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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10856

FusionGeneSummary for EAPP_USP13

check button Fusion gene summary
Fusion gene informationFusion gene name: EAPP_USP13
Fusion gene ID: 10856
HgeneTgene
Gene symbol

EAPP

USP13

Gene ID

55837

8975

Gene nameE2F associated phosphoproteinubiquitin specific peptidase 13
SynonymsBM036|C14orf11ISOT3|IsoT-3
Cytomap

14q13.1

3q26.33

Type of geneprotein-codingprotein-coding
DescriptionE2F-associated phosphoproteinubiquitin carboxyl-terminal hydrolase 13deubiquitinating enzyme 13ubiquitin specific peptidase 13 (isopeptidase T-3)ubiquitin specific protease 13 (isopeptidase T-3)ubiquitin thioesterase 13ubiquitin thiolesterase 13ubiquitin-specific-processing pro
Modification date2018052320180519
UniProtAcc

Q56P03

Q92995

Ensembl transtripts involved in fusion geneENST00000250454, ENST00000263966, 
ENST00000482333, ENST00000496897, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EAPP [Title/Abstract] AND USP13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEAPP

GO:0008284

positive regulation of cell proliferation

15716352

HgeneEAPP

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

15716352

HgeneEAPP

GO:0034244

negative regulation of transcription elongation from RNA polymerase II promoter

15716352

TgeneUSP13

GO:0010506

regulation of autophagy

21962518

TgeneUSP13

GO:0035523

protein K29-linked deubiquitination

26280536

TgeneUSP13

GO:0044313

protein K6-linked deubiquitination

26280536

TgeneUSP13

GO:0050821

protein stabilization

21659512|26280536

TgeneUSP13

GO:0070536

protein K63-linked deubiquitination

22216260|26280536


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BB-4217-01AEAPPchr14

34993903

-USP13chr3

179447977

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000250454ENST00000263966EAPPchr14

34993903

-USP13chr3

179447977

+
5CDS-3UTRENST00000250454ENST00000482333EAPPchr14

34993903

-USP13chr3

179447977

+
5CDS-3UTRENST00000250454ENST00000496897EAPPchr14

34993903

-USP13chr3

179447977

+

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FusionProtFeatures for EAPP_USP13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EAPP

Q56P03

USP13

Q92995

May play an important role in the fine-tuning of bothmajor E2F1 activities, the regulation of the cell-cycle and theinduction of apoptosis. Promotes S-phase entry, and inhibitsp14(ARP) expression. {ECO:0000269|PubMed:15716352}. Deubiquitinase that mediates deubiquitination of targetproteins such as BECN1, MITF, SKP2 and USP10 and is involved invarious processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop thatcontrols autophagy and p53/TP53 levels: mediates deubiquitinationof BECN1, a key regulator of autophagy, leading to stabilize thePIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, anessential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting theexistence of a regulatory system by which PIK3C3/VPS34-containingcomplexes regulate p53/TP53 protein levels via USP10 and USP13.Recruited by nuclear UFD1 and mediates deubiquitination of SKP2,thereby regulating endoplasmic reticulum-associated degradation(ERAD). Also regulates ERAD through the deubiquitination of UBL4Aa component of the BAG6/BAT3 complex. Mediates stabilization ofSIAH2 independently of deubiquitinase activity: bindsubiquitinated SIAH2 and acts by impairing SIAH2autoubiquitination. Has a weak deubiquitinase activity in vitroand preferentially cleaves 'Lys-63'-linked polyubiquitin chains.In contrast to USP5, it is not able to mediate unanchoredpolyubiquitin disassembly. Able to cleave ISG15 in vitro; however,additional experiments are required to confirm such data.{ECO:0000269|PubMed:17653289, ECO:0000269|PubMed:21571647,ECO:0000269|PubMed:21659512, ECO:0000269|PubMed:21811243,ECO:0000269|PubMed:21962518, ECO:0000269|PubMed:22216260,ECO:0000269|PubMed:24424410}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEAPPchr14:34993903chr3:179447977ENST00000250454-56122_127193286Compositional biasNote=Poly-Lys
TgeneUSP13chr14:34993903chr3:179447977ENST00000263966+721652_693362864DomainUBA 1
TgeneUSP13chr14:34993903chr3:179447977ENST00000263966+721727_767362864DomainUBA 2
TgeneUSP13chr14:34993903chr3:179447977ENST00000496897+721336_861297799DomainNote=USP
TgeneUSP13chr14:34993903chr3:179447977ENST00000496897+721652_693297799DomainUBA 1
TgeneUSP13chr14:34993903chr3:179447977ENST00000496897+721727_767297799DomainUBA 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUSP13chr14:34993903chr3:179447977ENST00000263966+721336_861362864DomainNote=USP
TgeneUSP13chr14:34993903chr3:179447977ENST00000263966+721209_281362864Zinc fingerUBP-type
TgeneUSP13chr14:34993903chr3:179447977ENST00000496897+721209_281297799Zinc fingerUBP-type


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FusionGeneSequence for EAPP_USP13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_695aa
MNRLPDDYDPYAVEEPSDEEPALSSSEDEVDVLLHGTPDQKRKLIRECLTGESESSSEDEFEKEMEAELNSTMKTMEDKLSSLGTGSSSG
NGKVATAPTRYYDDIYFDSDSEDEDRAVQVTKKKKKKQHKIPTNDELLYDPEKDNRDQAWVDAQRRGYHGLGPQRSRQQQPVPNSDAVLN
CPACMTTLCLDCQRYVGNLPRIFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPE
FSSNRQQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAMEAATNKDELIAYELTRREAEANRR
PLPELVRAKIPFSACLQAFSEPENVDDFWSSALQAKSAGVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSIDMPDLLDINHLRARGL
QPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWIIVHMEEPDFAEPLTMPGYG
GAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEMENNANANIISEAKPEGPRV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_2085nt
ATGAACCGGCTTCCGGATGACTACGACCCCTACGCGGTTGAAGAGCCTAGCGACGAGGAGCCGGCTTTGAGCAGCTCTGAGGATGAAGTG
GATGTGCTTTTACATGGAACTCCTGACCAAAAACGAAAACTCATCAGAGAATGTCTTACCGGAGAAAGTGAATCATCTAGTGAAGATGAA
TTTGAAAAGGAGATGGAAGCTGAATTAAATTCTACCATGAAAACAATGGAGGACAAGTTATCCTCTCTGGGAACTGGATCTTCCTCAGGA
AATGGAAAAGTTGCAACAGCTCCGACAAGGTACTACGATGATATATATTTTGATTCTGATTCCGAGGATGAAGACAGAGCAGTACAGGTG
ACCAAGAAAAAAAAGAAGAAACAACACAAGATTCCAACAAATGACGAATTACTGTATGATCCTGAAAAAGATAACAGAGATCAGGCCTGG
GTTGATGCACAGAGAAGGGGTTACCATGGTTTGGGACCACAGAGATCACGTCAACAACAGCCTGTTCCAAATAGTGATGCTGTCTTGAAT
TGTCCTGCCTGCATGACCACACTTTGCCTTGATTGCCAAAGGTATGTAGGAAACCTTCCCAGAATATTTGACTACTCGCCTTTAGATCCA
ACACAAGATTTCAACACACAGATGACTAAGTTAGGACATGGCCTTCTCTCAGGCCAGTATTCAAAGCCTCCGGTGAAATCTGAACTCATT
GAACAGGTGATGAAGGAGGAGCACAAGCCACAGCAGAACGGGATCTCTCCGCGCATGTTTAAGGCCTTTGTAAGCAAGAGCCACCCGGAA
TTCTCCTCTAACAGGCAGCAAGATGCCCAGGAATTCTTCTTGCACCTGGTGAATCTAGTAGAGAGGAACCGCATCGGCTCAGAAAACCCA
AGCGATGTTTTTCGTTTTTTGGTGGAAGAACGCATTCAGTGCTGTCAGACCCGGAAAGTCCGCTACACGGAGAGGGTGGATTACCTGATG
CAGTTACCTGTGGCCATGGAGGCGGCAACCAACAAGGATGAACTGATCGCTTATGAACTAACGAGAAGGGAAGCAGAAGCAAACAGAAGA
CCCCTTCCTGAGTTGGTACGTGCCAAGATACCATTTAGTGCCTGCCTTCAGGCCTTCTCTGAACCAGAAAATGTTGATGATTTCTGGAGC
AGTGCCCTACAAGCAAAGTCTGCGGGTGTGAAAACATCTCGCTTTGCTTCATTCCCTGAATACTTGGTAGTGCAGATAAAGAAGTTCACT
TTTGGTCTTGACTGGGTTCCCAAAAAATTTGATGTTTCTATTGATATGCCAGACCTACTTGATATCAACCATCTCCGAGCCAGGGGGTTA
CAGCCAGGAGAGGAAGAACTTCCAGACATCAGCCCCCCCATAGTCATTCCTGATGACTCAAAAGATCGCCTGATGAACCAATTGATAGAC
CCATCAGACATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGA
AATATGGGCGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGA
GGGGCAGCTTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATG
GGATTTCAGCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAG
TTTGAAGAAGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTC
AAGGATGGATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAA
AAGGAAGGAAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_EAPP_ENST00000250454_chr14_34993903_-_USP13_ENST00000263966_chr3_179447977_+_7427nt
GGGCGCTTTAGGGACTGGACTTGCAGTGTAAACAGAGACGCTGCAAATTGCTTGTGGACGGTGTAGGCCGCTGCAGGCCACCATGAACCG
GCTTCCGGATGACTACGACCCCTACGCGGTTGAAGAGCCTAGCGACGAGGAGCCGGCTTTGAGCAGCTCTGAGGATGAAGTGGATGTGCT
TTTACATGGAACTCCTGACCAAAAACGAAAACTCATCAGAGAATGTCTTACCGGAGAAAGTGAATCATCTAGTGAAGATGAATTTGAAAA
GGAGATGGAAGCTGAATTAAATTCTACCATGAAAACAATGGAGGACAAGTTATCCTCTCTGGGAACTGGATCTTCCTCAGGAAATGGAAA
AGTTGCAACAGCTCCGACAAGGTACTACGATGATATATATTTTGATTCTGATTCCGAGGATGAAGACAGAGCAGTACAGGTGACCAAGAA
AAAAAAGAAGAAACAACACAAGATTCCAACAAATGACGAATTACTGTATGATCCTGAAAAAGATAACAGAGATCAGGCCTGGGTTGATGC
ACAGAGAAGGGGTTACCATGGTTTGGGACCACAGAGATCACGTCAACAACAGCCTGTTCCAAATAGTGATGCTGTCTTGAATTGTCCTGC
CTGCATGACCACACTTTGCCTTGATTGCCAAAGGTATGTAGGAAACCTTCCCAGAATATTTGACTACTCGCCTTTAGATCCAACACAAGA
TTTCAACACACAGATGACTAAGTTAGGACATGGCCTTCTCTCAGGCCAGTATTCAAAGCCTCCGGTGAAATCTGAACTCATTGAACAGGT
GATGAAGGAGGAGCACAAGCCACAGCAGAACGGGATCTCTCCGCGCATGTTTAAGGCCTTTGTAAGCAAGAGCCACCCGGAATTCTCCTC
TAACAGGCAGCAAGATGCCCAGGAATTCTTCTTGCACCTGGTGAATCTAGTAGAGAGGAACCGCATCGGCTCAGAAAACCCAAGCGATGT
TTTTCGTTTTTTGGTGGAAGAACGCATTCAGTGCTGTCAGACCCGGAAAGTCCGCTACACGGAGAGGGTGGATTACCTGATGCAGTTACC
TGTGGCCATGGAGGCGGCAACCAACAAGGATGAACTGATCGCTTATGAACTAACGAGAAGGGAAGCAGAAGCAAACAGAAGACCCCTTCC
TGAGTTGGTACGTGCCAAGATACCATTTAGTGCCTGCCTTCAGGCCTTCTCTGAACCAGAAAATGTTGATGATTTCTGGAGCAGTGCCCT
ACAAGCAAAGTCTGCGGGTGTGAAAACATCTCGCTTTGCTTCATTCCCTGAATACTTGGTAGTGCAGATAAAGAAGTTCACTTTTGGTCT
TGACTGGGTTCCCAAAAAATTTGATGTTTCTATTGATATGCCAGACCTACTTGATATCAACCATCTCCGAGCCAGGGGGTTACAGCCAGG
AGAGGAAGAACTTCCAGACATCAGCCCCCCCATAGTCATTCCTGATGACTCAAAAGATCGCCTGATGAACCAATTGATAGACCCATCAGA
CATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGG
CGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGC
TTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCA
GCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGA
AGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGG
ATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGG
AAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACC
AAGCTAAACCTCAAATATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAAC
AACTAGACATGAAGGAATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAAT
TTCTATTAGTGATGATACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCA
TATTGCTGGTGGAGGATCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGC
CTCTGGAGAAACCAAATAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAG
TTGGGTGGGGCTTTATTTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAAT
AGAGCCTCTGCAATGAAAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGT
GAGACTTTTACTAGAAAAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAA
AAAGCAAGTAAATATTTTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCT
GAGTTATGCCTTTAAGTGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGT
ACTTTGTCAAAGGTAGGTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTC
TTTTTACCATCTCACATGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGC
CTCCGTTTCCTTGTTTTTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGAT
GTGACCAACAGTGTGATCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTG
GTTATTTCAGCATTTTAGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATA
ATTTTCCTACTGGTCCGTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCT
GTTTAACATGTATTTGTTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACAT
TGGGTTAGGATGTAGTGAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGAC
CGAGAGACATGGTGTCTAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCC
TGTGCCTCACTGTCCTCATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACA
GTGAACCTTCAATGAGTAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTG
GGAACAAATGAGATTGGCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAAC
TTGGATTTCCTAAAGCAGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCC
CCTTAGGGCAGAGTGAGTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTG
TTTTTTGGAATTGGGGGTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAAT
AAAACTTTTAAAAATCAGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCT
AGACATGTTGTAAAAAAATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATAT
GTGCTATTCTTTACTTCAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTAT
CTCAATATATACAAGGCAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAA
AAGTGGAATAACGTGTGGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTC
CCTGTATATGGGTGTCTGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTC
TTTGGAAAAGGTAATGTATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTG
GGATTTTCTTTTAAAGAAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAAT
ATTTTGGAATTGACCAGGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAG
CGGGGATAGCTCGAGCCTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGG
GTCTGTATCCTGACTCCACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAG
ATTAGCTCCAAAGTCCTCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATC
ACTTAGAGGTTTGGATGTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCC
CTCTGTTTGTATTCCTGCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTG
CCAAGGCTGGAGTACAGTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCT
GGGATTACTGGCGCACGCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAA
CTCTTGACCTCAACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGA
AAAAAACAACTTTCTAGTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAA
GCCTCAGAACTGCCTTCAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCT
AGAGCTGTGATCCCCAAATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATC
ACATCAGTACATGCCTTCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAG
ATAAAAGAAATCCTACGCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACT
CCATAAATCACTCTAAAAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTAC
TCAAAGTTTGGCTTGTTCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAA
ATATTTCACCAATATTTCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTAT
ATAATTGAAATTAAAATTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTT
ATACTTCTATTGGACAGCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTAT
CTAAATAGACAGAAACAACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTT
CTGCCGAAAAACCAATATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGG
AGCTGCTACCTTTGCTCTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAA
AATCCTCTTGTGGTTTCCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGA
TGTGCCGCTTGTCTCAGCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTT
GTATTTATTTTATTTTGCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATG


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FusionGenePPI for EAPP_USP13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EAPPAAR2, ELAVL1, UBQLN4, UBE3A, DDX23, TSSC4, USB1, SNRNP200, GPATCH1, DHX35, ECD, CDC5L, CRNKL1, IGHA1, WDR83, LZTS2, CD2BP2, SNRPN, SNRPE, KIAA1143, SLX1A, PRPF8, EFTUD2, AQR, CWC22, DHX38, DHX8, EAPP, HSF1, ISY1, NCDN, PLRG1, PRPF19, PRPF6, RUVBL1, RUVBL2, SLU7, SMYD4, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNW1, SRRM2, XAB2, ZNHIT2, USP39, SLC7A6OSUSP13DVL1, FUNDC2, SPRR2C, MYO15A, MRPL20, FNBP1L, TRIM55, TRIM63, CYLD, DLST, NEDD8, OGDH, UFD1L, SMC1A, UBL4A, ATXN3, USP5, SMC3, FAM115A, FAF2, CACYBP, KCTD3, NPLOC4, DIABLO, ITCH, KCTD10, PMS1, SIAH2, SKP2, UBC, RAD23A, THOC7, THOC1, UBE3C, LAPTM5, STAT1, PTEN, MOV10, VCP, AMFR, BAG6, GET4, SCCPDH, RPP25, YTHDF2, SYNCRIP, ACLY, TMEM173, RAD21, ZEB1, UIMC1, MDC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EAPP_USP13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EAPP_USP13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUSP13C0037274Dermatologic disorders1CTD_human
TgeneUSP13C0311375Arsenic Poisoning1CTD_human