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Fusion gene ID: 10976 |
FusionGeneSummary for EEF1E1_EYS |
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Fusion gene information | Fusion gene name: EEF1E1_EYS | Fusion gene ID: 10976 | Hgene | Tgene | Gene symbol | EEF1E1 | EYS | Gene ID | 9521 | 346007 |
Gene name | eukaryotic translation elongation factor 1 epsilon 1 | eyes shut homolog (Drosophila) | |
Synonyms | AIMP3|P18 | C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1 | |
Cytomap | 6p24.3 | 6q12 | |
Type of gene | protein-coding | protein-coding | |
Description | eukaryotic translation elongation factor 1 epsilon-1ARS-interacting multifunctional protein 3aminoacyl tRNA synthetase complex-interacting multifunctional protein 3multisynthase complex auxiliary component p18p18 component of aminoacyl-tRNA synthetase | protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O43324 | Q5T1H1 | |
Ensembl transtripts involved in fusion gene | ENST00000429723, ENST00000379715, ENST00000507463, | ENST00000503581, ENST00000370621, ENST00000370616, ENST00000393380, ENST00000342421, ENST00000370618, ENST00000486069, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 26 X 15 X 12=4680 |
# samples | 3 | 27 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(27/4680*10)=-4.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EEF1E1 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EEF1E1 | GO:2000774 | positive regulation of cellular senescence | 25465621 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A8-A0AD-01A | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000429723 | ENST00000503581 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000429723 | ENST00000370621 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000429723 | ENST00000370616 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000429723 | ENST00000393380 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000429723 | ENST00000342421 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000429723 | ENST00000370618 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000429723 | ENST00000486069 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000379715 | ENST00000503581 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000379715 | ENST00000370621 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000379715 | ENST00000370616 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000379715 | ENST00000393380 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000379715 | ENST00000342421 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000379715 | ENST00000370618 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000379715 | ENST00000486069 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000507463 | ENST00000503581 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000507463 | ENST00000370621 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000507463 | ENST00000370616 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000507463 | ENST00000393380 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000507463 | ENST00000342421 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-5UTR | ENST00000507463 | ENST00000370618 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
intron-intron | ENST00000507463 | ENST00000486069 | EEF1E1 | chr6 | 8095611 | - | EYS | chr6 | 66205886 | - |
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FusionProtFeatures for EEF1E1_EYS |
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Hgene | Tgene |
EEF1E1 | EYS |
Positive modulator of ATM response to DNA damage.{ECO:0000250|UniProtKB:Q9D1M4}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EEF1E1_EYS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EEF1E1_EYS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EEF1E1 | AIMP2, EPRS, KARS, IARS, DARS, MARS, QARS, RARS, AIMP1, ITGA4, DNAJA1, EIF2S1, EIF4G1, RPL15, RPL18, RPL7A, RPLP0, EIF2S3, HNRNPA2B1, IQGAP1, CCAR2, RPL13, RPL21, RPL23A, RPL24, RPL26, RPL27A, RPL36, HUWE1, CALCOCO2, NAT9, BLK, SDCBP, ATP6V1A, ATP6V1B2, CIAPIN1, TWF1, UBA1, LARS, RNASEH2C, MED4, PKN2, RAF1, STRN, CHAMP1, MCM2, COX15, DLD, HSD17B10, PDHA1, SOAT1, VDAC1 | EYS | EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EEF1E1_EYS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EEF1E1_EYS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | EYS | C1864446 | Retinitis Pigmentosa 25 | 2 | CTD_human;UNIPROT |
Tgene | EYS | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;ORPHANET |