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Fusion gene ID: 11115 |
FusionGeneSummary for EGFR_RCL1 |
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Fusion gene information | Fusion gene name: EGFR_RCL1 | Fusion gene ID: 11115 | Hgene | Tgene | Gene symbol | EGFR | RCL1 | Gene ID | 1956 | 10171 |
Gene name | epidermal growth factor receptor | RNA terminal phosphate cyclase like 1 | |
Synonyms | ERBB|ERBB1|HER1|NISBD2|PIG61|mENA | RNAC|RPCL1 | |
Cytomap | 7p11.2 | 9p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | epidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinas | RNA 3'-terminal phosphate cyclase-like proteinRNA cyclase homolog | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P00533 | Q9Y2P8 | |
Ensembl transtripts involved in fusion gene | ENST00000455089, ENST00000342916, ENST00000344576, ENST00000420316, ENST00000275493, ENST00000442591, ENST00000463948, ENST00000454757, | ENST00000381750, ENST00000381730, ENST00000381728, ENST00000448872, ENST00000381732, ENST00000445485, | |
Fusion gene scores | * DoF score | 18 X 8 X 8=1152 | 6 X 5 X 6=180 |
# samples | 17 | 6 | |
** MAII score | log2(17/1152*10)=-2.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EGFR [Title/Abstract] AND RCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EGFR | GO:0001934 | positive regulation of protein phosphorylation | 20551055 |
Hgene | EGFR | GO:0007165 | signal transduction | 10572067 |
Hgene | EGFR | GO:0007166 | cell surface receptor signaling pathway | 7736574 |
Hgene | EGFR | GO:0007173 | epidermal growth factor receptor signaling pathway | 7736574|12435727 |
Hgene | EGFR | GO:0008283 | cell proliferation | 17115032 |
Hgene | EGFR | GO:0008284 | positive regulation of cell proliferation | 7736574 |
Hgene | EGFR | GO:0010750 | positive regulation of nitric oxide mediated signal transduction | 12828935 |
Hgene | EGFR | GO:0018108 | peptidyl-tyrosine phosphorylation | 22732145 |
Hgene | EGFR | GO:0030307 | positive regulation of cell growth | 15467833 |
Hgene | EGFR | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 18483258 |
Hgene | EGFR | GO:0042177 | negative regulation of protein catabolic process | 17115032 |
Hgene | EGFR | GO:0042327 | positive regulation of phosphorylation | 15082764 |
Hgene | EGFR | GO:0043406 | positive regulation of MAP kinase activity | 10572067 |
Hgene | EGFR | GO:0045739 | positive regulation of DNA repair | 17115032 |
Hgene | EGFR | GO:0045740 | positive regulation of DNA replication | 17115032 |
Hgene | EGFR | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20551055 |
Hgene | EGFR | GO:0050679 | positive regulation of epithelial cell proliferation | 10572067 |
Hgene | EGFR | GO:0050999 | regulation of nitric-oxide synthase activity | 12828935 |
Hgene | EGFR | GO:0070141 | response to UV-A | 18483258 |
Hgene | EGFR | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 20551055 |
Hgene | EGFR | GO:0071392 | cellular response to estradiol stimulus | 20551055 |
Hgene | EGFR | GO:1900020 | positive regulation of protein kinase C activity | 22732145 |
Hgene | EGFR | GO:1903078 | positive regulation of protein localization to plasma membrane | 22732145 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-BR-6706-01A | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000455089 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000455089 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000455089 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000455089 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000455089 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000455089 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000342916 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000342916 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000342916 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000342916 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000342916 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000342916 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000344576 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000344576 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000344576 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000344576 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000344576 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000344576 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000420316 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000420316 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000420316 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000420316 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000420316 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000420316 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000275493 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000275493 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000275493 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000275493 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000275493 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000275493 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000442591 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000442591 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000442591 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
Frame-shift | ENST00000442591 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000442591 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
5CDS-intron | ENST00000442591 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-3CDS | ENST00000463948 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-3CDS | ENST00000463948 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-3CDS | ENST00000463948 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-3CDS | ENST00000463948 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-intron | ENST00000463948 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
3UTR-intron | ENST00000463948 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-3CDS | ENST00000454757 | ENST00000381750 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-3CDS | ENST00000454757 | ENST00000381730 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-3CDS | ENST00000454757 | ENST00000381728 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-3CDS | ENST00000454757 | ENST00000448872 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-intron | ENST00000454757 | ENST00000381732 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
intron-intron | ENST00000454757 | ENST00000445485 | EGFR | chr7 | 55087058 | + | RCL1 | chr9 | 4849447 | + |
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FusionProtFeatures for EGFR_RCL1 |
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Hgene | Tgene |
EGFR | RCL1 |
Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processingsteps at sites A0, A1 and A2 that are required for propermaturation of the 18S RNA (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EGFR_RCL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EGFR_RCL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EGFR | DCN, SHC1, SH3BGRL, STAT5A, PTPN11, CRK, CSK, CBLB, GRB2, STAT3, CTNNB1, CTNND1, JUP, AR, EGFR, CAMLG, PRKCA, HBEGF, TJP1, ATP5C1, SGSM2, WAS, EGF, INPPL1, DUSP3, AREG, PTK2, CBL, CBLC, CDH1, MAPK14, VAV1, VAV2, VAV3, STAT1, SRC, JAK2, HTT, PTK6, PTK2B, DOK2, SOS1, SOS2, CDC25A, NCK1, IGF1R, PRKAR1A, PRKACA, PLD2, ARF4, MAP4K1, NCK2, EPS15, PTPN6, SH2D3A, PLSCR1, GRB14, RASA1, GRB10, PTPN1, NRG1, CD44, PLCG1, SH3KBP1, PIK3C2B, SOCS1, SOCS3, CAV1, CAV3, ERBB3, CD82, SNX6, SNX1, SNX2, SNX4, STAT5B, RGS16, CEBPB, MUC1, GAB1, RIPK1, MAP3K14, PDGFRB, SHC3, CASP1, EREG, FER, ERBB2, HGS, NCAM1, HDAC6, AIP, PSMA7, MEGF6, SORBS2, HEXIM1, AHSA1, ALDOA, UROD, UCHL1, HSP90B1, CBR1, FAH, GOT1, RAB3A, CSRP1, CFL1, EEF1G, PRKAR1B, ATIC, STIP1, HSPA4, MDH1, PTGDS, MATR3, SEPP1, OAZ1, PSMD4, TPI1, GABARAPL2, ARF6, CNTN2, FKBP4, AKAP12, PTPN12, PRDX1, AHNAK, MAP3K12, GPM6B, DCTN2, COL9A3, DYNC1H1, FKBP8, SPCS2, PDK3, UBE2V2, ADRM1, RAP1GDS1, HSPA8, PPP5C, HSPA1A, FN1, TPM1, KCTD9P2, TMCO3, CEND1, RUSC2, SPARCL1, MGARP, PRCC, AP2M1, NDN, OLFM1, DNAJC4, VAPA, STUB1, PIN4, MAST1, MOB4, CCDC50, USP8, PCNA, EPN1, PDCD6IP, SH3GL2, LRIG1, UBASH3A, UBASH3B, HSP90AA1, TNK2, NDFIP1, NDFIP2, LGALS1, LGALS3, NEDD4, ZFYVE28, UBC, PIK3R2, SNRPD2, ACTA2, PIK3R1, ERRFI1, MTCO2P1, YWHAZ, SMURF2, OTUD7B, CALM1, USP2, YAP1, ATXN2, CD2AP, PRKCB, H2AFX, PPP2R3A, RABGEF1, PTPRJ, SOCS4, EPS8, STAM2, RIN1, SEC61B, EMD, TOM1L1, RBM10, TRAF2, HNRNPH1, BCLAF1, C11orf84, DOCK4, MYCBP, CRKL, TAB1, RIOK1, JAK1, CDK1, DDX60, ODF3L2, HCFC1, IRS2, RBM41, PICALM, MPV17, CALU, TRPV1, ESR1, ERBB4, HSP90AB1