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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10765

FusionGeneSummary for DYNC1I1_CXCL11

check button Fusion gene summary
Fusion gene informationFusion gene name: DYNC1I1_CXCL11
Fusion gene ID: 10765
HgeneTgene
Gene symbol

DYNC1I1

CXCL11

Gene ID

1780

6373

Gene namedynein cytoplasmic 1 intermediate chain 1C-X-C motif chemokine ligand 11
SynonymsDNCI1|DNCIC1H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1
Cytomap

7q21.3

4q21.1

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1C-X-C motif chemokine 11beta-R1chemokine (C-X-C motif) ligand 11interferon gamma-inducible protein 9interferon-inducible T-cell alpha chemoattractantsmall inducible cytokine B11small inducible cytokine subfamily B (Cys-X-Cys), member 11small induci
Modification date2018052320180523
UniProtAcc

O14576

O14625

Ensembl transtripts involved in fusion geneENST00000447467, ENST00000324972, 
ENST00000537881, ENST00000437599, 
ENST00000359388, ENST00000413338, 
ENST00000457059, ENST00000497626, 
ENST00000306621, ENST00000503860, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 1 X 4=16
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DYNC1I1 [Title/Abstract] AND CXCL11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCXCL11

GO:0006935

chemotaxis

12782716

TgeneCXCL11

GO:0030816

positive regulation of cAMP metabolic process

12782716

TgeneCXCL11

GO:0043950

positive regulation of cAMP-mediated signaling

12782716

TgeneCXCL11

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

12782716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-7658-01ADYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000447467ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000447467ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000324972ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000324972ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000537881ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000537881ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000437599ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000437599ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000359388ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000359388ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
intron-5UTRENST00000413338ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
intron-5UTRENST00000413338ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000457059ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
5CDS-5UTRENST00000457059ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
intron-5UTRENST00000497626ENST00000306621DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-
intron-5UTRENST00000497626ENST00000503860DYNC1I1chr7

95709800

+CXCL11chr4

76957217

-

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FusionProtFeatures for DYNC1I1_CXCL11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DYNC1I1

O14576

CXCL11

O14625

Acts as one of several non-catalytic accessorycomponents of the cytoplasmic dynein 1 complex that are thought tobe involved in linking dynein to cargos and to adapter proteinsthat regulate dynein function. Cytoplasmic dynein 1 acts as amotor for the intracellular retrograde motility of vesicles andorganelles along microtubules. The intermediate chains mediate thebinding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction ofcytoplasmic dynein with membranous organelles and kinetochores. Chemotactic for interleukin-activated T-cells but notunstimulated T-cells, neutrophils or monocytes. Induces calciumrelease in activated T-cells. Binds to CXCR3. May play animportant role in CNS diseases which involve T-cell recruitment.May play a role in skin immune responses.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DYNC1I1_CXCL11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DYNC1I1_CXCL11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DYNC1I1DYNLL2, DYNLRB1, DYNLL1, DYNLT1, DYNLT3, STAU1, DNM2, NUDT21, CADM4, C2orf44, FAM110A, KAT7, FBP1, TAOK1, RUNDC3B, MCC, FAM83D, RAP1GAP, DCTN1, GRB7, TK1, CDKN1A, NAGK, SMN1, RCC1, PIN1, ANXA7, KIAA0368, CUL3, EMILIN1, PAFAH1B1, KLC3, TUBB3, KCNA5, BICD2, DYNC1H1, DYNC1LI1, DCTN2, TRIM58, AMBRA1, BECN1, EP300, NDEL1, DCDC5, DYNC1LI2, WDR34, DISC1, DYNC1I2, RPL23, C15orf39, SAMD1, MGACXCL11CXCR3, MTUS2, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DYNC1I1_CXCL11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DYNC1I1_CXCL11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDYNC1I1C0031117Peripheral Neuropathy1CTD_human
TgeneCXCL11C0282488Interstitial Cystitis1CTD_human