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Fusion gene ID: 10638 |
FusionGeneSummary for DTD1_POU2F3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DTD1_POU2F3 | Fusion gene ID: 10638 | Hgene | Tgene | Gene symbol | DTD1 | POU2F3 | Gene ID | 92675 | 25833 |
| Gene name | D-tyrosyl-tRNA deacylase 1 | POU class 2 homeobox 3 | |
| Synonyms | C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68 | Epoc-1|OCT-11|OCT11|OTF-11|PLA-1|PLA1|Skn-1a | |
| Cytomap | 20p11.23 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2 | POU domain, class 2, transcription factor 3POU domain transcription factor OCT11aoctamer-binding protein 11octamer-binding transcription factor 11transcription factor PLA-1transcription factor Skn-1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TEA8 | Q9UKI9 | |
| Ensembl transtripts involved in fusion gene | ENST00000377452, ENST00000494921, | ENST00000260264, ENST00000543440, | |
| Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 3 X 2 X 3=18 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DTD1 [Title/Abstract] AND POU2F3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | POU2F3 | GO:0043922 | negative regulation by host of viral transcription | 14645924 |
| Tgene | POU2F3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12624109 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-38-4632-01A | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377452 | ENST00000260264 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| In-frame | ENST00000377452 | ENST00000543440 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| 3UTR-3CDS | ENST00000494921 | ENST00000260264 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
| 3UTR-3CDS | ENST00000494921 | ENST00000543440 | DTD1 | chr20 | 18608877 | + | POU2F3 | chr11 | 120186070 | + |
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FusionProtFeatures for DTD1_POU2F3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DTD1 | POU2F3 |
| Transcription factor that binds to the octamer motif(5'-ATTTGCAT-3'). Regulated the expression of a number of genessuch as SPRR2A or placental lactogen. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DTD1 | chr20:18608877 | chr11:120186070 | ENST00000377452 | + | 4 | 6 | 139_140 | 159 | 321 | Motif | Gly-cisPro motif%2C important for rejection of L-amino acids |
| Tgene | >POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000543440 | + | 9 | 13 | 354_425 | 356 | 437 | Compositional bias | Note=Ser-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000260264 | + | 9 | 13 | 354_425 | 358 | 439 | Compositional bias | Note=Ser-rich |
| Tgene | POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000260264 | + | 9 | 13 | 281_340 | 358 | 439 | DNA binding | Homeobox |
| Tgene | POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000543440 | + | 9 | 13 | 281_340 | 356 | 437 | DNA binding | Homeobox |
| Tgene | POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000260264 | + | 9 | 13 | 183_257 | 358 | 439 | Domain | POU-specific |
| Tgene | POU2F3 | chr20:18608877 | chr11:120186070 | ENST00000543440 | + | 9 | 13 | 183_257 | 356 | 437 | Domain | POU-specific |
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FusionGeneSequence for DTD1_POU2F3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000260264_chr11_120186070_+_240aa MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNK PDFHLAMPTEQAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQVSPSGSLGPLSVPPVHSTMPG >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000543440_chr11_120186070_+_240aa MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNK PDFHLAMPTEQAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGTATSDPKQVSPSGSLGPLSVPPVHSTMPG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000260264_chr11_120186070_+_720nt ATGAAGGCCGTGGTGCAGCGCGTCACCCGGGCCAGCGTCACAGTTGGAGGAGAGCAGATTAGTGCCATTGGAAGGGGCATATGTGTGTTG CTGGGTATTTCCCTGGAGGATACGCAGAAGGAACTGGAACACATGGTCCGAAAGATTCTAAACCTGCGTGTATTTGAGGATGAGAGTGGG AAGCACTGGTCGAAGAGTGTGATGGACAAACAGTACGAGATTCTGTGTGTCAGCCAGTTTACCCTCCAGTGTGTCCTGAAGGGAAACAAG CCTGATTTCCACCTAGCAATGCCCACGGAGCAGGCAGAGGGCTTCTACAACAGCTTCCTGGAGCAGCTGCGTAAAACATACAGGCCGGAG CTTATCAAAGATGGCAAGTTTGGGGCCTACATGCAGGTGCACATTCAGAATGATGGGCCTGTGACCATAGAGCTGGAATCGCCAGCTCCC GGCACTGCTACCTCTGACCCAAAGCAGGTATCTCCCTCAGGGTCTCTGGGCCCCCTCTCTGTCCCTCCTGTCCACAGTACCATGCCTGGA ACAGTAACGTCATCCTGTTCCCCTGGGAACAACAGCAGGCCTTCATCTCCTGGCTCAGGACTCCACGCCAGCAGCCCCACTGCATCTCAA AATAACTCCAAAGCAGCAGTGAACTCCGCCTCCAGTTTTAACTCTTCAGGATCTTGGTACCGATGGAATCATTCCACCTACCTCCACTGA >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000543440_chr11_120186070_+_720nt ATGAAGGCCGTGGTGCAGCGCGTCACCCGGGCCAGCGTCACAGTTGGAGGAGAGCAGATTAGTGCCATTGGAAGGGGCATATGTGTGTTG CTGGGTATTTCCCTGGAGGATACGCAGAAGGAACTGGAACACATGGTCCGAAAGATTCTAAACCTGCGTGTATTTGAGGATGAGAGTGGG AAGCACTGGTCGAAGAGTGTGATGGACAAACAGTACGAGATTCTGTGTGTCAGCCAGTTTACCCTCCAGTGTGTCCTGAAGGGAAACAAG CCTGATTTCCACCTAGCAATGCCCACGGAGCAGGCAGAGGGCTTCTACAACAGCTTCCTGGAGCAGCTGCGTAAAACATACAGGCCGGAG CTTATCAAAGATGGCAAGTTTGGGGCCTACATGCAGGTGCACATTCAGAATGATGGGCCTGTGACCATAGAGCTGGAATCGCCAGCTCCC GGCACTGCTACCTCTGACCCAAAGCAGGTATCTCCCTCAGGGTCTCTGGGCCCCCTCTCTGTCCCTCCTGTCCACAGTACCATGCCTGGA ACAGTAACGTCATCCTGTTCCCCTGGGAACAACAGCAGGCCTTCATCTCCTGGCTCAGGACTCCACGCCAGCAGCCCCACTGCATCTCAA AATAACTCCAAAGCAGCAGTGAACTCCGCCTCCAGTTTTAACTCTTCAGGATCTTGGTACCGATGGAATCATTCCACCTACCTCCACTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000260264_chr11_120186070_+_2452nt CTATCGCCAGGCCGAGAGTGGGCGTGGCCGACGTGGGGTGGGTAGCAGCCGACCGAGTCGGACCGGCCAGTTGGGCGCGCTTCCGGGTGT CACCTCCAGAGGGCGCCGGCTGCGGAGCCGCCCTCAGAGTCGCGAGGCCGGACGCAGCGCGGCGCCGCCCCACTCGCCCCAGCCGCCGCC ATGAAGGCCGTGGTGCAGCGCGTCACCCGGGCCAGCGTCACAGTTGGAGGAGAGCAGATTAGTGCCATTGGAAGGGGCATATGTGTGTTG CTGGGTATTTCCCTGGAGGATACGCAGAAGGAACTGGAACACATGGTCCGAAAGATTCTAAACCTGCGTGTATTTGAGGATGAGAGTGGG AAGCACTGGTCGAAGAGTGTGATGGACAAACAGTACGAGATTCTGTGTGTCAGCCAGTTTACCCTCCAGTGTGTCCTGAAGGGAAACAAG CCTGATTTCCACCTAGCAATGCCCACGGAGCAGGCAGAGGGCTTCTACAACAGCTTCCTGGAGCAGCTGCGTAAAACATACAGGCCGGAG CTTATCAAAGATGGCAAGTTTGGGGCCTACATGCAGGTGCACATTCAGAATGATGGGCCTGTGACCATAGAGCTGGAATCGCCAGCTCCC GGCACTGCTACCTCTGACCCAAAGCAGGTATCTCCCTCAGGGTCTCTGGGCCCCCTCTCTGTCCCTCCTGTCCACAGTACCATGCCTGGA ACAGTAACGTCATCCTGTTCCCCTGGGAACAACAGCAGGCCTTCATCTCCTGGCTCAGGACTCCACGCCAGCAGCCCCACTGCATCTCAA AATAACTCCAAAGCAGCAGTGAACTCCGCCTCCAGTTTTAACTCTTCAGGATCTTGGTACCGATGGAATCATTCCACCTACCTCCACTGA GACCAAAAAGTTTCTCCTACTCCAGCTGGCCCTGTATTCCCCCTGGAAGGAAGGGAATCATGCCTTCTATATACAGACAGATTGCCTTCA GAAGAGTGGAAGAAAATCTCCACTATCAATGAACCCAGACTCTTGTCTTCTTCAAGAGCAAGGGCCTCCGGAGATCCAAACTGTGATTGA ACCAAGTGCAGACTCCTAATGCTCTTGAAATACACAGCCCCTCCTAGGAGCTTACCATTTTCACCTTCCTTGCCTATGCCCTTGCCTTCT AGTTCCAAATATTTTAGCCAGCTTCACTGTGGCAATAGTCTTTCAGAGAAAAGACTTCTTGCTGTTATTCTCCAACTCATCCGTGGGCTT CTGGGGACAGCCATTTGGCTGGGGTGCCAAACACCAGAAGGGGAGATAATAGTTTTGACTCTGAACTTGGCCACAACCCCTGAACTGATC CCAAAATCTGTGAAAAGATTTGAATCTGATATCTCCACCAAAGCCTTGATGTTTTCTCTGTACAGCTAAGTTTTCTGATGGAATCTTCAT CTCACCCCATTTTCTTTTTAACCTCGCCCCCTTTTCTACAATCAAATCCATTCATTATTGCGCCCTCCAGGTCCCCTCCTTTTTGCAGAA GGTGTAAAAGAGCTGCCCTTGGTGGGTGCCCTGGGCATGTTGCAACGCCTGCTGGTGCCCTTCTGTCTGTCCACGTCTGCCTAGGGCTCA GGAGTGCTTGTTCTTTCCCTTCCTCCCTGTGTTTCTCTTTATCCTGTCCCCTCTCCTTTCTCCTGGCAGCAGAAAAGGAAGAACACAAGA GCAAACACACAACAATGATGGTGGCAAAGTACCTGTATATAGCCCTTTCCCATTTTTTGCATTATGTTCTTAACTCCTTAATGTGGAATT TTCCAGCAAAATGTTTAACTCAGGTGTGATTTTTGAAAATGTCTCTGTAATATTTTATCTTCTTTAAAAAAAAGGGGGGGAAATACCAAA GTGTGAAATACTGTGCTACCTTCCAGAGTTCCCACATGGGCTGGGATTTTTTTTTCTTTTTCTTTTTTTTTTTTTTTTTTGAGACAGTCT TGCTCCAGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCATGCTCTGCCACTTGGGTTCAAGCGATTCTCCTGCCTCAGCCT CTCAAGTAGCGGGATTACAGGCGCCCACCACCAAAAATTAGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGG TCAGGCTGGTCTTGAACTCCTGACCTCCTGATCCACCCACCTCAGCGTCCCGAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCTGGC CTGGGCTGGGAATCTTTGTTGACTTCTTTGGGAACATTATCTCTAGAGTCTGCTTTTTTGTGGGCCAGTTTGTAGAGATGTAACATGAAG CCATTCCAGAAATGGTAACTTAAAAAAAAAAAGACTACATGTCTAGGAAACTGTTGAGATTCAAAGGAATCTCACTGTTCCTAAATAAAT >In-frame_DTD1_ENST00000377452_chr20_18608877_+_POU2F3_ENST00000543440_chr11_120186070_+_1391nt CTATCGCCAGGCCGAGAGTGGGCGTGGCCGACGTGGGGTGGGTAGCAGCCGACCGAGTCGGACCGGCCAGTTGGGCGCGCTTCCGGGTGT CACCTCCAGAGGGCGCCGGCTGCGGAGCCGCCCTCAGAGTCGCGAGGCCGGACGCAGCGCGGCGCCGCCCCACTCGCCCCAGCCGCCGCC ATGAAGGCCGTGGTGCAGCGCGTCACCCGGGCCAGCGTCACAGTTGGAGGAGAGCAGATTAGTGCCATTGGAAGGGGCATATGTGTGTTG CTGGGTATTTCCCTGGAGGATACGCAGAAGGAACTGGAACACATGGTCCGAAAGATTCTAAACCTGCGTGTATTTGAGGATGAGAGTGGG AAGCACTGGTCGAAGAGTGTGATGGACAAACAGTACGAGATTCTGTGTGTCAGCCAGTTTACCCTCCAGTGTGTCCTGAAGGGAAACAAG CCTGATTTCCACCTAGCAATGCCCACGGAGCAGGCAGAGGGCTTCTACAACAGCTTCCTGGAGCAGCTGCGTAAAACATACAGGCCGGAG CTTATCAAAGATGGCAAGTTTGGGGCCTACATGCAGGTGCACATTCAGAATGATGGGCCTGTGACCATAGAGCTGGAATCGCCAGCTCCC GGCACTGCTACCTCTGACCCAAAGCAGGTATCTCCCTCAGGGTCTCTGGGCCCCCTCTCTGTCCCTCCTGTCCACAGTACCATGCCTGGA ACAGTAACGTCATCCTGTTCCCCTGGGAACAACAGCAGGCCTTCATCTCCTGGCTCAGGACTCCACGCCAGCAGCCCCACTGCATCTCAA AATAACTCCAAAGCAGCAGTGAACTCCGCCTCCAGTTTTAACTCTTCAGGATCTTGGTACCGATGGAATCATTCCACCTACCTCCACTGA GACCAAAAAGTTTCTCCTACTCCAGCTGGCCCTGTATTCCCCCTGGAAGGAAGGGAATCATGCCTTCTATATACAGACAGATTGCCTTCA GAAGAGTGGAAGAAAATCTCCACTATCAATGAACCCAGACTCTTGTCTTCTTCAAGAGCAAGGGCCTCCGGAGATCCAAACTGTGATTGA ACCAAGTGCAGACTCCTAATGCTCTTGAAATACACAGCCCCTCCTAGGAGCTTACCATTTTCACCTTCCTTGCCTATGCCCTTGCCTTCT AGTTCCAAATATTTTAGCCAGCTTCACTGTGGCAATAGTCTTTCAGAGAAAAGACTTCTTGCTGTTATTCTCCAACTCATCCGTGGGCTT CTGGGGACAGCCATTTGGCTGGGGTGCCAAACACCAGAAGGGGAGATAATAGTTTTGACTCTGAACTTGGCCACAACCCCTGAACTGATC |
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FusionGenePPI for DTD1_POU2F3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DTD1 | IQCB1, CDC45, TOPBP1, CSNK2A1, ANKMY2, HSF1, CYP1A1, CSNK1E, HARS, MAN2B1, SH2D4A, NEK2, POLK | POU2F3 | BCL6, CREBBP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DTD1_POU2F3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DTD1_POU2F3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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