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Fusion gene ID: 11100 |
FusionGeneSummary for EGFLAM_INPP4B |
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Fusion gene information | Fusion gene name: EGFLAM_INPP4B | Fusion gene ID: 11100 | Hgene | Tgene | Gene symbol | EGFLAM | INPP4B | Gene ID | 133584 | 8821 |
Gene name | EGF like, fibronectin type III and laminin G domains | inositol polyphosphate-4-phosphatase type II B | |
Synonyms | AGRINL|AGRNL|PIKA | - | |
Cytomap | 5p13.2-p13.1 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | pikachurinEGF-like, fibronectin type-III and laminin G-like domain-containing proteinagrin-like protein | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q63HQ2 | O15327 | |
Ensembl transtripts involved in fusion gene | ENST00000354891, ENST00000322350, ENST00000336740, ENST00000397202, ENST00000397210, ENST00000506135, ENST00000514476, | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | |
Fusion gene scores | * DoF score | 2 X 3 X 1=6 | 9 X 7 X 6=378 |
# samples | 4 | 9 | |
** MAII score | log2(4/6*10)=2.73696559416621 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EGFLAM [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG952183 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000354891 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000354891 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000322350 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000336740 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397202 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000397210 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000506135 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000513000 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000509777 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000262992 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000308502 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000508116 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000507861 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000506217 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
intron-intron | ENST00000514476 | ENST00000508084 | EGFLAM | chr5 | 38320667 | - | INPP4B | chr4 | 143072468 | + |
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FusionProtFeatures for EGFLAM_INPP4B |
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Hgene | Tgene |
EGFLAM | INPP4B |
Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EGFLAM_INPP4B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EGFLAM_INPP4B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EGFLAM_INPP4B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EGFLAM_INPP4B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |