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Fusion gene ID: 10745 |
FusionGeneSummary for DYM_TMC7 |
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Fusion gene information | Fusion gene name: DYM_TMC7 | Fusion gene ID: 10745 | Hgene | Tgene | Gene symbol | DYM | TMC7 | Gene ID | 54808 | 79905 |
Gene name | dymeclin | transmembrane channel like 7 | |
Synonyms | DMC|SMC | - | |
Cytomap | 18q21.1 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | dymeclindyggve-Melchior-Clausen syndrome protein | transmembrane channel-like protein 7 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q7RTS9 | Q7Z402 | |
Ensembl transtripts involved in fusion gene | ENST00000442713, ENST00000269445, ENST00000584977, ENST00000578396, | ENST00000569532, ENST00000304381, ENST00000421369, ENST00000561963, | |
Fusion gene scores | * DoF score | 11 X 7 X 8=616 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/616*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DYM [Title/Abstract] AND TMC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-ER-A196-01A | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000442713 | ENST00000569532 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
Frame-shift | ENST00000442713 | ENST00000304381 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
Frame-shift | ENST00000442713 | ENST00000421369 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
5CDS-intron | ENST00000442713 | ENST00000561963 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
Frame-shift | ENST00000269445 | ENST00000569532 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
Frame-shift | ENST00000269445 | ENST00000304381 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
Frame-shift | ENST00000269445 | ENST00000421369 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
5CDS-intron | ENST00000269445 | ENST00000561963 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000584977 | ENST00000569532 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000584977 | ENST00000304381 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000584977 | ENST00000421369 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-intron | ENST00000584977 | ENST00000561963 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000578396 | ENST00000569532 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000578396 | ENST00000304381 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-3CDS | ENST00000578396 | ENST00000421369 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
intron-intron | ENST00000578396 | ENST00000561963 | DYM | chr18 | 46783380 | - | TMC7 | chr16 | 19051611 | + |
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FusionProtFeatures for DYM_TMC7 |
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Hgene | Tgene |
DYM | TMC7 |
Probable ion channel. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DYM_TMC7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DYM_TMC7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DYM | HS2ST1, VSIG2, PNKD, P2RY12, PTGER3, DUSP28, SIGLECL1, EPHA1, VIPR1, CHRM3, CD70, FPR2, VIPR2, FZD10, TNFSF13B, SLCO1B1, OPRM1, PTPRN | TMC7 | HLCS, ZFAND2B, CIB1, PSMD11 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DYM_TMC7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DYM_TMC7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DYM | C3888088 | SMITH-MCCORT DYSPLASIA 1 | 3 | UNIPROT |
Hgene | DYM | C0265286 | Dyggve-Melchior-Clausen syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | DYM | C0036341 | Schizophrenia | 1 | PSYGENET |