	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 10815

FusionGeneSummary for DYRK1A_TTC3

Fusion gene summary

Fusion gene information	Fusion gene name: DYRK1A_TTC3
	Fusion gene ID: 10815
		Hgene	Tgene
	Gene symbol	DYRK1A	TTC3
	Gene ID	1859	7267
	Gene name	dual specificity tyrosine phosphorylation regulated kinase 1A	tetratricopeptide repeat domain 3
	Synonyms	DYRK\|DYRK1\|HP86\|MNB\|MNBH\|MRD7	DCRR1\|RNF105\|TPRDIII
	Cytomap	21q22.13	21q22.13
	Type of gene	protein-coding	protein-coding
	Description	dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs	E3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3
	Modification date	20180522	20180522
	UniProtAcc	Q13627	P53804
	Ensembl transtripts involved in fusion gene	ENST00000462274, ENST00000338785, ENST00000451934, ENST00000321219, ENST00000339659, ENST00000398960, ENST00000398956, ENST00000455387,	ENST00000355666, ENST00000399017, ENST00000354749, ENST00000479930, ENST00000540756, ENST00000399010,
Fusion gene scores	* DoF score	16 X 9 X 10=1440	9 X 12 X 7=756
	# samples	20	14
	** MAII score	log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/756*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DYRK1A [Title/Abstract] AND TTC3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DYRK1A	GO:0018108	peptidyl-tyrosine phosphorylation	9748265
Hgene	DYRK1A	GO:0033120	positive regulation of RNA splicing	28377597
Hgene	DYRK1A	GO:0038083	peptidyl-tyrosine autophosphorylation	24327345
Tgene	TTC3	GO:0006511	ubiquitin-dependent protein catabolic process	20059950
Tgene	TTC3	GO:0070936	protein K48-linked ubiquitination	20059950

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AR-A0U3-01A	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
TCGA	LD	LAML	TCGA-AB-2807-03A	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
TCGA	RV	LUAD	TCGA-67-3771-01A	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
TCGA	LD	STAD	TCGA-VQ-A8P8-01A	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
TCGA	LD	STAD	TCGA-VQ-A8PM-01A	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000462274	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
3UTR-3CDS	ENST00000462274	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
3UTR-3CDS	ENST00000462274	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
3UTR-3UTR	ENST00000462274	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
3UTR-5UTR	ENST00000462274	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
3UTR-intron	ENST00000462274	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-3CDS	ENST00000338785	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-3CDS	ENST00000338785	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-3CDS	ENST00000338785	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-3UTR	ENST00000338785	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-5UTR	ENST00000338785	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
5UTR-intron	ENST00000338785	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000451934	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000451934	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000451934	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000451934	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000451934	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000451934	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000321219	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000321219	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000321219	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000321219	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000321219	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000321219	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000339659	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000339659	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000339659	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000339659	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000339659	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000339659	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398960	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398960	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398960	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000398960	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000398960	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000398960	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398956	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398956	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000398956	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000398956	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000398956	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000398956	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000455387	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000455387	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-intron	ENST00000455387	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000462274	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000462274	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000462274	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000462274	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000462274	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-intron	ENST00000462274	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000338785	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000338785	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000338785	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000338785	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000338785	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000338785	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000451934	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000451934	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000451934	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000451934	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000451934	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000451934	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000321219	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000321219	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000321219	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000321219	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000321219	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000321219	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000339659	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000339659	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000339659	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000339659	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000339659	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000339659	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398960	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398960	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398960	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000398960	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000398960	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000398960	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398956	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398956	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
Frame-shit	ENST00000398956	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-3UTR	ENST00000398956	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-5UTR	ENST00000398956	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
5CDS-intron	ENST00000398956	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000455387	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3UTR	ENST00000455387	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-5UTR	ENST00000455387	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-intron	ENST00000455387	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38480692	+
intron-3CDS	ENST00000462274	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3CDS	ENST00000462274	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3CDS	ENST00000462274	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3UTR	ENST00000462274	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-intron	ENST00000462274	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-intron	ENST00000462274	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000338785	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000338785	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000338785	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000338785	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000338785	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000338785	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000451934	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000451934	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000451934	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000451934	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000451934	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000451934	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000321219	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000321219	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000321219	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000321219	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000321219	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000321219	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000339659	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000339659	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000339659	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000339659	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000339659	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000339659	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398960	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398960	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398960	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000398960	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000398960	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000398960	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398956	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398956	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
Frame-shit	ENST00000398956	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-3UTR	ENST00000398956	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000398956	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
5CDS-intron	ENST00000398956	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3CDS	ENST00000455387	ENST00000355666	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3CDS	ENST00000455387	ENST00000399017	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3CDS	ENST00000455387	ENST00000354749	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-3UTR	ENST00000455387	ENST00000479930	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-intron	ENST00000455387	ENST00000540756	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
intron-intron	ENST00000455387	ENST00000399010	DYRK1A	chr21	38792686	+	TTC3	chr21	38560796	+
3UTR-3CDS	ENST00000462274	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
3UTR-3CDS	ENST00000462274	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
3UTR-3CDS	ENST00000462274	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
3UTR-3UTR	ENST00000462274	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
3UTR-intron	ENST00000462274	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
3UTR-intron	ENST00000462274	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-3CDS	ENST00000338785	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-3CDS	ENST00000338785	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-3CDS	ENST00000338785	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-3UTR	ENST00000338785	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-intron	ENST00000338785	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
5UTR-intron	ENST00000338785	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000451934	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000451934	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000451934	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000451934	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000451934	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000451934	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000321219	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000321219	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000321219	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000321219	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000321219	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000321219	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000339659	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000339659	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000339659	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000339659	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000339659	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000339659	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398960	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398960	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398960	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000398960	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000398960	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000398960	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398956	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398956	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000398956	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000398956	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000398956	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000398956	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000455387	ENST00000355666	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000455387	ENST00000399017	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3CDS	ENST00000455387	ENST00000354749	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-3UTR	ENST00000455387	ENST00000479930	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000455387	ENST00000540756	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+
intron-intron	ENST00000455387	ENST00000399010	DYRK1A	chr21	38739930	+	TTC3	chr21	38567976	+

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FusionProtFeatures for DYRK1A_TTC3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DYRK1A Q13627	TTC3 P53804
Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. May play a rolein a signaling pathway regulating nuclear functions of cellproliferation. Modulates alternative splicing by phosphorylatingthe splice factor SRSF6 (By similarity). Exhibits a substratepreference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates theapoptotic process. Promotes cell survival upon genotoxic stressthrough phosphorylation of SIRT1. This in turn inhibits TP53activity and apoptosis (By similarity).{ECO:0000250\|UniProtKB:Q61214, ECO:0000250\|UniProtKB:Q9NR20,ECO:0000269\|PubMed:20981014, ECO:0000269\|PubMed:21127067,ECO:0000269\|PubMed:23665168, ECO:0000269\|PubMed:8769099}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for DYRK1A_TTC3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DYRK1A_TTC3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
DYRK1A	SFN, SRSF4, CCNL2, SRSF5, CLASRP, SRSF1, DCAF7, DNM1, HIST1H2BB, HIST1H3A, HIST1H4A, YWHAG, ELAVL1, CLTC, SH3GL2, ISG15, AMPH, PRD, HIPK2, MAP3K1, LATS2, LIN52, SMAD3, MAP3K5, SNCA, APP, BARD1, TRAF3, RBL1, RB1, LZTS2, TROAP, CCNA2, PRKAR1A, RBL2, CREBBP, EP300, FAM117B, GLCCI1, FAM53C, FAM117A, RNF169, DYNLL1, ABCD3, DYNLL2, SIPA1L1, FNTA, FNTB, PPP1R3F, KIAA0232, CCDC8, PRKACA, PRKACB, MOV10, NXF1, RFPL2, CTBP1, LIPH, NTRK1, MED23, XPO1, TBP, ID2, DYRK1A, EGLN2, FOXR2, PARK2, RAD54L2, BTRC, C10orf71, LRCH3, NXF2, TBC1D7, TSC1, TRIM25, BRCA1	TTC3	AKT1, AKT2, AKT3, UBE3A, UBC, UBE2D2, HSPB1, CSNK2A2, RAB5C, FGFR1OP, WAPAL, PARD6A, SMC6, KIF18A, DSN1, KRBOX4, DYNC2LI1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for DYRK1A_TTC3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DYRK1A_TTC3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 10815

FusionGeneSummary for DYRK1A_TTC3

FusionProtFeatures for DYRK1A_TTC3

FusionGeneSequence for DYRK1A_TTC3

FusionGenePPI for DYRK1A_TTC3

RelatedDrugs for DYRK1A_TTC3

RelatedDiseases for DYRK1A_TTC3