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Fusion gene ID: 10966 |
FusionGeneSummary for EEF1DP3_N4BP2L1 |
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Fusion gene information | Fusion gene name: EEF1DP3_N4BP2L1 | Fusion gene ID: 10966 | Hgene | Tgene | Gene symbol | EEF1DP3 | N4BP2L1 | Gene ID | 196549 | 90634 |
Gene name | eukaryotic translation elongation factor 1 delta pseudogene 3 | NEDD4 binding protein 2 like 1 | |
Synonyms | - | CG018 | |
Cytomap | 13q13.1 | 13q13.1 | |
Type of gene | pseudo | protein-coding | |
Description | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene | NEDD4-binding protein 2-like 1hypothetical gene CG018 | |
Modification date | 20180519 | 20180403 | |
UniProtAcc | Q5TBK1 | ||
Ensembl transtripts involved in fusion gene | ENST00000428783, | ENST00000380130, ENST00000380139, ENST00000530622, ENST00000459716, ENST00000380133, | |
Fusion gene scores | * DoF score | 4 X 2 X 2=16 | 3 X 3 X 2=18 |
# samples | 4 | 4 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EEF1DP3 [Title/Abstract] AND N4BP2L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A408-01A | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000428783 | ENST00000380130 | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
3UTR-3CDS | ENST00000428783 | ENST00000380139 | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
3UTR-5UTR | ENST00000428783 | ENST00000530622 | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
3UTR-5UTR | ENST00000428783 | ENST00000459716 | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
3UTR-5UTR | ENST00000428783 | ENST00000380133 | EEF1DP3 | chr13 | 32520318 | + | N4BP2L1 | chr13 | 32981909 | - |
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FusionProtFeatures for EEF1DP3_N4BP2L1 |
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Hgene | Tgene |
EEF1DP3 | N4BP2L1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EEF1DP3_N4BP2L1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EEF1DP3_N4BP2L1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EEF1DP3 | EEF1G | N4BP2L1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EEF1DP3_N4BP2L1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EEF1DP3_N4BP2L1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |