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Fusion gene ID: 10858 |
FusionGeneSummary for EARS2_VMP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EARS2_VMP1 | Fusion gene ID: 10858 | Hgene | Tgene | Gene symbol | EARS2 | VMP1 | Gene ID | 124454 | 81671 |
| Gene name | glutamyl-tRNA synthetase 2, mitochondrial | vacuole membrane protein 1 | |
| Synonyms | COXPD12|MSE1|gluRS | EPG3|TANGO5|TMEM49 | |
| Cytomap | 16p12.2 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable glutamate--tRNA ligase, mitochondrialglutamate tRNA ligase 2, mitochondrialglutamate--tRNA ligaseprobable glutamyl-tRNA synthetase, mitochondrial | vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5JPH6 | Q96GC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000449606, ENST00000563459, ENST00000564987, ENST00000564501, ENST00000563232, | ENST00000262291, ENST00000537567, ENST00000539763, ENST00000536180, ENST00000545362, ENST00000588617, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 24 X 11 X 12=3168 |
| # samples | 2 | 27 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(27/3168*10)=-3.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EARS2 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EARS2 | GO:0006424 | glutamyl-tRNA aminoacylation | 19805282 |
| Hgene | EARS2 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation | 19805282 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-83-5908-01A | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000449606 | ENST00000262291 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000449606 | ENST00000537567 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000449606 | ENST00000539763 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000449606 | ENST00000536180 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000449606 | ENST00000545362 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5CDS-intron | ENST00000449606 | ENST00000588617 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| Frame-shift | ENST00000563459 | ENST00000262291 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| Frame-shift | ENST00000563459 | ENST00000537567 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| Frame-shift | ENST00000563459 | ENST00000539763 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| Frame-shift | ENST00000563459 | ENST00000536180 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| Frame-shift | ENST00000563459 | ENST00000545362 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5CDS-intron | ENST00000563459 | ENST00000588617 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-3CDS | ENST00000564987 | ENST00000262291 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-3CDS | ENST00000564987 | ENST00000537567 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-3CDS | ENST00000564987 | ENST00000539763 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-3CDS | ENST00000564987 | ENST00000536180 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-3CDS | ENST00000564987 | ENST00000545362 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5UTR-intron | ENST00000564987 | ENST00000588617 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000564501 | ENST00000262291 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000564501 | ENST00000537567 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000564501 | ENST00000539763 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000564501 | ENST00000536180 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000564501 | ENST00000545362 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5CDS-intron | ENST00000564501 | ENST00000588617 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000563232 | ENST00000262291 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000563232 | ENST00000537567 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000563232 | ENST00000539763 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000563232 | ENST00000536180 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| In-frame | ENST00000563232 | ENST00000545362 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
| 5CDS-intron | ENST00000563232 | ENST00000588617 | EARS2 | chr16 | 23555835 | - | VMP1 | chr17 | 57915656 | + |
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FusionProtFeatures for EARS2_VMP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EARS2 | VMP1 |
| Catalyzes the attachment of glutamate to tRNA(Glu) in atwo-step reaction: glutamate is first activated by ATP to formGlu-AMP and then transferred to the acceptor end of tRNA(Glu).{ECO:0000250}. | Stress-induced protein that, when overexpressed,promotes formation of intracellular vacuoles followed by celldeath. May be involved in the cytoplasmic vacuolization of acinarcells during the early stage of acute pancreatitis. Plays a rolein the initial stages of the autophagic process through itsinteraction with BECN1 (By similarity). Involved in cell-celladhesion. Plays an essential role in formation of cell junctions.{ECO:0000250, ECO:0000269|PubMed:17724469}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EARS2 | chr16:23555835 | chr17:57915656 | ENST00000449606 | - | 3 | 9 | 45_53 | 161 | 524 | Motif | Note="HIGH" region |
| Hgene | EARS2 | chr16:23555835 | chr17:57915656 | ENST00000563459 | - | 3 | 10 | 45_53 | 161 | 1205 | Motif | Note="HIGH" region |
| Hgene | EARS2 | chr16:23555835 | chr17:57915656 | ENST00000449606 | - | 3 | 9 | 40_42 | 161 | 524 | Region | Glutamate binding |
| Hgene | EARS2 | chr16:23555835 | chr17:57915656 | ENST00000563459 | - | 3 | 10 | 40_42 | 161 | 1205 | Region | Glutamate binding |
| Tgene | >VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 327_363 | 324 | 407 | Topological domain | Cytoplasmic |
| Tgene | >VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 385_406 | 324 | 407 | Topological domain | Extracellular |
| Tgene | >VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 364_384 | 324 | 407 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EARS2 | chr16:23555835 | chr17:57915656 | ENST00000449606 | - | 3 | 9 | 284_288 | 161 | 524 | Motif | Note="KMSKS" region |
| Hgene | >EARS2 | chr16:23555835 | chr17:57915656 | ENST00000563459 | - | 3 | 10 | 284_288 | 161 | 1205 | Motif | Note="KMSKS" region |
| Hgene | >EARS2 | chr16:23555835 | chr17:57915656 | ENST00000449606 | - | 3 | 9 | 228_232 | 161 | 524 | Region | Glutamate binding |
| Hgene | >EARS2 | chr16:23555835 | chr17:57915656 | ENST00000563459 | - | 3 | 10 | 228_232 | 161 | 1205 | Region | Glutamate binding |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 131_250 | 324 | 407 | Topological domain | Extracellular |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 272_273 | 324 | 407 | Topological domain | Cytoplasmic |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 295_305 | 324 | 407 | Topological domain | Extracellular |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 2_43 | 324 | 407 | Topological domain | Cytoplasmic |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 65_77 | 324 | 407 | Topological domain | Extracellular |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 99_109 | 324 | 407 | Topological domain | Cytoplasmic |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 110_130 | 324 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 251_271 | 324 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 274_294 | 324 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 306_326 | 324 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 44_64 | 324 | 407 | Transmembrane | Helical |
| Tgene | VMP1 | chr16:23555835 | chr17:57915656 | ENST00000262291 | + | 9 | 12 | 78_98 | 324 | 407 | Transmembrane | Helical |
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FusionGeneSequence for EARS2_VMP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_244aa MAALLRRLLQRERPSAASGRPVGRREANLGTDAGVAVRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAEN IEDMLEWAGIPPDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRAVPGIGPSLQKPFQEYLE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_732nt ATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGGC ACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAAC TACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAAT ATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCGG TTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCTG AAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGAG GCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGTT GTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_1945nt GGGAGAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCC GCCCCGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGC ACCTGGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATC AGACTCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCG GTCCTGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCT GTTTCTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCAT CTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACT GGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCA AACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGC CTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAG TCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGG AATGTGATGTTCAGCAGCAAACTTGCAACAGACTGGCCTTCTGTTTGTTACTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCAC CGCACAAAAAAAGTTCCTAAGTATGTTAAATATGTCAAGCTTTTTAGGCTTGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAAT GTATATAAATTATCTAGATTGGATAACAGTCTTGCATGTTTATCATGTTACAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCAT CCTCAAAAAAGGGCCATTTTATGATGCATTGCACACCCTCTGGGGAAATTGATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTG GTGTCTTACAAGTGAGCTGACACCATTTTTTATTCTGTGTATTTAGAATGAAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATT CCAAAATTGTGTCCGTTTTCTTGAGCGTTTTGATTTTTTACTTTTAGCTTATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAAC AAGAATTTCTTAAGCTTTCTTTTATTTGCATGAGAGAGCCACTACCAAGGCATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCT AAATGGCACCTCTGGGATTGGCCTACCTGGGGATTTCTTGGTTTGTGAAAACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACT GGAGAGAGAAATTACCCATTTCTAAAAAAAAACCACACTCTGTCGTATCTGTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGAC ACAAATTTATATGTTAACCCAGTTTTCTTGCCGTTCTGTAAGTGTTTTATTCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGA >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_1024nt GGGAGAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCC GCCCCGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGC ACCTGGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATC AGACTCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCG GTCCTGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCT GTTTCTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCAT CTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACT GGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCA AACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGC CTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAG TCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_984nt GGGAGAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCC GCCCCGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGC ACCTGGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATC AGACTCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCG GTCCTGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCT GTTTCTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCAT CTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACT GGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCA AACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGC CTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAG >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_856nt GGGAGAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCC GCCCCGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGC ACCTGGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATC AGACTCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCG GTCCTGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCT GTTTCTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCAT CTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACT GGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCA AACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGC >In-frame_EARS2_ENST00000449606_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_1016nt GGGAGAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCC GCCCCGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGC ACCTGGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATC AGACTCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCG GTCCTGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCT GTTTCTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCAT CTCTGCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACT GGTTGTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCA AACGAATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGC CTTAAATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAG TCCATACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_2301nt ACAACACCCACCGCTCCCGCAGAGGCCGCTGGGAAGAGGCGAGCTGGCTGAGATTGGCCCCCGCAGCAGCCCCTAATCTCTCACAGCCCG GCCGGAAACAGGTGGAGGTTTCTATGGAGACCCGCCTCCTCCGCTCCCAGGTCCGGCCCCTGCCACGCTTTCGCTTTCCCAAGCTGAAGG GGGCGGGTCCGGGAAATAGCCCTTTCTCTGGCCTCTGCCCCCTGGTGGCGAGTGCGGCCGCAGCCGTCCAGGGGGGCGTGGGATTTCGCG CTAGGGGGCCTGTGACTTTAAGGGGCAAGGCTGCGCTGGCTGTGGCGGAGGCCGATTGGCTGGAAGCAGTCCCCGGAAGTGACGCAGGGA GAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCC CGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCT GGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGAC TCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCC TGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTT CTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCT GCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTT GTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACG AATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTA AATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCA TACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATG TGATGTTCAGCAGCAAACTTGCAACAGACTGGCCTTCTGTTTGTTACTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCA CAAAAAAAGTTCCTAAGTATGTTAAATATGTCAAGCTTTTTAGGCTTGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTAT ATAAATTATCTAGATTGGATAACAGTCTTGCATGTTTATCATGTTACAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTC AAAAAAGGGCCATTTTATGATGCATTGCACACCCTCTGGGGAAATTGATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGT CTTACAAGTGAGCTGACACCATTTTTTATTCTGTGTATTTAGAATGAAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAA AATTGTGTCCGTTTTCTTGAGCGTTTTGATTTTTTACTTTTAGCTTATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGA ATTTCTTAAGCTTTCTTTTATTTGCATGAGAGAGCCACTACCAAGGCATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAAT GGCACCTCTGGGATTGGCCTACCTGGGGATTTCTTGGTTTGTGAAAACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAG AGAGAAATTACCCATTTCTAAAAAAAAACCACACTCTGTCGTATCTGTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAA ATTTATATGTTAACCCAGTTTTCTTGCCGTTCTGTAAGTGTTTTATTCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTT >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_1380nt ACAACACCCACCGCTCCCGCAGAGGCCGCTGGGAAGAGGCGAGCTGGCTGAGATTGGCCCCCGCAGCAGCCCCTAATCTCTCACAGCCCG GCCGGAAACAGGTGGAGGTTTCTATGGAGACCCGCCTCCTCCGCTCCCAGGTCCGGCCCCTGCCACGCTTTCGCTTTCCCAAGCTGAAGG GGGCGGGTCCGGGAAATAGCCCTTTCTCTGGCCTCTGCCCCCTGGTGGCGAGTGCGGCCGCAGCCGTCCAGGGGGGCGTGGGATTTCGCG CTAGGGGGCCTGTGACTTTAAGGGGCAAGGCTGCGCTGGCTGTGGCGGAGGCCGATTGGCTGGAAGCAGTCCCCGGAAGTGACGCAGGGA GAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCC CGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCT GGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGAC TCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCC TGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTT CTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCT GCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTT GTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACG AATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTA AATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCA TACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATG >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_1340nt ACAACACCCACCGCTCCCGCAGAGGCCGCTGGGAAGAGGCGAGCTGGCTGAGATTGGCCCCCGCAGCAGCCCCTAATCTCTCACAGCCCG GCCGGAAACAGGTGGAGGTTTCTATGGAGACCCGCCTCCTCCGCTCCCAGGTCCGGCCCCTGCCACGCTTTCGCTTTCCCAAGCTGAAGG GGGCGGGTCCGGGAAATAGCCCTTTCTCTGGCCTCTGCCCCCTGGTGGCGAGTGCGGCCGCAGCCGTCCAGGGGGGCGTGGGATTTCGCG CTAGGGGGCCTGTGACTTTAAGGGGCAAGGCTGCGCTGGCTGTGGCGGAGGCCGATTGGCTGGAAGCAGTCCCCGGAAGTGACGCAGGGA GAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCC CGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCT GGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGAC TCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCC TGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTT CTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCT GCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTT GTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACG AATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTA AATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCA >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_1212nt ACAACACCCACCGCTCCCGCAGAGGCCGCTGGGAAGAGGCGAGCTGGCTGAGATTGGCCCCCGCAGCAGCCCCTAATCTCTCACAGCCCG GCCGGAAACAGGTGGAGGTTTCTATGGAGACCCGCCTCCTCCGCTCCCAGGTCCGGCCCCTGCCACGCTTTCGCTTTCCCAAGCTGAAGG GGGCGGGTCCGGGAAATAGCCCTTTCTCTGGCCTCTGCCCCCTGGTGGCGAGTGCGGCCGCAGCCGTCCAGGGGGGCGTGGGATTTCGCG CTAGGGGGCCTGTGACTTTAAGGGGCAAGGCTGCGCTGGCTGTGGCGGAGGCCGATTGGCTGGAAGCAGTCCCCGGAAGTGACGCAGGGA GAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCC CGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCT GGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGAC TCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCC TGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTT CTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCT GCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTT GTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACG AATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTA >In-frame_EARS2_ENST00000564501_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_1372nt ACAACACCCACCGCTCCCGCAGAGGCCGCTGGGAAGAGGCGAGCTGGCTGAGATTGGCCCCCGCAGCAGCCCCTAATCTCTCACAGCCCG GCCGGAAACAGGTGGAGGTTTCTATGGAGACCCGCCTCCTCCGCTCCCAGGTCCGGCCCCTGCCACGCTTTCGCTTTCCCAAGCTGAAGG GGGCGGGTCCGGGAAATAGCCCTTTCTCTGGCCTCTGCCCCCTGGTGGCGAGTGCGGCCGCAGCCGTCCAGGGGGGCGTGGGATTTCGCG CTAGGGGGCCTGTGACTTTAAGGGGCAAGGCTGCGCTGGCTGTGGCGGAGGCCGATTGGCTGGAAGCAGTCCCCGGAAGTGACGCAGGGA GAAGCCCACGTGTGCTATTCCATCCCACATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCC CGTAGGACGGCGCGAGGCCAACCTGGGCACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCT GGGTGGCCTCCGCACTGCCTTGTACAACTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGAC TCGCGTTGTGCCTGGGGCAGCGGAGAATATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCC TGCTGGGCCCTACCAGCAATCTCAGCGGTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTT CTGCTCACCCCAGCGGCTGGAGCTCCTGAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCT GCAGAAGCCATTTCAGGAGTACCTGGAGGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTT GTCCTGGATGTTTGAAAAGTTGGTCGTTGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACG AATCCAGCAGCGGTTGAACTCAGAGGAGAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTA AATTGGGAGGACTCCAAGCCGGGAAGGAAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCA TACTTTGCACTGACATACTTTTTCCTTCTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000262291_chr17_57915656_+_1914nt CATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGG CACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAA CTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAA TATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCG GTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCT GAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGA GGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGT TGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGA GAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGG AAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTT CTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGCAACAG ACTGGCCTTCTGTTTGTTACTTTCAAAAGGCCCACATGATACAATTAGAGAATTCCCACCGCACAAAAAAAGTTCCTAAGTATGTTAAAT ATGTCAAGCTTTTTAGGCTTGTCACAAATGATTGCTTTGTTTTCCTAAGTCATCAAAATGTATATAAATTATCTAGATTGGATAACAGTC TTGCATGTTTATCATGTTACAATTTAATATTCCATCCTGCCCAACCCTTCCTCTCCCATCCTCAAAAAAGGGCCATTTTATGATGCATTG CACACCCTCTGGGGAAATTGATCTTTAAATTTTGAGACAGTATAAGGAAAATCTGGTTGGTGTCTTACAAGTGAGCTGACACCATTTTTT ATTCTGTGTATTTAGAATGAAGTCTTGAAAAAAACTTTATAAAGACATCTTTAATCATTCCAAAATTGTGTCCGTTTTCTTGAGCGTTTT GATTTTTTACTTTTAGCTTATACCAGCTGAATGGCAGCCTTGCCTAATCCACCTACAACAAGAATTTCTTAAGCTTTCTTTTATTTGCAT GAGAGAGCCACTACCAAGGCATGTTTTGTTATGCTGAAACTGGGCTGCTGCATACTGCTAAATGGCACCTCTGGGATTGGCCTACCTGGG GATTTCTTGGTTTGTGAAAACAGGAGAGGAGAAATATCTCATACAAGTGAAAGGATACTGGAGAGAGAAATTACCCATTTCTAAAAAAAA ACCACACTCTGTCGTATCTGTGTTAATGTTTTCTAGCATGTACTCTGGTTTCAACAGACACAAATTTATATGTTAACCCAGTTTTCTTGC CGTTCTGTAAGTGTTTTATTCTTAGTGTGATTTTTTTCCATTGGGATGTTTTTGATTGAACTTGTTCATTTTGTTTTGCTTGGGAGGAAA >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000537567_chr17_57915656_+_993nt CATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGG CACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAA CTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAA TATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCG GTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCT GAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGA GGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGT TGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGA GAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGG AAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTT CTGTGCTAAGGTAAGGTATCCACCCTCGATGCAATCCACCTTGTGTTTTCTTAGGGTGGAATGTGATGTTCAGCAGCAAACTTGCAACAG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000539763_chr17_57915656_+_953nt CATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGG CACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAA CTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAA TATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCG GTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCT GAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGA GGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGT TGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGA GAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGG AAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTT >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000536180_chr17_57915656_+_825nt CATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGG CACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAA CTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAA TATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCG GTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCT GAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGA GGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGT TGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGA GAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGG >In-frame_EARS2_ENST00000563232_chr16_23555835_-_VMP1_ENST00000545362_chr17_57915656_+_985nt CATGGCGGCGCTCCTGAGGAGACTGCTGCAGCGCGAGAGGCCTTCGGCGGCCTCTGGCCGCCCCGTAGGACGGCGCGAGGCCAACCTGGG CACTGATGCCGGGGTTGCGGTGCGAGTGCGGTTCGCTCCCAGCCCCACAGGCTTCTTGCACCTGGGTGGCCTCCGCACTGCCTTGTACAA CTACATCTTTGCTAAGAAGTACCAGGGGAGCTTCATCCTGAGGCTAGAGGACACAGATCAGACTCGCGTTGTGCCTGGGGCAGCGGAGAA TATTGAGGACATGCTGGAGTGGGCAGGCATCCCGCCTGATGAGAGCCCCCGCCGGGGCGGTCCTGCTGGGCCCTACCAGCAATCTCAGCG GTTGGAGCTGTATGCCCAGGCCACAGAAGCGCTGCTGAAGACCGGAGCTGCTTACCCCTGTTTCTGCTCACCCCAGCGGCTGGAGCTCCT GAAGAAGGAGGCCTTGCGGAACCACCAGACGCCCCGTGCTGTCCCCGGCATAGGTCCATCTCTGCAGAAGCCATTTCAGGAGTACCTGGA GGCTCAACGGCAGAAGCTTCACCACAAAAGCGAAATGGGCACACCACAGGGAGAAAACTGGTTGTCCTGGATGTTTGAAAAGTTGGTCGT TGTCATGGTGTGTTACTTCATCCTATCTATCATTAACTCCATGGCACAAAGTTATGCCAAACGAATCCAGCAGCGGTTGAACTCAGAGGA GAAAACTAAATAAGTAGAGAAAGTTTTAAACTGCAGAAATTGGAGTGGATGGGTTCTGCCTTAAATTGGGAGGACTCCAAGCCGGGAAGG AAAATTCCCTTTTCCAACCTGTATCAATTTTTACAACTTTTTTCCTGAAAGCAGTTTAGTCCATACTTTGCACTGACATACTTTTTCCTT |
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FusionGenePPI for EARS2_VMP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EARS2 | BSG, NTRK1, MAS1 | VMP1 | HGS, ELAVL1, TJP1, KLK11, LPAR6, ERGIC3, FAF2, KRAS, TCTN2, TCTN3, TMEM216, DPEP1, CDH13, MAS1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EARS2_VMP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | EARS2 | Q5JPH6 | DB00142 | Glutamic Acid | Probable glutamate--tRNA ligase, mitochondrial | small molecule | approved|nutraceutical |
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RelatedDiseases for EARS2_VMP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EARS2 | C3554079 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 12 | 3 | ORPHANET;UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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