog 4hepatocellular carcinoma-associated protein 10/11hepatocellular carcinoma-associated protein HCA11ortholog of rat pincher | fibrous sheath-interacting protein 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9H223 | Q8NA03 | |
| Ensembl transtripts involved in fusion gene | ENST00000220325, | ENST00000350221, ENST00000559692, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: EHD4 [Title/Abstract] AND FSIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SB-01A | EHD4 | chr15 | 42211408 | - | FSIP1 | chr15 | 39910446 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000220325 | ENST00000350221 | EHD4 | chr15 | 42211408 | - | FSIP1 | chr15 | 39910446 | - |
| 5CDS-intron | ENST00000220325 | ENST00000559692 | EHD4 | chr15 | 42211408 | - | FSIP1 | chr15 | 39910446 | - |
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FusionProtFeatures for EHD4_FSIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EHD4 | FSIP1 |
| ATP- and membrane-binding protein that probably controlsmembrane reorganization/tubulation upon ATP hydrolysis. Plays arole in early endosomal transport. {ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:18331452}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 58_289 | 308 | 542 | Domain | Dynamin-type G |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 156_159 | 308 | 542 | Region | G3 motif |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 222_225 | 308 | 542 | Region | G4 motif |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 246_246 | 308 | 542 | Region | G5 motif |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 68_75 | 308 | 542 | Region | G1 motif |
| Hgene | EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 94_95 | 308 | 542 | Region | G2 motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 492_503 | 308 | 542 | Calcium binding | Ontology_term=ECO:0000250,ECO:0000255 |
| Hgene | >EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 447_535 | 308 | 542 | Domain | EH |
| Hgene | >EHD4 | chr15:42211408 | chr15:39910446 | ENST00000220325 | - | 4 | 6 | 479_514 | 308 | 542 | Domain | EF-hand |
| Tgene | FSIP1 | chr15:42211408 | chr15:39910446 | ENST00000350221 | - | 9 | 12 | 105_153 | 396 | 582 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for EHD4_FSIP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EHD4_ENST00000220325_chr15_42211408_-_FSIP1_ENST00000350221_chr15_39910446_-_494aa MFSWMGRQAGGRERAGGADAVQTVTGGLRSLYLRKVLPLEEAYRFHEFHSPALEDADFENKPMILLVGQYSTGKTTFIRYLLEQDFPGMR IGPEPTTDSFIAVMYGETEGSTPGNALVVDPKKPFRKLSRFGNAFLNRFMCSQLPNQVLKSISVIDSPGILSGEKQRISRGYDFCQVLQW FAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRVYGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDN RRLFEAEAQDLFRDIQSLPQKAAVRKLNDLIKRARLAKLESTSCLSEEQLKCLLDECILKQKSIIKLSSERKKEDIEDVTPVFPQLSRSI ISKLLNESETKVQKTEVEDADMLESEECEASKGYYLTKALTGHNMSEALVTEAENMKCLQFSKDVIISDTKDYFMSKTLGIGRLKRPSFL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EHD4_ENST00000220325_chr15_42211408_-_FSIP1_ENST00000350221_chr15_39910446_-_1482nt ATGTTCAGCTGGATGGGGCGGCAGGCGGGCGGGCGCGAACGCGCTGGCGGCGCGGACGCGGTGCAGACGGTGACGGGCGGGCTGCGCTCG CTCTACCTGCGCAAGGTGCTGCCGCTGGAGGAGGCGTACCGCTTCCACGAGTTCCACTCGCCTGCGCTGGAGGACGCCGACTTCGAGAAC AAGCCCATGATCCTGCTGGTGGGCCAGTACAGCACCGGCAAGACCACCTTCATCAGATACCTACTGGAGCAGGATTTCCCAGGCATGAGG ATTGGTCCGGAGCCCACCACAGACTCCTTCATCGCCGTGATGTATGGAGAGACTGAGGGCAGCACCCCAGGGAATGCTTTAGTCGTGGAC CCCAAAAAGCCGTTTAGAAAGCTCAGTCGCTTTGGAAACGCTTTCCTGAATCGATTCATGTGCTCACAGCTCCCCAATCAGGTCCTGAAG AGCATCAGCGTCATCGACAGCCCCGGCATCCTTTCTGGGGAGAAGCAGCGCATCAGCCGAGGCTATGACTTCTGCCAGGTCCTGCAGTGG TTTGCCGAGAGGGTGGACAGGATCATCCTGCTCTTTGACGCTCACAAGCTGGACATCTCAGATGAATTCTCAGAGGCCATCAAGGCCTTC CGGGGCCAGGACGACAAGATCCGTGTCGTGCTGAACAAGGCCGACCAAGTGGACACGCAGCAGCTGATGCGGGTCTACGGGGCCCTCATG TGGTCCCTAGGCAAGGTCATCAACACGCCCGAGGTACTGCGCGTCTACATTGGCTCCTTCTGGGCGCAGCCCCTGCAGAACACGGACAAC CGCCGGCTCTTCGAGGCTGAGGCCCAGGACCTCTTTAGAGACATCCAGAGCCTCCCCCAGAAGGCAGCGGTGCGCAAGCTCAACGACCTC ATCAAGCGAGCGAGGCTGGCCAAGTTAGAGTCCACATCATGTCTCTCTGAAGAACAGTTAAAGTGTCTTCTGGATGAATGCATACTTAAA CAAAAATCCATCATTAAACTTTCTTCAGAAAGAAAAAAGGAAGACATTGAGGACGTAACACCTGTGTTCCCCCAGCTTTCCAGGTCCATC ATCTCTAAATTGCTAAATGAATCAGAAACAAAGGTCCAGAAAACTGAGGTAGAAGATGCAGATATGCTTGAGAGTGAAGAATGTGAAGCT TCTAAAGGCTACTATCTCACTAAAGCCTTGACTGGACATAACATGTCAGAAGCTCTTGTCACTGAAGCAGAGAATATGAAATGCCTTCAA TTTTCCAAGGACGTTATTATTAGTGACACAAAAGACTATTTTATGTCGAAGACTCTTGGCATTGGGAGACTGAAAAGGCCCTCCTTCTTA GATGATCCACTGTATGGTATCAGTGTGAGCCTTTCATCAGAAGACCAACATCTGAAACTCAGTTCTCCAGAGAATACAATAGCAGATGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EHD4_ENST00000220325_chr15_42211408_-_FSIP1_ENST00000350221_chr15_39910446_-_2415nt CCAGCGCGGCCGGGGCGGCTCAGTGCGAGCCGGGGAGAGTCGAACCCGGAGCAGGGTCCCATCCGAGCGTGGACTGGCGGCAGGATGTTC AGCTGGATGGGGCGGCAGGCGGGCGGGCGCGAACGCGCTGGCGGCGCGGACGCGGTGCAGACGGTGACGGGCGGGCTGCGCTCGCTCTAC CTGCGCAAGGTGCTGCCGCTGGAGGAGGCGTACCGCTTCCACGAGTTCCACTCGCCTGCGCTGGAGGACGCCGACTTCGAGAACAAGCCC ATGATCCTGCTGGTGGGCCAGTACAGCACCGGCAAGACCACCTTCATCAGATACCTACTGGAGCAGGATTTCCCAGGCATGAGGATTGGT CCGGAGCCCACCACAGACTCCTTCATCGCCGTGATGTATGGAGAGACTGAGGGCAGCACCCCAGGGAATGCTTTAGTCGTGGACCCCAAA AAGCCGTTTAGAAAGCTCAGTCGCTTTGGAAACGCTTTCCTGAATCGATTCATGTGCTCACAGCTCCCCAATCAGGTCCTGAAGAGCATC AGCGTCATCGACAGCCCCGGCATCCTTTCTGGGGAGAAGCAGCGCATCAGCCGAGGCTATGACTTCTGCCAGGTCCTGCAGTGGTTTGCC GAGAGGGTGGACAGGATCATCCTGCTCTTTGACGCTCACAAGCTGGACATCTCAGATGAATTCTCAGAGGCCATCAAGGCCTTCCGGGGC CAGGACGACAAGATCCGTGTCGTGCTGAACAAGGCCGACCAAGTGGACACGCAGCAGCTGATGCGGGTCTACGGGGCCCTCATGTGGTCC CTAGGCAAGGTCATCAACACGCCCGAGGTACTGCGCGTCTACATTGGCTCCTTCTGGGCGCAGCCCCTGCAGAACACGGACAACCGCCGG CTCTTCGAGGCTGAGGCCCAGGACCTCTTTAGAGACATCCAGAGCCTCCCCCAGAAGGCAGCGGTGCGCAAGCTCAACGACCTCATCAAG CGAGCGAGGCTGGCCAAGTTAGAGTCCACATCATGTCTCTCTGAAGAACAGTTAAAGTGTCTTCTGGATGAATGCATACTTAAACAAAAA TCCATCATTAAACTTTCTTCAGAAAGAAAAAAGGAAGACATTGAGGACGTAACACCTGTGTTCCCCCAGCTTTCCAGGTCCATCATCTCT AAATTGCTAAATGAATCAGAAACAAAGGTCCAGAAAACTGAGGTAGAAGATGCAGATATGCTTGAGAGTGAAGAATGTGAAGCTTCTAAA GGCTACTATCTCACTAAAGCCTTGACTGGACATAACATGTCAGAAGCTCTTGTCACTGAAGCAGAGAATATGAAATGCCTTCAATTTTCC AAGGACGTTATTATTAGTGACACAAAAGACTATTTTATGTCGAAGACTCTTGGCATTGGGAGACTGAAAAGGCCCTCCTTCTTAGATGAT CCACTGTATGGTATCAGTGTGAGCCTTTCATCAGAAGACCAACATCTGAAACTCAGTTCTCCAGAGAATACAATAGCAGATGAGCAGGAG ACTAAAGATGCAGCAGAAGAATGTAAAGAACCCTAATCAAGGACTTGCTGGGTGTGCTTTTCAGAAAGTTGGTAATGAAGTTAAATTAAA TTTCTTATTGAATTATTTGAATTCAATGAATGCACTGCAGAGACTATTCTTTATTGATTTTGACATTTGGAGTCGCTCTTTGTGGATTAT ATTTCCTTGATATTTTTGAGACTTGGGGTGTAATTGTTCAGTGGTTTTTGCTCATTAAAATTTCTGGGACCATTGTTTATAAATTTATTG CTAATCTTACAGTATTAGGATTCATTATAAAAACCAACATTTTAATGTATACGTGTTAGGGTAAAACTCGTTGAAGTGCTGTGATTGTCC TGTATTCAATTTTGTATGTTTCACCTCTACTGTGATTCAGACAGATCATGGTGGTCACTGGGAATTTTTGCTGTGGCCCTGCTTTTCCTT CTTCCCACTTGTCTCATGTCTGTGAAACTGGTACAACCTGCCATAAGATGAAATGAATTGTCTCAACAAAGCAATATTAGAAGAGCCTTT ACTATCTTATTGGTGATGACACGTTTCTTAAGTAGGAGTTTGAGTGAATTATTTGATATATTACTTTGTTAATAATAGTTAACAATAGTT TCTTATTTTCTTTCAGAGTTTGGGCCTTTTAGATTGCATCAAATAAAGATGAGCTACTTTAAAAGACAGTCTGCGGTACTATTTGAAGAG AGATGGTTTAGTTACAAGTCAGTAACTTAGATTCATGAGAAAATTTTGTGTTGACATTCCATAAGATGAGTTGGCATTAGAATTGGAAGT |
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FusionGenePPI for EHD4_FSIP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EHD4 | STYXL1, DGKQ, EHD1, RASGRF1, AFP, ADSL, SZRD1, CTPS2, AASDHPPT, GTF3C4, HIST1H2AB, NOL3, PLCG1, PSMG1, RPL38, ZC3HC1, LRSAM1, MTMR2, NT5C2, UBA2, CCDC8, EGFR, TGFBR2, FSD1, DDX19B, HEPACAM2, C19orf54, DDOST, STX7, UQCRC2, WARS, NTRK1, CLTC, MCM2, SNW1, CDC5L, CDH1, PTPRM, RBSN, EXOC8, VWA5A, IQCF1, TNFRSF13B, OLFM3, TPCN2, TRIM11, NTRK3, PCDHB16, TMEM52B | FSIP1 | AKAP4, APP, PTPN9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EHD4_FSIP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EHD4_FSIP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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