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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11059

FusionGeneSummary for EFNA1_ADAM15

check button Fusion gene summary
Fusion gene informationFusion gene name: EFNA1_ADAM15
Fusion gene ID: 11059
HgeneTgene
Gene symbol

EFNA1

ADAM15

Gene ID

1942

8751

Gene nameephrin A1ADAM metallopeptidase domain 15
SynonymsB61|ECKLG|EFL1|EPLG1|LERK-1|LERK1|TNFAIP4MDC15
Cytomap

1q22

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionephrin-A1TNF alpha-induced protein 4eph-related receptor tyrosine kinase ligand 1immediate early response protein B61ligand of eph-related kinase 1tumor necrosis factor, alpha-induced protein 4disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Modification date2018052320180522
UniProtAcc

P20827

Q13444

Ensembl transtripts involved in fusion geneENST00000368407, ENST00000368406, 
ENST00000469878, 
ENST00000449910, 
ENST00000368412, ENST00000359280, 
ENST00000356955, ENST00000355956, 
ENST00000360674, ENST00000368410, 
ENST00000271836, ENST00000368413, 
ENST00000531455, ENST00000447332, 
ENST00000472434, 
Fusion gene scores* DoF score4 X 4 X 4=642 X 2 X 2=8
# samples 42
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: EFNA1 [Title/Abstract] AND ADAM15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFNA1

GO:0016477

cell migration

10655584

HgeneEFNA1

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgeneEFNA1

GO:0034446

substrate adhesion-dependent cell spreading

10655584

HgeneEFNA1

GO:0048013

ephrin receptor signaling pathway

10655584

HgeneEFNA1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10655584

HgeneEFNA1

GO:1902004

positive regulation of amyloid-beta formation

24217950

TgeneADAM15

GO:0002418

immune response to tumor cell

22505472

TgeneADAM15

GO:0006915

apoptotic process

22505472

TgeneADAM15

GO:0045087

innate immune response

22505472

TgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-ZS-A9CF-01AEFNA1chr1

155104110

+ADAM15chr1

155034936

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000368407ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-intronENST00000368407ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368407ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+
Frame-shitENST00000368406ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-intronENST00000368406ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
5CDS-3UTRENST00000368406ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3CDSENST00000469878ENST00000449910EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368412EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000359280EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000356955EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000355956EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000360674EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368410EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000271836EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000368413EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000531455EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-intronENST00000469878ENST00000447332EFNA1chr1

155104110

+ADAM15chr1

155034936

+
3UTR-3UTRENST00000469878ENST00000472434EFNA1chr1

155104110

+ADAM15chr1

155034936

+

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FusionProtFeatures for EFNA1_ADAM15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFNA1

P20827

ADAM15

Q13444

Cell surface GPI-bound ligand for Eph receptors, afamily of receptor tyrosine kinases which are crucial formigration, repulsion and adhesion during neuronal, vascular andepithelial development. Binds promiscuously Eph receptors residingon adjacent cells, leading to contact-dependent bidirectionalsignaling into neighboring cells. Plays an important role inangiogenesis and tumor neovascularization. The recruitment ofVAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 iscritical for EFNA1-induced RAC1 GTPase activation and vascularendothelial cell migration and assembly. Exerts anti-oncogeniceffects in tumor cells through activation and down-regulation ofEPHA2. Activates EPHA2 by inducing tyrosine phosphorylation whichleads to its internalization and degradation. Acts as a negativeregulator in the tumorigenesis of gliomas by down-regulating EPHA2and FAK. Can evoke collapse of embryonic neuronal growth cone andregulates dendritic spine morphogenesis.{ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EFNA1_ADAM15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EFNA1_ADAM15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EFNA1PPBP, EEF1G, KAT5, EPHA4, EPHA3, XRCC6, GAREMADAM15SNX9, TRIP13, MAD2L2, SH3GL2, FYN, LCK, GRB2, MAD2L1, HCK, SRC, SNX30, NPHP1, ARHGEF7, LYN, YES1, SH3PXD2A, PACSIN3, SH3GLB1, ARHGEF6, NCK1, SORBS2, SH3RF3, MAPK3, MAPK1, PTK6, FBXO6, FHL3, SP4, RBPMS, NUP62, BANP, ADAM33, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EFNA1_ADAM15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EFNA1_ADAM15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEFNA1C1458155Mammary Neoplasms1CTD_human