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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10977

FusionGeneSummary for EEF1G_EEF1G

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1G_EEF1G
Fusion gene ID: 10977
HgeneTgene
Gene symbol

EEF1G

EEF1G

Gene ID

1937

1937

Gene nameeukaryotic translation elongation factor 1 gammaeukaryotic translation elongation factor 1 gamma
SynonymsEF1G|GIG35EF1G|GIG35
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chainelongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chain
Modification date2018052320180523
UniProtAcc

P26641

P26641

Ensembl transtripts involved in fusion geneENST00000329251, ENST00000378019, 
ENST00000532986, 
ENST00000329251, 
ENST00000378019, ENST00000532986, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 4 X 4=48
# samples 44
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF1G [Title/Abstract] AND EEF1G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI046948EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000329251ENST00000329251EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-3CDSENST00000329251ENST00000378019EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-5UTRENST00000329251ENST00000532986EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-3CDSENST00000378019ENST00000329251EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-3CDSENST00000378019ENST00000378019EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-5UTRENST00000378019ENST00000532986EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-3CDSENST00000532986ENST00000329251EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-3CDSENST00000532986ENST00000378019EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-
intron-5UTRENST00000532986ENST00000532986EEF1Gchr11

62334929

-EEF1Gchr11

62339115

-

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FusionProtFeatures for EEF1G_EEF1G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1G

P26641

EEF1G

P26641

Probably plays a role in anchoring the complex to othercellular components. Probably plays a role in anchoring the complex to othercellular components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF1G_EEF1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF1G_EEF1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF1G_EEF1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EEF1G_EEF1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource