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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10588

FusionGeneSummary for DSG2_DSG2

check button Fusion gene summary
Fusion gene informationFusion gene name: DSG2_DSG2
Fusion gene ID: 10588
HgeneTgene
Gene symbol

DSG2

DSG2

Gene ID

1829

1829

Gene namedesmoglein 2desmoglein 2
SynonymsCDHF5|HDGCCDHF5|HDGC
Cytomap

18q12.1

18q12.1

Type of geneprotein-codingprotein-coding
Descriptiondesmoglein-2cadherin family member 5desmoglein-2cadherin family member 5
Modification date2018051920180519
UniProtAcc

Q14126

Q14126

Ensembl transtripts involved in fusion geneENST00000261590, ENST00000585206, 
ENST00000261590, ENST00000585206, 
Fusion gene scores* DoF score5 X 5 X 4=1005 X 5 X 2=50
# samples 66
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DSG2 [Title/Abstract] AND DSG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDSG2

GO:0007155

cell adhesion

17559062

HgeneDSG2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

17559062

TgeneDSG2

GO:0007155

cell adhesion

17559062

TgeneDSG2

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

17559062


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW600916DSG2chr18

29127669

-DSG2chr18

29128247

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000261590ENST00000261590DSG2chr18

29127669

-DSG2chr18

29128247

-
3UTR-intronENST00000261590ENST00000585206DSG2chr18

29127669

-DSG2chr18

29128247

-
intron-3UTRENST00000585206ENST00000261590DSG2chr18

29127669

-DSG2chr18

29128247

-
intron-intronENST00000585206ENST00000585206DSG2chr18

29127669

-DSG2chr18

29128247

-

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FusionProtFeatures for DSG2_DSG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DSG2

Q14126

DSG2

Q14126

Component of intercellular desmosome junctions. Involvedin the interaction of plaque proteins and intermediate filamentsmediating cell-cell adhesion. Component of intercellular desmosome junctions. Involvedin the interaction of plaque proteins and intermediate filamentsmediating cell-cell adhesion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DSG2_DSG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DSG2_DSG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DSG2_DSG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DSG2_DSG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDSG2C1857777Arrhythmogenic Right Ventricular Dysplasia, Familial, 102CTD_human;UNIPROT
TgeneDSG2C1857777Arrhythmogenic Right Ventricular Dysplasia, Familial, 102CTD_human;UNIPROT