, HSPA5, CDC37, CTGF, RNF115, RNF126, APBB1, IRS4, SH2D1A, APBB3, APBA3, ABL1, FES, PLCG2, IRS1, ABL2, ZAP70, SYK, NUMB, BLK, BMX, SHC2, SLA, MAPK8IP2, DOK6, ANKS1B, CLNK, TNS4, DOK4, RIN2, PIK3R3, ANKS1A, APBB2, SH2D2A, SH2B1, CISH, DOK5, APPL1, MAPK8IP1, SH2B3, TLN1, NUMBL, ANKRD13A, ANKRD13B, ANKRD13D, MAP1LC3A, PTPN23, CHMP4A, DNAJA3, FBXO25, IGKC, IGHG1, TUBB, TUBA4A, TUBB4B, TUBB4A, TUBB2A, TUBB3, IGHG3, TUBB6, HBA1, CSE1L, EEF1A1, KRT86, AP1S1, IPO9, ATXN10, KPNB1, SNRPD1, HSPA2, XPO1, KIAA1524, AP1M2, IPO7, XPOT, PTRF, TNPO1, IPO5, PPP2R1A, DNAJA1, BAG2, HSD17B12, SGPL1, EXOC7, XPO4, PPP2R2A, GCN1L1, EIF2B2, PHGDH, FBXO6, LANCL2, SAAL1, SPTLC1, GEMIN6, DNAJA2, HOOK2, RANBP1, PEX19, ARL1, PPP6C, TNPO3, AP1G2, AP2A1, PPP2R1B, TNPO2, PPP2R5E, AP2B1, RPN1, LTN1, THADA, SEC61A1, EXOC5, TRAPPC3, PDIA3, COG7, IQGAP3, PIK3CB, GAPDH, MMS19, STRAP, MON2, EIF2B3, DARS, DFNA5, EXOC4, COG5, BZW2, DNAAF5, RCN2, COG6, THEM6, SLC39A11, COG4, PFKP, TECR, BUB3, TIMM50, AP1M1, ATP6V1H, OS9, XPO7, DNAJB12, P4HB, IPO4, PPP6R1, SEL1L, USP9X, EPRS, NCDN, EXOC8, PFKL, XPO5, TTC27, AP2A2, ITIH2, PRKDC, PHLDA1, HEATR3, DDX20, IPO11, LGALS8, PSMD2, IPO13, TPP1, EXOC6B, MARS, TBRG4, ZW10, ARHGEF5, AP1G1, IPO8, FDPS, COG1, ATP2A2, NUP85, XPO6, GEMIN4, ALDH3A2, NUP93, RANGAP1, ARFGEF1, EXOC6, ARMC8, TELO2, EIF2B5, PPARGC1A, IARS, EXOC3, NLRP10, KIAA1244, MTOR, DOPEY2, NCAPG2, TTI1, GBF1, SMC2, RNF213, ATR, NBEAL2, FDFT1, RARS, ACOT9, TOR4A, PLAA, TTI2, WDR26, NCAPH2, VAC14, CD59, BIRC3, BIRC2, RQCD1, CAV2, CLTA, CLTCL1, HOXC10, LYN, S100A7, S100A9, SEC13, SFN, SLC3A2, ATP1A1, ATP1B1, ALCAM, ICAM1, TUBA1A, RPA3, RPA2, RPA1, PANK4, HUWE1, OXSR1, PRKAG1, RPS6KA3, PLK1, PFKFB3, EPHA2, DNM1L, UBA2, MAP2K2, HK2, MAP2K4, AP3D1, DNM2, UBR4, RIOK2, SLC12A2, MAP2K3, HK1, ATP5L, PTPRF, ARHGAP1, ITCH, PDK1, TBK1, PLD3, STK26, PPP2R5C, UBE2G2, AP3M1, YES1, PFKM, PRKAA1, AP1S2, AP1B1, CSNK1A1, ACP1, CSNK2A1, AP2S1, CDK5, EIF2AK2, UCK2, UBE2S, AP3S1, VRK1, AKT2, SOCS5, DERL1, PML, DCBLD2, LRSAM1, DSG2, SSBP1, MYO1B, NGLY1, CANX, DPM1, DNAJB11, HSD17B10, DYNC1LI1, FAF2, YARS, IDH2, KIAA0368, SULT1A1, TFRC, CLPX, SRPR, VARS, LRRC40, MRTO4, EIF3M, TRMT10C, TIMM23, SSR4, EHD4, RPRD1A, MYO1D, FBL, HADHB, AFG3L2, CCDC47, SMC1A, SMC3, NDUFA9, UMPS, ITPA, SLFN11, CLPP, CPVL, TM9SF3, LONP1, RPL38, SNRPA1, COPA, APRT, NSF, NSUN5, ATAD1, AIFM1, POLDIP2, WDR6, SCFD1, NDUFS1, OAT, SAMHD1, MGST1, NDUFS3, SNRPF, CNP, ACADSB, ORC5, EIF2B4, PUS1, SDF2L1, IMMT, TARS, DDX47, ACTR2, EIF2B1, HLA-A, VPS4B, EHD1, PYCR2, MYO1C, CUL4B, DHRS7B, RFC5, OSBP, YBEY, EEF1B2, GCLM, GSTK1, TTC37, AK4, CARS2, MINOS1, PELO, MRPL10, FAR1, CTBP1, ABCF2, MPC2, LIMA1, ILVBL, NCAPG, TARS2, COX2, PNO1, IFIT5, EIF3K, CHCHD3, PUM1, TOR1AIP1, GNAS, EIF3F, CMSS1, RPS15A, TMEM97, ETF1, NCAPH, RFC3, TOMM22, STT3A, TUBGCP2, ASNS, HELLS, LARP4, PON2, ABCD3, CDIPT, SDF2, DIMT1, BCCIP, PTGES3, PC, SRPRB, SCAMP3, NAA10, UTP15, GNB2, TRMT2A, ADCK3, CTTN, RER1, IDH3B, LRWD1, C6orf120, BZW1, SLC1A5, TRMT1L, NSUN2, SFXN3, UFL1, SUGP2, IKBKAP, PDS5A, TNFRSF10B, ACACA, HYOU1, ATP5F1, FLOT2, NTPCR, CERS2, SCD, UQCRC2, ATP2B1, EIF4G2, SAMM50, NUBP2, DNAJC11, NCLN, SKIV2L, DIS3, LSR, ATXN7L3B, EMC3, CALR, PRIM1, RNMTL1, AAMP, ATAD3B, RAB18, RPL23, PRMT3, PDXDC1, AAAS, SUCLA2, CTBP2, KIF1A, TRAPPC5, ARMC6, SLC25A13, TBL3, CLU, ARHGEF2, ATP5A1, RPL22, FAM98A, IDH3A, DHCR24, FADS2, CKAP2, FARSA, CEBPZ, ADAR, NUP153, LRPPRC, OPA1, STOM, RFC4, TUBG1, LANCL1, TAF4, PSPC1, EWSR1, AAMDC, GRN, PSMD1, FN3KRP, TPM3, THOP1, CAP2, RPL4, BLM, PLS3, TPM4, NT5DC2, XRCC5, H1FX, MRPL9, LAT, PDGFRA, TNFRSF1A, IKBKG, SNCA, YWHAQ, YWHAB, PRKCE, MAPT, SHC4, DOK1, RAF1, BAIAP2, FGR, ACTN4, AKT1, HCK, RAPGEF1, SH3GL3, MAPK8, NR3C1, PTPN22, FRK, STAP2, ARRB1, LCP2, ITGB2, TGFA, ARRB2, PRKCZ, HDAC7, RET, SH2D3C, SLA2, CDH5, ITK, CDC25C, ITSN2, MAP3K3, PIM1, GRAP2, S100A4, SNX9, NTRK2, PTPN18, PAK1, MAPK9, WASL, TNS3, WASF3, ARHGEF7, SOCS6, APP, LRP1, STAT2, TLR2, RGS4, TMEM25, PTCH1, PTPRK, AKTIP, NTRK1, PIGS, TP53, ARHGAP32, PARK2, CTNNA1, FOS, HSPA1B, EZR, TXN, PPARG, KEAP1, NELL1, SUSD1, CSTA, HSPA9, ANO5, ANXA1, COL17A1, CTNNA2, HIST1H2AA, HSPB1, RPS15, RBM25, RPS26P11, SPRR1A, SERPINB4, SERAC1, SFPQ, PTPRD, MET, ITGB4, XRN2, GSTT1, DBR1, SLC7A5, VPS13A, YTHDF1, RPL17, ATP2B4, APOB, ESRRB, OSMR, HBA2, ACTB, MYH9, IQGAP1, PTPRU, PTPRB, FAM129B, LRIG2, KRAS, BBC3, GSTP1, L1CAM, RRAD, MIF, HIP1, ERCC1, ERCC4, CLCN5, MCM4, APEX1, NCL, NPM1, PARP1, LMNA, FUS, ERCC2, TRIM28, MCM3, MCM6, FEN1, ILF2, ILF3, DHX9, BRE, TOP1, BRAF, LTK, IGFBP2, CDH2, ITGB1, CCDC88A, PDP1, PTPRR, PTPN7, PTPRA, PTPRH, PTPRT, PPM1A, PPM1F, DUSP14, DUSP18, MPZL2, SSH1, FAM186A, SRRM4, CD300LB, SMTNL1, KRTAP16-1, MYO9A, BTBD18, IGLL5, RASA4B, PGRMC1, SUPT5H, ACACB, TRAFD1, EIF1AY, SEC16A, ZBTB22, PMM2, EPB41L2, FOXO3, HTATSF1, DYRK3, ZBTB14, DHX16, CEP104, EIF5B, NPHP4, DNAJC13, SPAG7, TOMM70A, SLITRK3, OR2F2, LUC7L3, LCA5L, ABCA1, HERC2, PAK4, DHFR, HLA-B, COL1A1, AHSG, MAS1, KRT1, HMGN2, RPLP2, SSB, CTSD, COL1A2, KRT16, HMGB1, FAM66E, ZCCHC18, CKMT1A, DRD2, GLUL, HMGA1, DDX5, TCP1, RPL7, CD58, NF1, IGHV1-2, PPIB, RPS3, EIF4B, TNC, PSMA3, PSMA4, U2AF2, CNTF, HMGB2, DPP4, MAP4, HSD11B1, POLR2A, GABRA3, KRT9, TRIM23, RPL3, RPS27, GRIK4, TUFM, ALDH7A1, RPL14, IDH3G, IRAK1, KCNQ1, HDGF, BTAF1, SUB1, MFAP1, EIF3B, SESN2, KRTAP10-9, RPS20, S100A10, HNRNPK, CNBP, RAB1A, TRA2B, YBX1, NTHL1, XIAP, SRSF2, AKAP17A, RPL6, SRSF11, SLC3A1, SSRP1, RASGEF1B, MIR22HG, C5orf28, BPTF, CSTF3, G3BP1, TCOF1, PDAP1, TCIRG1, HDAC1, CDK13, CIRBP, LRP8, PDE1C, UBAP2L, CAPRIN1, RBM39, DIP2A, CBX2, GRM4, STIL, DIXDC1, HERC1, E2F4, MICB, MRGPRG-AS1, P3H1, LRRK1, KRTAP15-1, PTPN20B, AASDH, ARHGAP29, FBLN7, SLC45A4, PAGE3, DOPEY1, CEP170, EYS, SWT1, KIAA1217, ATF7IP2, ZMYM4, CES4A, WWC2, HIST2H2AA3, NADSYN1, PLEKHA7, ADAM5, MAST2, ARMCX5, XRRA1, SCYL2, GIGYF2, EML6, LOC400499, USP34, USP31, CYS1, SMIM5, RSRC2, ZC3HAV1, PID1, SETX, OR2W3, PRSS42, NEK8, LRRTM4, HEATR4, ZNF573, SLC13A5, HRNR, CCDC60, FAM126B, SRRM1, CCDC146, ZZZ3, CENPL, MIER1, UNC80, EFCAB3, TRIML2, C2orf61, MRPL43, TOPAZ1, ZNF114, SERBP1, LSM14A, CTCFL, BBS10, MAPK15, CHD6, TRAF3IP1, HEXDC, LMBR1, KBTBD7, MUC16, DNAH7, TTN, ROBO4, SLC39A7, EDEM1, ZNF516, DHX38, DAZL, TMBIM1, TMEM159, DOCK10, MTBP, ELP4, MTMR8, RNF125, DNAH8, SCYL1, ZFR, PRICKLE1, RUNDC3B, SERPINB12, SMG1, PCNX, SPEN, TSG101, SPAG8, NABP2, ZFYVE21, SYT17, CNPY3, MTG1, C2orf49, PRR14, PLVAP, API5, NXF2, KATNBL1, SPATC1L, NUCKS1, RWDD1, DPEP3, REEP4, NOL6, RPF1, SNX29, TRPM3, IL1RAPL2, MLXIPL, INCENP, EXOSC3, SERTAD4, RLIM, GPATCH2, RCC2, HECW2, CRCT1, TMEM2, TEKT2, SLCO3A1, HN1, TNIK, GPATCH8, TRHDE, BAG5, GRID1, SLC45A2, MAGED2, ING4, ZC3H4, AGTPBP1, SHANK2, SRRM2, RUVBL2, COA3, NOSIP, CBY1, WIPI2, PCDHGA3, KRT3, KRT10, KRT2, KRT5, GOLGB1, GPR149, NF2, CTDSPL, SCGB1D4, DEFA1, ST8SIA4, HTR3A, PCDHB11, RAB31, PPP3CB, PPM1B, ILKAP, DUSP19, STYX, WBP2, PTEN, LINC01139, GPNMB, RGS2, PTPN2, HPN, UBE2J2 | RCL1 | HDGF, SIRT7, HECW2, MOV10, NXF1, BRCA1, SUZ12, EED, RNF2, IFI16, XPO1, HIST1H3E, TFG, PAPD5, GEMIN7, USF1, PTPN2, NCL, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EGFR_RCL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | EGFR | P00533 | DB00002 | Cetuximab | Epidermal growth factor receptor | biotech | approved |
Hgene | EGFR | P00533 | DB05294 | Vandetanib | Epidermal growth factor receptor | small molecule | approved |
Hgene | EGFR | P00533 | DB08916 | Afatinib | Epidermal growth factor receptor | small molecule | approved |
Hgene | EGFR | P00533 | DB00072 | Trastuzumab | Epidermal growth factor receptor | biotech | approved|investigational |
Hgene | EGFR | P00533 | DB00317 | Gefitinib | Epidermal growth factor receptor | small molecule | approved|investigational |
Hgene | EGFR | P00533 | DB00530 | Erlotinib | Epidermal growth factor receptor | small molecule | approved|investigational |
Hgene | EGFR | P00533 | DB01259 | Lapatinib | Epidermal growth factor receptor | small molecule | approved|investigational |
Hgene | EGFR | P00533 | DB01269 | Panitumumab | Epidermal growth factor receptor | biotech | approved|investigational |
Hgene | EGFR | P00533 | DB09559 | Necitumumab | Epidermal growth factor receptor | biotech | approved|investigational |
Hgene | EGFR | P00533 | DB00281 | Lidocaine | Epidermal growth factor receptor | small molecule | approved|vet_approved |
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RelatedDiseases for EGFR_RCL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EGFR | C0007131 | Non-Small Cell Lung Carcinoma | 16 | CTD_human |
Hgene | EGFR | C1458155 | Mammary Neoplasms | 6 | CTD_human |
Hgene | EGFR | C0024121 | Lung Neoplasms | 5 | CTD_human |
Hgene | EGFR | C0001418 | Adenocarcinoma | 4 | CTD_human |
Hgene | EGFR | C0007137 | Squamous cell carcinoma | 3 | CTD_human |
Hgene | EGFR | C0007873 | Uterine Cervical Neoplasm | 3 | CTD_human |
Hgene | EGFR | C0014859 | Esophageal Neoplasms | 3 | CTD_human |
Hgene | EGFR | C0017636 | Glioblastoma | 3 | CTD_human |
Hgene | EGFR | C0018671 | Head and Neck Neoplasms | 3 | CTD_human |
Hgene | EGFR | C0027627 | Neoplasm Metastasis | 3 | CTD_human |
Hgene | EGFR | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
Hgene | EGFR | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Hgene | EGFR | C0005695 | Bladder Neoplasm | 2 | CTD_human |
Hgene | EGFR | C0009375 | Colonic Neoplasms | 2 | CTD_human |
Hgene | EGFR | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Hgene | EGFR | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Hgene | EGFR | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Hgene | EGFR | C0027643 | Neoplasm Recurrence, Local | 2 | CTD_human |
Hgene | EGFR | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
Hgene | EGFR | C0919267 | ovarian neoplasm | 2 | CTD_human |
Hgene | EGFR | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | EGFR | C0005396 | Bile Duct Neoplasms | 1 | CTD_human |
Hgene | EGFR | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
Hgene | EGFR | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | EGFR | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | EGFR | C0016978 | gallbladder neoplasm | 1 | CTD_human |
Hgene | EGFR | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | EGFR | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | EGFR | C0024809 | Marijuana Abuse | 1 | PSYGENET |
Hgene | EGFR | C0025500 | Mesothelioma | 1 | CTD_human |
Hgene | EGFR | C0027439 | Nasopharyngeal Neoplasms | 1 | CTD_human |
Hgene | EGFR | C0029463 | Osteosarcoma | 1 | CTD_human |
Hgene | EGFR | C0030354 | Papilloma | 1 | CTD_human |
Hgene | EGFR | C0032580 | Adenomatous Polyposis Coli | 1 | CTD_human |
Hgene | EGFR | C0034885 | Rectal Neoplasms | 1 | CTD_human |
Hgene | EGFR | C0041696 | Unipolar Depression | 1 | PSYGENET |
Hgene | EGFR | C0085548 | Autosomal Recessive Polycystic Kidney Disease | 1 | CTD_human |
Hgene | EGFR | C0085762 | Alcohol abuse | 1 | PSYGENET |
Hgene | EGFR | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Hgene | EGFR | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Hgene | EGFR | C0206698 | Cholangiocarcinoma | 1 | CTD_human |
Hgene | EGFR | C0263454 | Chloracne | 1 | CTD_human |
Hgene | EGFR | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | EGFR | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | EGFR | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | EGFR | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Hgene | EGFR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Hgene | EGFR | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | EGFR | C2609414 | Acute kidney injury | 1 | CTD_human |
Hgene | EGFR | C4015130 | INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 2 | 1 | UNIPROT |