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Fusion gene ID: 1062 |
FusionGeneSummary for AGAP1_SORBS2 |
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Fusion gene information | Fusion gene name: AGAP1_SORBS2 | Fusion gene ID: 1062 | Hgene | Tgene | Gene symbol | AGAP1 | SORBS2 | Gene ID | 116987 | 8470 |
Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | sorbin and SH3 domain containing 2 | |
Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | ARGBP2|PRO0618 | |
Cytomap | 2q37.2 | 4q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UPQ3 | O94875 | |
Ensembl transtripts involved in fusion gene | ENST00000336665, ENST00000304032, ENST00000409538, ENST00000428334, ENST00000409457, | ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125, | |
Fusion gene scores | * DoF score | 25 X 11 X 14=3850 | 11 X 12 X 7=924 |
# samples | 26 | 15 | |
** MAII score | log2(26/3850*10)=-3.88827491744117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/924*10)=-2.62293035092018 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: AGAP1 [Title/Abstract] AND SORBS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE827936 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000336665 | ENST00000448662 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000336665 | ENST00000431808 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000336665 | ENST00000284776 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000437304 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000319471 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000449407 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000355634 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000393528 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000336665 | ENST00000418609 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000336665 | ENST00000498125 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000304032 | ENST00000448662 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000304032 | ENST00000431808 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000304032 | ENST00000284776 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000437304 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000319471 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000449407 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000355634 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000393528 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000304032 | ENST00000418609 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000304032 | ENST00000498125 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409538 | ENST00000448662 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409538 | ENST00000431808 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409538 | ENST00000284776 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000437304 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000319471 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000449407 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000355634 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000393528 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409538 | ENST00000418609 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409538 | ENST00000498125 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000428334 | ENST00000448662 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000428334 | ENST00000431808 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000428334 | ENST00000284776 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000437304 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000319471 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000449407 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000355634 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000393528 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000428334 | ENST00000418609 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000428334 | ENST00000498125 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409457 | ENST00000448662 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409457 | ENST00000431808 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409457 | ENST00000284776 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000437304 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000319471 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000449407 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000355634 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000393528 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-3UTR | ENST00000409457 | ENST00000418609 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
intron-intron | ENST00000409457 | ENST00000498125 | AGAP1 | chr2 | 236702727 | + | SORBS2 | chr4 | 186507136 | - |
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FusionProtFeatures for AGAP1_SORBS2 |
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Hgene | Tgene |
AGAP1 | SORBS2 |
GTPase-activating protein for ARF1 and, to a lesserextent, ARF5. Directly and specifically regulates the adapterprotein 3 (AP-3)-dependent trafficking of proteins in theendosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AGAP1_SORBS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AGAP1_SORBS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGAP1_SORBS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGAP1_SORBS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | AGAP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | SORBS2 | C0043094 | Weight Gain | 1 | CTD_human |