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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 11026

FusionGeneSummary for EFCAB14_EFCAB14

check button Fusion gene summary
Fusion gene informationFusion gene name: EFCAB14_EFCAB14
Fusion gene ID: 11026
HgeneTgene
Gene symbol

EFCAB14

EFCAB14

Gene ID

9813

9813

Gene nameEF-hand calcium binding domain 14EF-hand calcium binding domain 14
SynonymsKIAA0494KIAA0494
Cytomap

1p33

1p33

Type of geneprotein-codingprotein-coding
DescriptionEF-hand calcium-binding domain-containing protein 14EF-hand calcium-binding domain-containing protein 14
Modification date2018052220180522
UniProtAcc

O75071

O75071

Ensembl transtripts involved in fusion geneENST00000544071, ENST00000371933, 
ENST00000484461, 
ENST00000544071, 
ENST00000371933, ENST00000484461, 
Fusion gene scores* DoF score1 X 2 X 1=25 X 5 X 2=50
# samples 25
** MAII scorelog2(2/2*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: EFCAB14 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA252565EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
ChiTaRS3.1CB242814EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000544071ENST00000544071EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-3UTRENST00000544071ENST00000371933EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000544071ENST00000484461EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000371933ENST00000544071EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-3UTRENST00000371933ENST00000371933EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000371933ENST00000484461EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000484461ENST00000544071EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-3UTRENST00000484461ENST00000371933EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000484461ENST00000484461EFCAB14chr1

47142118

+EFCAB14chr1

47142091

-
intron-intronENST00000544071ENST00000544071EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-3UTRENST00000544071ENST00000371933EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-intronENST00000544071ENST00000484461EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-intronENST00000371933ENST00000544071EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-3UTRENST00000371933ENST00000371933EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-intronENST00000371933ENST00000484461EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-intronENST00000484461ENST00000544071EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-3UTRENST00000484461ENST00000371933EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-
intron-intronENST00000484461ENST00000484461EFCAB14chr1

47140961

+EFCAB14chr1

47141209

-

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FusionProtFeatures for EFCAB14_EFCAB14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFCAB14

O75071

EFCAB14

O75071


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EFCAB14_EFCAB14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EFCAB14_EFCAB14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EFCAB14_EFCAB14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EFCAB14_EFCAB14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource