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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11143

FusionGeneSummary for EHBP1_CTNND2

check button Fusion gene summary
Fusion gene informationFusion gene name: EHBP1_CTNND2
Fusion gene ID: 11143
HgeneTgene
Gene symbol

EHBP1

CTNND2

Gene ID

23301

1501

Gene nameEH domain binding protein 1catenin delta 2
SynonymsHPC12|NACSINGT24|NPRAP
Cytomap

2p15

5p15.2

Type of geneprotein-codingprotein-coding
DescriptionEH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50ecatenin delta-2T-cell delta-catenincatenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)neurojungin
Modification date2018051920180523
UniProtAcc

Q8NDI1

Q9UQB3

Ensembl transtripts involved in fusion geneENST00000405015, ENST00000431489, 
ENST00000354487, ENST00000263991, 
ENST00000405289, ENST00000496857, 
ENST00000304623, ENST00000359640, 
ENST00000511377, ENST00000458100, 
ENST00000503622, ENST00000495388, 
Fusion gene scores* DoF score6 X 9 X 8=43212 X 8 X 8=768
# samples 1212
** MAII scorelog2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/768*10)=-2.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EHBP1 [Title/Abstract] AND CTNND2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-EQ-8122-01AEHBP1chr2

62934430

+CTNND2chr5

11732384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000405015ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000405015ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405015ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-5UTRENST00000405015ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405015ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405015ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000431489ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000431489ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000431489ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-5UTRENST00000431489ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000431489ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000431489ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000354487ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000354487ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000354487ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-5UTRENST00000354487ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000354487ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000354487ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000263991ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000263991ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000263991ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-5UTRENST00000263991ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000263991ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000263991ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000405289ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
Frame-shiftENST00000405289ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405289ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-5UTRENST00000405289ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405289ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
5CDS-intronENST00000405289ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-3CDSENST00000496857ENST00000304623EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-3CDSENST00000496857ENST00000359640EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-intronENST00000496857ENST00000511377EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-5UTRENST00000496857ENST00000458100EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-intronENST00000496857ENST00000503622EHBP1chr2

62934430

+CTNND2chr5

11732384

-
intron-intronENST00000496857ENST00000495388EHBP1chr2

62934430

+CTNND2chr5

11732384

-

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FusionProtFeatures for EHBP1_CTNND2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHBP1

Q8NDI1

CTNND2

Q9UQB3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EHBP1_CTNND2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EHBP1_CTNND2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EHBP1EHD2, KHDRBS2, RPAP2, PACSIN1, COPS5, COPS6, IFT57, OFD1, TMEM17, XPO1, CDH1, SOAT1, NDUFS1, ACAP2, TRIM25CTNND2PDZD2, LRRC7, ATN1, ZBTB33, NUDT21, TTR, LNX1, CLK1, MCM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EHBP1_CTNND2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EHBP1_CTNND2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEHBP1C0033578Prostatic Neoplasms1CTD_human
TgeneCTNND2C0005586Bipolar Disorder1PSYGENET
TgeneCTNND2C0007621Neoplastic Cell Transformation1CTD_human
TgeneCTNND2C0017636Glioblastoma1CTD_human
TgeneCTNND2C0036341Schizophrenia1PSYGENET
TgeneCTNND2C0041696Unipolar Depression1PSYGENET
TgeneCTNND2C1269683Major Depressive Disorder1PSYGENET