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Fusion gene ID: 1069

FusionGeneSummary for AGAP1_WDR11

Fusion gene summary

Fusion gene information	Fusion gene name: AGAP1_WDR11
	Fusion gene ID: 1069
		Hgene	Tgene
	Gene symbol	AGAP1	WDR11
	Gene ID	116987	55717
	Gene name	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	WD repeat domain 11
	Synonyms	AGAP-1\|CENTG2\|GGAP1\|cnt-g2	BRWD2\|DR11\|HH14\|SRI1\|WDR15
	Cytomap	2q37.2	10q26.12
	Type of gene	protein-coding	protein-coding
	Description	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2	WD repeat-containing protein 11WD repeat domain 15WD repeat-containing protein 15bromodomain and WD repeat-containing protein 2sensitization to ricin complex subunit 1
	Modification date	20180523	20180523
	UniProtAcc	Q9UPQ3	Q9BZH6
	Ensembl transtripts involved in fusion gene	ENST00000336665, ENST00000304032, ENST00000409538, ENST00000428334, ENST00000409457,	ENST00000263461, ENST00000604509,
Fusion gene scores	* DoF score	25 X 11 X 14=3850	2 X 1 X 1=2
	# samples	26	2
	** MAII score	log2(26/3850*10)=-3.88827491744117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/2*10)=3.32192809488736
Context	PubMed: AGAP1 [Title/Abstract] AND WDR11 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-A8-A08O-01A	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000336665	ENST00000263461	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
5CDS-3UTR	ENST00000336665	ENST00000604509	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
In-frame	ENST00000304032	ENST00000263461	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
5CDS-3UTR	ENST00000304032	ENST00000604509	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
intron-3CDS	ENST00000409538	ENST00000263461	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
intron-3UTR	ENST00000409538	ENST00000604509	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
intron-3CDS	ENST00000428334	ENST00000263461	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
intron-3UTR	ENST00000428334	ENST00000604509	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
In-frame	ENST00000409457	ENST00000263461	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+
5CDS-3UTR	ENST00000409457	ENST00000604509	AGAP1	chr2	236403493	+	WDR11	chr10	122659541	+

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FusionProtFeatures for AGAP1_WDR11

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AGAP1 Q9UPQ3	WDR11 Q9BZH6
GTPase-activating protein for ARF1 and, to a lesserextent, ARF5. Directly and specifically regulates the adapterprotein 3 (AP-3)-dependent trafficking of proteins in theendosomal-lysosomal system. {ECO:0000269\|PubMed:12640130}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

893_940

838

1225

Repeat

Note=WD 9

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

1127_1147

838

1225

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

>>>>>>>>>>>>>>>>>>>>>>>>>>>

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

346_588

858

Domain

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

609_729

858

Domain

Arf-GAP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

346_588

805

Domain

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

609_729

805

Domain

Arf-GAP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

346_588

406

Domain

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

609_729

406

Domain

Arf-GAP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

122_126

858

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

178_181

858

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

78_85

858

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

122_126

805

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

178_181

805

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

78_85

805

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

122_126

406

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

178_181

406

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

78_85

406

Nucleotide binding

GTP

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

66_276

858

Region

Note=Small GTPase-like

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

66_276

805

Region

Note=Small GTPase-like

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

66_276

406

Region

Note=Small GTPase-like

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

768_797

858

Repeat

Note=ANK 1

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

801_830

858

Repeat

Note=ANK 2

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

768_797

805

Repeat

Note=ANK 1

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

801_830

805

Repeat

Note=ANK 2

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

768_797

406

Repeat

Note=ANK 1

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

801_830

406

Repeat

Note=ANK 2

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000304032

624_647

858

Zinc finger

C4-type

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000336665

624_647

805

Zinc finger

C4-type

Hgene

AGAP1

chr2:236403493

chr10:122659541

ENST00000409457

624_647

406

Zinc finger

C4-type

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

111_154

838

1225

Repeat

Note=WD 2

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

354_393

838

1225

Repeat

Note=WD 3

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

471_510

838

1225

Repeat

Note=WD 4

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

566_605

838

1225

Repeat

Note=WD 5

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

59_108

838

1225

Repeat

Note=WD 1

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

708_745

838

1225

Repeat

Note=WD 6

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

747_787

838

1225

Repeat

Note=WD 7

Tgene

WDR11

chr2:236403493

chr10:122659541

ENST00000263461

793_831

838

1225

Repeat

Note=WD 8

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FusionGeneSequence for AGAP1_WDR11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL

* Fusion transcript sequences (only coding sequence (CDS) region).

>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA

* Fusion transcript sequences (Full-length transcript).

>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2714nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2714nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2732nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTT
GAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAA
TCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCT
TGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGC
CAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTA
CTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACT
GCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTG
TTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGA
GGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCT
GGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATC
AAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTT
ATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCG
GAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGA
GTCCCCCAAGGAAGAACCCATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGG
CTGTGGCCACCGTCACAGTCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAG
CACATAAGCATCTATGTTGAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATAT
TTTATACTTTGGGAGAGAGCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCA
TTGATTAAATGTAAAGATTATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATA
CAGTCTTTCAAGAGAGATACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTG
AAAACACAGAACCGTTAATTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTAT
GTTTAGTCCGATAGGTGAGGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTT
GTACTTTAATGTTCTCTCTGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTAC

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FusionGenePPI for AGAP1_WDR11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
AGAP1	GRB7, TK1, SMN1, APP, SQSTM1, CBWD1, MIER2, XPO1, PRPF4, RHOA, ARF1, ARF6, RAC1, CDC42, P4HA3, PCDHA12, LZTS2, FLCN, PCDH20, PCDHA10, EPHA7, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, CDC25B, CDK16, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, TBC1D25, PPM1H, MAPKAP1, MAST3, RTKN, DENND4C, HDAC4, RAB3IP, TIAM1, PHLDB2, NADK, GAB2, KIAA1804, NF1, CBY1, CGN, RASAL2, MELK, PLEKHA7, MLLT4, DEPDC1B, KIF1C, SH3BP4, CAMSAP2, PLEKHA5, NAV1, EDC3, TRIM25	WDR11	GABARAPL1, UBXN7, NOTCH1, ZNF397, FAS, HLA-B, C17orf75, ALDH1L2, FBXW11, NAA40, PSMA1, PSMA2, PSMA4, PSMA6, UBA2, XPOT, NTRK1, TMEM17, TMEM216, PPM1H, CDC25A, TPCN2, FGF8, RNF19B, STYX

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for AGAP1_WDR11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AGAP1_WDR11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	AGAP1	C0004352	Autistic Disorder	1	CTD_human
Tgene	WDR11	C0036341	Schizophrenia	1	CTD_human
Tgene	WDR11	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	WDR11	C3540450	HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA	1	UNIPROT

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Fusion gene ID: 1069

FusionGeneSummary for AGAP1_WDR11

FusionProtFeatures for AGAP1_WDR11

FusionGeneSequence for AGAP1_WDR11

FusionGenePPI for AGAP1_WDR11

RelatedDrugs for AGAP1_WDR11

RelatedDiseases for AGAP1_WDR11