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Fusion gene ID: 10931 |
FusionGeneSummary for EDEM3_GBAP1 |
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Fusion gene information | Fusion gene name: EDEM3_GBAP1 | Fusion gene ID: 10931 | Hgene | Tgene | Gene symbol | EDEM3 | GBAP1 | Gene ID | 80267 | 2630 |
Gene name | ER degradation enhancing alpha-mannosidase like protein 3 | glucosylceramidase beta pseudogene 1 | |
Synonyms | C1orf22 | GBAP | |
Cytomap | 1q25.3 | 1q22 | |
Type of gene | protein-coding | pseudo | |
Description | ER degradation-enhancing alpha-mannosidase-like protein 3ER degradation enhancer, mannosidase alpha-like 3ER degradation-enhancing -mannosidase-like protein 3ER degradation-enhancing alpha-mannosidase-like 3alpha-1,2-mannosidase EDEM3 | glucosidase, beta, acid pseudogene 1glucosidase, beta; acid, pseudogeneglucosylceramidase-like protein | |
Modification date | 20180522 | 20180329 | |
UniProtAcc | Q9BZQ6 | ||
Ensembl transtripts involved in fusion gene | ENST00000318130, ENST00000367512, ENST00000466392, | ENST00000486869, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 3 X 3 X 3=27 |
# samples | 4 | 3 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EDEM3 [Title/Abstract] AND GBAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | M16328 | EDEM3 | chr1 | 184664531 | + | GBAP1 | chr1 | 155210991 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000318130 | ENST00000486869 | EDEM3 | chr1 | 184664531 | + | GBAP1 | chr1 | 155210991 | - |
intron-intron | ENST00000367512 | ENST00000486869 | EDEM3 | chr1 | 184664531 | + | GBAP1 | chr1 | 155210991 | - |
intron-intron | ENST00000466392 | ENST00000486869 | EDEM3 | chr1 | 184664531 | + | GBAP1 | chr1 | 155210991 | - |
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FusionProtFeatures for EDEM3_GBAP1 |
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Hgene | Tgene |
EDEM3 | GBAP1 |
Involved in endoplasmic reticulum-associated degradation(ERAD). Accelerates the glycoprotein ERAD by proteasomes, bycatalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in theN-glycans. Seems to have alpha 1,2-mannosidase activity (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:25092655}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EDEM3_GBAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EDEM3_GBAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EDEM3_GBAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EDEM3_GBAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |