FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10716

FusionGeneSummary for DUSP7_PBRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP7_PBRM1
Fusion gene ID: 10716
HgeneTgene
Gene symbol

DUSP7

PBRM1

Gene ID

1849

55193

Gene namedual specificity phosphatase 7polybromo 1
SynonymsMKPX|PYST2BAF180|PB1
Cytomap

3p21.2

3p21.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 7dual specificity protein phosphatase PYST2protein polybromo-1BRG1-associated factor 180polybromo-1D
Modification date2018052320180523
UniProtAcc

Q16829

Q86U86

Ensembl transtripts involved in fusion geneENST00000495880, ENST00000296483, 
ENST00000356770, ENST00000394830, 
ENST00000296302, ENST00000337303, 
ENST00000410007, ENST00000409057, 
ENST00000409114, ENST00000409767, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 5=125
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUSP7 [Title/Abstract] AND PBRM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUSP7

GO:0035335

peptidyl-tyrosine dephosphorylation

9788880

HgeneDUSP7

GO:0043407

negative regulation of MAP kinase activity

9788880


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A140-01ADUSP7chr3

52087956

-PBRM1chr3

52588895

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000495880ENST00000356770DUSP7chr3

52087956

-PBRM1chr3

52588895

-
In-frameENST00000495880ENST00000394830DUSP7chr3

52087956

-PBRM1chr3

52588895

-
In-frameENST00000495880ENST00000296302DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000495880ENST00000337303DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000495880ENST00000410007DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000495880ENST00000409057DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000495880ENST00000409114DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000495880ENST00000409767DUSP7chr3

52087956

-PBRM1chr3

52588895

-
In-frameENST00000296483ENST00000356770DUSP7chr3

52087956

-PBRM1chr3

52588895

-
In-frameENST00000296483ENST00000394830DUSP7chr3

52087956

-PBRM1chr3

52588895

-
In-frameENST00000296483ENST00000296302DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000296483ENST00000337303DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000296483ENST00000410007DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000296483ENST00000409057DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000296483ENST00000409114DUSP7chr3

52087956

-PBRM1chr3

52588895

-
5CDS-intronENST00000296483ENST00000409767DUSP7chr3

52087956

-PBRM1chr3

52588895

-

Top

FusionProtFeatures for DUSP7_PBRM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP7

Q16829

PBRM1

Q86U86

Dual specificity protein phosphatase (PubMed:9788880).Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also haslower activity towards MAPK14 and MAPK8 (PubMed:9788880). Inarrested oocytes, plays a role in meiotic resumption (Bysimilarity). Promotes nuclear envelope breakdown and activation ofthe CDK1/Cyclin-B complex in oocytes, probably bydephosphorylating and inactivating the conventional protein kinaseC (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCAand/or PRKCG (By similarity). Also important in oocytes for normalchromosome alignment on the metaphase plate and progression toanaphase, where it might regulate activity of the spindle-assemblycheckpoint (SAC) complex (By similarity).{ECO:0000250|UniProtKB:Q91Z46, ECO:0000269|PubMed:9788880}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23192_240266369Compositional biasSer-rich
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23192_240317420Compositional biasSer-rich
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-2368_187266369DomainRhodanese
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-2368_187317420DomainRhodanese
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-0281468_1599-11583Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028630_633-11583Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-23281468_159913971603Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-25301468_159913771583Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-24291468_159914291635Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-0301468_1599-11653Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030630_633-11653Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-0291468_1599-11598Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029630_633-11598Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-24291468_159914041610Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-0281379_1447-11583DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-25301379_144713771583DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-0301379_1447-11653DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-0291379_1447-11598DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-0281156_1272-11583DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028200_270-11583DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028400_470-11583DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028538_608-11583DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-02864_134-11583DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028676_746-11583DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028792_862-11583DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000337303-028956_1074-11583DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-0301156_1272-11653DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030200_270-11653DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030400_470-11653DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030538_608-11653DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-03064_134-11653DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030676_746-11653DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030792_862-11653DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000409114-030956_1074-11653DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-0291156_1272-11598DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029200_270-11598DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029400_470-11598DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029538_608-11598DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-02964_134-11598DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029676_746-11598DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029792_862-11598DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000409767-029956_1074-11598DomainBAH 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23308_376266369DomainTyrosine-protein phosphatase
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23308_376317420DomainTyrosine-protein phosphatase
HgeneDUSP7chr3:52087956chr3:52588895ENST00000296483-23331_337266369RegionSubstrate binding
HgeneDUSP7chr3:52087956chr3:52588895ENST00000495880-23331_337317420RegionSubstrate binding
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-25301468_159914841690Compositional biasNote=Pro-rich
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530630_63314841690Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328630_63313971603Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530630_63313771583Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429630_63314291635Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429630_63314041610Compositional biasNote=Poly-Asp
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-25301379_144714841690DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-23281379_144713971603DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-24291379_144714291635DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-24291379_144714041610DNA bindingHMG box
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-25301156_127214841690DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530200_27014841690DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530400_47014841690DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530538_60814841690DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-253064_13414841690DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530676_74614841690DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530792_86214841690DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000296302-2530956_107414841690DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-23281156_127213971603DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328200_27013971603DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328400_47013971603DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328538_60813971603DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-232864_13413971603DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328676_74613971603DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328792_86213971603DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000356770-2328956_107413971603DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-25301156_127213771583DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530200_27013771583DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530400_47013771583DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530538_60813771583DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-253064_13413771583DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530676_74613771583DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530792_86213771583DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000394830-2530956_107413771583DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-24291156_127214291635DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429200_27014291635DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429400_47014291635DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429538_60814291635DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-242964_13414291635DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429676_74614291635DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429792_86214291635DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000409057-2429956_107414291635DomainBAH 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-24291156_127214041610DomainBAH 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429200_27014041610DomainBromo 2
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429400_47014041610DomainBromo 3
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429538_60814041610DomainBromo 4
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-242964_13414041610DomainBromo 1
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429676_74614041610DomainBromo 5
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429792_86214041610DomainBromo 6
TgenePBRM1chr3:52087956chr3:52588895ENST00000410007-2429956_107414041610DomainBAH 1


Top

FusionGeneSequence for DUSP7_PBRM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_523aa
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIET
AINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQT
EYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYG
IKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGV
PGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGL

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_523aa
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIET
AINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQT
EYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYG
IKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGV
PGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGL

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_523aa
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIET
AINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQT
EYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYG
IKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMGGYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGV
PGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGL

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_472aa
MPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATA
EWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATE
SDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMG
GYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGP
HPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWR

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_472aa
MPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATA
EWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATE
SDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMG
GYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGP
HPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWR

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_472aa
MPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATA
EWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATE
SDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIGMMG
GYPPGLPPLQGPVDGLVSMGSMQPLHPGGPPPHHLPPGVPGLPGIPPPGVMNQGVAPMVGTPAPGGSPYGQQVGVLGPPGQQAPPPYPGP
HPAGPPVIQQPTTPMFVAPPPKTQRLLHSEAYLKYIEGLSAESNSISKWDQTLAARRRDVHLSKEQESRLPSHWLKSKGAHTTMADALWR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_1569nt
ATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAG
CCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTG
CAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACG
GCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGAC
AAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCC
GCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACA
GAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTG
CGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGC
CAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGC
ATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGAC
CACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTG
CAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTG
CCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATAT
GGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAG
CAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTC
AGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGC
CTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACC

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_1569nt
ATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAG
CCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTG
CAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACG
GCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGAC
AAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCC
GCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACA
GAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTG
CGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGC
CAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGC
ATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGAC
CACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTG
CAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTG
CCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATAT
GGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAG
CAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTC
AGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGC
CTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACC

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_1569nt
ATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAG
CCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTG
CAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACG
GCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGAC
AAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCC
GCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACA
GAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTG
CGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGC
CAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGC
ATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGAC
CACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTG
CAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTG
CCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATAT
GGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAG
CAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTC
AGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGC
CTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACC

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_1416nt
ATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAG
CTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATC
CGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCC
GAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTC
CAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCC
ACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAG
TCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACC
AACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTC
ACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGT
GGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCT
CCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGG
ACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCA
CATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAG
GCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTC
CATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGC

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_1416nt
ATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAG
CTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATC
CGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCC
GAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTC
CAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCC
ACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAG
TCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACC
AACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTC
ACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGT
GGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCT
CCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGG
ACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCA
CATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAG
GCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTC
CATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGC

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_1416nt
ATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAG
CTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATC
CGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCC
GAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTC
CAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCC
ACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAG
TCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACC
AACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTC
ACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGT
GGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCT
CCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGG
ACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCA
CATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAG
GCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTC
CATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_4464nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT
CAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTT
ATATACGGACACTTTTAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTT
CCTTCGTTTAAAACCAGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAG
AGGTTTTTGTCTTGGCTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACAC
ACACACAAGAGTTTACAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGT
TTGTTTCATGTGCCTGAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGG
TTTTAGATGTTTAATAGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGC
AGCTAATGTACCTCCTGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAG
TGATTTTTGCAGAACACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTC
ACAATTTATGCCTATAAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAG
GTATGCATGGAGGTGATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGC
ATAATTGTGAACAAGTAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTT
AAGTTTCAATGTTGTTATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAG
AAGGGAATCATAATTTAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGA
CCCTACAATAAACATTTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATA
GTAACTGGGTGATTGCCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAAT
CTGCTATGAATCAGTACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTAT
CTAGATACTTTAAATATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATAT
TGAATTTAAAAAAATGTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAA
TTGAATCATCATGGACTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGG
TTAAATTATTTATTTATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCAC
TGGGGGCCACGTGGGTCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCA
GGGGCTTCCCTAAAGCAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTT
TAGAATCATGTTTTTCTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAA
AAAAATTGACTCAAGAAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATG
GCCTAAATGTTTTCAAAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAAC
AGTATGTTTGTCAGCCAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAA
GAATTGAGAGGGGCACCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGG
TTTATTCTAATTTCTGTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAA

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_1975nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT
CAGTAGCCATTTTAGTTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTT

>In-frame_DUSP7_ENST00000495880_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_1826nt
CGCGGTGCGCGCGGAGGGCCGGGCGGGCGGGCGGGACGGAGGCCGGGAGGCCGGGAGGCCGGGGCGGCGGGCGCGCAGCTCGGCGGGAGG
CGGGCGCCCGGAGACGCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCT
CCCCATGAAAAACCAGCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTC
CGAGCCCGGTGCGGGGTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTG
GCTGCAGGAGGAGCTGGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGA
GACGGCCATCAACCTGGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGC
CGACAAGGAGCGCTTCGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGC
TCCCGCCTCCGTGCTCGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCA
AACAGAGTACTCTGAGCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGG
CCTGCGCATCAGCTCTGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATC
CAGCCAACCAGCCTTCCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTA
TGGCATCAAGTATATCCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTC
TGACCACTGGAGCCAGAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACC
TTTGCAGGGCCCAGTTGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGG
TGTGCCTGGCCTCCCGGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCC
ATATGGACAACAGGTGGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCAT
ACAGCAGCCAACAACACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGG
ACTCAGTGCGGAGTCCAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAG
CCGCCTACCCTCTCACTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGA
CACCCTCAACATTCGCCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGAT

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000356770_chr3_52588895_-_4359nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG
TTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTT
TAATAAGCTATTTCAATTTGTTTGTTATATTAAGTTGACTTTATCAAATACACAAAGATTTTTTTGCATATGTTTCCTTCGTTTAAAACC
AGTTTCATAATTGGTTGTATATGTAGACTTGGAGTTTTATCTTTTTACTTGTTGCCATGGAACTGAAACCATTAGAGGTTTTTGTCTTGG
CTTGGGGTTTTTGTTTTCTTGGTTTTGGGTTTTTTTATATATATATATAAAAGAACAAAATGAAAAAAAACACACACACACAAGAGTTTA
CAGATTAGTTTAAATTGATAATGAAATGTGAAGTTTGTCCTAGTTTACATCTTAGAGAGGGGAGTATACTTGTGTTTGTTTCATGTGCCT
GAATATCTTAAGCCACTTTCTGCAAAAGCTGTTTCTTACAGATGAAGTGCTTTCTTTGAAAGGTGGTTATTTAGGTTTTAGATGTTTAAT
AGACACAGCACATTTGCTCTATTAACTCAGAGGCTCACTACAGAAATATGTAATCAGTGCTGTGCATCTGTCTGCAGCTAATGTACCTCC
TGGACACCAGGAGGGGAAAAAGCACTTTTTCAATTGTGCTGAGTTAGACATCTGTGAGTTAGACTATGGTGTCAGTGATTTTTGCAGAAC
ACGTGCACAACCCTGAGGTATGTTTAATCTAGGCAGGTACGTTTAAGGATATTTTGATCTATTTATAATGAATTCACAATTTATGCCTAT
AAATTTCAGATGATTTAAAATTTTAAACCTGTTACATTGAAAAACATTGAAGTTCGTCTTGAAGAAAGCATTAAGGTATGCATGGAGGTG
ATTTATTTTTAAACATAACACCTAACCTAACATGGGTAAGAGAGTATGGAACTAGATATGAGCTGTATAAGAAGCATAATTGTGAACAAG
TAGATTGATTGCCTTCATATACAAGTATGTTTTAGTATTCCTTATTTCCTTATTATCAGATGTATTTTTTCTTTTAAGTTTCAATGTTGT
TATAATTCTCAACCAGAAATTTAATACTTTCTAAAATATTTTTTAAATTTAGCTTGTGCTTTTGAATTACAGGAGAAGGGAATCATAATT
TAATAAAACGCTTACTAGAAAGACCATTACAGATCCCAAACACTTGGGTTTGGTGACCCTGTCTTTCTTATATGACCCTACAATAAACAT
TTGAAGGCAGCATAGGATGGCAGACAGTAGGAACATTGTTTCACTTGGCGGCATGTTTTTGAAACCTGCTTTATAGTAACTGGGTGATTG
CCATTGTGGTAGAGCTTCCACTGCTGTTTATAATCTGAGAGAGTTAATCTCAGAGGATGCTTTTTTCCTTTTAATCTGCTATGAATCAGT
ACCCAGATGTTTAATTACTGTACTTATTAAATCATGAGGGCAAAAGAGTGTAGAATGGAAAAAAGTCTCTTGTATCTAGATACTTTAAAT
ATGGGAGGCCCTTTAACTTAATTGCCTTTAGTCAACCACTGGATTTGAATTTGCATCAAGTATTTTAAATAATATTGAATTTAAAAAAAT
GTATTGCAGTAGTGTGTCAGTACCTTATTGTTAAAGTGAGTCAGATAAATCTTCAATTCCTGGCTATTTGGGCAATTGAATCATCATGGA
CTGTATAATGCAATCAGATTATTTTGTTTCTAGACATCCTTGAATTACACCAAAGAACATGAAATTTAGTTGTGGTTAAATTATTTATTT
ATTTCATGCATTCATTTTATTTCCCTTAAGGTCTGGATGAGACTTCTTTGGGGAGCCTCTAAAAAAATTTTTCACTGGGGGCCACGTGGG
TCATTAGAAGCCAGAGCTCTCCTCCAGGCTCCTTCCCAGTGCCTAGAGGTGCTATAGGAAACATAGATCCAGCCAGGGGCTTCCCTAAAG
CAGTGCAGCACCGGCCCAGGGCATCACTAGACAGGCCCTAATTAAGTTTTTTTTAAAAAGCCTGTGTATTTATTTTAGAATCATGTTTTT
CTGTATATTAACTTGGGGGATATCGTTAATATTTAGGATATAAGATTTGAGGTCAGCCATCTTCAAAAAAGAAAAAAAAATTGACTCAAG
AAAGTACAAGTAAACTATACACCTTTTTTTCATAAGTTTTAGGAACTGTAGTAATGTGGCTTAGAAAGTATAATGGCCTAAATGTTTTCA
AAATGTAAGTTCCTGTGGAGAAGAATTGTTTATATTGCAAACGGGGGGACTGAGGGGAACCTGTAGGTTTAAAACAGTATGTTTGTCAGC
CAACTGATTTAAAAGGCCTTTAACTGTTTTGGTTGTTGTTTTTTTTTTAAGCCACTCTCCCCTTCCTATGAGGAAGAATTGAGAGGGGCA
CCTATTTCTGTAAAATCCCCAAATTGGTGTTGATGATTTTGAGCTTGAATGTTTTCATACCTGATTAAAACTTGGTTTATTCTAATTTCT
GTATCATATCATCTGAGGTTTACGTGGTAACTAGTCTTATAACATGTATGTATCTTTTTTTTGTTGTTCATCTAAAGCTTTTTAATCCAA

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000394830_chr3_52588895_-_1870nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG
TTACTGGGGGTGGGGGGAAGGAACAAAGGAGGATAATTTTTATTGCATTTTACTGTACATCACAAGGCCATTTTTATATACGGACACTTT

>In-frame_DUSP7_ENST00000296483_chr3_52087956_-_PBRM1_ENST00000296302_chr3_52588895_-_1721nt
GCGGCTGGGGCCCGCGCGGCCGGGGCGCCGTCCCAGGGCAGGGCTGCCCGGCCCCGGCCCCGGGCCGCCCGCGCTCCCCATGAAAAACCA
GCTCCGCGGCCCCCCAGCGCGGGCGCACATGTCGACTTCGGGGGCGGCGGCGGCTGGGGGCACCCGGGCGGGGTCCGAGCCCGGTGCGGG
GTCGGGGTCCGGCGCAGGCACCGGGGCGGGCGCGGCGACGGGGGCAGGGGCCATGCCCTGCAAGAGCGCCGAGTGGCTGCAGGAGGAGCT
GGAGGCGCGCGGCGGCGCGTCCTTGCTGCTGCTCGACTGCCGGCCGCACGAGCTCTTCGAGTCGTCGCACATCGAGACGGCCATCAACCT
GGCCATCCCGGGCCTCATGTTGCGCCGCCTGCGCAAGGGCAACCTGCCCATCCGCTCCATCATCCCCAACCACGCCGACAAGGAGCGCTT
CGCCACGCGCTGCAAGGCGGCCACCGTGCTGCTCTACGACGAGGCCACGGCCGAGTGGCAGCCCGAGCCCGGCGCTCCCGCCTCCGTGCT
CGGCCTGCTCCTACAGAAGCTGCGCGACGACGGCTGCCAGGCCTACTACCTCCAAGGTGGTTTCAACAAGTTTCAAACAGAGTACTCTGA
GCACTGCGAGACCAACGTGGACAGCTCTTCCTCGCCGAGCAGCTCGCCACCCACCTCAGTGCTGGGCCTGGGGGGCCTGCGCATCAGCTC
TGACTGCTCCGACGGCGAGTCGGACCGAGAGCTGCCCAGCAGTGCCACCGAGTCAGACGGCAGCCCTGTGCCATCCAGCCAACCAGCCTT
CCCTGTCCAGATCCTGCCCTACCTCTACCTCGGCTGCGCCAAGGACTCCACCAACCTGGACGTGCTCGGCAAGTATGGCATCAAGTATAT
CCTCAATGTCACACCCAACCTACCCAACGCCTTCGAGCACGGCGGCGAGTTCACCTACAAGCAGATCCCCATCTCTGACCACTGGAGCCA
GAACCTCTCCCAGTTCTTCCCTGAGGCCATCAGCTTCATTGGCATGATGGGTGGCTATCCGCCAGGCCTTCCACCTTTGCAGGGCCCAGT
TGATGGCCTTGTTAGCATGGGCAGCATGCAGCCACTTCACCCTGGGGGGCCTCCACCCCACCATCTTCCGCCAGGTGTGCCTGGCCTCCC
GGGCATCCCACCACCGGGTGTGATGAACCAAGGAGTGGCCCCTATGGTAGGGACTCCAGCACCAGGTGGAAGTCCATATGGACAACAGGT
GGGAGTTTTGGGGCCTCCAGGGCAGCAGGCACCACCTCCATATCCCGGCCCACATCCAGCTGGACCCCCTGTCATACAGCAGCCAACAAC
ACCCATGTTTGTAGCTCCCCCACCAAAGACCCAGCGGCTTCTTCACTCAGAGGCCTACCTGAAATACATTGAAGGACTCAGTGCGGAGTC
CAACAGCATTAGCAAGTGGGATCAGACACTGGCAGCTCGAAGACGCGACGTCCATTTGTCGAAAGAACAGGAGAGCCGCCTACCCTCTCA
CTGGCTGAAAAGCAAAGGGGCCCACACCACCATGGCAGATGCCCTCTGGCGCCTTCGAGATTTGATGCTCCGGGACACCCTCAACATTCG
CCAAGCATACAACCTAGAAAATGTTTAATCACATCATTACGTTTCTTTTATATAGAAGCATAAAGAGTTGTGGATCAGTAGCCATTTTAG


Top

FusionGenePPI for DUSP7_PBRM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DUSP7GHR, EEF1A1, ELAVL1, DUSP9, NEFH, CDK18, MAPK14, XPO1, SPOP, CDC25A, MTMR14, MTMR4, PTPN21PBRM1ARID1A, SMARCC2, SMARCC1, SMARCE1, HIST1H3A, HIST1H4A, HIST2H2BE, HIST2H2AC, CHD7, ARID2, SMARCD1, ACTL6A, SMARCB1, SMARCA4, SMARCAD1, HIST3H3, SIRT7, CALML5, APP, GTF3C5, TCHHL1, NOTCH1, MAML1, ZNF512B, HECW2, CDC20, ZDHHC17, OBSL1, EED, DPF3, NUP50, COPS3, BRD7, SCARNA22, IFI16, HIST1H3E, DPPA4, NANOG, POU5F1, TOP1, HDAC6, VHL, BCL7C, BCL7A, ZBTB48, UHRF2, BRD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DUSP7_PBRM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DUSP7_PBRM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePBRM1C0005586Bipolar Disorder3PSYGENET
TgenePBRM1C0007134Renal Cell Carcinoma2CTD_human
TgenePBRM1C0033975Psychotic Disorders1PSYGENET
TgenePBRM1C0036341Schizophrenia1PSYGENET
TgenePBRM1C0040100Thymoma1CTD_human
TgenePBRM1C0206698Cholangiocarcinoma1CTD_human
TgenePBRM1C0349204Nonorganic psychosis1PSYGENET