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Fusion gene ID: 11052 |
FusionGeneSummary for EFHD1_LEF1 |
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Fusion gene information | Fusion gene name: EFHD1_LEF1 | Fusion gene ID: 11052 | Hgene | Tgene | Gene symbol | EFHD1 | LEF1 | Gene ID | 80303 | 51176 |
Gene name | EF-hand domain family member D1 | lymphoid enhancer binding factor 1 | |
Synonyms | MST133|MSTP133|PP3051|SWS2 | LEF-1|TCF10|TCF1ALPHA|TCF7L3 | |
Cytomap | 2q37.1 | 4q25 | |
Type of gene | protein-coding | protein-coding | |
Description | EF-hand domain-containing protein D1EF-hand domain-containing protein 1swiprosin-2 | lymphoid enhancer-binding factor 1T cell-specific transcription factor 1-alphaTCF1-alpha | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q9BUP0 | Q9UJU2 | |
Ensembl transtripts involved in fusion gene | ENST00000409613, ENST00000264059, ENST00000409708, ENST00000410095, | ENST00000265165, ENST00000379951, ENST00000438313, ENST00000510624, ENST00000512172, ENST00000503879, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 2=8 |
# samples | 6 | 2 | |
** MAII score | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: EFHD1 [Title/Abstract] AND LEF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LEF1 | GO:0006366 | transcription by RNA polymerase II | 23001182 |
Tgene | LEF1 | GO:0008284 | positive regulation of cell proliferation | 19351848 |
Tgene | LEF1 | GO:0010628 | positive regulation of gene expression | 16344550 |
Tgene | LEF1 | GO:0016055 | Wnt signaling pathway | 10644691 |
Tgene | LEF1 | GO:0030854 | positive regulation of granulocyte differentiation | 19620402 |
Tgene | LEF1 | GO:0032696 | negative regulation of interleukin-13 production | 18445004 |
Tgene | LEF1 | GO:0032713 | negative regulation of interleukin-4 production | 18445004 |
Tgene | LEF1 | GO:0032714 | negative regulation of interleukin-5 production | 18445004 |
Tgene | LEF1 | GO:0043392 | negative regulation of DNA binding | 18445004 |
Tgene | LEF1 | GO:0043923 | positive regulation by host of viral transcription | 7657162 |
Tgene | LEF1 | GO:0045892 | negative regulation of transcription, DNA-templated | 18794125 |
Tgene | LEF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 7657162|10644691|17063141|19620402|20128911 |
Tgene | LEF1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11751639 |
Tgene | LEF1 | GO:0060070 | canonical Wnt signaling pathway | 20123964 |
Tgene | LEF1 | GO:0060326 | cell chemotaxis | 19576624 |
Tgene | LEF1 | GO:0071353 | cellular response to interleukin-4 | 18579517 |
Tgene | LEF1 | GO:0071899 | negative regulation of estrogen receptor binding | 18794125 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE144130 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000409613 | ENST00000265165 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409613 | ENST00000379951 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409613 | ENST00000438313 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409613 | ENST00000510624 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409613 | ENST00000512172 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-intron | ENST00000409613 | ENST00000503879 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000264059 | ENST00000265165 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000264059 | ENST00000379951 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000264059 | ENST00000438313 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000264059 | ENST00000510624 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000264059 | ENST00000512172 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-intron | ENST00000264059 | ENST00000503879 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409708 | ENST00000265165 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409708 | ENST00000379951 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409708 | ENST00000438313 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409708 | ENST00000510624 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000409708 | ENST00000512172 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-intron | ENST00000409708 | ENST00000503879 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000410095 | ENST00000265165 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000410095 | ENST00000379951 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000410095 | ENST00000438313 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000410095 | ENST00000510624 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-3CDS | ENST00000410095 | ENST00000512172 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
intron-intron | ENST00000410095 | ENST00000503879 | EFHD1 | chr2 | 233503439 | + | LEF1 | chr4 | 109084733 | + |
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FusionProtFeatures for EFHD1_LEF1 |
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Hgene | Tgene |
EFHD1 | LEF1 |
Acts as a calcium sensor for mitochondrial flash(mitoflash) activation, an event characterized by stochasticbursts of superoxide production (PubMed:26975899). May play a rolein neuronal differentiation (By similarity).{ECO:0000250|UniProtKB:Q9D4J1, ECO:0000269|PubMed:26975899}. | Participates in the Wnt signaling pathway. Activatestranscription of target genes in the presence of CTNNB1 and EP300.May play a role in hair cell differentiation and folliclemorphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivationmediated by LEF1 and CTNNB1. Regulates T-cell receptor alphaenhancer function. Binds DNA in a sequence-specific manner. PIAGantagonizes both Wnt-dependent and Wnt-independent activation byLEF1 (By similarity). Isoform 3 lacks the CTNNB1 interactiondomain and may be an antagonist for Wnt signaling. Isoform 5transcriptionally activates the fibronectin promoter, binds to andrepresses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellularaggregation and increasing cell migration of pancreatic cancercells. Isoform 1 transcriptionally activates MYC and CCND1expression and enhances proliferation of pancreatic tumor cells.{ECO:0000250, ECO:0000269|PubMed:11266540,ECO:0000269|PubMed:19653274, ECO:0000269|PubMed:2010090}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EFHD1_LEF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EFHD1_LEF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EFHD1_LEF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LEF1 | Q9UJU2 | DB00903 | Etacrynic acid | Lymphoid enhancer-binding factor 1 | small molecule | approved|investigational |
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RelatedDiseases for EFHD1_LEF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EFHD1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | EFHD1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Tgene | LEF1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | LEF1 | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |
Tgene | LEF1 | C0036503 | Sebaceous Gland Neoplasms | 1 | CTD_human |