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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10734

FusionGeneSummary for DXO_CLK2

check button Fusion gene summary
Fusion gene informationFusion gene name: DXO_CLK2
Fusion gene ID: 10734
HgeneTgene
Gene symbol

DXO

CLK2

Gene ID

1797

9894

Gene namedecapping exoribonucleasetelomere maintenance 2
SynonymsDOM3L|DOM3Z|NG6|RAI1CLK2|TEL2|YHFS
Cytomap

6p21.33

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiondecapping and exoribonuclease proteinprotein Dom3Ztelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homolog
Modification date2018051920180523
UniProtAcc

O77932

P49760

Ensembl transtripts involved in fusion geneENST00000337523, ENST00000375349, 
ENST00000478221, ENST00000375356, 
ENST00000427690, ENST00000426498, 
ENST00000453742, ENST00000497174, 
ENST00000458308, ENST00000432110, 
ENST00000414092, ENST00000496506, 
ENST00000443250, ENST00000439989, 
ENST00000454430, ENST00000468514, 
ENST00000399936, ENST00000399937, 
ENST00000383330, ENST00000488461, 
ENST00000427627, ENST00000446967, 
ENST00000419797, ENST00000463957, 
ENST00000361168, ENST00000368361, 
ENST00000355560, ENST00000497188, 
ENST00000536801, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: DXO [Title/Abstract] AND CLK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BJ992471DXOchr6

3272618

-CLK2chr1

155243211

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000337523ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000337523ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000337523ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000337523ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000337523ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375349ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000375349ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000375349ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375349ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375349ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000478221ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000478221ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000478221ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000478221ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000478221ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375356ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000375356ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000375356ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375356ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000375356ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427690ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000427690ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000427690ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427690ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427690ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000426498ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000426498ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000426498ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000426498ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000426498ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000453742ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000453742ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000453742ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000453742ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000453742ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000497174ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000497174ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000497174ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000497174ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000497174ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000458308ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000458308ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000458308ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000458308ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000458308ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000432110ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000432110ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000432110ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000432110ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000432110ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000414092ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000414092ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000414092ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000414092ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000414092ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000496506ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000496506ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000496506ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000496506ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000496506ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000443250ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000443250ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000443250ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000443250ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000443250ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000439989ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000439989ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000439989ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000439989ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000439989ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000454430ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000454430ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000454430ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000454430ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000454430ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000468514ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000468514ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000468514ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000468514ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000468514ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399936ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000399936ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000399936ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399936ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399936ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399937ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000399937ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000399937ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399937ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000399937ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000383330ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000383330ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000383330ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000383330ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000383330ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000488461ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000488461ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000488461ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000488461ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000488461ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427627ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000427627ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000427627ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427627ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000427627ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000446967ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000446967ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000446967ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000446967ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000446967ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000419797ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000419797ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000419797ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000419797ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000419797ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000463957ENST00000361168DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000463957ENST00000368361DXOchr6

3272618

-CLK2chr1

155243211

-
intron-5UTRENST00000463957ENST00000355560DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000463957ENST00000497188DXOchr6

3272618

-CLK2chr1

155243211

-
intron-intronENST00000463957ENST00000536801DXOchr6

3272618

-CLK2chr1

155243211

-

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FusionProtFeatures for DXO_CLK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DXO

O77932

CLK2

P49760

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DXO_CLK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DXO_CLK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DXO_CLK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DXO_CLK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource