	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 11115

FusionGeneSummary for EGFR_RCL1

Fusion gene summary

Fusion gene information	Fusion gene name: EGFR_RCL1
	Fusion gene ID: 11115
		Hgene	Tgene
	Gene symbol	EGFR	RCL1
	Gene ID	1956	10171
	Gene name	epidermal growth factor receptor	RNA terminal phosphate cyclase like 1
	Synonyms	ERBB\|ERBB1\|HER1\|NISBD2\|PIG61\|mENA	RNAC\|RPCL1
	Cytomap	7p11.2	9p24.1
	Type of gene	protein-coding	protein-coding
	Description	epidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas	RNA 3'-terminal phosphate cyclase-like proteinRNA cyclase homolog
	Modification date	20180527	20180523
	UniProtAcc	P00533	Q9Y2P8
	Ensembl transtripts involved in fusion gene	ENST00000455089, ENST00000342916, ENST00000344576, ENST00000420316, ENST00000275493, ENST00000442591, ENST00000463948, ENST00000454757,	ENST00000381750, ENST00000381730, ENST00000381728, ENST00000448872, ENST00000381732, ENST00000445485,
Fusion gene scores	* DoF score	18 X 8 X 8=1152	6 X 5 X 6=180
	# samples	17	6
	** MAII score	log2(17/1152*10)=-2.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EGFR [Title/Abstract] AND RCL1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EGFR	GO:0001934	positive regulation of protein phosphorylation	20551055
Hgene	EGFR	GO:0007165	signal transduction	10572067
Hgene	EGFR	GO:0007166	cell surface receptor signaling pathway	7736574
Hgene	EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	7736574\|12435727
Hgene	EGFR	GO:0008283	cell proliferation	17115032
Hgene	EGFR	GO:0008284	positive regulation of cell proliferation	7736574
Hgene	EGFR	GO:0010750	positive regulation of nitric oxide mediated signal transduction	12828935
Hgene	EGFR	GO:0018108	peptidyl-tyrosine phosphorylation	22732145
Hgene	EGFR	GO:0030307	positive regulation of cell growth	15467833
Hgene	EGFR	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle	18483258
Hgene	EGFR	GO:0042177	negative regulation of protein catabolic process	17115032
Hgene	EGFR	GO:0042327	positive regulation of phosphorylation	15082764
Hgene	EGFR	GO:0043406	positive regulation of MAP kinase activity	10572067
Hgene	EGFR	GO:0045739	positive regulation of DNA repair	17115032
Hgene	EGFR	GO:0045740	positive regulation of DNA replication	17115032
Hgene	EGFR	GO:0045944	positive regulation of transcription by RNA polymerase II	20551055
Hgene	EGFR	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Hgene	EGFR	GO:0050999	regulation of nitric-oxide synthase activity	12828935
Hgene	EGFR	GO:0070141	response to UV-A	18483258
Hgene	EGFR	GO:0070374	positive regulation of ERK1 and ERK2 cascade	20551055
Hgene	EGFR	GO:0071392	cellular response to estradiol stimulus	20551055
Hgene	EGFR	GO:1900020	positive regulation of protein kinase C activity	22732145
Hgene	EGFR	GO:1903078	positive regulation of protein localization to plasma membrane	22732145

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	STAD	TCGA-BR-6706-01A	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shit	ENST00000455089	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000455089	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000455089	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000455089	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000455089	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000455089	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000342916	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000342916	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000342916	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000342916	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000342916	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000342916	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000344576	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000344576	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000344576	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000344576	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000344576	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000344576	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000420316	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000420316	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000420316	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000420316	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000420316	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000420316	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000275493	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000275493	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000275493	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000275493	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000275493	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000275493	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000442591	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000442591	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000442591	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
Frame-shit	ENST00000442591	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000442591	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
5CDS-intron	ENST00000442591	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-3CDS	ENST00000463948	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-3CDS	ENST00000463948	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-3CDS	ENST00000463948	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-3CDS	ENST00000463948	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-intron	ENST00000463948	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
3UTR-intron	ENST00000463948	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-3CDS	ENST00000454757	ENST00000381750	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-3CDS	ENST00000454757	ENST00000381730	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-3CDS	ENST00000454757	ENST00000381728	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-3CDS	ENST00000454757	ENST00000448872	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-intron	ENST00000454757	ENST00000381732	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+
intron-intron	ENST00000454757	ENST00000445485	EGFR	chr7	55087058	+	RCL1	chr9	4849447	+

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FusionProtFeatures for EGFR_RCL1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EGFR P00533	RCL1 Q9Y2P8
	Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processingsteps at sites A0, A1 and A2 that are required for propermaturation of the 18S RNA (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for EGFR_RCL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EGFR_RCL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
EGFR	DCN, SHC1, SH3BGRL, STAT5A, PTPN11, CRK, CSK, CBLB, GRB2, STAT3, CTNNB1, CTNND1, JUP, AR, EGFR, CAMLG, PRKCA, HBEGF, TJP1, ATP5C1, SGSM2, WAS, EGF, INPPL1, DUSP3, AREG, PTK2, CBL, CBLC, CDH1, MAPK14, VAV1, VAV2, VAV3, STAT1, SRC, JAK2, HTT, PTK6, PTK2B, DOK2, SOS1, SOS2, CDC25A, NCK1, IGF1R, PRKAR1A, PRKACA, PLD2, ARF4, MAP4K1, NCK2, EPS15, PTPN6, SH2D3A, PLSCR1, GRB14, RASA1, GRB10, PTPN1, NRG1, CD44, PLCG1, SH3KBP1, PIK3C2B, SOCS1, SOCS3, CAV1, CAV3, ERBB3, CD82, SNX6, SNX1, SNX2, SNX4, STAT5B, RGS16, CEBPB, MUC1, GAB1, RIPK1, MAP3K14, PDGFRB, SHC3, CASP1, EREG, FER, ERBB2, HGS, NCAM1, HDAC6, AIP, PSMA7, MEGF6, SORBS2, HEXIM1, AHSA1, ALDOA, UROD, UCHL1, HSP90B1, CBR1, FAH, GOT1, RAB3A, CSRP1, CFL1, EEF1G, PRKAR1B, ATIC, STIP1, HSPA4, MDH1, PTGDS, MATR3, SEPP1, OAZ1, PSMD4, TPI1, GABARAPL2, ARF6, CNTN2, FKBP4, AKAP12, PTPN12, PRDX1, AHNAK, MAP3K12, GPM6B, DCTN2, COL9A3, DYNC1H1, FKBP8, SPCS2, PDK3, UBE2V2, ADRM1, RAP1GDS1, HSPA8, PPP5C, HSPA1A, FN1, TPM1, KCTD9P2, TMCO3, CEND1, RUSC2, SPARCL1, MGARP, PRCC, AP2M1, NDN, OLFM1, DNAJC4, VAPA, STUB1, PIN4, MAST1, MOB4, CCDC50, USP8, PCNA, EPN1, PDCD6IP, SH3GL2, LRIG1, UBASH3A, UBASH3B, HSP90AA1, TNK2, NDFIP1, NDFIP2, LGALS1, LGALS3, NEDD4, ZFYVE28, UBC, PIK3R2, SNRPD2, ACTA2, PIK3R1, ERRFI1, MTCO2P1, YWHAZ, SMURF2, OTUD7B, CALM1, USP2, YAP1, ATXN2, CD2AP, PRKCB, H2AFX, PPP2R3A, RABGEF1, PTPRJ, SOCS4, EPS8, STAM2, RIN1, SEC61B, EMD, TOM1L1, RBM10, TRAF2, HNRNPH1, BCLAF1, C11orf84, DOCK4, MYCBP, CRKL, TAB1, RIOK1, JAK1, CDK1, DDX60, ODF3L2, HCFC1, IRS2, RBM41, PICALM, MPV17, CALU, TRPV1, ESR1, ERBB4, HSP90AB1, HSPA5, CDC37, CTGF, RNF115, RNF126, APBB1, IRS4, SH2D1A, APBB3, APBA3, ABL1, FES, PLCG2, IRS1, ABL2, ZAP70, SYK, NUMB, BLK, BMX, SHC2, SLA, MAPK8IP2, DOK6, ANKS1B, CLNK, TNS4, DOK4, RIN2, PIK3R3, ANKS1A, APBB2, SH2D2A, SH2B1, CISH, DOK5, APPL1, MAPK8IP1, SH2B3, TLN1, NUMBL, ANKRD13A, ANKRD13B, ANKRD13D, MAP1LC3A, PTPN23, CHMP4A, DNAJA3, FBXO25, IGKC, IGHG1, TUBB, TUBA4A, TUBB4B, TUBB4A, TUBB2A, TUBB3, IGHG3, TUBB6, HBA1, CSE1L, EEF1A1, KRT86, AP1S1, IPO9, ATXN10, KPNB1, SNRPD1, HSPA2, XPO1, KIAA1524, AP1M2, IPO7, XPOT, PTRF, TNPO1, IPO5, PPP2R1A, DNAJA1, BAG2, HSD17B12, SGPL1, EXOC7, XPO4, PPP2R2A, GCN1L1, EIF2B2, PHGDH, FBXO6, LANCL2, SAAL1, SPTLC1, GEMIN6, DNAJA2, HOOK2, RANBP1, PEX19, ARL1, PPP6C, TNPO3, AP1G2, AP2A1, PPP2R1B, TNPO2, PPP2R5E, AP2B1, RPN1, LTN1, THADA, SEC61A1, EXOC5, TRAPPC3, PDIA3, COG7, IQGAP3, PIK3CB, GAPDH, MMS19, STRAP, MON2, EIF2B3, DARS, DFNA5, EXOC4, COG5, BZW2, DNAAF5, RCN2, COG6, THEM6, SLC39A11, COG4, PFKP, TECR, BUB3, TIMM50, AP1M1, ATP6V1H, OS9, XPO7, DNAJB12, P4HB, IPO4, PPP6R1, SEL1L, USP9X, EPRS, NCDN, EXOC8, PFKL, XPO5, TTC27, AP2A2, ITIH2, PRKDC, PHLDA1, HEATR3, DDX20, IPO11, LGALS8, PSMD2, IPO13, TPP1, EXOC6B, MARS, TBRG4, ZW10, ARHGEF5, AP1G1, IPO8, FDPS, COG1, ATP2A2, NUP85, XPO6, GEMIN4, ALDH3A2, NUP93, RANGAP1, ARFGEF1, EXOC6, ARMC8, TELO2, EIF2B5, PPARGC1A, IARS, EXOC3, NLRP10, KIAA1244, MTOR, DOPEY2, NCAPG2, TTI1, GBF1, SMC2, RNF213, ATR, NBEAL2, FDFT1, RARS, ACOT9, TOR4A, PLAA, TTI2, WDR26, NCAPH2, VAC14, CD59, BIRC3, BIRC2, RQCD1, CAV2, CLTA, CLTCL1, HOXC10, LYN, S100A7, S100A9, SEC13, SFN, SLC3A2, ATP1A1, ATP1B1, ALCAM, ICAM1, TUBA1A, RPA3, RPA2, RPA1, PANK4, HUWE1, OXSR1, PRKAG1, RPS6KA3, PLK1, PFKFB3, EPHA2, DNM1L, UBA2, MAP2K2, HK2, MAP2K4, AP3D1, DNM2, UBR4, RIOK2, SLC12A2, MAP2K3, HK1, ATP5L, PTPRF, ARHGAP1, ITCH, PDK1, TBK1, PLD3, STK26, PPP2R5C, UBE2G2, AP3M1, YES1, PFKM, PRKAA1, AP1S2, AP1B1, CSNK1A1, ACP1, CSNK2A1, AP2S1, CDK5, EIF2AK2, UCK2, UBE2S, AP3S1, VRK1, AKT2, SOCS5, DERL1, PML, DCBLD2, LRSAM1, DSG2, SSBP1, MYO1B, NGLY1, CANX, DPM1, DNAJB11, HSD17B10, DYNC1LI1, FAF2, YARS, IDH2, KIAA0368, SULT1A1, TFRC, CLPX, SRPR, VARS, LRRC40, MRTO4, EIF3M, TRMT10C, TIMM23, SSR4, EHD4, RPRD1A, MYO1D, FBL, HADHB, AFG3L2, CCDC47, SMC1A, SMC3, NDUFA9, UMPS, ITPA, SLFN11, CLPP, CPVL, TM9SF3, LONP1, RPL38, SNRPA1, COPA, APRT, NSF, NSUN5, ATAD1, AIFM1, POLDIP2, WDR6, SCFD1, NDUFS1, OAT, SAMHD1, MGST1, NDUFS3, SNRPF, CNP, ACADSB, ORC5, EIF2B4, PUS1, SDF2L1, IMMT, TARS, DDX47, ACTR2, EIF2B1, HLA-A, VPS4B, EHD1, PYCR2, MYO1C, CUL4B, DHRS7B, RFC5, OSBP, YBEY, EEF1B2, GCLM, GSTK1, TTC37, AK4, CARS2, MINOS1, PELO, MRPL10, FAR1, CTBP1, ABCF2, MPC2, LIMA1, ILVBL, NCAPG, TARS2, COX2, PNO1, IFIT5, EIF3K, CHCHD3, PUM1, TOR1AIP1, GNAS, EIF3F, CMSS1, RPS15A, TMEM97, ETF1, NCAPH, RFC3, TOMM22, STT3A, TUBGCP2, ASNS, HELLS, LARP4, PON2, ABCD3, CDIPT, SDF2, DIMT1, BCCIP, PTGES3, PC, SRPRB, SCAMP3, NAA10, UTP15, GNB2, TRMT2A, ADCK3, CTTN, RER1, IDH3B, LRWD1, C6orf120, BZW1, SLC1A5, TRMT1L, NSUN2, SFXN3, UFL1, SUGP2, IKBKAP, PDS5A, TNFRSF10B, ACACA, HYOU1, ATP5F1, FLOT2, NTPCR, CERS2, SCD, UQCRC2, ATP2B1, EIF4G2, SAMM50, NUBP2, DNAJC11, NCLN, SKIV2L, DIS3, LSR, ATXN7L3B, EMC3, CALR, PRIM1, RNMTL1, AAMP, ATAD3B, RAB18, RPL23, PRMT3, PDXDC1, AAAS, SUCLA2, CTBP2, KIF1A, TRAPPC5, ARMC6, SLC25A13, TBL3, CLU, ARHGEF2, ATP5A1, RPL22, FAM98A, IDH3A, DHCR24, FADS2, CKAP2, FARSA, CEBPZ, ADAR, NUP153, LRPPRC, OPA1, STOM, RFC4, TUBG1, LANCL1, TAF4, PSPC1, EWSR1, AAMDC, GRN, PSMD1, FN3KRP, TPM3, THOP1, CAP2, RPL4, BLM, PLS3, TPM4, NT5DC2, XRCC5, H1FX, MRPL9, LAT, PDGFRA, TNFRSF1A, IKBKG, SNCA, YWHAQ, YWHAB, PRKCE, MAPT, SHC4, DOK1, RAF1, BAIAP2, FGR, ACTN4, AKT1, HCK, RAPGEF1, SH3GL3, MAPK8, NR3C1, PTPN22, FRK, STAP2, ARRB1, LCP2, ITGB2, TGFA, ARRB2, PRKCZ, HDAC7, RET, SH2D3C, SLA2, CDH5, ITK, CDC25C, ITSN2, MAP3K3, PIM1, GRAP2, S100A4, SNX9, NTRK2, PTPN18, PAK1, MAPK9, WASL, TNS3, WASF3, ARHGEF7, SOCS6, APP, LRP1, STAT2, TLR2, RGS4, TMEM25, PTCH1, PTPRK, AKTIP, NTRK1, PIGS, TP53, ARHGAP32, PARK2, CTNNA1, FOS, HSPA1B, EZR, TXN, PPARG, KEAP1, NELL1, SUSD1, CSTA, HSPA9, ANO5, ANXA1, COL17A1, CTNNA2, HIST1H2AA, HSPB1, RPS15, RBM25, RPS26P11, SPRR1A, SERPINB4, SERAC1, SFPQ, PTPRD, MET, ITGB4, XRN2, GSTT1, DBR1, SLC7A5, VPS13A, YTHDF1, RPL17, ATP2B4, APOB, ESRRB, OSMR, HBA2, ACTB, MYH9, IQGAP1, PTPRU, PTPRB, FAM129B, LRIG2, KRAS, BBC3, GSTP1, L1CAM, RRAD, MIF, HIP1, ERCC1, ERCC4, CLCN5, MCM4, APEX1, NCL, NPM1, PARP1, LMNA, FUS, ERCC2, TRIM28, MCM3, MCM6, FEN1, ILF2, ILF3, DHX9, BRE, TOP1, BRAF, LTK, IGFBP2, CDH2, ITGB1, CCDC88A, PDP1, PTPRR, PTPN7, PTPRA, PTPRH, PTPRT, PPM1A, PPM1F, DUSP14, DUSP18, MPZL2, SSH1, FAM186A, SRRM4, CD300LB, SMTNL1, KRTAP16-1, MYO9A, BTBD18, IGLL5, RASA4B, PGRMC1, SUPT5H, ACACB, TRAFD1, EIF1AY, SEC16A, ZBTB22, PMM2, EPB41L2, FOXO3, HTATSF1, DYRK3, ZBTB14, DHX16, CEP104, EIF5B, NPHP4, DNAJC13, SPAG7, TOMM70A, SLITRK3, OR2F2, LUC7L3, LCA5L, ABCA1, HERC2, PAK4, DHFR, HLA-B, COL1A1, AHSG, MAS1, KRT1, HMGN2, RPLP2, SSB, CTSD, COL1A2, KRT16, HMGB1, FAM66E, ZCCHC18, CKMT1A, DRD2, GLUL, HMGA1, DDX5, TCP1, RPL7, CD58, NF1, IGHV1-2, PPIB, RPS3, EIF4B, TNC, PSMA3, PSMA4, U2AF2, CNTF, HMGB2, DPP4, MAP4, HSD11B1, POLR2A, GABRA3, KRT9, TRIM23, RPL3, RPS27, GRIK4, TUFM, ALDH7A1, RPL14, IDH3G, IRAK1, KCNQ1, HDGF, BTAF1, SUB1, MFAP1, EIF3B, SESN2, KRTAP10-9, RPS20, S100A10, HNRNPK, CNBP, RAB1A, TRA2B, YBX1, NTHL1, XIAP, SRSF2, AKAP17A, RPL6, SRSF11, SLC3A1, SSRP1, RASGEF1B, MIR22HG, C5orf28, BPTF, CSTF3, G3BP1, TCOF1, PDAP1, TCIRG1, HDAC1, CDK13, CIRBP, LRP8, PDE1C, UBAP2L, CAPRIN1, RBM39, DIP2A, CBX2, GRM4, STIL, DIXDC1, HERC1, E2F4, MICB, MRGPRG-AS1, P3H1, LRRK1, KRTAP15-1, PTPN20B, AASDH, ARHGAP29, FBLN7, SLC45A4, PAGE3, DOPEY1, CEP170, EYS, SWT1, KIAA1217, ATF7IP2, ZMYM4, CES4A, WWC2, HIST2H2AA3, NADSYN1, PLEKHA7, ADAM5, MAST2, ARMCX5, XRRA1, SCYL2, GIGYF2, EML6, LOC400499, USP34, USP31, CYS1, SMIM5, RSRC2, ZC3HAV1, PID1, SETX, OR2W3, PRSS42, NEK8, LRRTM4, HEATR4, ZNF573, SLC13A5, HRNR, CCDC60, FAM126B, SRRM1, CCDC146, ZZZ3, CENPL, MIER1, UNC80, EFCAB3, TRIML2, C2orf61, MRPL43, TOPAZ1, ZNF114, SERBP1, LSM14A, CTCFL, BBS10, MAPK15, CHD6, TRAF3IP1, HEXDC, LMBR1, KBTBD7, MUC16, DNAH7, TTN, ROBO4, SLC39A7, EDEM1, ZNF516, DHX38, DAZL, TMBIM1, TMEM159, DOCK10, MTBP, ELP4, MTMR8, RNF125, DNAH8, SCYL1, ZFR, PRICKLE1, RUNDC3B, SERPINB12, SMG1, PCNX, SPEN, TSG101, SPAG8, NABP2, ZFYVE21, SYT17, CNPY3, MTG1, C2orf49, PRR14, PLVAP, API5, NXF2, KATNBL1, SPATC1L, NUCKS1, RWDD1, DPEP3, REEP4, NOL6, RPF1, SNX29, TRPM3, IL1RAPL2, MLXIPL, INCENP, EXOSC3, SERTAD4, RLIM, GPATCH2, RCC2, HECW2, CRCT1, TMEM2, TEKT2, SLCO3A1, HN1, TNIK, GPATCH8, TRHDE, BAG5, GRID1, SLC45A2, MAGED2, ING4, ZC3H4, AGTPBP1, SHANK2, SRRM2, RUVBL2, COA3, NOSIP, CBY1, WIPI2, PCDHGA3, KRT3, KRT10, KRT2, KRT5, GOLGB1, GPR149, NF2, CTDSPL, SCGB1D4, DEFA1, ST8SIA4, HTR3A, PCDHB11, RAB31, PPP3CB, PPM1B, ILKAP, DUSP19, STYX, WBP2, PTEN, LINC01139, GPNMB, RGS2, PTPN2, HPN, UBE2J2	RCL1	HDGF, SIRT7, HECW2, MOV10, NXF1, BRCA1, SUZ12, EED, RNF2, IFI16, XPO1, HIST1H3E, TFG, PAPD5, GEMIN7, USF1, PTPN2, NCL, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for EGFR_RCL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	EGFR	P00533	DB00002	Cetuximab	Epidermal growth factor receptor	biotech	approved
Hgene	EGFR	P00533	DB05294	Vandetanib	Epidermal growth factor receptor	small molecule	approved
Hgene	EGFR	P00533	DB08916	Afatinib	Epidermal growth factor receptor	small molecule	approved
Hgene	EGFR	P00533	DB00072	Trastuzumab	Epidermal growth factor receptor	biotech	approved\|investigational
Hgene	EGFR	P00533	DB00317	Gefitinib	Epidermal growth factor receptor	small molecule	approved\|investigational
Hgene	EGFR	P00533	DB00530	Erlotinib	Epidermal growth factor receptor	small molecule	approved\|investigational
Hgene	EGFR	P00533	DB01259	Lapatinib	Epidermal growth factor receptor	small molecule	approved\|investigational
Hgene	EGFR	P00533	DB01269	Panitumumab	Epidermal growth factor receptor	biotech	approved\|investigational
Hgene	EGFR	P00533	DB09559	Necitumumab	Epidermal growth factor receptor	biotech	approved\|investigational
Hgene	EGFR	P00533	DB00281	Lidocaine	Epidermal growth factor receptor	small molecule	approved\|vet_approved

Top

RelatedDiseases for EGFR_RCL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EGFR	C0007131	Non-Small Cell Lung Carcinoma	16	CTD_human
Hgene	EGFR	C1458155	Mammary Neoplasms	6	CTD_human
Hgene	EGFR	C0024121	Lung Neoplasms	5	CTD_human
Hgene	EGFR	C0001418	Adenocarcinoma	4	CTD_human
Hgene	EGFR	C0007137	Squamous cell carcinoma	3	CTD_human
Hgene	EGFR	C0007873	Uterine Cervical Neoplasm	3	CTD_human
Hgene	EGFR	C0014859	Esophageal Neoplasms	3	CTD_human
Hgene	EGFR	C0017636	Glioblastoma	3	CTD_human
Hgene	EGFR	C0018671	Head and Neck Neoplasms	3	CTD_human
Hgene	EGFR	C0027627	Neoplasm Metastasis	3	CTD_human
Hgene	EGFR	C0033578	Prostatic Neoplasms	3	CTD_human
Hgene	EGFR	C0038356	Stomach Neoplasms	3	CTD_human
Hgene	EGFR	C0005695	Bladder Neoplasm	2	CTD_human
Hgene	EGFR	C0009375	Colonic Neoplasms	2	CTD_human
Hgene	EGFR	C0009404	Colorectal Neoplasms	2	CTD_human
Hgene	EGFR	C0024668	Mammary Neoplasms, Experimental	2	CTD_human
Hgene	EGFR	C0027626	Neoplasm Invasiveness	2	CTD_human
Hgene	EGFR	C0027643	Neoplasm Recurrence, Local	2	CTD_human
Hgene	EGFR	C0152013	Adenocarcinoma of lung (disorder)	2	CTD_human
Hgene	EGFR	C0919267	ovarian neoplasm	2	CTD_human
Hgene	EGFR	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Hgene	EGFR	C0005396	Bile Duct Neoplasms	1	CTD_human
Hgene	EGFR	C0007193	Cardiomyopathy, Dilated	1	CTD_human
Hgene	EGFR	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	EGFR	C0014175	Endometriosis	1	CTD_human
Hgene	EGFR	C0016978	gallbladder neoplasm	1	CTD_human
Hgene	EGFR	C0021655	Insulin Resistance	1	CTD_human
Hgene	EGFR	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	EGFR	C0024809	Marijuana Abuse	1	PSYGENET
Hgene	EGFR	C0025500	Mesothelioma	1	CTD_human
Hgene	EGFR	C0027439	Nasopharyngeal Neoplasms	1	CTD_human
Hgene	EGFR	C0029463	Osteosarcoma	1	CTD_human
Hgene	EGFR	C0030354	Papilloma	1	CTD_human
Hgene	EGFR	C0032580	Adenomatous Polyposis Coli	1	CTD_human
Hgene	EGFR	C0034885	Rectal Neoplasms	1	CTD_human
Hgene	EGFR	C0041696	Unipolar Depression	1	PSYGENET
Hgene	EGFR	C0085548	Autosomal Recessive Polycystic Kidney Disease	1	CTD_human
Hgene	EGFR	C0085762	Alcohol abuse	1	PSYGENET
Hgene	EGFR	C0149925	Small cell carcinoma of lung	1	CTD_human
Hgene	EGFR	C0206686	Adrenocortical carcinoma	1	CTD_human
Hgene	EGFR	C0206698	Cholangiocarcinoma	1	CTD_human
Hgene	EGFR	C0263454	Chloracne	1	CTD_human
Hgene	EGFR	C0279626	Squamous cell carcinoma of esophagus	1	CTD_human
Hgene	EGFR	C0345967	Malignant mesothelioma	1	CTD_human
Hgene	EGFR	C0376634	Craniofacial Abnormalities	1	CTD_human
Hgene	EGFR	C0993582	Arthritis, Experimental	1	CTD_human
Hgene	EGFR	C1269683	Major Depressive Disorder	1	PSYGENET
Hgene	EGFR	C2239176	Liver carcinoma	1	CTD_human
Hgene	EGFR	C2609414	Acute kidney injury	1	CTD_human
Hgene	EGFR	C4015130	INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2	1	UNIPROT

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Fusion gene ID: 11115

FusionGeneSummary for EGFR_RCL1

FusionProtFeatures for EGFR_RCL1

FusionGeneSequence for EGFR_RCL1

FusionGenePPI for EGFR_RCL1

RelatedDrugs for EGFR_RCL1

RelatedDiseases for EGFR_RCL1