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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11060

FusionGeneSummary for EFNA1_BRD2

check button Fusion gene summary
Fusion gene informationFusion gene name: EFNA1_BRD2
Fusion gene ID: 11060
HgeneTgene
Gene symbol

EFNA1

BRD2

Gene ID

1942

6046

Gene nameephrin A1bromodomain containing 2
SynonymsB61|ECKLG|EFL1|EPLG1|LERK-1|LERK1|TNFAIP4BRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3
Cytomap

1q22

6p21.32

Type of geneprotein-codingprotein-coding
Descriptionephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1immediate early response protein B61ligand of eph-related kinase 1tumor necrosis factor, alpha-induced protein 4bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
Modification date2018052320180519
UniProtAcc

P20827

P25440

Ensembl transtripts involved in fusion geneENST00000368407, ENST00000368406, 
ENST00000469878, 
ENST00000374825, 
ENST00000496118, ENST00000580234, 
ENST00000374831, ENST00000395289, 
ENST00000443797, ENST00000395287, 
ENST00000449085, ENST00000438194, 
ENST00000466744, ENST00000383108, 
ENST00000547895, ENST00000549843, 
ENST00000442863, ENST00000552513, 
ENST00000442219, ENST00000498329, 
ENST00000488549, ENST00000425201, 
ENST00000399529, ENST00000399528, 
ENST00000550142, ENST00000548837, 
ENST00000399527, ENST00000549236, 
ENST00000482105, ENST00000414731, 
ENST00000449118, ENST00000550598, 
ENST00000479973, ENST00000546777, 
ENST00000450320, ENST00000547286, 
ENST00000552587, ENST00000549126, 
ENST00000553146, ENST00000448067, 
ENST00000436979, ENST00000466208, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 9 X 2=126
# samples 410
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EFNA1 [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFNA1

GO:0016477

cell migration

10655584

HgeneEFNA1

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgeneEFNA1

GO:0034446

substrate adhesion-dependent cell spreading

10655584

HgeneEFNA1

GO:0048013

ephrin receptor signaling pathway

10655584

HgeneEFNA1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10655584

HgeneEFNA1

GO:1902004

positive regulation of amyloid-beta formation

24217950

TgeneBRD2

GO:0006357

regulation of transcription by RNA polymerase II

18406326


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI873279EFNA1chr1

155107009

-BRD2chr6

4429503

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000368407ENST00000374825EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000496118EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000580234EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000374831EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000395289EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000443797EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000395287EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000449085EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000438194EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000466744EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000383108EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000547895EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000549843EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000442863EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000552513EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000442219EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000498329EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000488549EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000425201EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000399529EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000399528EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000550142EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000548837EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000399527EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000549236EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000482105EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000414731EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000449118EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000550598EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000479973EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000546777EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000450320EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000547286EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368407ENST00000552587EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368407ENST00000549126EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368407ENST00000553146EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368407ENST00000448067EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368407ENST00000436979EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368407ENST00000466208EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000374825EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000496118EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000580234EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000374831EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000395289EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000443797EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000395287EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000449085EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000438194EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000466744EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000383108EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000547895EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000549843EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000442863EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000552513EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000442219EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000498329EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000488549EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000425201EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000399529EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000399528EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000550142EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000548837EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000399527EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000549236EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000482105EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000414731EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000449118EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000550598EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000479973EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000546777EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000450320EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000547286EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368406ENST00000552587EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368406ENST00000549126EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368406ENST00000553146EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368406ENST00000448067EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-3UTRENST00000368406ENST00000436979EFNA1chr1

155107009

-BRD2chr6

4429503

-
3UTR-intronENST00000368406ENST00000466208EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000374825EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000496118EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000580234EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000374831EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000395289EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000443797EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000395287EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000449085EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000438194EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000466744EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000383108EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000547895EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000549843EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000442863EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000552513EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000442219EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000498329EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000488549EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000425201EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000399529EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000399528EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000550142EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000548837EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000399527EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000549236EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000482105EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000414731EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000449118EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000550598EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000479973EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000546777EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000450320EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000547286EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-3UTRENST00000469878ENST00000552587EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-3UTRENST00000469878ENST00000549126EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-3UTRENST00000469878ENST00000553146EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-3UTRENST00000469878ENST00000448067EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-3UTRENST00000469878ENST00000436979EFNA1chr1

155107009

-BRD2chr6

4429503

-
intron-intronENST00000469878ENST00000466208EFNA1chr1

155107009

-BRD2chr6

4429503

-

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FusionProtFeatures for EFNA1_BRD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFNA1

P20827

BRD2

P25440

Cell surface GPI-bound ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. Plays an important role inangiogenesis and tumor neovascularization. The recruitment ofVAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 iscritical for EFNA1-induced RAC1 GTPase activation and vascularendothelial cell migration and assembly. Exerts anti-oncogeniceffects in tumor cells through activation and down-regulation ofEPHA2. Activates EPHA2 by inducing tyrosine phosphorylation whichleads to its internalization and degradation. Acts as a negativeregulator in the tumorigenesis of gliomas by down-regulating EPHA2and FAK. Can evoke collapse of embryonic neuronal growth cone andregulates dendritic spine morphogenesis.{ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EFNA1_BRD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EFNA1_BRD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EFNA1_BRD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EFNA1_BRD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEFNA1C1458155Mammary Neoplasms1CTD_human
TgeneBRD2C0017636Glioblastoma1CTD_human
TgeneBRD2C0025149Medulloblastoma1CTD_human