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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 10953

FusionGeneSummary for EED_TPCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: EED_TPCN2
Fusion gene ID: 10953
HgeneTgene
Gene symbol

EED

TPCN2

Gene ID

8726

219931

Gene nameembryonic ectoderm developmenttwo pore segment channel 2
SynonymsCOGIS|HEED|WAIT1SHEP10|TPC2
Cytomap

11q14.2

11q13.3

Type of geneprotein-codingprotein-coding
Descriptionpolycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development proteintwo pore calcium channel protein 2voltage-dependent calcium channel protein TPC2
Modification date2018052320180522
UniProtAcc

O75530

Q8NHX9

Ensembl transtripts involved in fusion geneENST00000263360, ENST00000528180, 
ENST00000327320, ENST00000351625, 
ENST00000527888, 
ENST00000294309, 
ENST00000542467, ENST00000442692, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 7 X 6=420
# samples 310
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/420*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EED [Title/Abstract] AND TPCN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTPCN2

GO:0006874

cellular calcium ion homeostasis

19387438


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HI-7171-01AEEDchr11

85956385

+TPCN2chr11

68834971

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263360ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000263360ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000263360ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000528180ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000528180ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000528180ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000327320ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000327320ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000327320ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000351625ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
In-frameENST00000351625ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
5CDS-3UTRENST00000351625ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3CDSENST00000527888ENST00000294309EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3CDSENST00000527888ENST00000542467EEDchr11

85956385

+TPCN2chr11

68834971

+
intron-3UTRENST00000527888ENST00000442692EEDchr11

85956385

+TPCN2chr11

68834971

+

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FusionProtFeatures for EED_TPCN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EED

O75530

TPCN2

Q8NHX9

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3,leading to transcriptional repression of the affected target gene.Also recognizes 'Lys-26' trimethylated histone H1 with the effectof inhibiting PRC2 complex methyltransferase activity onnucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognitionhas the opposite effect, enabling the propagation of thisrepressive mark. The PRC2/EED-EZH2 complex may also serve as arecruiting platform for DNA methyltransferases, thereby linkingtwo epigenetic repression systems. Genes repressed by thePRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.{ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106,ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737,ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870,ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918,ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}. Nicotinic acid adenine dinucleotide phosphate (NAADP)receptor that may function as one of the major voltage-gatedCa(2+) channels (VDCC) across the lysosomal membrane. May beinvolved in smooth muscle contraction.{ECO:0000269|PubMed:19387438, ECO:0000269|PubMed:19620632}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625255_279242753IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625636_658242753IntramembraneHelical%3B Pore-forming
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625240_254242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625280_289242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625311_436242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625460_465242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625487_502242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625524_554242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625576_580242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625602_635242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625659_673242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625695_752242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625290_310242753TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625437_459242753TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625466_486242753TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625503_523242753TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625555_575242753TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625581_601242753TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625674_694242753TransmembraneHelical%3B Name%3DS6 of repeat II

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112142_18538442RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112188_22838442RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112234_27538442RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112304_34138442RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112359_39938442RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+112408_44138442RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+11291_13438442RepeatNote=WD 1
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111142_18538401RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111188_22838401RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111234_27538401RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111304_34138401RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111359_39938401RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+111408_44138401RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+11191_13438401RepeatNote=WD 1
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113142_18538467RepeatNote=WD 2
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113188_22838467RepeatNote=WD 3
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113234_27538467RepeatNote=WD 4
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113304_34138467RepeatNote=WD 5
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113359_39938467RepeatNote=WD 6
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+113408_44138467RepeatNote=WD 7
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+11391_13438467RepeatNote=WD 1
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+62517_20242753Compositional biasNote=Poly-Gly
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625106_127242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625149_155242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625177_183242753Topological domainExtracellular
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+6251_84242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625205_218242753Topological domainCytoplasmic
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625128_148242753TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625156_176242753TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625184_204242753TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+625219_239242753TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneTPCN2chr11:85956385chr11:68834971ENST00000294309+62585_105242753TransmembraneHelical%3B Name%3DS1 of repeat I


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FusionGeneSequence for EED_TPCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_549aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL
MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN
WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ

>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_367aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_549aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL
MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN
WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_367aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_549aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL
MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN
WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_367aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_549aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL
MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNN
WQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQ

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_367aa
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIV
FTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVR
SYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNC
VFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLNFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_1647nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG

>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1101nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_1647nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1101nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_1647nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1101nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_1647nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1101nt
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_2904nt
ATTCGCCAGATGGGGGAAGCCAGGGGGAAGCAGGTTACTGTTTTTGCATTTCTATCTTCAAGGAAGAATTAGGTTATGAATAGTTCCGTG
AATAGTCAGGAAGCGCTGTCCTCCAAGTTCAAGATTAAGGAAACGTGGCATGCACAGCTAAAGCAAGAGGTGACGTCTTGTATCTTCCCC
CGTTTCCTGGGACATTGGTGGTGTAGCCCATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGG
CTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATAC
TTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGG
GAAGGAGCCAGGAAGCCGCGCGGGAGGGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGC
TGGGCGCGATTTGCGACAGTGGGGGGGGCGGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGG
CGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGG
GAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATG
GGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCG
ATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACC
TGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGG
CTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGC
TTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGT
TTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCC
AGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGG
ATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGC
TCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGG
AGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCA
TGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGG
TGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTG
TGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACT
TCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACT
CAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGA
ACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGT
TCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGG
GCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGG
CAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGC
TGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTC
AGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCT
GACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGT
TTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGATTGCCAGTTATTTTCATCAATAAGTCTTGCAAAG

>In-frame_EED_ENST00000263360_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_2037nt
ATTCGCCAGATGGGGGAAGCCAGGGGGAAGCAGGTTACTGTTTTTGCATTTCTATCTTCAAGGAAGAATTAGGTTATGAATAGTTCCGTG
AATAGTCAGGAAGCGCTGTCCTCCAAGTTCAAGATTAAGGAAACGTGGCATGCACAGCTAAAGCAAGAGGTGACGTCTTGTATCTTCCCC
CGTTTCCTGGGACATTGGTGGTGTAGCCCATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGG
CTGAAACGTCTTTGGAAGGAGGAAGGGGGTGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATAC
TTAATACTGCCCTCTTAATCCAACGGACCTTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGG
GAAGGAGCCAGGAAGCCGCGCGGGAGGGCGCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGC
TGGGCGCGATTTGCGACAGTGGGGGGGGCGGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGG
CGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGG
GAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATG
GGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCG
ATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACC
TGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGG
CTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGC
TTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGT
TTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCC
AGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGG
ATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGC
TCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCC
TTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGG
ATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCC
GTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAA
GAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGG

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_2695nt
ATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGG
TGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACC
TTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCCGCGCGGGAGGGC
GCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGC
GGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGG
CAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAG
AAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTC
CAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAAC
CGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTC
CGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTG
GGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCAC
AAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGA
AGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGAC
TACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGAT
GACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGG
TACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTG
CCACACCCAGGCTGGAGGCCGGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTC
CTGCGTATCATCCCCAGCATGAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATC
CTGGTGGTGGTCTACTACGTATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCC
CCTGCCAATGGCTCGGCGCCCTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACT
CTGTGGAACTTGATGGTGGTGAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTA
TTGTGGTGGCTGGTGTCGTCTGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGC
CACCTGCAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAG
GATGAGCTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGA
GAGAGGCTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCA
CTAAGCTGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCC
TCCGCTTTCTTTTATAGCTGCTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCC
CCTGTCCCCTGCAGCTTCCGTGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAG
ACTTCCGGGGCATTCAGGTGGGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTG

>In-frame_EED_ENST00000528180_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1828nt
ATTCCACAGACTTTCGCTCCCTAGCAGCGGGTCGGAGATCGAAGGAACGGGCCAATTGCGGCTGAAACGTCTTTGGAAGGAGGAAGGGGG
TGAGGGAGCATCCCTTTGAGTTTCGCCTCTTCTCGAGGCGGTGGTGGGAAGGGAGACATACTTAATACTGCCCTCTTAATCCAACGGACC
TTACATCGTGTAGACTGCCGGGAGGGCGGCGGGAAAAGGGCAAGACGGGAGTTGGGGAAGGGAAGGAGCCAGGAAGCCGCGCGGGAGGGC
GCGCGCGCGCGCCCCTTTTTCAGCAGTGTGGCGGGGTCGCACGCACGCCCGCCTCGGCGGCTGGGCGCGATTTGCGACAGTGGGGGGGGC
GGTGGAGGTGGCGGCGGCAGCGGCAACTTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGG
CAGGAACCTGGAGGGAGGCGGAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAG
AAGCTGAGCAGTGACGAGAACAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTC
CAGAACCTGCCTGAGTCTCTGACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAAC
CGGGCCTATGCCATCTTCTTCATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTC
CGGGGCTACCTGATGAAATCTCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTG
GGGGAGGGAGGAGCCTTCCCTCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCAC
AAACAGGCCATGATGGAGAAGGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGA
AGTGTGGTTAAAGAGCACCCGCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGAC
TACCTGGGGAACCTCATCGCCCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGAT
GACTTCATCCTGGGGATTCTCAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGG
TACCTGTCCTACCCCAGCAACGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTG
CAGCCCCTTGCTGGGACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAG
CTCACAGAGAGGCTGAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGG
CTGGCCTACACAGGTGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGC
TGGGGACAGGAACCAAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCT

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_2308nt
TTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAAT
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCCGGAGATG
GTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCATGAAGCTG
ATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGTATTTGCC
ATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCCCTGTGGG
AGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGTGAACAAC
TGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTCTGTCATC
TGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCA
GAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAG
CACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGT
CATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCT
TTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGT
GAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCGTGGTGCC
TTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTGGGGATGC
TGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGGGTTCTGA

>In-frame_EED_ENST00000327320_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1441nt
TTTGCGGCAAGCTCGGGCCGGGCTTGCTTGACGGCGGTGTGGCGGAGGCCCCGCCCCAGGCGGCAGGAACCTGGAGGGAGGCGGAGGAAT
ATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAACAGCAAT
CCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCTGACTTCC
CTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTTCATAGTC
TTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATCTCTCCAG
ACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCCTCAGGCA
GTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAAGGTGCGT
TCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCCGCCGAGG
CCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGCCCTGGCA
AACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCTCAACTGC
GTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAACGTGTTT
GACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCCAGAGGCC
ACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCAGCACCCG
CACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCGTCATGGA
AGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCCTTTGCGT
GTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAGTGAGAAT

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000294309_chr11_68834971_+_2225nt
GAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAA
CAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCT
GACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTT
CATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATC
TCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCC
TCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAA
GGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCC
GCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGC
CCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCT
CAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAA
CGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGGTTTTGGAGATCTCAACTCTGGCTGTGTACCGATTGCCACACCCAGGCTGGAGGCC
GGAGATGGTGGGCCTGCTGTCGCTGTGGGACATGACCCGCATGCTGAACATGCTCATCGTGTTCCGCTTCCTGCGTATCATCCCCAGCAT
GAAGCTGATGGCCGTGGTGGCCAGTACCGTCCTGGGCCTGGTGCAGAACATGCGTGCGTTTGGCGGGATCCTGGTGGTGGTCTACTACGT
ATTTGCCATCATTGGGATCAACTTGTTTAGAGGCGTCATTGTGGCTCTTCCTGGAAACAGCAGCCTGGCCCCTGCCAATGGCTCGGCGCC
CTGTGGGAGCTTCGAGCAGCTGGAGTACTGGGCCAACAACTTCGATGACTTTGCGGCTGCCCTGGTCACTCTGTGGAACTTGATGGTGGT
GAACAACTGGCAGGTGTTTCTGGATGCATATCGGCGCTACTCAGGCCCGTGGTCCAAGATCTATTTTGTATTGTGGTGGCTGGTGTCGTC
TGTCATCTGGGTCAACCTGTTTCTGGCCCTGATTCTGGAGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGG
GACCCCAGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCT
GAGCCAGCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGG
TGCCCGTCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACC
AAGTCCTTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTG
CTTCAGTGAGAATTCCCTCGTCGACTCCACAGGGACCTTTCAGACAAAAATGCAAGAAGCAGCGGCCTCCCCTGTCCCCTGCAGCTTCCG
TGGTGCCTTTGCTGCCGGCAGCCCTTGGGGACCACAGGCCTGACCAGGGCCTGCACAGGTTAACCGTCAGACTTCCGGGGCATTCAGGTG
GGGATGCTGGTGGTTTGACATGGAGAGAACCTTGACTGTGTTTTATTATTTCATGGCTTGTATGAGTGTGACTGGGTGTGTTTCTTTAGG

>In-frame_EED_ENST00000351625_chr11_85956385_+_TPCN2_ENST00000542467_chr11_68834971_+_1358nt
GAGGAATATGTCCGAGAGGGAAGTGTCGACTGCGCCGGCGGGAACAGACATGCCTGCGGCCAAGAAGCAGAAGCTGAGCAGTGACGAGAA
CAGCAATCCAGACCTCTCTGGAGACGAGAATCAGGATGATGGGCAGGACAGGGAGAGGCTGACCTACTTCCAGAACCTGCCTGAGTCTCT
GACTTCCCTCCTGGTGCTGCTGACCACGGCCAACAACCCCGATGTGATGATTCCTGCGTATTCCAAGAACCGGGCCTATGCCATCTTCTT
CATAGTCTTCACTGTGATAGGAAGCCTGTTTCTGATGAACCTGCTGACAGCCATCATCTACAGTCAGTTCCGGGGCTACCTGATGAAATC
TCTCCAGACCTCGCTGTTTCGGAGGCGGCTGGGAACCCGGGCTGCCTTTGAAGTCCTATCCTCCATGGTGGGGGAGGGAGGAGCCTTCCC
TCAGGCAGTTGGGGTGAAGCCCCAGAACTTGCTGCAGGTGCTTCAGAAGGTCCAGCTGGACAGCTCCCACAAACAGGCCATGATGGAGAA
GGTGCGTTCCTATGGCAGTGTTCTGCTCTCAGCTGAGGAGTTTCAGAAGCTCTTCAACGAGCTTGACAGAAGTGTGGTTAAAGAGCACCC
GCCGAGGCCCGAGTACCAGTCTCCGTTTCTGCAGAGCGCCCAGTTCCTCTTCGGCCACTACTACTTTGACTACCTGGGGAACCTCATCGC
CCTGGCAAACCTGGTGTCCATTTGCGTGTTCCTGGTGCTGGATGCAGATGTGCTGCCTGCTGAGCGTGATGACTTCATCCTGGGGATTCT
CAACTGCGTCTTCATTGTGTACTACCTGTTGGAGATGCTGCTCAAGGTCTTTGCCCTGGGCCTGCGAGGGTACCTGTCCTACCCCAGCAA
CGTGTTTGACGGGCTCCTCACCGTTGTCCTGCTGAACTTCCTTCACAAGTGGGACCCCCGCAGCCACCTGCAGCCCCTTGCTGGGACCCC
AGAGGCCACCTACCAGATGACTGTGGAGCTCCTGTTCAGGGATATTCTGGAGGAGCCCGGGGAGGATGAGCTCACAGAGAGGCTGAGCCA
GCACCCGCACCTGTGGCTGTGCAGGTGACGTCCGGGCTGCCGTCCCAGCAGGGGCGGCAGGAGAGAGAGGCTGGCCTACACAGGTGCCCG
TCATGGAAGAGGCGGCCATGCTGTGGCCAGCCAGGCAGGAAGAGACCTTTCCTCTGACGGACCACTAAGCTGGGGACAGGAACCAAGTCC
TTTGCGTGTGGCCCAACAACCATCTACAGAACAGCTGCTGGTGCTTCAGGGAGGCGCCGTGCCCTCCGCTTTCTTTTATAGCTGCTTCAG


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FusionGenePPI for EED_TPCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EEDITGA4, EZH2, PPP1R8, ITGAE, HDAC2, TGS1, PPP1CA, HDAC1, ITGB7, SUZ12, RBBP4, AEBP2, VAV1, HIST1H3A, EZH1, EED, DDB1, CUL4A, HIST1H1A, HIST1H1C, DNMT1, DNMT3A, DNMT3B, KDM5A, SETD8, EPC1, E2F6, PHF1, USP7, PHF19, HIST3H3, NUDT21, ZBED8, SELENBP1, RPS10, DUSP23, FHL1, MAP1LC3B, UBE2W, CDK2AP2, TSC22D1, CTSL, ZFP42, PJA1, EHMT1, SMYD3, EPC2, HIC1, YY1, SS18, SSX2, SIRT1, ASXL1, ADAM17, BRCA1, JARID2, RNF2, BMI1, FBXO11, SNRNP70, RING1, CBX8, SNRPA, EIF3A, APOBEC3B, PRDX4, PHC1, PCGF2, PHC3, RBM12B, SRRM2, LUC7L3, MGA, UTP20, PHC2, RYBP, HSP90B1, CBX7, SPEN, AHCTF1, CHD2, NXF1, RSL1D1, PAWR, CTCF, KDM2A, TXNDC5, GTF3C3, PCGF1, ABCF1, PPWD1, FTSJ3, EIF3B, RAB7A, PCGF6, RFC5, NUP188, NUP98, PRPF6, BCOR, RPN2, DSG2, KCNMA1, CRNKL1, CUL1, DDX52, CBX4, PNO1, CBX3, STAG1, SMPD4, MYH9, ENO1, CLK3, ZMYM2, RBM15, DCAF13, PRPF38A, SKP1, MRPL20, CPSF7, SMARCA1, RPS3, HSPA5, BPTF, EP400, SIN3A, RIF1, RAB5B, NRDE2, BAZ2A, POGZ, BAZ1B, CWC22, ACIN1, CLK2, NOM1, RRP12, SLTM, BRIX1, DDX47, CENPV, NAA40, BCAS2, RCL1, RPL18A, SLC25A5, NIFK, RPL9, RPS11, SF3B6, DIDO1, TRA2B, SRRT, HNRNPUL1, KRT19, RPS8, HNRNPH2, PRPF19, MYH10, H1F0, SRSF8, AR, RPL23, TRIP12, PDS5B, RPL14, SRSF2, PBRM1, MAGT1, NOC2L, NUP85, RPL31, DDX27, TM7SF2, NOLC1, DDX50, DYNLL1, RAC1, FASN, INTS1, GTPBP4, EHMT2, NOL11, NCBP1, RBM28, RPL3, SLC25A3, RPL29, RPL7A, SNRPA1, CLTC, CASZ1, KIF20A, NDRG1, HOXB13, DDX6, U2AF2, HNRNPAB, DDX18, MAGOHB, RPL12, KIF4A, TCERG1, SUPT6H, FUBP3, NOL10, GRN, SF1, NOL6, SEPT9, RBM4, API5, STRBP, MYBBP1A, NUP205, SNRPD1, CEBPZ, NUP133, RPS4X, OSTC, H2AFY2, GTF3C1, VTN, RPS28, RPL30, MEN1, INTS3, GTF3C4, NUP107, SMARCA2, RPL24, RPL22, ZNF638, C9orf114, NFIB, RPL23A, EMG1, RPS7, H1FX, RPS24, RPS26, SKIV2L2, DDX42, EXOSC4, GATAD2B, DSTN, GAPDH, RAB14, HSP90AB1, MAP1B, UTP14A, MDC1, RBM25, TP53BP1, GLYR1, CKAP5, GNL3, SF3A1, RAD21, HMGB2, RUVBL2, SRP14, TAF15, SNRPD3, SNRPD2, SAFB, NAT10, SAFB2, TRRAP, SMCHD1, WDR3, SCAF4, TBL3, ZNF687, DDOST, PUF60, KIAA0020, NPM3, RAB1B, IGKC, WIZ, MYEF2, XRCC1, XRCC5, PSPC1, PNKP, CDC5L, CCDC71, HSPD1, CPSF6, EEF1B2, SNRPF, TUBA1B, RPL8, JUP, NIPBL, RAD50, MTA1, FBL, NUP93, RPL27A, DAD1, DYNLL2, ALYREF, FOXA1, TFAM, EEF1D, SF3A3, EBNA1BP2, C1QB, KRT6A, LBR, PCBP1, PKP2, PWP2, HEATR1, RPL13A, ARGLU1, HNRNPDL, MRE11A, PHB2, FUBP1, SRSF10, EFTUD2, SF3B1, HCFC1, EIF4A3, RAN, RPS23, CPSF1, CFL1, RPS16, RPN1, PRPF40A, NHP2L1, SMARCC1, TRA2A, SRSF6, TOP1, RBM14, RPS14, XRCC6, ERH, TPR, TCOF1, PABPN1, ARID1A, DEK, RUVBL1, PRPF8, NUP160, HNRNPA0, RPL18, ZNF326, RANBP2, KPNB1, PHB, IMP3, TARDBP, POLR2A, DKC1, CHD4, VARS, SON, NCL, PPP1CB, LMNB2, TMPO, SMARCA4, RPL11, PPIB, LMNA, HSPA9, SRSF9, PDS5A, HNRNPA3, THOC2, RPL7, RALY, PTBP1, KDM1A, SMARCC2, NOP2, PKP3, HP1BP3, IGHV3-23, SRSF3, DDX3X, SMC3, HNRNPUL2, HNRNPA1, KHSRP, PCBP2, LIG3, DDX5, SSRP1, NOP58, PDCD11, HNRNPH3, HNRNPL, H2AFY, SUPT16H, RBM39, SRSF7, NOP56, SF3B3, ADNP, SRSF1, SYNCRIP, SNRNP200, SMC1A, PLEC, IGHG1, SMARCA5, DDX39B, ADAR, GTF2I, HSPA8, TRIM28, ACTG1, NUP210, RPS27A, HNRNPD, DDX39A, KRT2, HNRNPF, ELAVL1, DHX15, ILF2, KRT18, ILF3, MATR3, HNRNPK, DDX17, HNRNPA2B1, SFPQ, EEF1G, HNRNPR, NONO, LMNB1, RBMX, FLOT2, DDX21, FLOT1, KRT8, HNRNPC, HNRNPU, HNRNPH1, DHX9, HIST4H4, KRT1, HNRNPM, PRKDC, NUMA1, DSP, UROS, RBBP7, SRPK2, DDX10, TCEA1, TFAP2A, PLK1, NR2C2, C10orf12, RRP9, MTF2, C17orf96, PRDM14, MDM2, HNF4A, INTU, BTRC, FBXW11, CLASRP, SMPD3, GNB2L1, UHRF2TPCN2ANKRD27, AGBL5, USP32, DENND6A, TRAPPC8, WDR44, PTPRA, CLCN3, FBXO10, ARRB2, RRAGB, PI4K2A, RELT, AP3B1, WDR11, TSR3, PCDH9, DIP2A, RAB6B, ZRANB3, AP3D1, CD320, DDX11L8, VAMP3, CERK, OCRL, AP3S1, APPL1, HK3, MAP2K7, DAGLB, B4GALT5, TMEM56, RNF149, LRP10, VAMP2, ACP2, SNX17, PTPRD, BMPR1A, STX6, TRAPPC5, EHD4, CSNK1G3, NDFIP1, FGFR1, NOMO3, UXS1, EBP, ZDHHC18, NOMO1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEEDchr11:85956385chr11:68834971ENST00000263360+11281_44138442EZH2
HgeneEEDchr11:85956385chr11:68834971ENST00000327320+11181_44138401EZH2
HgeneEEDchr11:85956385chr11:68834971ENST00000351625+11381_44138467EZH2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EED_TPCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EED_TPCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEDC0027809Neurilemmoma1CTD_human
HgeneEEDC0206727Nerve Sheath Tumors1CTD_human