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Fusion gene ID: 10610 |
FusionGeneSummary for DSTN_FBXO31 |
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Fusion gene information | Fusion gene name: DSTN_FBXO31 | Fusion gene ID: 10610 | Hgene | Tgene | Gene symbol | DSTN | FBXO31 | Gene ID | 11034 | 79791 |
Gene name | destrin, actin depolymerizing factor | F-box protein 31 | |
Synonyms | ACTDP|ADF|HEL32|bA462D18.2 | FBX14|FBXO14|Fbx31|MRT45|pp2386 | |
Cytomap | 20p12.1 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | destrinactin-depolymerizing factorbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP))epididymis luminal protein 32 | F-box only protein 31SCF ubiquitin ligase specificity factorputative breast cancer tumor-suppressor | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P60981 | Q5XUX0 | |
Ensembl transtripts involved in fusion gene | ENST00000246069, ENST00000474024, | ENST00000311635, ENST00000563956, | |
Fusion gene scores | * DoF score | 10 X 4 X 7=280 | 3 X 3 X 3=27 |
# samples | 10 | 3 | |
** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DSTN [Title/Abstract] AND FBXO31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DSTN | GO:0030042 | actin filament depolymerization | 11812157 |
Tgene | FBXO31 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
Tgene | FBXO31 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 19412162 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF886494 | DSTN | chr20 | 17588489 | + | FBXO31 | chr16 | 87394196 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000246069 | ENST00000311635 | DSTN | chr20 | 17588489 | + | FBXO31 | chr16 | 87394196 | - |
3UTR-intron | ENST00000246069 | ENST00000563956 | DSTN | chr20 | 17588489 | + | FBXO31 | chr16 | 87394196 | - |
3UTR-intron | ENST00000474024 | ENST00000311635 | DSTN | chr20 | 17588489 | + | FBXO31 | chr16 | 87394196 | - |
3UTR-intron | ENST00000474024 | ENST00000563956 | DSTN | chr20 | 17588489 | + | FBXO31 | chr16 | 87394196 | - |
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FusionProtFeatures for DSTN_FBXO31 |
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Hgene | Tgene |
DSTN | FBXO31 |
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. {ECO:0000269|PubMed:11812157}. | Component of some SCF (SKP1-cullin-F-box) protein ligasecomplex that plays a central role in G1 arrest following DNAdamage. Specifically recognizes phosphorylated cyclin-D1 (CCND1),promoting its ubiquitination and degradation by the proteasome,resulting in G1 arrest. May act as a tumor suppressor.{ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DSTN_FBXO31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DSTN_FBXO31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DSTN_FBXO31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DSTN_FBXO31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |