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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10976

FusionGeneSummary for EEF1E1_EYS

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF1E1_EYS
Fusion gene ID: 10976
HgeneTgene
Gene symbol

EEF1E1

EYS

Gene ID

9521

346007

Gene nameeukaryotic translation elongation factor 1 epsilon 1eyes shut homolog (Drosophila)
SynonymsAIMP3|P18C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
Cytomap

6p24.3

6q12

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation elongation factor 1 epsilon-1ARS-interacting multifunctional protein 3aminoacyl tRNA synthetase complex-interacting multifunctional protein 3multisynthase complex auxiliary component p18p18 component of aminoacyl-tRNA synthetaseprotein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
Modification date2018051920180519
UniProtAcc

O43324

Q5T1H1

Ensembl transtripts involved in fusion geneENST00000429723, ENST00000379715, 
ENST00000507463, 
ENST00000503581, 
ENST00000370621, ENST00000370616, 
ENST00000393380, ENST00000342421, 
ENST00000370618, ENST00000486069, 
Fusion gene scores* DoF score3 X 3 X 2=1826 X 15 X 12=4680
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF1E1 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEEF1E1

GO:2000774

positive regulation of cellular senescence

25465621


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A0AD-01AEEF1E1chr6

8095611

-EYSchr6

66205886

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000429723ENST00000503581EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000429723ENST00000370621EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000429723ENST00000370616EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000429723ENST00000393380EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000429723ENST00000342421EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000429723ENST00000370618EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000429723ENST00000486069EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000379715ENST00000503581EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000379715ENST00000370621EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000379715ENST00000370616EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000379715ENST00000393380EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000379715ENST00000342421EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000379715ENST00000370618EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000379715ENST00000486069EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000507463ENST00000503581EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000507463ENST00000370621EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000507463ENST00000370616EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000507463ENST00000393380EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000507463ENST00000342421EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-5UTRENST00000507463ENST00000370618EEF1E1chr6

8095611

-EYSchr6

66205886

-
intron-intronENST00000507463ENST00000486069EEF1E1chr6

8095611

-EYSchr6

66205886

-

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FusionProtFeatures for EEF1E1_EYS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF1E1

O43324

EYS

Q5T1H1

Positive modulator of ATM response to DNA damage.{ECO:0000250|UniProtKB:Q9D1M4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EEF1E1_EYS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EEF1E1_EYS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EEF1E1AIMP2, EPRS, KARS, IARS, DARS, MARS, QARS, RARS, AIMP1, ITGA4, DNAJA1, EIF2S1, EIF4G1, RPL15, RPL18, RPL7A, RPLP0, EIF2S3, HNRNPA2B1, IQGAP1, CCAR2, RPL13, RPL21, RPL23A, RPL24, RPL26, RPL27A, RPL36, HUWE1, CALCOCO2, NAT9, BLK, SDCBP, ATP6V1A, ATP6V1B2, CIAPIN1, TWF1, UBA1, LARS, RNASEH2C, MED4, PKN2, RAF1, STRN, CHAMP1, MCM2, COX15, DLD, HSD17B10, PDHA1, SOAT1, VDAC1EYSEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EEF1E1_EYS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EEF1E1_EYS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEYSC1864446Retinitis Pigmentosa 252CTD_human;UNIPROT
TgeneEYSC0035334Retinitis Pigmentosa1CTD_human;ORPHANET