|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10643 |
FusionGeneSummary for DTL_AGBL4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DTL_AGBL4 | Fusion gene ID: 10643 | Hgene | Tgene | Gene symbol | DTL | AGBL4 | Gene ID | 51514 | 84871 |
| Gene name | denticleless E3 ubiquitin protein ligase homolog | ATP/GTP binding protein like 4 | |
| Synonyms | CDT2|DCAF2|L2DTL|RAMP | CCP6 | |
| Cytomap | 1q32.3 | 1p33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | denticleless protein homologDDB1- and CUL4-associated factor 2RA-regulated nuclear matrix-associated proteinlethal(2) denticleless protein homologretinoic acid-regulated nuclear matrix-associated protein | cytosolic carboxypeptidase 6 | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | Q9NZJ0 | Q5VU57 | |
| Ensembl transtripts involved in fusion gene | ENST00000366991, ENST00000542077, ENST00000475419, | ENST00000371839, ENST00000371838, ENST00000371836, ENST00000334103, ENST00000497451, | |
| Fusion gene scores | * DoF score | 2 X 1 X 3=6 | 12 X 10 X 7=840 |
| # samples | 3 | 12 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(12/840*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DTL [Title/Abstract] AND AGBL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DTL | GO:0000209 | protein polyubiquitination | 18794347 |
| Hgene | DTL | GO:0006511 | ubiquitin-dependent protein catabolic process | 18794347 |
| Hgene | DTL | GO:0006513 | protein monoubiquitination | 20129063 |
| Hgene | DTL | GO:0006974 | cellular response to DNA damage stimulus | 20129063 |
| Hgene | DTL | GO:0009411 | response to UV | 18794347 |
| Hgene | DTL | GO:0019985 | translesion synthesis | 20129063 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-49-4501-01A | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000366991 | ENST00000371839 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| In-frame | ENST00000366991 | ENST00000371838 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| In-frame | ENST00000366991 | ENST00000371836 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 5CDS-intron | ENST00000366991 | ENST00000334103 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 5CDS-intron | ENST00000366991 | ENST00000497451 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| In-frame | ENST00000542077 | ENST00000371839 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| In-frame | ENST00000542077 | ENST00000371838 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| In-frame | ENST00000542077 | ENST00000371836 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 5CDS-intron | ENST00000542077 | ENST00000334103 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 5CDS-intron | ENST00000542077 | ENST00000497451 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 3UTR-3CDS | ENST00000475419 | ENST00000371839 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 3UTR-3CDS | ENST00000475419 | ENST00000371838 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 3UTR-3CDS | ENST00000475419 | ENST00000371836 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 3UTR-intron | ENST00000475419 | ENST00000334103 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
| 3UTR-intron | ENST00000475419 | ENST00000497451 | DTL | chr1 | 212220759 | + | AGBL4 | chr1 | 50317190 | - |
Top |
FusionProtFeatures for DTL_AGBL4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DTL | AGBL4 |
| Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3ubiquitin-protein ligase complex required for cell cycle control,DNA damage response and translesion DNA synthesis. The DCX(DTL)complex, also named CRL4(CDT2) complex, mediates thepolyubiquitination and subsequent degradation of CDT1,CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906,PubMed:16949367, PubMed:16964240, PubMed:17085480,PubMed:18703516, PubMed:18794347, PubMed:18794348,PubMed:19332548, PubMed:20129063, PubMed:23478441,PubMed:23478445, PubMed:23677613, PubMed:27906959). CDT1degradation in response to DNA damage is necessary to ensureproper cell cycle regulation of DNA replication (PubMed:16861906,PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradationduring S phase or following UV irradiation is essential to controlreplication licensing (PubMed:18794348, PubMed:19332548). KMT5Adegradation is also important for a proper regulation ofmechanisms such as TGF-beta signaling, cell cycle progression, DNArepair and cell migration (PubMed:23478445). Most substratesrequire their interaction with PCNA for their polyubiquitination:substrates interact with PCNA via their PIP-box, and thosecontaining the 'K+4' motif in the PIP box, recruit the DCX(DTL)complex, leading to their degradation. In undamaged proliferatingcells, the DCX(DTL) complex also promotes the 'Lys-164'monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063,PubMed:23478441, PubMed:23478445, PubMed:23677613).{ECO:0000269|PubMed:16861906, ECO:0000269|PubMed:16949367,ECO:0000269|PubMed:16964240, ECO:0000269|PubMed:17085480,ECO:0000269|PubMed:18703516, ECO:0000269|PubMed:18794347,ECO:0000269|PubMed:18794348, ECO:0000269|PubMed:19332548,ECO:0000269|PubMed:20129063, ECO:0000269|PubMed:23478441,ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23677613,ECO:0000269|PubMed:27906959}. | Metallocarboxypeptidase that mediates deglutamylation oftarget proteins. Catalyzes the deglutamylation of polyglutamateside chains generated by post-translational polyglutamylation inproteins such as tubulins. Also removes polyglutamates from thecarboxy-terminus of target proteins such as MYLK. Mediatesdeglutamylation of CGAS, regulating the antiviral activity ofCGAS. Acts as a long-chain deglutamylase and specifically shortenslong polyglutamate chains, while it is not able to remove thebranching point glutamate, a process catalyzed by AGBL5/CCP5.{ECO:0000250|UniProtKB:Q09LZ8}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 47_89 | 153 | 731 | Repeat | Note=WD 1 |
| Hgene | DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 96_135 | 153 | 731 | Repeat | Note=WD 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 168_171 | 153 | 731 | Motif | Note=DDB1-binding motif |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 197_203 | 153 | 731 | Motif | Nuclear localization signal |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 243_246 | 153 | 731 | Motif | Note=DDB1-binding motif |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 138_178 | 153 | 731 | Repeat | Note=WD 3 |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 214_253 | 153 | 731 | Repeat | Note=WD 4 |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 267_308 | 153 | 731 | Repeat | Note=WD 5 |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 313_354 | 153 | 731 | Repeat | Note=WD 6 |
| Hgene | >DTL | chr1:212220759 | chr1:50317190 | ENST00000366991 | + | 5 | 15 | 358_398 | 153 | 731 | Repeat | Note=WD 7 |
Top |
FusionGeneSequence for DTL_AGBL4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_646aa MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKC FKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQ PKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQR LPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGA EQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREYLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWVHPTLHGVKQ LIVQMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQRQAIFPKLLCQNAEDFSYSSTSFNRDAVKAGTGRRFLGGLLDHTSYCY TLEVSFYSYIISGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNPVVEKVAIPMPRLRNKEIEVQRRKEKSPPYKHPLLRGPASNYPNSKG >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_463aa MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKC FKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQ PKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQR LPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGA EQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREYLVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWVHPTLHGVKQ >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_360aa MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKC FKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQ PKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQR LPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPAGRWSWX >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_604aa MLFNSVLRQPQLGVLRNAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGEL IGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQPKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFR VWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYT YTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGAEQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREY LVFKIAPMLNPDGVYLGNYRCSLMGFDLNRHWLDPSPWVHPTLHGVKQLIVQMYNDPKTSLEFYIDIHAHSTMMNGFMYGNIFEDEERFQ RQAIFPKLLCQNAEDFSYSSTSFNRDAVKAGTGRRFLGGLLDHTSYCYTLEVSFYSYIISGTTAAVPYTEEAYMKLGRNVARTFLDYYRL >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_421aa MLFNSVLRQPQLGVLRNAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGEL IGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQPKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFR VWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYT YTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGAEQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREY >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_318aa MLFNSVLRQPQLGVLRNAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGEL IGTCKGHQCSLKSVAFSKFEKGNDMGNDDAIGGNVSKYIVLPTGYCGQPKKGHLIFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFR VWFNFTVENVKESQRVIFNIVNFSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREEDIYQFAYCYPYT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_1938nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACT GGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAACAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCT CCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGC TTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAA ACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAG TTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAG CCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTG TTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTC AACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGG CTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAA GATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTAC TTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCA GAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTA AGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAAT TACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAA CTCATCGTCCAGATGTACAACGACCCAAAAACAAGCCTGGAGTTTTATATTGACATCCATGCCCACTCCACCATGATGAATGGCTTCATG TATGGCAACATCTTTGAGGATGAGGAACGGTTCCAGAGGCAGGCCATTTTTCCCAAGCTCCTCTGCCAGAATGCTGAGGACTTCTCCTAT TCCAGCACATCCTTTAACCGGGACGCTGTGAAAGCAGGAACTGGCCGTCGCTTCCTCGGTGGACTCCTGGACCACACTTCCTATTGCTAC ACCCTAGAGGTCTCCTTCTACAGCTACATCATCAGTGGCACCACGGCTGCTGTGCCCTACACTGAAGAAGCCTATATGAAGCTGGGGCGG AATGTGGCAAGAACCTTTTTGGACTATTATCGGCTGAACCCCGTGGTTGAAAAGGTGGCAATTCCCATGCCGAGACTGCGAAATAAAGAA ATAGAAGTCCAGAGAAGGAAAGAAAAATCCCCTCCTTACAAGCACCCACTCCTGCGGGGCCCAGCCAGCAACTACCCCAACAGCAAAGGG >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_1389nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACT GGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAACAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCT CCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGC TTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAA ACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAG TTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAG CCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTG TTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTC AACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGG CTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAA GATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTAC TTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCA GAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTA AGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAAT TACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAA >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_1080nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACT GGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAACAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCT CCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGC TTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAA ACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAG TTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAG CCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTG TTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTC AACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGG CTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAA GATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTAC TTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGCTGGAAGATGGAGCTGGTGA >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_1812nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAA GAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTT GACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTG ATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCC ATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTT GAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGA GTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTAT AGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCG GACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACA TACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAA CGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCAC CCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATAC CTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGT CACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAAAAACAAGC CTGGAGTTTTATATTGACATCCATGCCCACTCCACCATGATGAATGGCTTCATGTATGGCAACATCTTTGAGGATGAGGAACGGTTCCAG AGGCAGGCCATTTTTCCCAAGCTCCTCTGCCAGAATGCTGAGGACTTCTCCTATTCCAGCACATCCTTTAACCGGGACGCTGTGAAAGCA GGAACTGGCCGTCGCTTCCTCGGTGGACTCCTGGACCACACTTCCTATTGCTACACCCTAGAGGTCTCCTTCTACAGCTACATCATCAGT GGCACCACGGCTGCTGTGCCCTACACTGAAGAAGCCTATATGAAGCTGGGGCGGAATGTGGCAAGAACCTTTTTGGACTATTATCGGCTG AACCCCGTGGTTGAAAAGGTGGCAATTCCCATGCCGAGACTGCGAAATAAAGAAATAGAAGTCCAGAGAAGGAAAGAAAAATCCCCTCCT TACAAGCACCCACTCCTGCGGGGCCCAGCCAGCAACTACCCCAACAGCAAAGGGGACAAGAAGAGCTCAGTGAACCACAAAGACCCTTCA >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_1263nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAA GAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTT GACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTG ATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCC ATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTT GAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGA GTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTAT AGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCG GACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACA TACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAA CGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCAC CCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATAC CTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGT CACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAGTAAGTAAC >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_954nt ATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAA GAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTT GACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTG ATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCC ATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTT GAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGA GTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTAT AGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCG GACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACA TACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_3570nt CGCGGTTTGTCCGCGCCTCTGCTACCCCCTGCGCAGGCGCTCAAGGAGCTCTTGGACTCCAGGTTCCCGCGGCTGGGAGAAAAGGAGGCG GGGATCCGAAGGGGGAAATGACTCTGAGGCGCCCGGACGTCGCTCGGAAGCCAATCAGAGAGCGTGACGTCAGTTTGGCGCGGAGTTTGG CGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTTGGAGGCA TTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGA GAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACTGGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAA CAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTG TTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCT GGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACAT GCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGA ATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTA ACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCA ACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGA TGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGA AGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCT TCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTG ACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAA CACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCA AGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGG ATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAAAAACAAGCCTGGAGTTTT ATATTGACATCCATGCCCACTCCACCATGATGAATGGCTTCATGTATGGCAACATCTTTGAGGATGAGGAACGGTTCCAGAGGCAGGCCA TTTTTCCCAAGCTCCTCTGCCAGAATGCTGAGGACTTCTCCTATTCCAGCACATCCTTTAACCGGGACGCTGTGAAAGCAGGAACTGGCC GTCGCTTCCTCGGTGGACTCCTGGACCACACTTCCTATTGCTACACCCTAGAGGTCTCCTTCTACAGCTACATCATCAGTGGCACCACGG CTGCTGTGCCCTACACTGAAGAAGCCTATATGAAGCTGGGGCGGAATGTGGCAAGAACCTTTTTGGACTATTATCGGCTGAACCCCGTGG TTGAAAAGGTGGCAATTCCCATGCCGAGACTGCGAAATAAAGAAATAGAAGTCCAGAGAAGGAAAGAAAAATCCCCTCCTTACAAGCACC CACTCCTGCGGGGCCCAGCCAGCAACTACCCCAACAGCAAAGGGGACAAGAAGAGCTCAGTGAACCACAAAGACCCTTCAACCCCTTTTT AAAGACACGGAGTCCTGGGAGGTCTTATGGGGACAGGAGCATGCATTTTCTGCTGGGGAATGAAATTAATCACTCTTCTCTAGCTTCCAA GGATTTGTGGATTAATGCATAGGCTAGTGAAAGGGAAGGGATACAATGAGAAACTTCATCACTGATTTTCCCTTTTTCCAATGGAAAATC AATTGTAAGCCTTCAGCTCAAAAAGCTCAGGAACAAAATAGGAGATCGGAACCAGGTGAGCACAGATGCTATTTTCTACAACATAGAGAT CTTCCAAGATGAGGAAAACCTACACATCCCTTTTAAGAGATTTGACACATATCAGGTCAGTTCTTTCAAAGCCACTTTACATTTTTAAGT TTTATAGTTACTGCAGATGGTTACCTTTTAAATAGGCTTGGTTGTTTACAGCTTTAGAAATGCAGTGTTTGTATTTTCTGATCCAAAACA ACAGCAACAACACATGCAACCAAAGGGCAAATGCATCCTAGGGAACAATGGGACAGAATTTTTGAAATCAACGGTGGACTTAAATATATG GTCACTGTATCTAAGCTGCATGCTTGCTGATTCCCTCAAACCCCAGCATGCAGATTTAGAAAACTGTTTTGAGAGCTGTTTCCCAATTTC CTCGGTAGTTTAATTAAAATTTTAGCTCTAAAGACAAAAAGCACTGGTCACTCATTTTAAAAGGTTTATTATGGTTAAGGTCTCCAGATC CCAGGTGACAGGGATTAAGCCTGGCCCCTGAAGATGTAGGCATTGCTAATCTGCAATGAGGAAAGGGTGATTGCCAGGCAAGGAAGATGC AAAAGACAGAAGGATGCACCCTGAGGCAGGGAGGAATGATAAAATAAAACAGTAGTAGCAATTCCCAAGGTGTGGCAAGCTAAATATTGG CATTTTTGTGAAGAGTAAAGTGCCTTTGTATGATGAATGGGTCCAGGGGGGTCTGCTCCCTTCCTGTCTGTGGAAACAGCAGGCTGAGTC ACCATGACAGCCTGCTAATTAAAATGACCTCCCGGAAATGAGGATTAGAACACAGGGAGAGGAAGGGAGGCTCCAGGGAGGAAAATCCCT TAGCACAGAGCTCCACTAAAGCATTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTGAGTTGGAGATTATTGAAGTTTGCTACAAAAAT CAAAAAGAAAACTTGTTCTCCTTTGCATGCTAGTTTTCAGAAATGATGACAAAGAGCCATATGTTGATTGGCTACAAATGTCATGTTGTA >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_1976nt CGCGGTTTGTCCGCGCCTCTGCTACCCCCTGCGCAGGCGCTCAAGGAGCTCTTGGACTCCAGGTTCCCGCGGCTGGGAGAAAAGGAGGCG GGGATCCGAAGGGGGAAATGACTCTGAGGCGCCCGGACGTCGCTCGGAAGCCAATCAGAGAGCGTGACGTCAGTTTGGCGCGGAGTTTGG CGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTTGGAGGCA TTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGA GAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACTGGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAA CAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTG TTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCT GGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACAT GCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGA ATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTA ACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCA ACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGA TGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGA AGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCT TCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTG ACCTCCTGACGATAACCAGCCCTGACAATCTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAA CACCCTCATCATTTGTGTGCCAAGGGATCATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCA AGATCGCACCAATGCTCAATCCTGATGGAGTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGG ATCCCTCTCCATGGGTCCATCCTACCCTGCATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAGTAAGTAACTGAATGCCCT CCACAGCTGCTGATCTATGGCTTGATCTGGGAAAGGGCAGCATTGTATTGGGAAAGTCCACTAGAAGCTGCAAATTAGGAATACATAGCT AAAACCAGGGAGGCACTAGGCCTGCTCTTCTCTGAATCCAGCAGACCCAAGGACCTTCTCCCAATCTCTTTTCCTGCAACCTCTCACAAA >In-frame_DTL_ENST00000366991_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_2090nt CGCGGTTTGTCCGCGCCTCTGCTACCCCCTGCGCAGGCGCTCAAGGAGCTCTTGGACTCCAGGTTCCCGCGGCTGGGAGAAAAGGAGGCG GGGATCCGAAGGGGGAAATGACTCTGAGGCGCCCGGACGTCGCTCGGAAGCCAATCAGAGAGCGTGACGTCAGTTTGGCGCGGAGTTTGG CGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTTGGAGGCA TTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGCGTCCTGA GAAATGGATGGTCTTCACAATACCCTCTTCAATCCCTTCTGACTGGTTATCAGTGCAGTGGTAATGATGAACACACTTCTTATGGAGAAA CAGGAGTCCCAGTTCCTCCTTTTGGATGTACCTTCTCTTCTGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTG TTCGATTGTATAACACAGAATCACAAAGTTTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCT GGGTTCCTGGTGAACTTAAACTTGTTACAGCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACAT GCAAAGGTCATCAATGCAGCCTCAAGTCAGTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGA ATGTGAGCAAATATATAGTGCTTCCAACTGGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTA ACCTGGGCCGGGTGGACCAGGTCTCTGAGTTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCA ACTTTACTGTTGAAAATGTGAAAGAATCACAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGA TGGCCCCTATGGTGAAATCTACCAGCAGACCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGA AGAACTATGTGATGTCCTTTGCCTTTTGTTTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCT TCCAACATTACCTTGACAGCCTGCAAAAGAGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTG ACCTCCTGACGATAACCAGCCCTGCTGGAAGATGGAGCTGGTGAAATCATTTGCTTCTGAAGGAGAATGGTGGCCTTTCCAAATTTGACT ATCAGATATGAATTTGACCTAATCTCGGGAATGTTTCCGGCTGGAAGATGGAGCTGGTGAAATCATTTGCTTCTGAAGGAGAATGGTGGC CTTTCCAAATTTGACTATCAGATATGAATTTGACCTAATCTCGGGAATGTTTCCGGTAAGACTGCAGACTCTCAGGTGCTTAAGAAGTCA CTGAGGCTCTGGACAAACAGGAACGTATTAGCTTTTTGCCTACTGACTACACAGCCTCCACCATTCACCCAAAATGGATCTGCATCTCCC AGGTGCATCTGCAAGCACACAAAAACACACACTGGGAAGGGGTATGAGCTGAGGTTAGTCCTAGGTGCTGCACTTTCTATTCCTGACATA TCAGGATGTGTGGGAGGGAGGCCAAAGCTGCAGCACCAGGCTGGGCTTCCAGTCCTGTTGCTACTGTGGAAGCTGGCTCCAGACAGGTGG GGGCAGCAAAGAGCCAGCCTGTATGGTCAGCTGGGATTCTAGTTGACCAAAGCTGTTGGGAGAACTCAAGCTCATCAGTGTGGCAAGTTA GACAACTTGATCTGGACACATGCATAAATGGAACAGGGGTCCAGATACCCACAGGATTAATACTAATAAACCATTTTGCTTAAGCAGCAA >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371839_chr1_50317190_-_3271nt AGTTTGGCGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTT GGAGGCATTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGC GTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGT TTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACA GCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCA GTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACT GGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAG TTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCA CAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGA CCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGT TTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAG AGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAAT CTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATC ATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGA GTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTG CATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAAAAACAAGCCTGGAGTTTTATATTGACATCCATGCCCACTCCACCATG ATGAATGGCTTCATGTATGGCAACATCTTTGAGGATGAGGAACGGTTCCAGAGGCAGGCCATTTTTCCCAAGCTCCTCTGCCAGAATGCT GAGGACTTCTCCTATTCCAGCACATCCTTTAACCGGGACGCTGTGAAAGCAGGAACTGGCCGTCGCTTCCTCGGTGGACTCCTGGACCAC ACTTCCTATTGCTACACCCTAGAGGTCTCCTTCTACAGCTACATCATCAGTGGCACCACGGCTGCTGTGCCCTACACTGAAGAAGCCTAT ATGAAGCTGGGGCGGAATGTGGCAAGAACCTTTTTGGACTATTATCGGCTGAACCCCGTGGTTGAAAAGGTGGCAATTCCCATGCCGAGA CTGCGAAATAAAGAAATAGAAGTCCAGAGAAGGAAAGAAAAATCCCCTCCTTACAAGCACCCACTCCTGCGGGGCCCAGCCAGCAACTAC CCCAACAGCAAAGGGGACAAGAAGAGCTCAGTGAACCACAAAGACCCTTCAACCCCTTTTTAAAGACACGGAGTCCTGGGAGGTCTTATG GGGACAGGAGCATGCATTTTCTGCTGGGGAATGAAATTAATCACTCTTCTCTAGCTTCCAAGGATTTGTGGATTAATGCATAGGCTAGTG AAAGGGAAGGGATACAATGAGAAACTTCATCACTGATTTTCCCTTTTTCCAATGGAAAATCAATTGTAAGCCTTCAGCTCAAAAAGCTCA GGAACAAAATAGGAGATCGGAACCAGGTGAGCACAGATGCTATTTTCTACAACATAGAGATCTTCCAAGATGAGGAAAACCTACACATCC CTTTTAAGAGATTTGACACATATCAGGTCAGTTCTTTCAAAGCCACTTTACATTTTTAAGTTTTATAGTTACTGCAGATGGTTACCTTTT AAATAGGCTTGGTTGTTTACAGCTTTAGAAATGCAGTGTTTGTATTTTCTGATCCAAAACAACAGCAACAACACATGCAACCAAAGGGCA AATGCATCCTAGGGAACAATGGGACAGAATTTTTGAAATCAACGGTGGACTTAAATATATGGTCACTGTATCTAAGCTGCATGCTTGCTG ATTCCCTCAAACCCCAGCATGCAGATTTAGAAAACTGTTTTGAGAGCTGTTTCCCAATTTCCTCGGTAGTTTAATTAAAATTTTAGCTCT AAAGACAAAAAGCACTGGTCACTCATTTTAAAAGGTTTATTATGGTTAAGGTCTCCAGATCCCAGGTGACAGGGATTAAGCCTGGCCCCT GAAGATGTAGGCATTGCTAATCTGCAATGAGGAAAGGGTGATTGCCAGGCAAGGAAGATGCAAAAGACAGAAGGATGCACCCTGAGGCAG GGAGGAATGATAAAATAAAACAGTAGTAGCAATTCCCAAGGTGTGGCAAGCTAAATATTGGCATTTTTGTGAAGAGTAAAGTGCCTTTGT ATGATGAATGGGTCCAGGGGGGTCTGCTCCCTTCCTGTCTGTGGAAACAGCAGGCTGAGTCACCATGACAGCCTGCTAATTAAAATGACC TCCCGGAAATGAGGATTAGAACACAGGGAGAGGAAGGGAGGCTCCAGGGAGGAAAATCCCTTAGCACAGAGCTCCACTAAAGCATTTTTT GTTTGTTTGTTTGTTTGTTTGTTTGTTTGAGTTGGAGATTATTGAAGTTTGCTACAAAAATCAAAAAGAAAACTTGTTCTCCTTTGCATG CTAGTTTTCAGAAATGATGACAAAGAGCCATATGTTGATTGGCTACAAATGTCATGTTGTATATACAGCTTCTCCCCTGGGTTCGTTTTG >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371838_chr1_50317190_-_1677nt AGTTTGGCGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTT GGAGGCATTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGC GTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGT TTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACA GCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCA GTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACT GGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAG TTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCA CAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGA CCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGT TTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAG AGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGACAAT CTCCGGGAAGGGGCAGAGCAGAAGGTGGTATTCATCACAGGACGAGTCCACCCAGGGGAAACACCCTCATCATTTGTGTGCCAAGGGATC ATTGACTTCCTTGTAAGCCAGCACCCTATTGCCTGTGTCCTCCGGGAATACCTGGTCTTCAAGATCGCACCAATGCTCAATCCTGATGGA GTCTACCTGGGCAATTACAGGTGTTCTCTGATGGGATTTGATCTGAATCGTCACTGGCTGGATCCCTCTCCATGGGTCCATCCTACCCTG CATGGAGTGAAACAACTCATCGTCCAGATGTACAACGACCCAGTAAGTAACTGAATGCCCTCCACAGCTGCTGATCTATGGCTTGATCTG GGAAAGGGCAGCATTGTATTGGGAAAGTCCACTAGAAGCTGCAAATTAGGAATACATAGCTAAAACCAGGGAGGCACTAGGCCTGCTCTT CTCTGAATCCAGCAGACCCAAGGACCTTCTCCCAATCTCTTTTCCTGCAACCTCTCACAAATAGTGGATTCAGTTTTGGAGGTCTGGAGG >In-frame_DTL_ENST00000542077_chr1_212220759_+_AGBL4_ENST00000371836_chr1_50317190_-_1791nt AGTTTGGCGGCCGGGGCTTACAGTGGCGGGAGTTGGAGGCGATAACGATTTGTGTTGTGAGAGGCGCAAGCTGCGATTTCTGCTGAACTT GGAGGCATTTCTACGACTTTTCTCTCAGCTGAGGCTTTTCCTCCGACCCTGATGCTCTTCAATTCGGTGCTCCGCCAGCCCCAGCTTGGC GTCCTGAGAAATGCTCCCAATATGGAACATGTACTAGCAGTTGCCAATGAAGAAGGCTTTGTTCGATTGTATAACACAGAATCACAAAGT TTCAGAAAGAAGTGCTTCAAAGAATGGATGGCTCACTGGAATGCCGTCTTTGACCTGGCCTGGGTTCCTGGTGAACTTAAACTTGTTACA GCAGCAGGTGATCAAACAGCCAAATTTTGGGACGTAAAAGCTGGTGAGCTGATTGGAACATGCAAAGGTCATCAATGCAGCCTCAAGTCA GTTGCCTTTTCTAAGTTTGAGAAAGGCAATGATATGGGAAATGATGATGCCATTGGAGGGAATGTGAGCAAATATATAGTGCTTCCAACT GGCTATTGTGGACAGCCCAAGAAAGGACATCTTATCTTTGATGCTTGCTTTGAAAGTGGTAACCTGGGCCGGGTGGACCAGGTCTCTGAG TTTGAGTATGATCTGTTCATTAGGCCGGACACCTGTAATCCACGCTTCCGAGTCTGGTTCAACTTTACTGTTGAAAATGTGAAAGAATCA CAGAGGGTCATTTTCAACATTGTTAACTTCAGTAAAACCAAGAGTCTCTATAGAGATGGGATGGCCCCTATGGTGAAATCTACCAGCAGA CCAAAATGGCAAAGGCTGCCACCCAAAAATGTTTACTACTACCGCTGCCCGGACCATAGGAAGAACTATGTGATGTCCTTTGCCTTTTGT TTTGACCGAGAAGAAGATATTTACCAGTTTGCTTACTGCTACCCATATACATACACTCGCTTCCAACATTACCTTGACAGCCTGCAAAAG AGAAACATGGATTACTTCTTTCGGGAGCAGCTGGGCCAGAGTGTGCAACAACGAAAGCTTGACCTCCTGACGATAACCAGCCCTGCTGGA AGATGGAGCTGGTGAAATCATTTGCTTCTGAAGGAGAATGGTGGCCTTTCCAAATTTGACTATCAGATATGAATTTGACCTAATCTCGGG AATGTTTCCGGCTGGAAGATGGAGCTGGTGAAATCATTTGCTTCTGAAGGAGAATGGTGGCCTTTCCAAATTTGACTATCAGATATGAAT TTGACCTAATCTCGGGAATGTTTCCGGTAAGACTGCAGACTCTCAGGTGCTTAAGAAGTCACTGAGGCTCTGGACAAACAGGAACGTATT AGCTTTTTGCCTACTGACTACACAGCCTCCACCATTCACCCAAAATGGATCTGCATCTCCCAGGTGCATCTGCAAGCACACAAAAACACA CACTGGGAAGGGGTATGAGCTGAGGTTAGTCCTAGGTGCTGCACTTTCTATTCCTGACATATCAGGATGTGTGGGAGGGAGGCCAAAGCT GCAGCACCAGGCTGGGCTTCCAGTCCTGTTGCTACTGTGGAAGCTGGCTCCAGACAGGTGGGGGCAGCAAAGAGCCAGCCTGTATGGTCA GCTGGGATTCTAGTTGACCAAAGCTGTTGGGAGAACTCAAGCTCATCAGTGTGGCAAGTTAGACAACTTGATCTGGACACATGCATAAAT |
Top |
FusionGenePPI for DTL_AGBL4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DTL | CDKN1A, COPS6, DDB1, CUL4B, CUL4A, WDR5, SETD8, KAT2A, PCNA, MSH6, MSH2, TP53, MDM2, COPS5, AURKB, TOB1, ATR, TUBG1, DDA1, COPS3, COPS4, CHEK1, CFTR, SHPRH, HLTF, RAD18, FBXO11, LYN, CDT1, FBXO18, TDG, YWHAE, YWHAQ, YWHAZ, YWHAB, YWHAG, YWHAH, SFN, UBE2D1, UBE2N, TCEAL1, C9orf41, ERCC5, UBE2I, COPS7A, WHSC1, RBX1, UBE2E2, UBE2E3, UBE2E1, POLD4, CCT3, PFDN2, CCT7, SSSCA1, COPS8, GLMN, PDDC1, CAMK2D, DEF8 | AGBL4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DTL_AGBL4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for DTL_AGBL4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DTL | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | DTL | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Tgene | AGBL4 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|