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Fusion gene ID: 10734 |
FusionGeneSummary for DXO_CLK2 |
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Fusion gene information | Fusion gene name: DXO_CLK2 | Fusion gene ID: 10734 | Hgene | Tgene | Gene symbol | DXO | CLK2 | Gene ID | 1797 | 9894 |
Gene name | decapping exoribonuclease | telomere maintenance 2 | |
Synonyms | DOM3L|DOM3Z|NG6|RAI1 | CLK2|TEL2|YHFS | |
Cytomap | 6p21.33 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | decapping and exoribonuclease proteinprotein Dom3Z | telomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O77932 | P49760 | |
Ensembl transtripts involved in fusion gene | ENST00000337523, ENST00000375349, ENST00000478221, ENST00000375356, ENST00000427690, ENST00000426498, ENST00000453742, ENST00000497174, ENST00000458308, ENST00000432110, ENST00000414092, ENST00000496506, ENST00000443250, ENST00000439989, ENST00000454430, ENST00000468514, ENST00000399936, ENST00000399937, ENST00000383330, ENST00000488461, ENST00000427627, ENST00000446967, ENST00000419797, ENST00000463957, | ENST00000361168, ENST00000368361, ENST00000355560, ENST00000497188, ENST00000536801, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: DXO [Title/Abstract] AND CLK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BJ992471 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000337523 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000337523 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000337523 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000337523 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000337523 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375349 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000375349 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000375349 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375349 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375349 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000478221 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000478221 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000478221 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000478221 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000478221 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375356 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000375356 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000375356 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375356 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000375356 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427690 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000427690 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000427690 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427690 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427690 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000426498 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000426498 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000426498 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000426498 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000426498 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000453742 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000453742 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000453742 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000453742 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000453742 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000497174 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000497174 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000497174 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000497174 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000497174 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000458308 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000458308 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000458308 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000458308 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000458308 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000432110 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000432110 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000432110 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000432110 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000432110 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000414092 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000414092 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000414092 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000414092 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000414092 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000496506 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000496506 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000496506 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000496506 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000496506 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000443250 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000443250 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000443250 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000443250 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000443250 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000439989 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000439989 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000439989 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000439989 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000439989 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000454430 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000454430 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000454430 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000454430 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000454430 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000468514 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000468514 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000468514 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000468514 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000468514 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399936 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000399936 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000399936 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399936 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399936 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399937 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000399937 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000399937 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399937 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000399937 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000383330 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000383330 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000383330 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000383330 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000383330 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000488461 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000488461 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000488461 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000488461 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000488461 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427627 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000427627 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000427627 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427627 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000427627 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000446967 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000446967 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000446967 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000446967 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000446967 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000419797 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000419797 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000419797 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000419797 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000419797 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000463957 | ENST00000361168 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000463957 | ENST00000368361 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-5UTR | ENST00000463957 | ENST00000355560 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000463957 | ENST00000497188 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
intron-intron | ENST00000463957 | ENST00000536801 | DXO | chr6 | 3272618 | - | CLK2 | chr1 | 155243211 | - |
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FusionProtFeatures for DXO_CLK2 |
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Hgene | Tgene |
DXO | CLK2 |
Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DXO_CLK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DXO_CLK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DXO_CLK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DXO_CLK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |