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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10815

FusionGeneSummary for DYRK1A_TTC3

check button Fusion gene summary
Fusion gene informationFusion gene name: DYRK1A_TTC3
Fusion gene ID: 10815
HgeneTgene
Gene symbol

DYRK1A

TTC3

Gene ID

1859

7267

Gene namedual specificity tyrosine phosphorylation regulated kinase 1Atetratricopeptide repeat domain 3
SynonymsDYRK|DYRK1|HP86|MNB|MNBH|MRD7DCRR1|RNF105|TPRDIII
Cytomap

21q22.13

21q22.13

Type of geneprotein-codingprotein-coding
Descriptiondual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologsE3 ubiquitin-protein ligase TTC3RING finger protein 105RING-type E3 ubiquitin transferase TTC3TPR repeat protein 3TPR repeat protein Dtetratricopeptide repeat protein 3
Modification date2018052220180522
UniProtAcc

Q13627

P53804

Ensembl transtripts involved in fusion geneENST00000462274, ENST00000338785, 
ENST00000451934, ENST00000321219, 
ENST00000339659, ENST00000398960, 
ENST00000398956, ENST00000455387, 
ENST00000355666, ENST00000399017, 
ENST00000354749, ENST00000479930, 
ENST00000540756, ENST00000399010, 
Fusion gene scores* DoF score16 X 9 X 10=14409 X 12 X 7=756
# samples 2014
** MAII scorelog2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/756*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DYRK1A [Title/Abstract] AND TTC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDYRK1A

GO:0018108

peptidyl-tyrosine phosphorylation

9748265

HgeneDYRK1A

GO:0033120

positive regulation of RNA splicing

28377597

HgeneDYRK1A

GO:0038083

peptidyl-tyrosine autophosphorylation

24327345

TgeneTTC3

GO:0006511

ubiquitin-dependent protein catabolic process

20059950

TgeneTTC3

GO:0070936

protein K48-linked ubiquitination

20059950


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0U3-01ADYRK1Achr21

38739930

+TTC3chr21

38480692

+
TCGALDLAMLTCGA-AB-2807-03ADYRK1Achr21

38792686

+TTC3chr21

38480692

+
TCGARVLUADTCGA-67-3771-01ADYRK1Achr21

38792686

+TTC3chr21

38560796

+
TCGALDSTADTCGA-VQ-A8P8-01ADYRK1Achr21

38792686

+TTC3chr21

38480692

+
TCGALDSTADTCGA-VQ-A8PM-01ADYRK1Achr21

38739930

+TTC3chr21

38567976

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462274ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
3UTR-3CDSENST00000462274ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
3UTR-3CDSENST00000462274ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
3UTR-3UTRENST00000462274ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
3UTR-5UTRENST00000462274ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
3UTR-intronENST00000462274ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-3CDSENST00000338785ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-3CDSENST00000338785ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-3CDSENST00000338785ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-3UTRENST00000338785ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-5UTRENST00000338785ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
5UTR-intronENST00000338785ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000451934ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000451934ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000451934ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000451934ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000451934ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000451934ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000321219ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000321219ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000321219ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000321219ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000321219ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000321219ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000339659ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000339659ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000339659ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000339659ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000339659ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000339659ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398960ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398960ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398960ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000398960ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000398960ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000398960ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398956ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398956ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000398956ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000398956ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000398956ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000398956ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3UTRENST00000455387ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-5UTRENST00000455387ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-intronENST00000455387ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38480692

+
intron-3CDSENST00000462274ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000462274ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000462274ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3UTRENST00000462274ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-5UTRENST00000462274ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-intronENST00000462274ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000338785ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000338785ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000338785ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000338785ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000338785ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000338785ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000451934ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000451934ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000451934ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000451934ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000451934ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000451934ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000321219ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000321219ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000321219ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000321219ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000321219ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000321219ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000339659ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000339659ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000339659ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000339659ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000339659ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000339659ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398960ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398960ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398960ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000398960ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000398960ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000398960ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398956ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398956ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
Frame-shitENST00000398956ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-3UTRENST00000398956ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-5UTRENST00000398956ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
5CDS-intronENST00000398956ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000455387ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3UTRENST00000455387ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-5UTRENST00000455387ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-intronENST00000455387ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38480692

+
intron-3CDSENST00000462274ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3CDSENST00000462274ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3CDSENST00000462274ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3UTRENST00000462274ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-intronENST00000462274ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-intronENST00000462274ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000338785ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000338785ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000338785ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000338785ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000338785ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000338785ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000451934ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000451934ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000451934ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000451934ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000451934ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000451934ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000321219ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000321219ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000321219ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000321219ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000321219ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000321219ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000339659ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000339659ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000339659ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000339659ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000339659ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000339659ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398960ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398960ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398960ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000398960ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000398960ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000398960ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398956ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398956ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
Frame-shitENST00000398956ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-3UTRENST00000398956ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000398956ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
5CDS-intronENST00000398956ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3CDSENST00000455387ENST00000355666DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3CDSENST00000455387ENST00000399017DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3CDSENST00000455387ENST00000354749DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-3UTRENST00000455387ENST00000479930DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-intronENST00000455387ENST00000540756DYRK1Achr21

