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Fusion gene ID: 10765 |
FusionGeneSummary for DYNC1I1_CXCL11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DYNC1I1_CXCL11 | Fusion gene ID: 10765 | Hgene | Tgene | Gene symbol | DYNC1I1 | CXCL11 | Gene ID | 1780 | 6373 |
| Gene name | dynein cytoplasmic 1 intermediate chain 1 | C-X-C motif chemokine ligand 11 | |
| Synonyms | DNCI1|DNCIC1 | H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1 | |
| Cytomap | 7q21.3 | 4q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1 | C-X-C motif chemokine 11beta-R1chemokine (C-X-C motif) ligand 11interferon gamma-inducible protein 9interferon-inducible T-cell alpha chemoattractantsmall inducible cytokine B11small inducible cytokine subfamily B (Cys-X-Cys), member 11small induci | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14576 | O14625 | |
| Ensembl transtripts involved in fusion gene | ENST00000447467, ENST00000324972, ENST00000537881, ENST00000437599, ENST00000359388, ENST00000413338, ENST00000457059, ENST00000497626, | ENST00000306621, ENST00000503860, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 4 X 1 X 4=16 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DYNC1I1 [Title/Abstract] AND CXCL11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CXCL11 | GO:0006935 | chemotaxis | 12782716 |
| Tgene | CXCL11 | GO:0030816 | positive regulation of cAMP metabolic process | 12782716 |
| Tgene | CXCL11 | GO:0043950 | positive regulation of cAMP-mediated signaling | 12782716 |
| Tgene | CXCL11 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 12782716 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-43-7658-01A | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000447467 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000447467 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000324972 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000324972 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000537881 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000537881 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000437599 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000437599 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000359388 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000359388 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| intron-5UTR | ENST00000413338 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| intron-5UTR | ENST00000413338 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000457059 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| 5CDS-5UTR | ENST00000457059 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| intron-5UTR | ENST00000497626 | ENST00000306621 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
| intron-5UTR | ENST00000497626 | ENST00000503860 | DYNC1I1 | chr7 | 95709800 | + | CXCL11 | chr4 | 76957217 | - |
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FusionProtFeatures for DYNC1I1_CXCL11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DYNC1I1 | CXCL11 |
| Acts as one of several non-catalytic accessorycomponents of the cytoplasmic dynein 1 complex that are thought tobe involved in linking dynein to cargos and to adapter proteinsthat regulate dynein function. Cytoplasmic dynein 1 acts as amotor for the intracellular retrograde motility of vesicles andorganelles along microtubules. The intermediate chains mediate thebinding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction ofcytoplasmic dynein with membranous organelles and kinetochores. | Chemotactic for interleukin-activated T-cells but notunstimulated T-cells, neutrophils or monocytes. Induces calciumrelease in activated T-cells. Binds to CXCR3. May play animportant role in CNS diseases which involve T-cell recruitment.May play a role in skin immune responses. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DYNC1I1_CXCL11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DYNC1I1_CXCL11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DYNC1I1 | DYNLL2, DYNLRB1, DYNLL1, DYNLT1, DYNLT3, STAU1, DNM2, NUDT21, CADM4, C2orf44, FAM110A, KAT7, FBP1, TAOK1, RUNDC3B, MCC, FAM83D, RAP1GAP, DCTN1, GRB7, TK1, CDKN1A, NAGK, SMN1, RCC1, PIN1, ANXA7, KIAA0368, CUL3, EMILIN1, PAFAH1B1, KLC3, TUBB3, KCNA5, BICD2, DYNC1H1, DYNC1LI1, DCTN2, TRIM58, AMBRA1, BECN1, EP300, NDEL1, DCDC5, DYNC1LI2, WDR34, DISC1, DYNC1I2, RPL23, C15orf39, SAMD1, MGA | CXCL11 | CXCR3, MTUS2, SMARCB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DYNC1I1_CXCL11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DYNC1I1_CXCL11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DYNC1I1 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | CXCL11 | C0282488 | Interstitial Cystitis | 1 | CTD_human |
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