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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10939

FusionGeneSummary for EDNRB-AS1_SFTPB

check button Fusion gene summary
Fusion gene informationFusion gene name: EDNRB-AS1_SFTPB
Fusion gene ID: 10939
HgeneTgene
Gene symbol

EDNRB-AS1

SFTPB

Gene ID

100505518

6439

Gene nameEDNRB antisense RNA 1surfactant protein B
Synonyms-PSP-B|SFTB3|SFTP3|SMDP1|SP-B
Cytomap

13q22.3

2p11.2

Type of genencRNAprotein-coding
Description-pulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe)
Modification date2018032920180523
UniProtAcc

P07988

Ensembl transtripts involved in fusion geneENST00000422405, ENST00000519937, 
ENST00000342375, ENST00000393822, 
ENST00000409383, 
Fusion gene scores* DoF score1 X 1 X 1=112 X 10 X 2=240
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/240*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EDNRB-AS1 [Title/Abstract] AND SFTPB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK290699EDNRB-AS1chr13

78472138

-SFTPBchr2

85886299

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000422405ENST00000519937EDNRB-AS1chr13

78472138

-SFTPBchr2

85886299

-
intron-3UTRENST00000422405ENST00000342375EDNRB-AS1chr13

78472138

-SFTPBchr2

85886299

-
intron-3UTRENST00000422405ENST00000393822EDNRB-AS1chr13

78472138

-SFTPBchr2

85886299

-
intron-intronENST00000422405ENST00000409383EDNRB-AS1chr13

78472138

-SFTPBchr2

85886299

-

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FusionProtFeatures for EDNRB-AS1_SFTPB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EDNRB-AS1

SFTPB

P07988

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Pulmonary surfactant-associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases thecollapse pressure of palmitic acid to nearly 70 millinewtons permeter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EDNRB-AS1_SFTPB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EDNRB-AS1_SFTPB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EDNRB-AS1_SFTPB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EDNRB-AS1_SFTPB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSFTPBC0019284Diaphragmatic Hernia2CTD_human
TgeneSFTPBC0024115Lung diseases1CTD_human
TgeneSFTPBC0024121Lung Neoplasms1CTD_human
TgeneSFTPBC1968602Surfactant Metabolism Dysfunction, Pulmonary, 11CTD_human;ORPHANET;UNIPROT