FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1069

FusionGeneSummary for AGAP1_WDR11

check button Fusion gene summary
Fusion gene informationFusion gene name: AGAP1_WDR11
Fusion gene ID: 1069
HgeneTgene
Gene symbol

AGAP1

WDR11

Gene ID

116987

55717

Gene nameArfGAP with GTPase domain, ankyrin repeat and PH domain 1WD repeat domain 11
SynonymsAGAP-1|CENTG2|GGAP1|cnt-g2BRWD2|DR11|HH14|SRI1|WDR15
Cytomap

2q37.2

10q26.12

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2WD repeat-containing protein 11WD repeat domain 15WD repeat-containing protein 15bromodomain and WD repeat-containing protein 2sensitization to ricin complex subunit 1
Modification date2018052320180523
UniProtAcc

Q9UPQ3

Q9BZH6

Ensembl transtripts involved in fusion geneENST00000336665, ENST00000304032, 
ENST00000409538, ENST00000428334, 
ENST00000409457, 
ENST00000263461, 
ENST00000604509, 
Fusion gene scores* DoF score25 X 11 X 14=38502 X 1 X 1=2
# samples 262
** MAII scorelog2(26/3850*10)=-3.88827491744117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: AGAP1 [Title/Abstract] AND WDR11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A08O-01AAGAP1chr2

236403493

+WDR11chr10

122659541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336665ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000336665ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
In-frameENST00000304032ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000304032ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3CDSENST00000409538ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3UTRENST00000409538ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3CDSENST00000428334ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
intron-3UTRENST00000428334ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+
In-frameENST00000409457ENST00000263461AGAP1chr2

236403493

+WDR11chr10

122659541

+
5CDS-3UTRENST00000409457ENST00000604509AGAP1chr2

236403493

+WDR11chr10

122659541

+

Top

FusionProtFeatures for AGAP1_WDR11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AGAP1

Q9UPQ3

WDR11

Q9BZH6

GTPase-activating protein for ARF1 and, to a lesserextent, ARF5. Directly and specifically regulates the adapterprotein 3 (AP-3)-dependent trafficking of proteins in theendosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829893_9408381225RepeatNote=WD 9
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+18291127_11478381225TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118346_58854858DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118609_72954858DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117346_58854805DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117609_72954805DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110346_58854406DomainPH
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110609_72954406DomainArf-GAP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118122_12654858Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118178_18154858Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+11878_8554858Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117122_12654805Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117178_18154805Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+11778_8554805Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110122_12654406Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110178_18154406Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+11078_8554406Nucleotide bindingGTP
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+11866_27654858RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+11766_27654805RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+11066_27654406RegionNote=Small GTPase-like
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118768_79754858RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118801_83054858RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117768_79754805RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117801_83054805RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110768_79754406RepeatNote=ANK 1
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110801_83054406RepeatNote=ANK 2
HgeneAGAP1chr2:236403493chr10:122659541ENST00000304032+118624_64754858Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659541ENST00000336665+117624_64754805Zinc fingerC4-type
HgeneAGAP1chr2:236403493chr10:122659541ENST00000409457+110624_64754406Zinc fingerC4-type
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829111_1548381225RepeatNote=WD 2
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829354_3938381225RepeatNote=WD 3
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829471_5108381225RepeatNote=WD 4
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829566_6058381225RepeatNote=WD 5
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+182959_1088381225RepeatNote=WD 1
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829708_7458381225RepeatNote=WD 6
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829747_7878381225RepeatNote=WD 7
TgeneWDR11chr2:236403493chr10:122659541ENST00000263461+1829793_8318381225RepeatNote=WD 8


Top

FusionGeneSequence for AGAP1_WDR11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_441aa
MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISH
VDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLD
ICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVA
TNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_1323nt
ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC
TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCC
TATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCAT
GTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGAT
CCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCAC
TACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGAT
ATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTAT
GATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAAC
CAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCA
ACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAG
ACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGAC
CACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTT
CACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAA
CTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_AGAP1_ENST00000336665_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2714nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_AGAP1_ENST00000304032_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2714nt
CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC
AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG
GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC
AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG
CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC
CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG
GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT
CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG
GGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTTGAAAGCCTTCTTATTACA
CCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAATCTCCTCCAAGAACAGTT
GAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCTTGTTTCAAGGCTCTATGG
TGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGCCAGCACAACAGCTCCTAA
AGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTACTTTCAGAAATTTCAGCT
AGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACTGCTCTTGGGTCAAACAGA
CAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTGTTTAGTCACTACTGTCAC
CTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGAGGGCGTTCAGTTGCTCTG
CCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCTGGCAAAAGTCCGTTTGAA
TCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATCAAAGGCTCTCCTGGTTCT
CCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTTATTTGTGGAAGCTTGCCT
CAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCGGAGTTTGAAGAACCTCGG
TTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGAGTCCCCCAAGGAAGAACC
CATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGGCTGTGGCCACCGTCACAG
TCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAGCACATAAGCATCTATGTT
GAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATATTTTATACTTTGGGAGAGA
GCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCATTGATTAAATGTAAAGAT
TATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATACAGTCTTTCAAGAGAGAT
ACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTGAAAACACAGAACCGTTAA
TTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTATGTTTAGTCCGATAGGTGA
GGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTTGTACTTTAATGTTCTCTC
TGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTACAAACATGATAAATAAATT

>In-frame_AGAP1_ENST00000409457_chr2_236403493_+_WDR11_ENST00000263461_chr10_122659541_+_2732nt
GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC
CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC
CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC
TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC
TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC
GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC
CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC
TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT
GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGAGCCTGTGTGGTGCCCCTATCTCCTTGTTCCAAGGGCCTCTCTTGCCTT
GAAAGCCTTCTTATTACACCAGCCTTGGAATGGACAGTATTCTTTGGACATTTCTCATGTTGACTATCCAGAAAATGAAGAAATAAAGAA
TCTCCTCCAAGAACAGTTGAATTCATTGTCTAATGACATAAAGAAACTGTTGCTTGATCCAGAATTCACTCTCTTGCAGAGGTGCCTGCT
TGTTTCAAGGCTCTATGGTGATGAATCGGAGCTGCACTTCTGGACTGTCGCTGCCCACTACCTGCACAGCTTATCCCAGGAAAAGTCAGC
CAGCACAACAGCTCCTAAAGAAGCTGCTCCTCGAGACAAACTGAGCAACCCACTGGATATATGCTATGACGTGCTCTGTGAAAATGCCTA
CTTTCAGAAATTTCAGCTAGAAAGGGTTAATCTGCAGGAAGTGAAACGGTCAACTTATGATCATACAAGGAAATGTACAGACCAGCTACT
GCTCTTGGGTCAAACAGACAGAGCTGTGCAGTTGCTGTTGGAAACAAGTGCAGATAACCAGCATTATTACTGTGATTCACTGAAAGCCTG
TTTAGTCACTACTGTCACCTCGTCAGGCCCCTCTCAGAGCACCATTAAGTTGGTGGCAACGAATATGATTGCCAATGGCAAATTGGCAGA
GGGCGTTCAGTTGCTCTGCCTGATAGATAAGGCTGCAGACGCCTGCCGCTACCTGCAGACATACGGCGAGTGGAATCGGGCTGCATGGCT
GGCAAAAGTCCGTTTGAATCCTGAGGAGTGTGCCGATGTTTTAAGGCGGTGGGTTGACCACCTTTGTTCTCCACAAGTCAATCAGAAATC
AAAGGCTCTCCTGGTTCTCCTCTCTCTGGGCTGCTTTTTTAGCGTGGCAGAGACGCTTCACAGCATGAGATACTTTGATAGAGCAGCCTT
ATTTGTGGAAGCTTGCCTCAAGTATGGAGCATTTGAAGTCACTGAGGACACAGAGAAACTCATCACTGCTATATATGCAGATTATGCCCG
GAGTTTGAAGAACCTCGGTTTTAAGCAGGGAGCAGTTCTCTTTGCTTCAAAAGCCGGAGCAGCTGGCAAAGACTTATTGAATGAGCTTGA
GTCCCCCAAGGAAGAACCCATTGAAGAGTGACAGCTTAATAAATGCCAGGGAATCTGACCTGGAAGGCAGATGGGAGGGGGCTGGTCTGG
CTGTGGCCACCGTCACAGTCCAGGATGAAGAGGAGTACAGGGTCCTGTGAGCTGTTTGACCACTGTTCTAAGACTATGTGTGCCCAAAAG
CACATAAGCATCTATGTTGAGAGTAAGTTTGTATCCTGCGTTGGTCTCAGAAAGAACGTGAATGCTTAAGATTTTGAAAGTACATAATAT
TTTATACTTTGGGAGAGAGCTTTAAGAGTCCCTGGAAATACTTTTTAATTTTTTTAACTTAAAATTCAAGAGACTGAATCACTTTTCTCA
TTGATTAAATGTAAAGATTATTGAGAAACCTATAGTAAATGAAATTTGTGAGATGTTTTCTCAAATATATGCTGTGCCTGTACTTATATA
CAGTCTTTCAAGAGAGATACAAACAAGGCAGAAACATTTAAACTAGTATTAAAGGTAGTTTACCAAAGCATTTTTTGTTTTCTTACCTTG
AAAACACAGAACCGTTAATTCCTTGGTTTAAGCAGTTGCTAAGTTTTGTAATTTTAGGCTCAGAGGACCATAGGAGGTTTTAAGATTTAT
GTTTAGTCCGATAGGTGAGGTCTTTGATATTTTGAATTTTAACTCCTTTTATGATACATCACAGTAACCTCATTTTTGAAGTCTTTCTTT
GTACTTTAATGTTCTCTCTGTTCTAATAGTTGAAGTATGAGATGTAACTATTATAAACTGTTGCTGAAAACATAAATGTCTGTAACTTAC


Top

FusionGenePPI for AGAP1_WDR11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AGAP1GRB7, TK1, SMN1, APP, SQSTM1, CBWD1, MIER2, XPO1, PRPF4, RHOA, ARF1, ARF6, RAC1, CDC42, P4HA3, PCDHA12, LZTS2, FLCN, PCDH20, PCDHA10, EPHA7, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, CDC25B, CDK16, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, TBC1D25, PPM1H, MAPKAP1, MAST3, RTKN, DENND4C, HDAC4, RAB3IP, TIAM1, PHLDB2, NADK, GAB2, KIAA1804, NF1, CBY1, CGN, RASAL2, MELK, PLEKHA7, MLLT4, DEPDC1B, KIF1C, SH3BP4, CAMSAP2, PLEKHA5, NAV1, EDC3, TRIM25WDR11GABARAPL1, UBXN7, NOTCH1, ZNF397, FAS, HLA-B, C17orf75, ALDH1L2, FBXW11, NAA40, PSMA1, PSMA2, PSMA4, PSMA6, UBA2, XPOT, NTRK1, TMEM17, TMEM216, PPM1H, CDC25A, TPCN2, FGF8, RNF19B, STYX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for AGAP1_WDR11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for AGAP1_WDR11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGAP1C0004352Autistic Disorder1CTD_human
TgeneWDR11C0036341Schizophrenia1CTD_human
TgeneWDR11C0236969Substance-Related Disorders1CTD_human
TgeneWDR11C3540450HYPOGONADOTROPIC HYPOGONADISM 14 WITH OR WITHOUT ANOSMIA1UNIPROT