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Fusion gene ID: 10801 |
FusionGeneSummary for DYRK1A_ACOXL |
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Fusion gene information | Fusion gene name: DYRK1A_ACOXL | Fusion gene ID: 10801 | Hgene | Tgene | Gene symbol | DYRK1A | ACOXL | Gene ID | 1859 | 55289 |
Gene name | dual specificity tyrosine phosphorylation regulated kinase 1A | acyl-CoA oxidase like | |
Synonyms | DYRK|DYRK1|HP86|MNB|MNBH|MRD7 | - | |
Cytomap | 21q22.13 | 2q13 | |
Type of gene | protein-coding | protein-coding | |
Description | dual specificity tyrosine-phosphorylation-regulated kinase 1AMNB/DYRK protein kinasedual specificity YAK1-related kinasedual specificity tyrosine-(Y)-phosphorylation regulated kinase 1Amnb protein kinase homolog hp86protein kinase minibrain homologs | acyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like protein | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q13627 | Q9NUZ1 | |
Ensembl transtripts involved in fusion gene | ENST00000462274, ENST00000338785, ENST00000451934, ENST00000321219, ENST00000339659, ENST00000398960, ENST00000398956, ENST00000455387, | ENST00000389811, ENST00000439055, ENST00000340561, ENST00000496981, | |
Fusion gene scores | * DoF score | 16 X 9 X 10=1440 | 3 X 3 X 2=18 |
# samples | 20 | 3 | |
** MAII score | log2(20/1440*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DYRK1A [Title/Abstract] AND ACOXL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DYRK1A | GO:0018108 | peptidyl-tyrosine phosphorylation | 9748265 |
Hgene | DYRK1A | GO:0033120 | positive regulation of RNA splicing | 28377597 |
Hgene | DYRK1A | GO:0038083 | peptidyl-tyrosine autophosphorylation | 24327345 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF333889 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000462274 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000462274 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000462274 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000462274 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000338785 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000338785 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000338785 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000338785 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000451934 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000451934 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000451934 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000451934 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000321219 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000321219 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000321219 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000321219 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000339659 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000339659 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000339659 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000339659 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398960 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398960 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398960 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398960 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398956 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398956 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398956 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000398956 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000455387 | ENST00000389811 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000455387 | ENST00000439055 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000455387 | ENST00000340561 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
intron-intron | ENST00000455387 | ENST00000496981 | DYRK1A | chr21 | 38782650 | + | ACOXL | chr2 | 111812719 | + |
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FusionProtFeatures for DYRK1A_ACOXL |
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Hgene | Tgene |
DYRK1A | ACOXL |
Dual-specificity kinase which possesses bothserine/threonine and tyrosine kinase activities. May play a rolein a signaling pathway regulating nuclear functions of cellproliferation. Modulates alternative splicing by phosphorylatingthe splice factor SRSF6 (By similarity). Exhibits a substratepreference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates theapoptotic process. Promotes cell survival upon genotoxic stressthrough phosphorylation of SIRT1. This in turn inhibits TP53activity and apoptosis (By similarity).{ECO:0000250|UniProtKB:Q61214, ECO:0000250|UniProtKB:Q9NR20,ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067,ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DYRK1A_ACOXL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DYRK1A_ACOXL |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DYRK1A_ACOXL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DYRK1A_ACOXL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ACOXL | C0023434 | Chronic Lymphocytic Leukemia | 1 | CTD_human |