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Fusion gene ID: 10939 |
FusionGeneSummary for EDNRB-AS1_SFTPB |
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Fusion gene information | Fusion gene name: EDNRB-AS1_SFTPB | Fusion gene ID: 10939 | Hgene | Tgene | Gene symbol | EDNRB-AS1 | SFTPB | Gene ID | 100505518 | 6439 |
Gene name | EDNRB antisense RNA 1 | surfactant protein B | |
Synonyms | - | PSP-B|SFTB3|SFTP3|SMDP1|SP-B | |
Cytomap | 13q22.3 | 2p11.2 | |
Type of gene | ncRNA | protein-coding | |
Description | - | pulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe) | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | P07988 | ||
Ensembl transtripts involved in fusion gene | ENST00000422405, | ENST00000519937, ENST00000342375, ENST00000393822, ENST00000409383, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 12 X 10 X 2=240 |
# samples | 1 | 14 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/240*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EDNRB-AS1 [Title/Abstract] AND SFTPB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK290699 | EDNRB-AS1 | chr13 | 78472138 | - | SFTPB | chr2 | 85886299 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000422405 | ENST00000519937 | EDNRB-AS1 | chr13 | 78472138 | - | SFTPB | chr2 | 85886299 | - |
intron-3UTR | ENST00000422405 | ENST00000342375 | EDNRB-AS1 | chr13 | 78472138 | - | SFTPB | chr2 | 85886299 | - |
intron-3UTR | ENST00000422405 | ENST00000393822 | EDNRB-AS1 | chr13 | 78472138 | - | SFTPB | chr2 | 85886299 | - |
intron-intron | ENST00000422405 | ENST00000409383 | EDNRB-AS1 | chr13 | 78472138 | - | SFTPB | chr2 | 85886299 | - |
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FusionProtFeatures for EDNRB-AS1_SFTPB |
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Hgene | Tgene |
EDNRB-AS1 | SFTPB |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Pulmonary surfactant-associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases thecollapse pressure of palmitic acid to nearly 70 millinewtons permeter. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EDNRB-AS1_SFTPB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EDNRB-AS1_SFTPB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EDNRB-AS1_SFTPB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EDNRB-AS1_SFTPB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SFTPB | C0019284 | Diaphragmatic Hernia | 2 | CTD_human |
Tgene | SFTPB | C0024115 | Lung diseases | 1 | CTD_human |
Tgene | SFTPB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | SFTPB | C1968602 | Surfactant Metabolism Dysfunction, Pulmonary, 1 | 1 | CTD_human;ORPHANET;UNIPROT |