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Fusion gene ID: 10588 |
FusionGeneSummary for DSG2_DSG2 |
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Fusion gene information | Fusion gene name: DSG2_DSG2 | Fusion gene ID: 10588 | Hgene | Tgene | Gene symbol | DSG2 | DSG2 | Gene ID | 1829 | 1829 |
Gene name | desmoglein 2 | desmoglein 2 | |
Synonyms | CDHF5|HDGC | CDHF5|HDGC | |
Cytomap | 18q12.1 | 18q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | desmoglein-2cadherin family member 5 | desmoglein-2cadherin family member 5 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q14126 | Q14126 | |
Ensembl transtripts involved in fusion gene | ENST00000261590, ENST00000585206, | ENST00000261590, ENST00000585206, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 5 X 5 X 2=50 |
# samples | 6 | 6 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DSG2 [Title/Abstract] AND DSG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DSG2 | GO:0007155 | cell adhesion | 17559062 |
Hgene | DSG2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 17559062 |
Tgene | DSG2 | GO:0007155 | cell adhesion | 17559062 |
Tgene | DSG2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 17559062 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW600916 | DSG2 | chr18 | 29127669 | - | DSG2 | chr18 | 29128247 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000261590 | ENST00000261590 | DSG2 | chr18 | 29127669 | - | DSG2 | chr18 | 29128247 | - |
3UTR-intron | ENST00000261590 | ENST00000585206 | DSG2 | chr18 | 29127669 | - | DSG2 | chr18 | 29128247 | - |
intron-3UTR | ENST00000585206 | ENST00000261590 | DSG2 | chr18 | 29127669 | - | DSG2 | chr18 | 29128247 | - |
intron-intron | ENST00000585206 | ENST00000585206 | DSG2 | chr18 | 29127669 | - | DSG2 | chr18 | 29128247 | - |
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FusionProtFeatures for DSG2_DSG2 |
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Hgene | Tgene |
DSG2 | DSG2 |
Component of intercellular desmosome junctions. Involvedin the interaction of plaque proteins and intermediate filamentsmediating cell-cell adhesion. | Component of intercellular desmosome junctions. Involvedin the interaction of plaque proteins and intermediate filamentsmediating cell-cell adhesion. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DSG2_DSG2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DSG2_DSG2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DSG2_DSG2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DSG2_DSG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DSG2 | C1857777 | Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 | 2 | CTD_human;UNIPROT |
Tgene | DSG2 | C1857777 | Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 | 2 | CTD_human;UNIPROT |