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Fusion gene ID: 10962 |
FusionGeneSummary for EEF1A2_ZBTB46 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EEF1A2_ZBTB46 | Fusion gene ID: 10962 | Hgene | Tgene | Gene symbol | EEF1A2 | ZBTB46 | Gene ID | 1917 | 140685 |
| Gene name | eukaryotic translation elongation factor 1 alpha 2 | zinc finger and BTB domain containing 46 | |
| Synonyms | EEF1AL|EF-1-alpha-2|EF1A|EIEE33|HS1|MRD38|STN|STNL | BTBD4|BZEL|RINZF|ZNF340|dJ583P15.7|dJ583P15.8 | |
| Cytomap | 20q13.33 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | elongation factor 1-alpha 2eukaryotic elongation factor 1 A-2statin-S1 | zinc finger and BTB domain-containing protein 46BTB (POZ) domain containing 4BTB-ZF protein expressed in effector lymphocytesBTB/POZ domain-containing protein 4zinc finger protein 340 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q05639 | Q86UZ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000298049, ENST00000217182, | ENST00000245663, ENST00000395104, ENST00000302995, ENST00000480766, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 7 X 3 X 5=105 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/105*10)=-0.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EEF1A2 [Title/Abstract] AND ZBTB46 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EEF1A2 | GO:0090218 | positive regulation of lipid kinase activity | 17088255 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-2656-01A | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000298049 | ENST00000245663 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| In-frame | ENST00000298049 | ENST00000395104 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| Frame-shit | ENST00000298049 | ENST00000302995 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| 5CDS-intron | ENST00000298049 | ENST00000480766 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| Frame-shit | ENST00000217182 | ENST00000245663 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| Frame-shit | ENST00000217182 | ENST00000395104 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| Frame-shit | ENST00000217182 | ENST00000302995 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
| 5CDS-intron | ENST00000217182 | ENST00000480766 | EEF1A2 | chr20 | 62124490 | - | ZBTB46 | chr20 | 62407315 | - |
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FusionProtFeatures for EEF1A2_ZBTB46 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EEF1A2 | ZBTB46 |
| This protein promotes the GTP-dependent binding ofaminoacyl-tRNA to the A-site of ribosomes during proteinbiosynthesis. | Function as a transcriptional repressor for PRDM1.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 5_242 | 257 | 464 | Domain | Note=tr-type G |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 5_242 | 257 | 464 | Domain | Note=tr-type G |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 91_95 | 257 | 464 | Nucleotide binding | GTP |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 91_95 | 257 | 464 | Nucleotide binding | GTP |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 14_21 | 257 | 464 | Region | G1 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 153_156 | 257 | 464 | Region | G4 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 194_196 | 257 | 464 | Region | G5 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 70_74 | 257 | 464 | Region | G2 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000217182 | - | 5 | 8 | 91_94 | 257 | 464 | Region | G3 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 14_21 | 257 | 464 | Region | G1 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 153_156 | 257 | 464 | Region | G4 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 194_196 | 257 | 464 | Region | G5 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 70_74 | 257 | 464 | Region | G2 |
| Hgene | EEF1A2 | chr20:62124490 | chr20:62407315 | ENST00000298049 | - | 4 | 7 | 91_94 | 257 | 464 | Region | G3 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000245663 | - | 1 | 5 | 418_436 | 312 | 590 | Zinc finger | C2H2-type 1 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000245663 | - | 1 | 5 | 446_468 | 312 | 590 | Zinc finger | C2H2-type 2 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000302995 | - | 1 | 7 | 418_436 | 312 | 374 | Zinc finger | C2H2-type 1 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000302995 | - | 1 | 7 | 446_468 | 312 | 374 | Zinc finger | C2H2-type 2 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000395104 | - | 0 | 4 | 418_436 | 312 | 590 | Zinc finger | C2H2-type 1 |
| Tgene | >ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000395104 | - | 0 | 4 | 446_468 | 312 | 590 | Zinc finger | C2H2-type 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000245663 | - | 1 | 5 | 31_99 | 312 | 590 | Domain | BTB |
| Tgene | ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000302995 | - | 1 | 7 | 31_99 | 312 | 374 | Domain | BTB |
| Tgene | ZBTB46 | chr20:62124490 | chr20:62407315 | ENST00000395104 | - | 0 | 4 | 31_99 | 312 | 590 | Domain | BTB |
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FusionGeneSequence for EEF1A2_ZBTB46 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000245663_chr20_62407315_-_535aa MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITII DAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGDADLSVTEASSSD SRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIR KKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCA >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000395104_chr20_62407315_-_535aa MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITII DAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGDADLSVTEASSSD SRGERAELYAQVEEGLLGGEASYLGPPLTPEKDDALHQATAVANLRAALMSKNSLLSLKADVLGDDGSLLFEYLPRGAHSLSLNEFTVIR KKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEICGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIRHGSRRHGVCTDCA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000245663_chr20_62407315_-_1605nt ATGGGCAAGGAGAAGACCCACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCTACAAA TGCGGAGGTATTGACAAAAGGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTG GACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATC GATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTG GGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTG GGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAG ATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGG TTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGC CCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGATGCGGACCTGTCCGTCACCGAAGCCAGCAGCTCCGAC AGCCGAGGAGAGAGGGCCGAGCTCTATGCACAGGTGGAGGAGGGTCTCCTGGGAGGAGAAGCCAGCTATCTGGGCCCTCCCCTCACCCCA GAGAAGGACGACGCCCTGCATCAGGCCACCGCGGTGGCCAACCTGCGCGCGGCGCTCATGAGTAAGAACAGCCTGCTGTCGCTGAAGGCC GACGTGCTGGGGGATGACGGCTCCCTGCTGTTCGAGTACCTGCCCAGAGGGGCCCACTCGCTGTCCCTGAATGAGTTCACGGTGATCAGG AAGAAGTTCAAGTGTCCGTACTGCAGCTTCTCGGCCATGCACCAGTGCATCCTCAAGCGACACATGCGCTCGCACACGGGAGAGCGGCCC TACCCCTGCGAGATCTGCGGGAAGAAGTTCACGCGGCGCGAGCACATGAAGCGCCACACGCTGGTCCACAGCAAGGACAAGAAGTATGTG TGCAAGGTGTGCAGCCGCGTCTTCATGTCCGCCGCCAGCGTGGGCATCAGGCATGGCTCCAGGCGCCACGGTGTGTGCACCGACTGTGCT GGCCGCGGCATGGCCGGGCCCCTGGACCATGGCGGCGGAGGCGGCGAGGGCTCTCCAGAGGCGCTGTTCCCAGGCGACGGGCCCTATCTG GAGGACCCTGAGGACCCACGAGGGGAGGCGGAGGAGCTGGGCGAGGACGACGAGGGCCTGGCCCCTGAGGATGCGCTGTTGGCGGACGAC >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000395104_chr20_62407315_-_1605nt ATGGGCAAGGAGAAGACCCACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCTACAAA TGCGGAGGTATTGACAAAAGGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTG GACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATC GATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTG GGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTG GGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAG ATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGG TTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGC CCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGATGCGGACCTGTCCGTCACCGAAGCCAGCAGCTCCGAC AGCCGAGGAGAGAGGGCCGAGCTCTATGCACAGGTGGAGGAGGGTCTCCTGGGAGGAGAAGCCAGCTATCTGGGCCCTCCCCTCACCCCA GAGAAGGACGACGCCCTGCATCAGGCCACCGCGGTGGCCAACCTGCGCGCGGCGCTCATGAGTAAGAACAGCCTGCTGTCGCTGAAGGCC GACGTGCTGGGGGATGACGGCTCCCTGCTGTTCGAGTACCTGCCCAGAGGGGCCCACTCGCTGTCCCTGAATGAGTTCACGGTGATCAGG AAGAAGTTCAAGTGTCCGTACTGCAGCTTCTCGGCCATGCACCAGTGCATCCTCAAGCGACACATGCGCTCGCACACGGGAGAGCGGCCC TACCCCTGCGAGATCTGCGGGAAGAAGTTCACGCGGCGCGAGCACATGAAGCGCCACACGCTGGTCCACAGCAAGGACAAGAAGTATGTG TGCAAGGTGTGCAGCCGCGTCTTCATGTCCGCCGCCAGCGTGGGCATCAGGCATGGCTCCAGGCGCCACGGTGTGTGCACCGACTGTGCT GGCCGCGGCATGGCCGGGCCCCTGGACCATGGCGGCGGAGGCGGCGAGGGCTCTCCAGAGGCGCTGTTCCCAGGCGACGGGCCCTATCTG GAGGACCCTGAGGACCCACGAGGGGAGGCGGAGGAGCTGGGCGAGGACGACGAGGGCCTGGCCCCTGAGGATGCGCTGTTGGCGGACGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000245663_chr20_62407315_-_4940nt AATCACTGCAGCCCCCCTCGCCCTGAGCCAGAGCACCCCGGGTCCCGCCAGCCCCTCACACTCCCAGCAAAATGGGCAAGGAGAAGACCC ACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCTACAAATGCGGAGGTATTGACAAAA GGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGC GTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCG ACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCA TCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACT CCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCA CCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGG AGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGC GCCTGCCGCTGCAGGACGTGTACAAGATTGGCGATGCGGACCTGTCCGTCACCGAAGCCAGCAGCTCCGACAGCCGAGGAGAGAGGGCCG AGCTCTATGCACAGGTGGAGGAGGGTCTCCTGGGAGGAGAAGCCAGCTATCTGGGCCCTCCCCTCACCCCAGAGAAGGACGACGCCCTGC ATCAGGCCACCGCGGTGGCCAACCTGCGCGCGGCGCTCATGAGTAAGAACAGCCTGCTGTCGCTGAAGGCCGACGTGCTGGGGGATGACG GCTCCCTGCTGTTCGAGTACCTGCCCAGAGGGGCCCACTCGCTGTCCCTGAATGAGTTCACGGTGATCAGGAAGAAGTTCAAGTGTCCGT ACTGCAGCTTCTCGGCCATGCACCAGTGCATCCTCAAGCGACACATGCGCTCGCACACGGGAGAGCGGCCCTACCCCTGCGAGATCTGCG GGAAGAAGTTCACGCGGCGCGAGCACATGAAGCGCCACACGCTGGTCCACAGCAAGGACAAGAAGTATGTGTGCAAGGTGTGCAGCCGCG TCTTCATGTCCGCCGCCAGCGTGGGCATCAGGCATGGCTCCAGGCGCCACGGTGTGTGCACCGACTGTGCTGGCCGCGGCATGGCCGGGC CCCTGGACCATGGCGGCGGAGGCGGCGAGGGCTCTCCAGAGGCGCTGTTCCCAGGCGACGGGCCCTATCTGGAGGACCCTGAGGACCCAC GAGGGGAGGCGGAGGAGCTGGGCGAGGACGACGAGGGCCTGGCCCCTGAGGATGCGCTGTTGGCGGACGACAAGGATGAGGAAGACTCGC CGCGGCCGCGCAGCCCCCCAGGAGGCCCTGACAAGGACTTCGCCTGGCTCTCCTAGGCCCGCCCGCCGGCAGGGTCGGTGGCTGCCTCGC TCCGTCCACCCGTGTGTGTGTCCGGTGGGTCTCCACTGCGGGGCCAGGGCCACGCTCACCCCTCTCGCGGCCCCTCCTCTGCTTCCCCCT GAACCCACCCCCCACGGAAACCAGCCCTGCGGGCTAAGCAGGTGCGACCCCAGCAAGAGGGGTGCTCTGGGACCAGACATGAAGTGAGTT GGGGGAGGGCACAGGGTGGGTTTGAGTGAAGGGAGAGCACGGTCCTAAGTCCCCAGCAGGTGGTGCGGGTGTGTGAGTGGCCCCTGTGAT GGCCAGCCTGGCTTGGACACGTGATGGGCCTGTGGCCGGGTCCAGTGGGCACTGGGCGGGGTGGTGTGTTCGGCCCAGAGGCCCCTGGCC TGAGCAGGTGCAGAGTTTTACAGACACCCGGTCAGCCCGGCTGGAGCCCGCCCTCCCCTCCCCTAGCAGCCAGGTCACTGCCTGTGGCTG CAGCCGTGGCCCGTGGTGCAGCCGTGGCCCATGGCAGCCTGTAGAATCCAGGTGCACAGAGAGCCCTGCCACCGTCTTACCTCTGGGCTT TGGTGCTTAACACACAACACAGCTGCAGACCCTGCTGGAGGCCGAGGGCTCCAGGTGCTATCTTAGGTGGACACAGCCCTGGGGGCTCCT TCCAGGAGGGGACCCTCAGCCCTGTGCCCCCCACCACTTCAGGCCACACCAGGTTCCCTCTGCAAGGGCCTCGGCTCAGTCGTGTGCACT TCCTCGGAGAGCCTTGGGCTGCCACGTCCACCCCGGGCTCTGCCCGTCCTGTTCTGCCCATGGCCCAGCCCGGCCGCTCCTGCTGACCCC TCCTGGACGGGCTGGAGCTGGGCTCCTGCCTTTGCTGCTAACACTGGAGGCGGTGTTCCTAACTGCAGTGTGCTGCTTACACCTCCCCGC GTGGGTAACCAAATTTTTAAGTAGTCAGAGACATATCGAGGTAGTTACATAAAATTATTTTGTTTGGCATTATTTTTCTCACTCGAAGAA ACTATATAGGGTTGTTTTTCCTTTAGCTTGTGCTCAAGTCCTCTTGCTGTGTTTTCAGAAGCACTCACATGTTCTTTCTTTTCCTGAGTG AAAAGCAAAGGTCCCACGGTGTGTGCTGTGGTGCACCGCCTGGCTTTGGGGGTCCCGGAGGCAGGCTGCCTAGACTCACAGCCTCGGGAC CGTTGCCACGGCCTGTCTTCTCGTTCAGGCCTGCCTCTGACAGCACTCACCATGAGGACATTCCATCCTTCACCCCCTCCTCTGGCACAG GCCACCACTGCGGTGCTGTGCCTTCAGATGGGAGGTGGGCGCGGTGGCCTCCTCCTTCCCTCCAGGACCTGCCCGTGTGAAGACCCCCCG GAGTGCTGAGCTTCAGGGCTGCGTGGAAAGAGTTTTTACTCTCTTTTTCTAGCCTGTATACCAGGCTTTTCCCCACATTGTCAGGTAGAG CACCAGCTTCCCTGACCGCTGCTGCTCGGGGAGGGCTGGGGCTGGCCGGGGGTCCTGTGGAGGAGTACATGGAGGACTCCAGGTACAGCG CAGGAGTCACGGCTTTTGTTTTTTGACATTGGCCCCCGGTTCTACCAATGACAGGGTGCCCTGGCTGGAGCTGTCATCACACACACCCCT CAGCTCGGAGGCTGTGGGCTCCTCAAAGCTGGAGAAAGAGGCCAAGATTTTTCTGCACACGGAGTGTGGGGATAGGAGCCGGGCCAAGCG CTGGCCCCTCAGCGGTGAGCCCTGCCCACTCTTACCGAGCAAGGTGGGTGGCTCTGGCACGAGTCCCCCAGGGGGAGAGCATGGCTACCA GGGAGCTGCAGCGGAGCCCTCCAGCCCTCACCCCAGGCCAGCCCCACCCCGGCCTCTTTGAGAATTCTCAGAACTTTGTACCTTTCCCCT GATTTTTAAACCCTTTTTCTAAACAGACTGACTTTCTTACAAAATGCATTTGGAAACCAGACCTTTGCTACCCACCAATGTCTCTGGGTT TTGTACCAGTCCCTGCTCTCAGGCCACCCTGCCCAGGACCCAGGCCCGCCTCCCCCTCCACACTCAGGATGTCCTGCTCCATCTGGCCGG CTCACTCCGTGTGGCCTGCCTTTGCTGACCGTTTTGGGGTTCCCCGCCGGAGCTACAGGGGCATTTTCTTCCCTAAAACCAACAGTGTCC CACTGACCTCCCCAAGTGTTTGCTGCGTGGCAGATTTCCTGTTCTTGTTCGCAGTTTGCCGACTGAAGAGTGTGGGATTTCCGAGGCCCA GGTGAGCACGTCCATCTCAGGAGGCGTGGAGGGAAAAGACATGTCATGAAGGGTTTTTTTTATGTGACTGATTTTTTTTTAAATCGATGT TCAAACTAATAAATATTTTTTTATGAAGAGGAAAAATGTGTAGATTACATTTCACATTTTGTATTTTTGTTTGTGTCTGTTTGTATTTTG GTGTTTACAACACCAAAGTGGGAAATACAGTCCATTGGGGATGGTGTTATTTGGGGGCGGGGAGGGGGCAGGGACACCACGATTTTTCTG TCAAGCTCTGGATCCTGACCAGGTTGTACACTGGGGCTCTCTGAGCTTTGGGACACAGGACACTGCCAGGGCTACGTAGGGAACTGACTC AGAAGACGCAGCTTACTGCTTCCAACTTTGCACATCTTCCTCTTTAAAAAACTGAGAAAATGCAAAAACTGGAACTTTTTGCAATATTAT AAAAGAAGTAATCTTATTTTAGCTCATTCTGTGACATGTGCGACTCTTAAGAAAGCCATACTTAATGGTGGTGGTTTTTTTTAGATCTTA TATTGTGTTTTGTATGCAGCCCTTTTAGAACTACTTGTAGTGAGGGTGCTGTGTGTGCTTTTCTTAAATATTTATTTTTTTCAACATGCT TTCAACCTGTCAACAAAAACAAAACACACAAAAAAAGGGCAGTGTTTGAAGATTGTTGATTTTTTTCTGGGGATAATCTATATTATATTG ACTTCCTATTACTTATTATAAACCTGTGTTTGTATTGGAGATGTGTCTACTATTGGGGGAAGAGGTTCTCGTAATCGCTCGGTGGGAAAT CATGGCTCTGCCGTCCTGCCTCTCTGTGGCCGTGGGTTCACGTGGCCTCTGCGGTGAGTCTCCAAGTTTCTGCCTAGGCGCCTGTGCGTT >In-frame_EEF1A2_ENST00000298049_chr20_62124490_-_ZBTB46_ENST00000395104_chr20_62407315_-_4081nt AATCACTGCAGCCCCCCTCGCCCTGAGCCAGAGCACCCCGGGTCCCGCCAGCCCCTCACACTCCCAGCAAAATGGGCAAGGAGAAGACCC ACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCTACAAATGCGGAGGTATTGACAAAA GGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAAGGCGGAGC GTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGGCCACCGCG ACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGAGGCGGGCA TCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAAAATGGACT CCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAACCCGGCCA CCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTGGAAGGTGG AGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAAGCCCCTGC GCCTGCCGCTGCAGGACGTGTACAAGATTGGCGATGCGGACCTGTCCGTCACCGAAGCCAGCAGCTCCGACAGCCGAGGAGAGAGGGCCG AGCTCTATGCACAGGTGGAGGAGGGTCTCCTGGGAGGAGAAGCCAGCTATCTGGGCCCTCCCCTCACCCCAGAGAAGGACGACGCCCTGC ATCAGGCCACCGCGGTGGCCAACCTGCGCGCGGCGCTCATGAGTAAGAACAGCCTGCTGTCGCTGAAGGCCGACGTGCTGGGGGATGACG GCTCCCTGCTGTTCGAGTACCTGCCCAGAGGGGCCCACTCGCTGTCCCTGAATGAGTTCACGGTGATCAGGAAGAAGTTCAAGTGTCCGT ACTGCAGCTTCTCGGCCATGCACCAGTGCATCCTCAAGCGACACATGCGCTCGCACACGGGAGAGCGGCCCTACCCCTGCGAGATCTGCG GGAAGAAGTTCACGCGGCGCGAGCACATGAAGCGCCACACGCTGGTCCACAGCAAGGACAAGAAGTATGTGTGCAAGGTGTGCAGCCGCG TCTTCATGTCCGCCGCCAGCGTGGGCATCAGGCATGGCTCCAGGCGCCACGGTGTGTGCACCGACTGTGCTGGCCGCGGCATGGCCGGGC CCCTGGACCATGGCGGCGGAGGCGGCGAGGGCTCTCCAGAGGCGCTGTTCCCAGGCGACGGGCCCTATCTGGAGGACCCTGAGGACCCAC GAGGGGAGGCGGAGGAGCTGGGCGAGGACGACGAGGGCCTGGCCCCTGAGGATGCGCTGTTGGCGGACGACAAGGATGAGGAAGACTCGC CGCGGCCGCGCAGCCCCCCAGGAGGCCCTGACAAGGACTTCGCCTGGCTCTCCTAGGCCCGCCCGCCGGCAGGGTCGGTGGCTGCCTCGC TCCGTCCACCCGTGTGTGTGTCCGGTGGGTCTCCACTGCGGGGCCAGGGCCACGCTCACCCCTCTCGCGGCCCCTCCTCTGCTTCCCCCT GAACCCACCCCCCACGGAAACCAGCCCTGCGGGCTAAGCAGGTGCGACCCCAGCAAGAGGGGTGCTCTGGGACCAGACATGAAGTGAGTT GGGGGAGGGCACAGGGTGGGTTTGAGTGAAGGGAGAGCACGGTCCTAAGTCCCCAGCAGGTGGTGCGGGTGTGTGAGTGGCCCCTGTGAT GGCCAGCCTGGCTTGGACACGTGATGGGCCTGTGGCCGGGTCCAGTGGGCACTGGGCGGGGTGGTGTGTTCGGCCCAGAGGCCCCTGGCC TGAGCAGGTGCAGAGTTTTACAGACACCCGGTCAGCCCGGCTGGAGCCCGCCCTCCCCTCCCCTAGCAGCCAGGTCACTGCCTGTGGCTG CAGCCGTGGCCCGTGGTGCAGCCGTGGCCCATGGCAGCCTGTAGAATCCAGGTGCACAGAGAGCCCTGCCACCGTCTTACCTCTGGGCTT TGGTGCTTAACACACAACACAGCTGCAGACCCTGCTGGAGGCCGAGGGCTCCAGGTGCTATCTTAGGTGGACACAGCCCTGGGGGCTCCT TCCAGGAGGGGACCCTCAGCCCTGTGCCCCCCACCACTTCAGGCCACACCAGGTTCCCTCTGCAAGGGCCTCGGCTCAGTCGTGTGCACT TCCTCGGAGAGCCTTGGGCTGCCACGTCCACCCCGGGCTCTGCCCGTCCTGTTCTGCCCATGGCCCAGCCCGGCCGCTCCTGCTGACCCC TCCTGGACGGGCTGGAGCTGGGCTCCTGCCTTTGCTGCTAACACTGGAGGCGGTGTTCCTAACTGCAGTGTGCTGCTTACACCTCCCCGC GTGGGTAACCAAATTTTTAAGTAGTCAGAGACATATCGAGGTAGTTACATAAAATTATTTTGTTTGGCATTATTTTTCTCACTCGAAGAA ACTATATAGGGTTGTTTTTCCTTTAGCTTGTGCTCAAGTCCTCTTGCTGTGTTTTCAGAAGCACTCACATGTTCTTTCTTTTCCTGAGTG AAAAGCAAAGGTCCCACGGTGTGTGCTGTGGTGCACCGCCTGGCTTTGGGGGTCCCGGAGGCAGGCTGCCTAGACTCACAGCCTCGGGAC CGTTGCCACGGCCTGTCTTCTCGTTCAGGCCTGCCTCTGACAGCACTCACCATGAGGACATTCCATCCTTCACCCCCTCCTCTGGCACAG GCCACCACTGCGGTGCTGTGCCTTCAGATGGGAGGTGGGCGCGGTGGCCTCCTCCTTCCCTCCAGGACCTGCCCGTGTGAAGACCCCCCG GAGTGCTGAGCTTCAGGGCTGCGTGGAAAGAGTTTTTACTCTCTTTTTCTAGCCTGTATACCAGGCTTTTCCCCACATTGTCAGGTAGAG CACCAGCTTCCCTGACCGCTGCTGCTCGGGGAGGGCTGGGGCTGGCCGGGGGTCCTGTGGAGGAGTACATGGAGGACTCCAGGTACAGCG CAGGAGTCACGGCTTTTGTTTTTTGACATTGGCCCCCGGTTCTACCAATGACAGGGTGCCCTGGCTGGAGCTGTCATCACACACACCCCT CAGCTCGGAGGCTGTGGGCTCCTCAAAGCTGGAGAAAGAGGCCAAGATTTTTCTGCACACGGAGTGTGGGGATAGGAGCCGGGCCAAGCG CTGGCCCCTCAGCGGTGAGCCCTGCCCACTCTTACCGAGCAAGGTGGGTGGCTCTGGCACGAGTCCCCCAGGGGGAGAGCATGGCTACCA GGGAGCTGCAGCGGAGCCCTCCAGCCCTCACCCCAGGCCAGCCCCACCCCGGCCTCTTTGAGAATTCTCAGAACTTTGTACCTTTCCCCT GATTTTTAAACCCTTTTTCTAAACAGACTGACTTTCTTACAAAATGCATTTGGAAACCAGACCTTTGCTACCCACCAATGTCTCTGGGTT TTGTACCAGTCCCTGCTCTCAGGCCACCCTGCCCAGGACCCAGGCCCGCCTCCCCCTCCACACTCAGGATGTCCTGCTCCATCTGGCCGG CTCACTCCGTGTGGCCTGCCTTTGCTGACCGTTTTGGGGTTCCCCGCCGGAGCTACAGGGGCATTTTCTTCCCTAAAACCAACAGTGTCC CACTGACCTCCCCAAGTGTTTGCTGCGTGGCAGATTTCCTGTTCTTGTTCGCAGTTTGCCGACTGAAGAGTGTGGGATTTCCGAGGCCCA GGTGAGCACGTCCATCTCAGGAGGCGTGGAGGGAAAAGACATGTCATGAAGGGTTTTTTTTATGTGACTGATTTTTTTTTAAATCGATGT |
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FusionGenePPI for EEF1A2_ZBTB46 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EEF1A2 | VARS, EEF1D, EEF1B2, MGMT, SRRM2, PTEN, MAPK6, ARRB1, ARRB2, TCF3, ISG15, FBXO25, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, UBXN6, TTLL12, YWHAE, BTK, CD81, IGSF8, CDK3, PARK2, AHCY, SHFM1, RPA3, RPA2, RPA1, ERG, TRIM25, LGR4, UBC, AURKA, CEP57, HAUS2, CEP76, TUBG1, VCP, ABTB1, PBDC1, NXPH2, NUFIP1, DGUOK, C4orf19, HEXIM1, HOMER1, TMEM25, WDR53, DCP2, DDHD2, GJA1, RNF26, EEF1G, FAM177A1, PLK2, CDK7, ACTB, ACTG1, POLR1A, EEF2, EFTUD2, GMPPB, GORASP2, PABPC1, PABPC3, PKLR, PKM, POLR2A, PSMD1, RPL12, RPL30, RPL4, RPSA, STK11, ID2, CRY2, MCM2, MCM5, ESRRB, CDC37, CDC73, DPF3, WWP2, EEF1A1, N6AMT2, CARS, PSG1, IL36A, FGB, SNRNP27, PITHD1, RAB1A, GTF2E2, CTAGE5, ZNF490, GYPA, LRRC56, MLLT6, FUOM, CKS1B, TPT1, NCSTN, HSPB8, GJB7, SLC38A7, SLC13A5, SREK1IP1, TBXAS1, BTNL3, RPS11, PPIAL4G, DHX57, ST6GALNAC1, USP47, TLE3, DBF4, FLT4, CYLD, MTF1 | ZBTB46 | DESI1, ELAVL1, CUL1, EHMT1, PRPF8, GATAD2B, GATAD2A, MBD3, MTA1, AP2A1, AP2A2, RGPD5, DDX23, ZBTB10, EHMT2, FBXL17, BTRC, FBXW11, ZNF318, WIZ, SUFU, FBXO21, SNRNP200, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EEF1A2_ZBTB46 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EEF1A2_ZBTB46 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EEF1A2 | C4225337 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 33 | 2 | UNIPROT |
| Hgene | EEF1A2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | EEF1A2 | C4225343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 38 | 1 | UNIPROT |
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