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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10615

FusionGeneSummary for DSTYK_CSRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DSTYK_CSRP1
Fusion gene ID: 10615
HgeneTgene
Gene symbol

DSTYK

CSRP1

Gene ID

25778

1465

Gene namedual serine/threonine and tyrosine protein kinasecysteine and glycine rich protein 1
SynonymsCAKUT1|DustyPK|HDCMD38P|RIP5|RIPK5|SPG23CRP|CRP1|CSRP|CYRP|D1S181E|HEL-141|HEL-S-286
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptiondual serine/threonine and tyrosine protein kinaseRIP-homologous kinasedusty PKdusty protein kinasereceptor-interacting serine/threonine-protein kinase 5sgK496sugen kinase 496cysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286
Modification date2018052220180519
UniProtAcc

Q6XUX3

P21291

Ensembl transtripts involved in fusion geneENST00000367160, ENST00000367161, 
ENST00000367162, 		ENST00000367306, 
ENST00000340006, ENST00000531916, 
ENST00000532460, ENST00000533432, 
ENST00000526723, ENST00000458271, 
Fusion gene scores* DoF score7 X 2 X 8=1124 X 6 X 4=96
# samples 86
** MAII scorelog2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DSTYK [Title/Abstract] AND CSRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSTYK

GO:0044344

cellular response to fibroblast growth factor stimulus

23862974


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N8-A56S-01ADSTYKchr1

205180399

-CSRP1chr1

201454504

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000367160ENST00000367306DSTYKchr1

205180399

-CSRP1chr1

201454504

-
In-frameENST00000367160ENST00000340006DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367160ENST00000531916DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367160ENST00000532460DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367160ENST00000533432DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367160ENST00000526723DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367160ENST00000458271DSTYKchr1

205180399

-CSRP1chr1

201454504

-
In-frameENST00000367161ENST00000367306DSTYKchr1

205180399

-CSRP1chr1

201454504

-
In-frameENST00000367161ENST00000340006DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367161ENST00000531916DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367161ENST00000532460DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367161ENST00000533432DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367161ENST00000526723DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367161ENST00000458271DSTYKchr1

205180399

-CSRP1chr1

201454504

-
In-frameENST00000367162ENST00000367306DSTYKchr1

205180399

-CSRP1chr1

201454504

-
In-frameENST00000367162ENST00000340006DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367162ENST00000531916DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367162ENST00000532460DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367162ENST00000533432DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367162ENST00000526723DSTYKchr1

205180399

-CSRP1chr1

201454504

-
5CDS-intronENST00000367162ENST00000458271DSTYKchr1

205180399

-CSRP1chr1

201454504

-

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FusionProtFeatures for DSTYK_CSRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSTYK

Q6XUX3

CSRP1

P21291

Could play a role in neuronal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-11215_2288885Compositional biasNote=Poly-Gly
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-11269_7288885Compositional biasNote=Poly-Gly
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-11315_2288930Compositional biasNote=Poly-Gly
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-11369_7288930Compositional biasNote=Poly-Gly
TgeneCSRP1chr1:205180399chr1:201454504ENST00000340006-36176_187137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000367306-47176_187137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000532460-36176_187137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000533432-36176_187137194Compositional biasNote=Gly-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-112189_21588885Coiled coilOntology_term=ECO:0000255
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-112395_43188885Coiled coilOntology_term=ECO:0000255
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-113189_21588930Coiled coilOntology_term=ECO:0000255
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-113395_43188930Coiled coilOntology_term=ECO:0000255
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-112652_90688885DomainProtein kinase
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-113652_90688930DomainProtein kinase
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367161-112658_66688885Nucleotide bindingATP
HgeneDSTYKchr1:205180399chr1:201454504ENST00000367162-113658_66688930Nucleotide bindingATP
TgeneCSRP1chr1:205180399chr1:201454504ENST00000340006-3663_78137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000367306-4763_78137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000532460-3663_78137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000533432-3663_78137194Compositional biasNote=Gly-rich
TgeneCSRP1chr1:205180399chr1:201454504ENST00000340006-3610_61137194DomainLIM zinc-binding 1
TgeneCSRP1chr1:205180399chr1:201454504ENST00000340006-36119_170137194DomainLIM zinc-binding 2
TgeneCSRP1chr1:205180399chr1:201454504ENST00000367306-4710_61137194DomainLIM zinc-binding 1
TgeneCSRP1chr1:205180399chr1:201454504ENST00000367306-47119_170137194DomainLIM zinc-binding 2
TgeneCSRP1chr1:205180399chr1:201454504ENST00000532460-3610_61137194DomainLIM zinc-binding 1
TgeneCSRP1chr1:205180399chr1:201454504ENST00000532460-36119_170137194DomainLIM zinc-binding 2
TgeneCSRP1chr1:205180399chr1:201454504ENST00000533432-3610_61137194DomainLIM zinc-binding 1
TgeneCSRP1chr1:205180399chr1:201454504ENST00000533432-36119_170137194DomainLIM zinc-binding 2
TgeneCSRP1chr1:205180399chr1:201454504ENST00000340006-3664_69137194MotifNuclear localization signal
TgeneCSRP1chr1:205180399chr1:201454504ENST00000367306-4764_69137194MotifNuclear localization signal
TgeneCSRP1chr1:205180399chr1:201454504ENST00000532460-3664_69137194MotifNuclear localization signal
TgeneCSRP1chr1:205180399chr1:201454504ENST00000533432-3664_69137194MotifNuclear localization signal


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FusionGeneSequence for DSTYK_CSRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL

>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_145aa
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHNHTCLSSLTGGGGAERGPAGDVAETGLQAVL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG

>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_436nt
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGC
TTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTG
GCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_1683nt
GGGGAGGAGGGAGGCCGGGCCTGCGGCCGGGGACCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGG
CAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGG
ACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGG
CGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCA
AGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCA
AGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCTTGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTT
TTCATCGCCATTCCATTCCCAGCAGCTTTGGAGACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTG
GGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCCTGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGT
AGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAGCAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTG
CGTGTCCATCATCAGCTGACCAAGACACCTGAGGACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAA
GACCAAGATGAGGAGGGGGGAAGGCTGGGTTTTTTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCA
GAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTCACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGG
CCTCTTGCCTTTGAGTCTTTGTGGAATGGATAGCCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGA
TGTTGTTTGATCTTCTCAAACATCTAGTTCCCTGCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGG
CTCAAATCTTCATTTATCTCTGGCCTTAACCCTGGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCT
GCTTGATCCTCAGATGTGGAGGGAGGTAGGCACTGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCC
TTTAACCCAAGACCCTGCCTCTTCCACTCCACCCTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGA
ATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCCTCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGC

>In-frame_DSTYK_ENST00000367160_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_1679nt
GGGGAGGAGGGAGGCCGGGCCTGCGGCCGGGGACCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGG
CAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGCGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGG
ACGGCTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGG
CGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGATGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCA
AGTGTGGCAAAGGCCTTGAGTCAACCACCCTGGCAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCA
AGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCTTGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTT
TTCATCGCCATTCCATTCCCAGCAGCTTTGGAGACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTG
GGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCCTGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGT
AGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAGCAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTG
CGTGTCCATCATCAGCTGACCAAGACACCTGAGGACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAA
GACCAAGATGAGGAGGGGGGAAGGCTGGGTTTTTTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCA
GAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTCACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGG
CCTCTTGCCTTTGAGTCTTTGTGGAATGGATAGCCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGA
TGTTGTTTGATCTTCTCAAACATCTAGTTCCCTGCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGG
CTCAAATCTTCATTTATCTCTGGCCTTAACCCTGGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCT
GCTTGATCCTCAGATGTGGAGGGAGGTAGGCACTGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCC
TTTAACCCAAGACCCTGCCTCTTCCACTCCACCCTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGA
ATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCCTCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGC

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_1650nt
CCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGG
CGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAA
GTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGA
TGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGG
CAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCAAGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCT
TGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTTTTCATCGCCATTCCATTCCCAGCAGCTTTGGAG
ACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTGGGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCC
TGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGTAGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAG
CAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTGCGTGTCCATCATCAGCTGACCAAGACACCTGAG
GACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAAGACCAAGATGAGGAGGGGGGAAGGCTGGGTTTT
TTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCAGAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTC
ACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGGCCTCTTGCCTTTGAGTCTTTGTGGAATGGATAG
CCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGATGTTGTTTGATCTTCTCAAACATCTAGTTCCCT
GCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGGCTCAAATCTTCATTTATCTCTGGCCTTAACCCT
GGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCTGCTTGATCCTCAGATGTGGAGGGAGGTAGGCAC
TGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCCTTTAACCCAAGACCCTGCCTCTTCCACTCCACC
CTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGAATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCC
TCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGCTGCAGGCATGGGCTGTACCCAAGCTGATTTCTC

>In-frame_DSTYK_ENST00000367161_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_1646nt
CCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGG
CGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAA
GTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGA
TGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGG
CAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCAAGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCT
TGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTTTTCATCGCCATTCCATTCCCAGCAGCTTTGGAG
ACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTGGGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCC
TGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGTAGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAG
CAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTGCGTGTCCATCATCAGCTGACCAAGACACCTGAG
GACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAAGACCAAGATGAGGAGGGGGGAAGGCTGGGTTTT
TTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCAGAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTC
ACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGGCCTCTTGCCTTTGAGTCTTTGTGGAATGGATAG
CCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGATGTTGTTTGATCTTCTCAAACATCTAGTTCCCT
GCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGGCTCAAATCTTCATTTATCTCTGGCCTTAACCCT
GGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCTGCTTGATCCTCAGATGTGGAGGGAGGTAGGCAC
TGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCCTTTAACCCAAGACCCTGCCTCTTCCACTCCACC
CTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGAATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCC
TCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGCTGCAGGCATGGGCTGTACCCAAGCTGATTTCTC

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000367306_chr1_201454504_-_1650nt
CCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGG
CGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAA
GTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGA
TGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGG
CAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCAAGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCT
TGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTTTTCATCGCCATTCCATTCCCAGCAGCTTTGGAG
ACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTGGGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCC
TGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGTAGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAG
CAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTGCGTGTCCATCATCAGCTGACCAAGACACCTGAG
GACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAAGACCAAGATGAGGAGGGGGGAAGGCTGGGTTTT
TTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCAGAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTC
ACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGGCCTCTTGCCTTTGAGTCTTTGTGGAATGGATAG
CCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGATGTTGTTTGATCTTCTCAAACATCTAGTTCCCT
GCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGGCTCAAATCTTCATTTATCTCTGGCCTTAACCCT
GGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCTGCTTGATCCTCAGATGTGGAGGGAGGTAGGCAC
TGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCCTTTAACCCAAGACCCTGCCTCTTCCACTCCACC
CTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGAATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCC
TCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGCTGCAGGCATGGGCTGTACCCAAGCTGATTTCTC

>In-frame_DSTYK_ENST00000367162_chr1_205180399_-_CSRP1_ENST00000340006_chr1_201454504_-_1646nt
CCGAGCCGCAAAGACAGAGCGGGCAGAGGCGATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGG
CGGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGGCTGCGACAGAACCTGCGCGAGACCCAGAA
GTTCTTCCGCGACATCAAGTGCTCCCACAACCACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGA
TGTCGCCGAAACCGGGCTGCAGGCGGTCCTGGCATAAGGCCTGCTTTCGATGTGCCAAGTGTGGCAAAGGCCTTGAGTCAACCACCCTGG
CAGACAAGGATGGCGAGATTTACTGCAAAGGATGTTATGCTAAAAACTTCGGGCCCAAGGGCTTTGGTTTTGGGCAAGGAGCTGGGGCCT
TGGTCCACTCTGAGTGAGGCCACCATCACCCACCACACCCTGCCCACTCCTGCGCTTTTCATCGCCATTCCATTCCCAGCAGCTTTGGAG
ACCTCCAGGATTATTTCTCTGTCAGCCCTGCCACATATCACTAATGACTTGAACTTGGGCATCTGGCTCCCTTTGGTTTGGGGGTCTGCC
TGAGGTCCCACCCCACTAAAGGGCTCCCCAGGCCTGGGATCTGACACCATCACCAGTAGGAGACCTCAGTGTTTTGGGTCTAGGTGAGAG
CAGGCCCCTCTCCCCACACCTCGCCCCACAGAGCTCTGTTCTTAGCCTCCTGTGCTGCGTGTCCATCATCAGCTGACCAAGACACCTGAG
GACACATCTTGGCACCCAGAGGAGCAGCAGCAACAGGCTGGAGGGAGAGGGAAGCAAGACCAAGATGAGGAGGGGGGAAGGCTGGGTTTT
TTGGATCTCAGAGATTCTCCTCTGTGGGAAAGAGGTTGAGCTTCCTGGTGTCCCTCAGAGTAAGCCTGAGGAGTCCCAGCTTAGGGAGTC
ACTATTGGAGGCAGAGAGGCATGCAGGCAGGGTCCTAGGAGCCCCTGCTTCTCCAGGCCTCTTGCCTTTGAGTCTTTGTGGAATGGATAG
CCTCCCACTAGGACTGGGAGGAGAATAACCCAGGTCTTAAGGACCCCAAAGTCAGGATGTTGTTTGATCTTCTCAAACATCTAGTTCCCT
GCTTGATGGGAGGATCCTAATGAAATACCTGAAACATATATTGGCATTTATCAATGGCTCAAATCTTCATTTATCTCTGGCCTTAACCCT
GGCTCCTGAGGCTGCGGCCAGCAGAGCCCAGGCCAGGGCTCTGTTCTTGCCACACCTGCTTGATCCTCAGATGTGGAGGGAGGTAGGCAC
TGCCTCAGTCTTCATCCAAACACCTTTCCCTTTGCCCTGAGACCTCAGAATCTTCCCTTTAACCCAAGACCCTGCCTCTTCCACTCCACC
CTTCTCCAGGGACCCTTAGATCACATCACTCCACCCCTGCCAGGCCCCAGGTTAGGAATAGTGGTGGGAGGAAGGGGAAAGGGCTGGGCC
TCACCGCTCCCAGCAACTGAAAGGACAACACTATCTGGAGCCACCCACTGAAAGGGCTGCAGGCATGGGCTGTACCCAAGCTGATTTCTC


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FusionGenePPI for DSTYK_CSRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DSTYKIKBKE, RAB14, HSPE1, MTPN, PSMB1, UBE2K, PSMB3, MAD2L1, ATP5F1, RPS9, DDT, LSM12, RAB5C, CTDSP1, CEP170, B3GNT3, DCAF15, ARHGAP25, CDK13, CLTC, IL1R2, CDH13, RAB2B, DCTN1, CD79B, GRPR, BSG, FRMD1, LAMP3, SLAMF1, P2RX2, CCL22, DEF8, NCR3LG1, PLA2G10, DKKL1, TRIM25CSRP1CSRP1, EGFR, APP, GRB2, ACTN1, BAG3, YBX3, MACF1, PRKAR2A, SUZ12, RNF2, BMI1, ACAA2, CFL1, HSPB1, NUP214, UFM1, FUBP3, TALDO1, ESR1, CNTRL, ASCC2, ASCC1, TRIP4, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DSTYK_CSRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCSRP1P21291DB11638ArtenimolCysteine and glycine-rich protein 1small moleculeapproved|investigational

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RelatedDiseases for DSTYK_CSRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSTYKC4017279CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT 1, SUSCEPTIBILITY TO1UNIPROT
TgeneCSRP1C0005586Bipolar Disorder1PSYGENET
TgeneCSRP1C0014173Endometrial Hyperplasia1CTD_human
TgeneCSRP1C0033578Prostatic Neoplasms1CTD_human
TgeneCSRP1C0746402manic symptom1PSYGENET