	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 11142

FusionGeneSummary for EHBP1_COMMD1

Fusion gene summary

Fusion gene information	Fusion gene name: EHBP1_COMMD1
	Fusion gene ID: 11142
		Hgene	Tgene
	Gene symbol	EHBP1	COMMD1
	Gene ID	23301	150684
	Gene name	EH domain binding protein 1	copper metabolism domain containing 1
	Synonyms	HPC12\|NACSIN	C2orf5\|MURR1
	Cytomap	2p15	2p15
	Type of gene	protein-coding	protein-coding
	Description	EH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50e	COMM domain-containing protein 1copper metabolism (Murr1) domain containing 1copper metabolism gene MURR1protein Murr1
	Modification date	20180519	20180523
	UniProtAcc	Q8NDI1	Q8N668
	Ensembl transtripts involved in fusion gene	ENST00000405015, ENST00000431489, ENST00000354487, ENST00000263991, ENST00000405289, ENST00000496857,	ENST00000472729, ENST00000311832, ENST00000538736,
Fusion gene scores	* DoF score	6 X 9 X 8=432	8 X 5 X 8=320
	# samples	12	13
	** MAII score	log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/320*10)=-1.29956028185891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EHBP1 [Title/Abstract] AND COMMD1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	COMMD1	GO:0031398	positive regulation of protein ubiquitination	17183367\|21741370
Tgene	COMMD1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	15799966\|16573520
Tgene	COMMD1	GO:0048227	plasma membrane to endosome transport	21741370
Tgene	COMMD1	GO:0055070	copper ion homeostasis	14685266
Tgene	COMMD1	GO:1902306	negative regulation of sodium ion transmembrane transport	14645214
Tgene	COMMD1	GO:2000009	negative regulation of protein localization to cell surface	21741370

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-GV-A40E-01A	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
TCGA	RV	BRCA	TCGA-AR-A1AO-01A	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
TCGA	RV	LIHC	TCGA-DD-A3A5-01A	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
TCGA	RV	LUAD	TCGA-44-7660-01A	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
TCGA	RV	LUSC	TCGA-63-A5MR-01A	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
TCGA	RV	STAD	TCGA-VQ-A925-01A	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62998527	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
3UTR-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	63223901	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	63182795	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405015	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000431489	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000354487	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000263991	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-intron	ENST00000405289	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
intron-intron	ENST00000496857	ENST00000538736	EHBP1	chr2	62991496	+	COMMD1	chr2	62362966	+
5CDS-3UTR	ENST00000405015	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405015	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000431489	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000354487	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000263991	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
5CDS-3UTR	ENST00000405289	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000472729	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000311832	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+
intron-3UTR	ENST00000496857	ENST00000538736	EHBP1	chr2	62974587	+	COMMD1	chr2	62227836	+

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FusionProtFeatures for EHBP1_COMMD1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EHBP1 Q8NDI1	COMMD1 Q8N668
	Proposed scaffold protein that is implicated in diversephysiological processes and whose function may be in part linkedto its ability to regulate ubiquitination of specific cellularproteins. Can modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes by displacing CAND1; in vitro promotes CRL E3activity and dissociates CAND1 from CUL1 and CUL2(PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunitRELA and its subsequent proteasomal degradation. Down-regulatesNF-kappa-B activity (PubMed:15799966, PubMed:17183367,PubMed:20048074). Involved in the regulation of membraneexpression and ubiquitination of SLC12A2 (PubMed:23515529).Modulates Na(+) transport in epithelial cells by regulation ofapical cell surface expression of amiloride-sensitive sodiumchannel (ENaC) subunits and by promoting their ubiquitinationpresumably involving NEDD4L. Promotes the localization of SCNN1Dto recycling endosomes (PubMed:14645214, PubMed:20237237,PubMed:21741370). Promotes CFTR cell surface expression throughregulation of its ubiquitination (PubMed:21483833). Down-regulatesSOD1 activity by interfering with its homodimerization(PubMed:20595380). Plays a role in copper ion homeostasis.Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function isproposed to depend on its association within the CCC complex andcooperation with the WASH complex on early endosomes(PubMed:25355947). Can bind one copper ion per monomer(PubMed:17309234). May function to facilitate biliary copperexcretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in theregulation of HIF1A-mediated transcription; competes withARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNAbinding and impaired transcriptional activation by HIF-1(PubMed:20458141). {ECO:0000269\|PubMed:14645214,ECO:0000269\|PubMed:14685266, ECO:0000269\|PubMed:15799966,ECO:0000269\|PubMed:16573520, ECO:0000269\|PubMed:17183367,ECO:0000269\|PubMed:17309234, ECO:0000269\|PubMed:20048074,ECO:0000269\|PubMed:20237237, ECO:0000269\|PubMed:20458141,ECO:0000269\|PubMed:20595380, ECO:0000269\|PubMed:21483833,ECO:0000269\|PubMed:21741370, ECO:0000269\|PubMed:21778237,ECO:0000269\|PubMed:23515529, ECO:0000269\|PubMed:25355947}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for EHBP1_COMMD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EHBP1_COMMD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
EHBP1	EHD2, KHDRBS2, RPAP2, PACSIN1, COPS5, COPS6, IFT57, OFD1, TMEM17, XPO1, CDH1, SOAT1, NDUFS1, ACAP2, TRIM25	COMMD1	NFKBIA, XIAP, SOCS1, CUL2, TCEB1, RELA, CUL1, CUL3, CUL4A, CUL4B, CUL5, CUL7, HIF1A, HSPA4, CLU, CFTR, SCNN1D, KAT2A, AKT1, SGK1, SCNN1B, SPP1, NAIP, BIRC3, CDKN2A, NMRAL1, SOD1, ATP7B, COMMD1, COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD10, REL, RELB, NFKB1, NFKB2, SCNN1G, ATP7A, BARD1, BRCA1, LIG4, VCP, SLC12A2, CCDC22, BAHCC1, EP300, CCDC93, C16orf62, SCLT1, PARK2, FAM45A, COMMD9, DSCR3, E2F6, TFDP1, BCR, VPS29, VPS33B, STK11IP, TTF2, NFYC, KIF2B, FAM167A, TRIM16L, G6PD, ATAD3C, TBC1D4, RAD21, TRIM25, FAM107A

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for EHBP1_COMMD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EHBP1_COMMD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EHBP1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	COMMD1	C0019189	Hepatitis, Chronic	2	CTD_human
Tgene	COMMD1	C0020517	Hypersensitivity	1	CTD_human
Tgene	COMMD1	C0023890	Liver Cirrhosis	1	CTD_human
Tgene	COMMD1	C0041755	Adverse reaction to drug	1	CTD_human
Tgene	COMMD1	C1876165	Copper-Overload Cirrhosis	1	CTD_human

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Fusion gene ID: 11142

FusionGeneSummary for EHBP1_COMMD1

FusionProtFeatures for EHBP1_COMMD1

FusionGeneSequence for EHBP1_COMMD1

FusionGenePPI for EHBP1_COMMD1

RelatedDrugs for EHBP1_COMMD1

RelatedDiseases for EHBP1_COMMD1