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Fusion gene ID: 10707 |
FusionGeneSummary for DUSP22_CECR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DUSP22_CECR5 | Fusion gene ID: 10707 | Hgene | Tgene | Gene symbol | DUSP22 | CECR5 | Gene ID | 56940 | 27440 |
| Gene name | dual specificity phosphatase 22 | haloacid dehalogenase like hydrolase domain containing 5 | |
| Synonyms | JKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHX | CECR5 | |
| Cytomap | 6p25.3 | 22q11.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity protein phosphatase 22JNK-stimulating phosphatase 1JNK-stimulatory phosphatase-1MAP kinase phosphatase xhomolog of mouse dual specificity phosphatase LMW-DSP2low molecular weight dual specificity phosphatase 2mitogen-activated prote | haloacid dehalogenase-like hydrolase domain-containing 5cat eye syndrome chromosome region, candidate 5cat eye syndrome critical region protein 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NRW4 | ||
| Ensembl transtripts involved in fusion gene | ENST00000344450, ENST00000603453, ENST00000605315, ENST00000419235, ENST00000605035, ENST00000605863, ENST00000603290, ENST00000604971, | ENST00000155674, ENST00000336737, ENST00000399852, ENST00000480451, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DUSP22 [Title/Abstract] AND CECR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-DA-A1I8-06A | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344450 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| In-frame | ENST00000344450 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5CDS-intron | ENST00000344450 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5CDS-5UTR | ENST00000344450 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000603453 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000603453 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-intron | ENST00000603453 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-5UTR | ENST00000603453 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000605315 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000605315 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-intron | ENST00000605315 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-5UTR | ENST00000605315 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| In-frame | ENST00000419235 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| In-frame | ENST00000419235 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5CDS-intron | ENST00000419235 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5CDS-5UTR | ENST00000419235 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5UTR-3CDS | ENST00000605035 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5UTR-3CDS | ENST00000605035 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5UTR-intron | ENST00000605035 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| 5UTR-5UTR | ENST00000605035 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000605863 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000605863 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-intron | ENST00000605863 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-5UTR | ENST00000605863 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000603290 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000603290 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-intron | ENST00000603290 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-5UTR | ENST00000603290 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000604971 | ENST00000155674 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-3CDS | ENST00000604971 | ENST00000336737 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-intron | ENST00000604971 | ENST00000399852 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
| intron-5UTR | ENST00000604971 | ENST00000480451 | DUSP22 | chr6 | 311962 | + | CECR5 | chr22 | 17630635 | - |
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FusionProtFeatures for DUSP22_CECR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DUSP22 | CECR5 |
| Activates the Jnk signaling pathway. Dephosphorylatesand deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). {ECO:0000250,ECO:0000269|PubMed:11717427}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DUSP22 | chr6:311962 | chr22:17630635 | ENST00000344450 | + | 3 | 8 | 65_133 | 46 | 185 | Domain | Note=Tyrosine-protein phosphatase |
| Hgene | >DUSP22 | chr6:311962 | chr22:17630635 | ENST00000419235 | + | 3 | 7 | 65_133 | 46 | 206 | Domain | Note=Tyrosine-protein phosphatase |
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FusionGeneSequence for DUSP22_CECR5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_428aa MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLESPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVV FVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRL KTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKV TGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSC >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_428aa MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLESPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVV FVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRL KTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKV TGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSC >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_428aa MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLESPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVV FVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRL KTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKV TGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSC >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_428aa MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLESPPTFGFLLDIDGVLVRGHRVIPAALKAFRRLVNSQGQLRVPVV FVTNAGNILQHSKAQELSALLGCEVDADQVILSHSPMKLFSEYHEKRMLVSGQGPVMENAQGLGFRNVVTVDELRMAFPLLDMVDLERRL KTTPLPRNDFPRIEGVLLLGEPVRWETSLQLIMDVLLSNGSPGAGLATPPYPHLPVLASNMDLLWMAEAKMPRFGHGTFLLCLETIYQKV TGKELRYEGLMGKPSILTYQYAEDLIRRQAERRGWAAPIRKLYAVGDNPMSDVYGANLFHQYLQKATHDGAPELGAGGTRQQQPSASQSC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_1284nt ATGGGGAATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAG GTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTG CTTGTGCGGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTT TTTGTTACAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTT ATCCTCTCTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCC CAGGGACTGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTA AAGACCACGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAG CTGATCATGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAAC ATGGATCTCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTG ACGGGCAAGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCG GAGAGGCGGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCAC CAGTACCTGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGC ATCTCCATCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCAC GGGCACCGAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGC >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_1284nt ATGGGGAATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAG GTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTG CTTGTGCGGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTT TTTGTTACAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTT ATCCTCTCTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCC CAGGGACTGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTA AAGACCACGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAG CTGATCATGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAAC ATGGATCTCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTG ACGGGCAAGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCG GAGAGGCGGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCAC CAGTACCTGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGC ATCTCCATCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCAC GGGCACCGAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGC >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_1284nt ATGGGGAATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAG GTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTG CTTGTGCGGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTT TTTGTTACAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTT ATCCTCTCTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCC CAGGGACTGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTA AAGACCACGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAG CTGATCATGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAAC ATGGATCTCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTG ACGGGCAAGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCG GAGAGGCGGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCAC CAGTACCTGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGC ATCTCCATCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCAC GGGCACCGAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGC >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_1284nt ATGGGGAATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAG GTGACACATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTG CTTGTGCGGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTT TTTGTTACAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTT ATCCTCTCTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCC CAGGGACTGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTA AAGACCACGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAG CTGATCATGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAAC ATGGATCTCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTG ACGGGCAAGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCG GAGAGGCGGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCAC CAGTACCTGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGC ATCTCCATCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCAC GGGCACCGAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_2237nt GAGCCCGAGCCTAGTGCCTCCCACGCCCGGCGGCCGCGAGCCGGGGTCCGCGAGGGCGGAGTGGGGCGCGGCAGCCAGGAACCCGACTAC GAATCCCAGGGTGCGGGCGGGCGGAGCGAGGAGGGACGCTGGGCCTGCCCGGTGCGCACGGGGGCGGGGACCGGCAAGGCGGGACCATTT CCCGGCATAGGCTCCGGTGCCCCTGCCCGGCTCCCGCCGGGAAGTTCTAGGCCGCCGCACAGAAAGCCCTGCCCTCCACGCCGGGTCTCT GGAGCGCCCTGGGTTGCCCGGCCGGTCCCTGCCGCTGACTTGTTGACACTGCGAGCACTCAGTCCCTCCCGCGCGCCTCCTCCCCGCCCG CCCCGCCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGGGA ATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACAC ATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTGCTTGTGC GGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTTTTTGTTA CAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTTATCCTCT CTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCCCAGGGAC TGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTAAAGACCA CGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAGCTGATCA TGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAACATGGATC TCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTGACGGGCA AGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCGGAGAGGC GGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCACCAGTACC TGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGCATCTCCA TCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCACGGGCACC GAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGCAAGGAGG GCTGGGCTTTGGAGTGAGGGCAGTGCGGTGGAGGTGAGGGGGTGAGCCTGGACCTGTGGGCGAGTCCCATTGGCTGGGCTCTGGCCTGAT CACTGGGCTCAGGTCAGGGCTTGGTTCCCTTGCCACCCTTCTTGCTGCCCCATGAGTGTGGCATTACTGGTCACTTGGAAGAAGACAGTG ACTCTTTTTCCCTGCTGGGTAGCATTTTGTATGGAACGGTTGGAATTTTCTGGGCCCAGTTCCCACGTGCCTTTCGTGGCAGTCTAACCT CAGGCCATTCTCTTCCCCTGTGTGCCTCAGTGTCCTTCTCATTTCAGTAGGGACTTCTGAAATGGGGGAGGCAGTGTGGAATACTGTGGA TGTCTGTGCAGAGCCTTTGCCGGCACTGAAGGCATGCAGCCTGTCGGCAGAGTGTCTTAACACCAGATGCTACTTTTTACTGTATTGTAG >In-frame_DUSP22_ENST00000344450_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_2228nt GAGCCCGAGCCTAGTGCCTCCCACGCCCGGCGGCCGCGAGCCGGGGTCCGCGAGGGCGGAGTGGGGCGCGGCAGCCAGGAACCCGACTAC GAATCCCAGGGTGCGGGCGGGCGGAGCGAGGAGGGACGCTGGGCCTGCCCGGTGCGCACGGGGGCGGGGACCGGCAAGGCGGGACCATTT CCCGGCATAGGCTCCGGTGCCCCTGCCCGGCTCCCGCCGGGAAGTTCTAGGCCGCCGCACAGAAAGCCCTGCCCTCCACGCCGGGTCTCT GGAGCGCCCTGGGTTGCCCGGCCGGTCCCTGCCGCTGACTTGTTGACACTGCGAGCACTCAGTCCCTCCCGCGCGCCTCCTCCCCGCCCG CCCCGCCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGGGA ATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACAC ATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTGCTTGTGC GGGGCCACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTTTTTGTTA CAAATGCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTTATCCTCT CTCACAGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCCCAGGGAC TGGGCTTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTAAAGACCA CGCCCCTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAGCTGATCA TGGATGTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAACATGGATC TCCTGTGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTGACGGGCA AGGAGCTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCGGAGAGGC GGGGCTGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCACCAGTACC TGCAGAAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGCATCTCCA TCCTGGTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCACGGGCACC GAGACTTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGCAAGGAGG GCTGGGCTTTGGAGTGAGGGCAGTGCGGTGGAGGTGAGGGGGTGAGCCTGGACCTGTGGGCGAGTCCCATTGGCTGGGCTCTGGCCTGAT CACTGGGCTCAGGTCAGGGCTTGGTTCCCTTGCCACCCTTCTTGCTGCCCCATGAGTGTGGCATTACTGGTCACTTGGAAGAAGACAGTG ACTCTTTTTCCCTGCTGGGTAGCATTTTGTATGGAACGGTTGGAATTTTCTGGGCCCAGTTCCCACGTGCCTTTCGTGGCAGTCTAACCT CAGGCCATTCTCTTCCCCTGTGTGCCTCAGTGTCCTTCTCATTTCAGTAGGGACTTCTGAAATGGGGGAGGCAGTGTGGAATACTGTGGA TGTCTGTGCAGAGCCTTTGCCGGCACTGAAGGCATGCAGCCTGTCGGCAGAGTGTCTTAACACCAGATGCTACTTTTTACTGTATTGTAG >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000155674_chr22_17630635_-_1872nt CCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGGGAATGGG ATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACACATATT CTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTGCTTGTGCGGGGC CACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTTTTTGTTACAAAT GCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTTATCCTCTCTCAC AGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCCCAGGGACTGGGC TTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTAAAGACCACGCCC CTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAGCTGATCATGGAT GTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAACATGGATCTCCTG TGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTGACGGGCAAGGAG CTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCGGAGAGGCGGGGC TGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCACCAGTACCTGCAG AAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGCATCTCCATCCTG GTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCACGGGCACCGAGAC TTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGCAAGGAGGGCTGG GCTTTGGAGTGAGGGCAGTGCGGTGGAGGTGAGGGGGTGAGCCTGGACCTGTGGGCGAGTCCCATTGGCTGGGCTCTGGCCTGATCACTG GGCTCAGGTCAGGGCTTGGTTCCCTTGCCACCCTTCTTGCTGCCCCATGAGTGTGGCATTACTGGTCACTTGGAAGAAGACAGTGACTCT TTTTCCCTGCTGGGTAGCATTTTGTATGGAACGGTTGGAATTTTCTGGGCCCAGTTCCCACGTGCCTTTCGTGGCAGTCTAACCTCAGGC CATTCTCTTCCCCTGTGTGCCTCAGTGTCCTTCTCATTTCAGTAGGGACTTCTGAAATGGGGGAGGCAGTGTGGAATACTGTGGATGTCT GTGCAGAGCCTTTGCCGGCACTGAAGGCATGCAGCCTGTCGGCAGAGTGTCTTAACACCAGATGCTACTTTTTACTGTATTGTAGTTTAT >In-frame_DUSP22_ENST00000419235_chr6_311962_+_CECR5_ENST00000336737_chr22_17630635_-_1863nt CCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGGGAATGGG ATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACACATATT CTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGAGCCCACCCACCTTTGGGTTCCTGTTGGACATCGATGGAGTGCTTGTGCGGGGC CACAGAGTGATCCCTGCTGCTCTGAAAGCCTTCCGAAGGCTGGTGAACTCCCAGGGGCAGCTGCGGGTGCCCGTGGTTTTTGTTACAAAT GCTGGGAACATCTTACAACACAGCAAAGCCCAGGAGCTGTCAGCCCTGCTGGGGTGCGAGGTGGATGCAGACCAAGTTATCCTCTCTCAC AGCCCCATGAAGCTCTTCTCCGAGTACCATGAGAAGCGGATGCTGGTGTCTGGACAGGGGCCCGTGATGGAAAATGCCCAGGGACTGGGC TTCCGAAATGTCGTCACCGTGGATGAGCTGCGGATGGCCTTTCCTCTGCTTGACATGGTGGACCTGGAGCGGCGGCTAAAGACCACGCCC CTCCCGAGGAATGACTTCCCCCGCATTGAAGGGGTGCTCCTCCTAGGGGAGCCGGTCCGCTGGGAGACCAGCCTGCAGCTGATCATGGAT GTCCTCCTCAGCAATGGGAGCCCTGGGGCTGGCCTGGCAACACCCCCCTACCCCCACCTCCCCGTCCTAGCCAGCAACATGGATCTCCTG TGGATGGCTGAAGCCAAGATGCCCAGGTTTGGACATGGCACCTTTCTGCTGTGCCTGGAAACCATTTACCAGAAAGTGACGGGCAAGGAG CTGAGATACGAGGGCCTGATGGGCAAACCCAGCATCCTCACTTACCAGTATGCCGAGGACCTGATCAGGCGACAGGCGGAGAGGCGGGGC TGGGCCGCCCCCATCCGGAAGCTCTATGCTGTGGGTGATAACCCTATGTCTGACGTATACGGCGCCAACCTGTTCCACCAGTACCTGCAG AAGGCAACGCATGATGGGGCGCCAGAACTAGGGGCCGGGGGCACACGGCAGCAACAGCCCTCAGCAAGCCAGAGCTGCATCTCCATCCTG GTGTGTACAGGCGTCTACAATCCCAGGAACCCACAGTCCACGGAGCCTGTCCTTGGAGGAGGGGAGCCTCCATTCCACGGGCACCGAGAC TTATGCTTCAGTCCAGGGCTCATGGAGGCCTCCCACGTGGTGAATGACGTGAATGAGGCTGTGCAGCTGGTCTTCCGCAAGGAGGGCTGG GCTTTGGAGTGAGGGCAGTGCGGTGGAGGTGAGGGGGTGAGCCTGGACCTGTGGGCGAGTCCCATTGGCTGGGCTCTGGCCTGATCACTG GGCTCAGGTCAGGGCTTGGTTCCCTTGCCACCCTTCTTGCTGCCCCATGAGTGTGGCATTACTGGTCACTTGGAAGAAGACAGTGACTCT TTTTCCCTGCTGGGTAGCATTTTGTATGGAACGGTTGGAATTTTCTGGGCCCAGTTCCCACGTGCCTTTCGTGGCAGTCTAACCTCAGGC CATTCTCTTCCCCTGTGTGCCTCAGTGTCCTTCTCATTTCAGTAGGGACTTCTGAAATGGGGGAGGCAGTGTGGAATACTGTGGATGTCT GTGCAGAGCCTTTGCCGGCACTGAAGGCATGCAGCCTGTCGGCAGAGTGTCTTAACACCAGATGCTACTTTTTACTGTATTGTAGTTTAT |
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FusionGenePPI for DUSP22_CECR5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DUSP22 | HOXA1, HSD17B4, RPL27A, DUSP22, ARF5, TAGLN2, DUSP23, VTI1B, SVIP, PGRMC1, PGRMC2, RAB14, DUSP28, TMEM11, HMOX2, NME1, MFF, KRAS, TMX1, PRAF2, MOSPD1, SRPR, RAB5C, PTRH2, RAB5A, APRT, HRAS, MCL1, APOL2, ATXN10, GNAI3, SAMM50, SNAP23, SYNGR1, GNAI1, ERGIC1, GNAI2, MTCH1, DCAKD, RAB10, RAB9A, STX16, TLDC1, WDR18, NME3, CYB5B, FAM177A1, TIMM17B, TMCO1, PCYOX1, RAP1A, NME2P1, TMEM70, CHP1, TIMM17A, MTCH2, QKI, ARF1, CHCHD3, ARF4, TMX3, ARL1, SCAMP3, TOMM40, PPM1A, CANT1, TMUB1, IGKC, DIABLO, GNA14, NRN1, CCNYL1, LARS2, GNAQ, HPCAL1, ERICH5, C12orf75, PTPRG, POTEF, KCTD21, ARFIP2, UBTD2, FBXO7, INPP5A, LAMTOR1, ULBP3, ULBP2, PAG1, IKBIP, EIF4E2, CTNNA2, SRP54, GNA11, SPECC1L, GNG5, YES1, VAMP3, GNA13, CSNK1G3, LAMTOR4, PALM, CUEDC1, GNAO1 | CECR5 | ICT1, SHBG, NANOG, POU5F1, CECR5, TIMM44, PMPCB, PDK3, ECH1, PMPCA, MSRB2, POLDIP2, CDKN3, HSPD1, SSH3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DUSP22_CECR5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DUSP22_CECR5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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