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Fusion gene ID: 10856 |
FusionGeneSummary for EAPP_USP13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EAPP_USP13 | Fusion gene ID: 10856 | Hgene | Tgene | Gene symbol | EAPP | USP13 | Gene ID | 55837 | 8975 |
| Gene name | E2F associated phosphoprotein | ubiquitin specific peptidase 13 | |
| Synonyms | BM036|C14orf11 | ISOT3|IsoT-3 | |
| Cytomap | 14q13.1 | 3q26.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E2F-associated phosphoprotein | ubiquitin carboxyl-terminal hydrolase 13deubiquitinating enzyme 13ubiquitin specific peptidase 13 (isopeptidase T-3)ubiquitin specific protease 13 (isopeptidase T-3)ubiquitin thioesterase 13ubiquitin thiolesterase 13ubiquitin-specific-processing pro | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q56P03 | Q92995 | |
| Ensembl transtripts involved in fusion gene | ENST00000250454, | ENST00000263966, ENST00000482333, ENST00000496897, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: EAPP [Title/Abstract] AND USP13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EAPP | GO:0008284 | positive regulation of cell proliferation | 15716352 |
| Hgene | EAPP | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 15716352 |
| Hgene | EAPP | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter | 15716352 |
| Tgene | USP13 | GO:0010506 | regulation of autophagy | 21962518 |
| Tgene | USP13 | GO:0035523 | protein K29-linked deubiquitination | 26280536 |
| Tgene | USP13 | GO:0044313 | protein K6-linked deubiquitination | 26280536 |
| Tgene | USP13 | GO:0050821 | protein stabilization | 21659512|26280536 |
| Tgene | USP13 | GO:0070536 | protein K63-linked deubiquitination | 22216260|26280536 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-BB-4217-01A | EAPP | chr14 | 34993903 | - | USP13 | chr3 | 179447977 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000250454 | ENST00000263966 | EAPP | chr14 | 34993903 | - | USP13 | chr3 | 179447977 | + |
| 5CDS-3UTR | ENST00000250454 | ENST00000482333 | EAPP | chr14 | 34993903 | - | USP13 | chr3 | 179447977 | + |
| 5CDS-3UTR | ENST00000250454 | ENST00000496897 | EAPP | chr14 | 34993903 | - | USP13 | chr3 | 179447977 | + |
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FusionProtFeatures for EAPP_USP13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EAPP | USP13 |
| May play an important role in the fine-tuning of bothmajor E2F1 activities, the regulation of the cell-cycle and theinduction of apoptosis. Promotes S-phase entry, and inhibitsp14(ARP) expression. {ECO:0000269|PubMed:15716352}. | Deubiquitinase that mediates deubiquitination of targetproteins such as BECN1, MITF, SKP2 and USP10 and is involved invarious processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop thatcontrols autophagy and p53/TP53 levels: mediates deubiquitinationof BECN1, a key regulator of autophagy, leading to stabilize thePIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, anessential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting theexistence of a regulatory system by which PIK3C3/VPS34-containingcomplexes regulate p53/TP53 protein levels via USP10 and USP13.Recruited by nuclear UFD1 and mediates deubiquitination of SKP2,thereby regulating endoplasmic reticulum-associated degradation(ERAD). Also regulates ERAD through the deubiquitination of UBL4Aa component of the BAG6/BAT3 complex. Mediates stabilization ofSIAH2 independently of deubiquitinase activity: bindsubiquitinated SIAH2 and acts by impairing SIAH2autoubiquitination. Has a weak deubiquitinase activity in vitroand preferentially cleaves 'Lys-63'-linked polyubiquitin chains.In contrast to USP5, it is not able to mediate unanchoredpolyubiquitin disassembly. Able to cleave ISG15 in vitro; however,additional experiments are required to confirm such data.{ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647,ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243,ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260,ECO:0000269|PubMed:24424410}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EAPP | chr14:34993903 | chr3:179447977 | ENST00000250454 | - | 5 | 6 | 122_127 | 193 | 286 | Compositional bias | Note=Poly-Lys |
| Tgene | >USP13 | chr14:34993903 | chr3:179447977 | ENST00000263966 | + | 7 | 21 | 652_693 | 362 | 864 | Domain | UBA 1 |
| Tgene | >USP13 | chr14:34993903 | chr3:179447977 | ENST00000263966 | + | 7 | 21 | 727_767 | 362 | 864 | Domain | UBA 2 |
| Tgene | >USP13 | chr14:34993903 | chr3:179447977 | ENST00000496897 | + | 7 | 21 | 336_861 | 297 | 799 | Domain | Note=USP |
| Tgene | >USP13 | chr14:34993903 | chr3:179447977 | ENST00000496897 | + | 7 | 21 | 652_693 | 297 | 799 | Domain | UBA 1 |
| Tgene | >USP13 | chr14:34993903 | chr3:179447977 | ENST00000496897 | + | 7 | 21 | 727_767 | 297 | 799 | Domain | UBA 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | USP13 | chr14:34993903 | chr3:179447977 | ENST00000263966 | + | 7 | 21 | 336_861 | 362 | 864 | Domain | Note=USP |
| Tgene | USP13 | chr14:34993903 | chr3:179447977 | ENST00000263966 | + | 7 | 21 | 209_281 | 362 | 864 | Zinc finger | UBP-type |
| Tgene | USP13 | chr14:34993903 | chr3:179447977 | ENST00000496897 | + | 7 | 21 | 209_281 | 297 | 799 | Zinc finger | UBP-type |
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FusionGeneSequence for EAPP_USP13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_695aa MNRLPDDYDPYAVEEPSDEEPALSSSEDEVDVLLHGTPDQKRKLIRECLTGESESSSEDEFEKEMEAELNSTMKTMEDKLSSLGTGSSSG NGKVATAPTRYYDDIYFDSDSEDEDRAVQVTKKKKKKQHKIPTNDELLYDPEKDNRDQAWVDAQRRGYHGLGPQRSRQQQPVPNSDAVLN CPACMTTLCLDCQRYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPE FSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRR PLPELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSIDMPDLLDINHLRARGL QPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYG GAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEMENNANANIISEAKPEGPRV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_2085nt ATGAACCGGCTTCCGGATGACTACGACCCCTACGCGGTTGAAGAGCCTAGCGACGAGGAGCCGGCTTTGAGCAGCTCTGAGGATGAAGTG GATGTGCTTTTACATGGAACTCCTGACCAAAAACGAAAACTCATCAGAGAATGTCTTACCGGAGAAAGTGAATCATCTAGTGAAGATGAA TTTGAAAAGGAGATGGAAGCTGAATTAAATTCTACCATGAAAACAATGGAGGACAAGTTATCCTCTCTGGGAACTGGATCTTCCTCAGGA AATGGAAAAGTTGCAACAGCTCCGACAAGGTACTACGATGATATATATTTTGATTCTGATTCCGAGGATGAAGACAGAGCAGTACAGGTG ACCAAGAAAAAAAAGAAGAAACAACACAAGATTCCAACAAATGACGAATTACTGTATGATCCTGAAAAAGATAACAGAGATCAGGCCTGG GTTGATGCACAGAGAAGGGGTTACCATGGTTTGGGACCACAGAGATCACGTCAACAACAGCCTGTTCCAAATAGTGATGCTGTCTTGAAT TGTCCTGCCTGCATGACCACACTTTGCCTTGATTGCCAAAGGTATGTAGGAAACCTTCCCAGAATATTTGACTACTCGCCTTTAGATCCA ACACAAGATTTCAACACACAGATGACTAAGTTAGGACATGGCCTTCTCTCAGGCCAGTATTCAAAGCCTCCGGTGAAATCTGAACTCATT GAACAGGTGATGAAGGAGGAGCACAAGCCACAGCAGAACGGGATCTCTCCGCGCATGTTTAAGGCCTTTGTAAGCAAGAGCCACCCGGAA TTCTCCTCTAACAGGCAGCAAGATGCCCAGGAATTCTTCTTGCACCTGGTGAATCTAGTAGAGAGGAACCGCATCGGCTCAGAAAACCCA AGCGATGTTTTTCGTTTTTTGGTGGAAGAACGCATTCAGTGCTGTCAGACCCGGAAAGTCCGCTACACGGAGAGGGTGGATTACCTGATG CAGTTACCTGTGGCCATGGAGGCGGCAACCAACAAGGATGAACTGATCGCTTATGAACTAACGAGAAGGGAAGCAGAAGCAAACAGAAGA CCCCTTCCTGAGTTGGTACGTGCCAAGATACCATTTAGTGCCTGCCTTCAGGCCTTCTCTGAACCAGAAAATGTTGATGATTTCTGGAGC AGTGCCCTACAAGCAAAGTCTGCGGGTGTGAAAACATCTCGCTTTGCTTCATTCCCTGAATACTTGGTAGTGCAGATAAAGAAGTTCACT TTTGGTCTTGACTGGGTTCCCAAAAAATTTGATGTTTCTATTGATATGCCAGACCTACTTGATATCAACCATCTCCGAGCCAGGGGGTTA CAGCCAGGAGAGGAAGAACTTCCAGACATCAGCCCCCCCATAGTCATTCCTGATGACTCAAAAGATCGCCTGATGAACCAATTGATAGAC CCATCAGACATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGA AATATGGGCGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGA GGGGCAGCTTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATG GGATTTCAGCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAG TTTGAAGAAGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTC AAGGATGGATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAA AAGGAAGGAAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_7427nt GGGCGCTTTAGGGACTGGACTTGCAGTGTAAACAGAGACGCTGCAAATTGCTTGTGGACGGTGTAGGCCGCTGCAGGCCACCATGAACCG GCTTCCGGATGACTACGACCCCTACGCGGTTGAAGAGCCTAGCGACGAGGAGCCGGCTTTGAGCAGCTCTGAGGATGAAGTGGATGTGCT TTTACATGGAACTCCTGACCAAAAACGAAAACTCATCAGAGAATGTCTTACCGGAGAAAGTGAATCATCTAGTGAAGATGAATTTGAAAA GGAGATGGAAGCTGAATTAAATTCTACCATGAAAACAATGGAGGACAAGTTATCCTCTCTGGGAACTGGATCTTCCTCAGGAAATGGAAA AGTTGCAACAGCTCCGACAAGGTACTACGATGATATATATTTTGATTCTGATTCCGAGGATGAAGACAGAGCAGTACAGGTGACCAAGAA AAAAAAGAAGAAACAACACAAGATTCCAACAAATGACGAATTACTGTATGATCCTGAAAAAGATAACAGAGATCAGGCCTGGGTTGATGC ACAGAGAAGGGGTTACCATGGTTTGGGACCACAGAGATCACGTCAACAACAGCCTGTTCCAAATAGTGATGCTGTCTTGAATTGTCCTGC CTGCATGACCACACTTTGCCTTGATTGCCAAAGGTATGTAGGAAACCTTCCCAGAATATTTGACTACTCGCCTTTAGATCCAACACAAGA TTTCAACACACAGATGACTAAGTTAGGACATGGCCTTCTCTCAGGCCAGTATTCAAAGCCTCCGGTGAAATCTGAACTCATTGAACAGGT GATGAAGGAGGAGCACAAGCCACAGCAGAACGGGATCTCTCCGCGCATGTTTAAGGCCTTTGTAAGCAAGAGCCACCCGGAATTCTCCTC TAACAGGCAGCAAGATGCCCAGGAATTCTTCTTGCACCTGGTGAATCTAGTAGAGAGGAACCGCATCGGCTCAGAAAACCCAAGCGATGT TTTTCGTTTTTTGGTGGAAGAACGCATTCAGTGCTGTCAGACCCGGAAAGTCCGCTACACGGAGAGGGTGGATTACCTGATGCAGTTACC TGTGGCCATGGAGGCGGCAACCAACAAGGATGAACTGATCGCTTATGAACTAACGAGAAGGGAAGCAGAAGCAAACAGAAGACCCCTTCC TGAGTTGGTACGTGCCAAGATACCATTTAGTGCCTGCCTTCAGGCCTTCTCTGAACCAGAAAATGTTGATGATTTCTGGAGCAGTGCCCT ACAAGCAAAGTCTGCGGGTGTGAAAACATCTCGCTTTGCTTCATTCCCTGAATACTTGGTAGTGCAGATAAAGAAGTTCACTTTTGGTCT TGACTGGGTTCCCAAAAAATTTGATGTTTCTATTGATATGCCAGACCTACTTGATATCAACCATCTCCGAGCCAGGGGGTTACAGCCAGG AGAGGAAGAACTTCCAGACATCAGCCCCCCCATAGTCATTCCTGATGACTCAAAAGATCGCCTGATGAACCAATTGATAGACCCATCAGA CATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGG CGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGC TTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCA GCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGA AGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGG ATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGG AAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACC AAGCTAAACCTCAAATATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAAC AACTAGACATGAAGGAATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAAT TTCTATTAGTGATGATACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCA TATTGCTGGTGGAGGATCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGC CTCTGGAGAAACCAAATAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAG TTGGGTGGGGCTTTATTTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAAT AGAGCCTCTGCAATGAAAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGT GAGACTTTTACTAGAAAAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAA AAAGCAAGTAAATATTTTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCT GAGTTATGCCTTTAAGTGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGT ACTTTGTCAAAGGTAGGTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTC TTTTTACCATCTCACATGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGC CTCCGTTTCCTTGTTTTTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGAT GTGACCAACAGTGTGATCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTG GTTATTTCAGCATTTTAGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATA ATTTTCCTACTGGTCCGTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCT GTTTAACATGTATTTGTTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACAT TGGGTTAGGATGTAGTGAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGAC CGAGAGACATGGTGTCTAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCC TGTGCCTCACTGTCCTCATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACA GTGAACCTTCAATGAGTAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTG GGAACAAATGAGATTGGCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAAC TTGGATTTCCTAAAGCAGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCC CCTTAGGGCAGAGTGAGTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTG TTTTTTGGAATTGGGGGTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAAT AAAACTTTTAAAAATCAGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCT AGACATGTTGTAAAAAAATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATAT GTGCTATTCTTTACTTCAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTAT CTCAATATATACAAGGCAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAA AAGTGGAATAACGTGTGGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTC CCTGTATATGGGTGTCTGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTC TTTGGAAAAGGTAATGTATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTG GGATTTTCTTTTAAAGAAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAAT ATTTTGGAATTGACCAGGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAG CGGGGATAGCTCGAGCCTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGG GTCTGTATCCTGACTCCACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAG ATTAGCTCCAAAGTCCTCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATC ACTTAGAGGTTTGGATGTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCC CTCTGTTTGTATTCCTGCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTG CCAAGGCTGGAGTACAGTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCT GGGATTACTGGCGCACGCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAA CTCTTGACCTCAACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGA AAAAAACAACTTTCTAGTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAA GCCTCAGAACTGCCTTCAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCT AGAGCTGTGATCCCCAAATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATC ACATCAGTACATGCCTTCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAG ATAAAAGAAATCCTACGCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACT CCATAAATCACTCTAAAAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTAC TCAAAGTTTGGCTTGTTCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAA ATATTTCACCAATATTTCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTAT ATAATTGAAATTAAAATTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTT ATACTTCTATTGGACAGCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTAT CTAAATAGACAGAAACAACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTT CTGCCGAAAAACCAATATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGG AGCTGCTACCTTTGCTCTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAA AATCCTCTTGTGGTTTCCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGA TGTGCCGCTTGTCTCAGCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTT GTATTTATTTTATTTTGCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATG |
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FusionGenePPI for EAPP_USP13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EAPP | AAR2, ELAVL1, UBQLN4, UBE3A, DDX23, TSSC4, USB1, SNRNP200, GPATCH1, DHX35, ECD, CDC5L, CRNKL1, IGHA1, WDR83, LZTS2, CD2BP2, SNRPN, SNRPE, KIAA1143, SLX1A, PRPF8, EFTUD2, AQR, CWC22, DHX38, DHX8, EAPP, HSF1, ISY1, NCDN, PLRG1, PRPF19, PRPF6, RUVBL1, RUVBL2, SLU7, SMYD4, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNW1, SRRM2, XAB2, ZNHIT2, USP39, SLC7A6OS | USP13 | DVL1, FUNDC2, SPRR2C, MYO15A, MRPL20, FNBP1L, TRIM55, TRIM63, CYLD, DLST, NEDD8, OGDH, UFD1L, SMC1A, UBL4A, ATXN3, USP5, SMC3, FAM115A, FAF2, CACYBP, KCTD3, NPLOC4, DIABLO, ITCH, KCTD10, PMS1, SIAH2, SKP2, UBC, RAD23A, THOC7, THOC1, UBE3C, LAPTM5, STAT1, PTEN, MOV10, VCP, AMFR, BAG6, GET4, SCCPDH, RPP25, YTHDF2, SYNCRIP, ACLY, TMEM173, RAD21, ZEB1, UIMC1, MDC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EAPP_USP13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EAPP_USP13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | USP13 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Tgene | USP13 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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