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Fusion gene ID: 10963 |
FusionGeneSummary for EEF1B2_CDR1 |
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Fusion gene information | Fusion gene name: EEF1B2_CDR1 | Fusion gene ID: 10963 | Hgene | Tgene | Gene symbol | EEF1B2 | CDR1 | Gene ID | 1933 | 1038 |
Gene name | eukaryotic translation elongation factor 1 beta 2 | cerebellar degeneration related protein 1 | |
Synonyms | EEF1B|EEF1B1|EF1B | CDR|CDR34|CDR62A | |
Cytomap | 2q33.3 | Xq27.1 | |
Type of gene | protein-coding | protein-coding | |
Description | elongation factor 1-betaEF-1-betaeukaryotic translation elongation factor 1 beta 1 | cerebellar degeneration-related antigen 1cerebellar degeneration-related protein 1, 34kDa | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P24534 | P51861 | |
Ensembl transtripts involved in fusion gene | ENST00000236957, ENST00000392221, ENST00000392222, | ENST00000370532, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 5 X 1=10 |
# samples | 1 | 23 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(23/10*10)=4.52356195605701 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EEF1B2 [Title/Abstract] AND CDR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA486448 | EEF1B2 | chr2 | 207027239 | + | CDR1 | chrX | 139866568 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000236957 | ENST00000370532 | EEF1B2 | chr2 | 207027239 | + | CDR1 | chrX | 139866568 | + |
5CDS-5UTR | ENST00000392221 | ENST00000370532 | EEF1B2 | chr2 | 207027239 | + | CDR1 | chrX | 139866568 | + |
5CDS-5UTR | ENST00000392222 | ENST00000370532 | EEF1B2 | chr2 | 207027239 | + | CDR1 | chrX | 139866568 | + |
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FusionProtFeatures for EEF1B2_CDR1 |
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Hgene | Tgene |
EEF1B2 | CDR1 |
EF-1-beta and EF-1-delta stimulate the exchange of GDPbound to EF-1-alpha to GTP. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EEF1B2_CDR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EEF1B2_CDR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EEF1B2_CDR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EEF1B2_CDR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EEF1B2 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
Hgene | EEF1B2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | EEF1B2 | C3714756 | Intellectual Disability | 1 | CTD_human |