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Fusion gene ID: 10935 |
FusionGeneSummary for EDF1_DPP7 |
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Fusion gene information | Fusion gene name: EDF1_DPP7 | Fusion gene ID: 10935 | Hgene | Tgene | Gene symbol | EDF1 | DPP7 | Gene ID | 8721 | 29952 |
Gene name | endothelial differentiation related factor 1 | dipeptidyl peptidase 7 | |
Synonyms | CFAP280|EDF-1|MBF1 | DPP2|DPPII|QPP | |
Cytomap | 9q34.3 | 9q34.3 | |
Type of gene | protein-coding | protein-coding | |
Description | endothelial differentiation-related factor 1multiprotein bridging factor 1 | dipeptidyl peptidase 2DPP IIcarboxytripeptidasedipeptidyl aminopeptidase IIdipeptidyl arylamidase IIdipeptidyl-peptidase IIquiescent cell proline dipeptidase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O60869 | Q9UHL4 | |
Ensembl transtripts involved in fusion gene | ENST00000371649, ENST00000224073, ENST00000371648, | ENST00000371579, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/8*10)=1.90689059560852 | |
Context | PubMed: EDF1 [Title/Abstract] AND DPP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EDF1 | GO:0043388 | positive regulation of DNA binding | 10567391 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-7901-01A | EDF1 | chr9 | 139760633 | - | DPP7 | chr9 | 140005402 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000371649 | ENST00000371579 | EDF1 | chr9 | 139760633 | - | DPP7 | chr9 | 140005402 | - |
In-frame | ENST00000224073 | ENST00000371579 | EDF1 | chr9 | 139760633 | - | DPP7 | chr9 | 140005402 | - |
In-frame | ENST00000371648 | ENST00000371579 | EDF1 | chr9 | 139760633 | - | DPP7 | chr9 | 140005402 | - |
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FusionProtFeatures for EDF1_DPP7 |
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Hgene | Tgene |
EDF1 | DPP7 |
Transcriptional coactivator stimulating NR5A1 andligand-dependent NR1H3/LXRA and PPARG transcriptional activities.Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1.Regulates nitric oxid synthase activity probably by sequesteringcalmodulin in the cytoplasm. May function in endothelial cellsdifferentiation, hormone-induced cardiomyocytes hypertrophy andlipid metabolism. {ECO:0000269|PubMed:10567391,ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053,ECO:0000269|PubMed:9813014}. | Plays an important role in the degradation of someoligopeptides. {ECO:0000269|PubMed:15487984}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000224073 | - | 1 | 5 | 92_111 | 26 | 149 | DNA binding | H-T-H motif |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000371648 | - | 1 | 4 | 92_111 | 26 | 140 | DNA binding | H-T-H motif |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000224073 | - | 1 | 5 | 81_135 | 26 | 149 | Domain | HTH cro/C1-type |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000371648 | - | 1 | 4 | 81_135 | 26 | 140 | Domain | HTH cro/C1-type |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000224073 | - | 1 | 5 | 81_88 | 26 | 149 | Motif | Note=IQ motif |
Hgene | >EDF1 | chr9:139760633 | chr9:140005402 | ENST00000371648 | - | 1 | 4 | 81_88 | 26 | 140 | Motif | Note=IQ motif |
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FusionGeneSequence for EDF1_DPP7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_EDF1_ENST00000371649_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_95aa MAESDWDTVTVLRKKGPTAAQAKSKQIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGP >In-frame_EDF1_ENST00000224073_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_95aa MAESDWDTVTVLRKKGPTAAQAKSKQIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGP >In-frame_EDF1_ENST00000371648_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_95aa MAESDWDTVTVLRKKGPTAAQAKSKQIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_EDF1_ENST00000371649_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_285nt ATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGATTCGGAGGAAC CTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGCCTCCCACCCAGAAGATCCTGCTTCCGTG GTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGAGCAGCAGCCAGCTCTGCGTGGGGGGCCC >In-frame_EDF1_ENST00000224073_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_285nt ATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGATTCGGAGGAAC CTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGCCTCCCACCCAGAAGATCCTGCTTCCGTG GTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGAGCAGCAGCCAGCTCTGCGTGGGGGGCCC >In-frame_EDF1_ENST00000371648_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_285nt ATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGATTCGGAGGAAC CTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGCCTCCCACCCAGAAGATCCTGCTTCCGTG GTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGAGCAGCAGCCAGCTCTGCGTGGGGGGCCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_EDF1_ENST00000371649_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_418nt CCGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAG GCCAAATCCAAGCAGATTCGGAGGAACCTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGCC TCCCACCCAGAAGATCCTGCTTCCGTGGTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGAG CAGCAGCCAGCTCTGCGTGGGGGGCCCAGACTCAGCCTCTGAGCACAGGACTGGAGGGGTCTCAAGGCTCCTCATGGAGTGGGGGCTTCA >In-frame_EDF1_ENST00000224073_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_419nt GCCGGACGGACGCTCGTCTTCGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCA GGCCAAATCCAAGCAGATTCGGAGGAACCTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGC CTCCCACCCAGAAGATCCTGCTTCCGTGGTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGA GCAGCAGCCAGCTCTGCGTGGGGGGCCCAGACTCAGCCTCTGAGCACAGGACTGGAGGGGTCTCAAGGCTCCTCATGGAGTGGGGGCTTC >In-frame_EDF1_ENST00000371648_chr9_139760633_-_DPP7_ENST00000371579_chr9_140005402_-_399nt CGCCCGCCATGGCCGAGAGCGACTGGGACACGGTGACGGTGCTGCGCAAGAAGGGCCCTACGGCCGCCCAGGCCAAATCCAAGCAGATTC GGAGGAACCTGAGTGCCTCAGTCATCGCCGTCACCATCCAGGGGGGAGCGCACCACCTCGACCTCAGAGCCTCCCACCCAGAAGATCCTG CTTCCGTGGTTGAGGCGCGGAAGCTGGAGGCCACCATCATCGGCGAGTGGGTAAAGGCAGCCAGGCGTGAGCAGCAGCCAGCTCTGCGTG GGGGGCCCAGACTCAGCCTCTGAGCACAGGACTGGAGGGGTCTCAAGGCTCCTCATGGAGTGGGGGCTTCACTCAAGCAGCTGGCGGCAG |
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FusionGenePPI for EDF1_DPP7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EDF1 | NR5A2, NR1H3, PPARG, RXRA, TBP, NR5A1, JUN, NRL, CEBPA, MAPK6, UBE2I, IDH3G, MEOX2, MOV10, SOX4, DNAJB1, DHX29, IMPDH1, RNASEH2A, HNRNPF, HIST1H3A, EWSR1, DPPA4, NANOG, RC3H1, TRIM25 | DPP7 | SELENBP1, MYCBP, XRN1, FBXO6, CSTB, PLCG1, RIC8A, SARNP, WDR61, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | EDF1 | chr9:139760633 | chr9:140005402 | ENST00000224073 | - | 1 | 5 | 37_113 | 26 | 149 | NR5A2%2C PPARG and NR1H3 |
Hgene | EDF1 | chr9:139760633 | chr9:140005402 | ENST00000371648 | - | 1 | 4 | 37_113 | 26 | 140 | NR5A2%2C PPARG and NR1H3 |
Hgene | EDF1 | chr9:139760633 | chr9:140005402 | ENST00000224073 | - | 1 | 5 | 69_108 | 26 | 149 | TBP and NR5A1 |
Hgene | EDF1 | chr9:139760633 | chr9:140005402 | ENST00000371648 | - | 1 | 4 | 69_108 | 26 | 140 | TBP and NR5A1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EDF1_DPP7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EDF1_DPP7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | DPP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | DPP7 | C0027540 | Necrosis | 1 | CTD_human |