38792686

+TTC3chr21

38560796

+
intron-intronENST00000455387ENST00000399010DYRK1Achr21

38792686

+TTC3chr21

38560796

+
3UTR-3CDSENST00000462274ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38567976

+
3UTR-3CDSENST00000462274ENST00000399017DYRK1Achr21

38739930

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38567976

+
3UTR-3CDSENST00000462274ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38567976

+
3UTR-3UTRENST00000462274ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38567976

+
3UTR-intronENST00000462274ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
3UTR-intronENST00000462274ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38567976

+
5UTR-3CDSENST00000338785ENST00000355666DYRK1Achr21

38739930

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38567976

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5UTR-3CDSENST00000338785ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38567976

+
5UTR-3CDSENST00000338785ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38567976

+
5UTR-3UTRENST00000338785ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38567976

+
5UTR-intronENST00000338785ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
5UTR-intronENST00000338785ENST00000399010DYRK1Achr21

38739930

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38567976

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intron-3CDSENST00000451934ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000451934ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38567976

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intron-3CDSENST00000451934ENST00000354749DYRK1Achr21

38739930

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intron-3UTRENST00000451934ENST00000479930DYRK1Achr21

38739930

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intron-intronENST00000451934ENST00000540756DYRK1Achr21

38739930

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38567976

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intron-intronENST00000451934ENST00000399010DYRK1Achr21

38739930

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38567976

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intron-3CDSENST00000321219ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000321219ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000321219ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3UTRENST00000321219ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000321219ENST00000540756DYRK1Achr21

38739930

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intron-intronENST00000321219ENST00000399010DYRK1Achr21

38739930

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38567976

+
intron-3CDSENST00000339659ENST00000355666DYRK1Achr21

38739930

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intron-3CDSENST00000339659ENST00000399017DYRK1Achr21

38739930

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intron-3CDSENST00000339659ENST00000354749DYRK1Achr21

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+
intron-3UTRENST00000339659ENST00000479930DYRK1Achr21

38739930

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38567976

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intron-intronENST00000339659ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000339659ENST00000399010DYRK1Achr21

38739930

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38567976

+
intron-3CDSENST00000398960ENST00000355666DYRK1Achr21

38739930

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intron-3CDSENST00000398960ENST00000399017DYRK1Achr21

38739930

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38567976

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intron-3CDSENST00000398960ENST00000354749DYRK1Achr21

38739930

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38567976

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intron-3UTRENST00000398960ENST00000479930DYRK1Achr21

38739930

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intron-intronENST00000398960ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000398960ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000398956ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000398956ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000398956ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38567976

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intron-3UTRENST00000398956ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000398956ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000398956ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000455387ENST00000355666DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000455387ENST00000399017DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3CDSENST00000455387ENST00000354749DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-3UTRENST00000455387ENST00000479930DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000455387ENST00000540756DYRK1Achr21

38739930

+TTC3chr21

38567976

+
intron-intronENST00000455387ENST00000399010DYRK1Achr21

38739930

+TTC3chr21

38567976

+

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FusionProtFeatures for DYRK1A_TTC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYRK1A

Q13627

TTC3

P53804

Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. May play a rolein a signaling pathway regulating nuclear functions of cellproliferation. Modulates alternative splicing by phosphorylatingthe splice factor SRSF6 (By similarity). Exhibits a substratepreference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates theapoptotic process. Promotes cell survival upon genotoxic stressthrough phosphorylation of SIRT1. This in turn inhibits TP53activity and apoptosis (By similarity).{ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20,ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067,ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DYRK1A_TTC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DYRK1A_TTC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DYRK1ASFN, SRSF4, CCNL2, SRSF5, CLASRP, SRSF1, DCAF7, DNM1, HIST1H2BB, HIST1H3A, HIST1H4A, YWHAG, ELAVL1, CLTC, SH3GL2, ISG15, AMPH, PRD, HIPK2, MAP3K1, LATS2, LIN52, SMAD3, MAP3K5, SNCA, APP, BARD1, TRAF3, RBL1, RB1, LZTS2, TROAP, CCNA2, PRKAR1A, RBL2, CREBBP, EP300, FAM117B, GLCCI1, FAM53C, FAM117A, RNF169, DYNLL1, ABCD3, DYNLL2, SIPA1L1, FNTA, FNTB, PPP1R3F, KIAA0232, CCDC8, PRKACA, PRKACB, MOV10, NXF1, RFPL2, CTBP1, LIPH, NTRK1, MED23, XPO1, TBP, ID2, DYRK1A, EGLN2, FOXR2, PARK2, RAD54L2, BTRC, C10orf71, LRCH3, NXF2, TBC1D7, TSC1, TRIM25, BRCA1TTC3AKT1, AKT2, AKT3, UBE3A, UBC, UBE2D2, HSPB1, CSNK2A2, RAB5C, FGFR1OP, WAPAL, PARD6A, SMC6, KIF18A, DSN1, KRBOX4, DYNC2LI1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DYRK1A_TTC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DYRK1A_TTC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource