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Fusion gene ID: 1058 |
FusionGeneSummary for AGAP1_PINX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AGAP1_PINX1 | Fusion gene ID: 1058 | Hgene | Tgene | Gene symbol | AGAP1 | PINX1 | Gene ID | 116987 | 54984 |
| Gene name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | PIN2 (TERF1) interacting telomerase inhibitor 1 | |
| Synonyms | AGAP-1|CENTG2|GGAP1|cnt-g2 | Gno1|LPTL|LPTS|Pxr1 | |
| Cytomap | 2q37.2 | 8p23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2 | PIN2/TERF1-interacting telomerase inhibitor 167-11-3 proteinPIN2-interacting protein 1TRF1-interacting protein 1hepatocellular carcinoma-related putative tumor suppressorliver-related putative tumor suppressorpin2-interacting protein X1protein 67-1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UPQ3 | Q96BK5 | |
| Ensembl transtripts involved in fusion gene | ENST00000336665, ENST00000304032, ENST00000409538, ENST00000428334, ENST00000409457, | ENST00000314787, ENST00000426190, ENST00000519088, ENST00000520018, | |
| Fusion gene scores | * DoF score | 25 X 11 X 14=3850 | 4 X 3 X 3=36 |
| # samples | 26 | 3 | |
| ** MAII score | log2(26/3850*10)=-3.88827491744117 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AGAP1 [Title/Abstract] AND PINX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PINX1 | GO:0007004 | telomere maintenance via telomerase | 11701125 |
| Tgene | PINX1 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle | 11701125 |
| Tgene | PINX1 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 11701125 |
| Tgene | PINX1 | GO:0051974 | negative regulation of telomerase activity | 11701125 |
| Tgene | PINX1 | GO:1902570 | protein localization to nucleolus | 24415760 |
| Tgene | PINX1 | GO:1904744 | positive regulation of telomeric DNA binding | 19265708|24415760 |
| Tgene | PINX1 | GO:1904751 | positive regulation of protein localization to nucleolus | 19265708 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1544-01A | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336665 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000336665 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000336665 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| 5CDS-intron | ENST00000336665 | ENST00000520018 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000304032 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000304032 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000304032 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| 5CDS-intron | ENST00000304032 | ENST00000520018 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000409538 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000409538 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000409538 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-intron | ENST00000409538 | ENST00000520018 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000428334 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000428334 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-3CDS | ENST00000428334 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| intron-intron | ENST00000428334 | ENST00000520018 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000314787 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000426190 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| In-frame | ENST00000409457 | ENST00000519088 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
| 5CDS-intron | ENST00000409457 | ENST00000520018 | AGAP1 | chr2 | 236403493 | + | PINX1 | chr8 | 10683754 | - |
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FusionProtFeatures for AGAP1_PINX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AGAP1 | PINX1 |
| GTPase-activating protein for ARF1 and, to a lesserextent, ARF5. Directly and specifically regulates the adapterprotein 3 (AP-3)-dependent trafficking of proteins in theendosomal-lysosomal system. {ECO:0000269|PubMed:12640130}. | Microtubule-binding protein essential for faithfulchromosome segregation. Mediates TRF1 and TERT accumulation innucleolus and enhances TRF1 binding to telomeres. Inhibitstelomerase activity. May inhibit cell proliferation and act astumor suppressor. {ECO:0000269|PubMed:15381700,ECO:0000269|PubMed:17198684, ECO:0000269|PubMed:19117989,ECO:0000269|PubMed:19265708, ECO:0000269|PubMed:19393617,ECO:0000269|PubMed:19553660}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | - | 3 | 7 | 287_297 | 100 | 329 | Motif | Note=TBM |
| Tgene | >PINX1 | chr2:236403493 | chr8:10683754 | ENST00000519088 | - | 3 | 6 | 287_297 | 100 | 175 | Motif | Note=TBM |
| Tgene | >PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | - | 3 | 7 | 254_328 | 100 | 329 | Region | Note=Telomerase inhibitory domain (TID) |
| Tgene | >PINX1 | chr2:236403493 | chr8:10683754 | ENST00000519088 | - | 3 | 6 | 254_328 | 100 | 175 | Region | Note=Telomerase inhibitory domain (TID) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 346_588 | 54 | 858 | Domain | PH |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 609_729 | 54 | 858 | Domain | Arf-GAP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 346_588 | 54 | 805 | Domain | PH |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 609_729 | 54 | 805 | Domain | Arf-GAP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 346_588 | 54 | 406 | Domain | PH |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 609_729 | 54 | 406 | Domain | Arf-GAP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 122_126 | 54 | 858 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 178_181 | 54 | 858 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 78_85 | 54 | 858 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 122_126 | 54 | 805 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 178_181 | 54 | 805 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 78_85 | 54 | 805 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 122_126 | 54 | 406 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 178_181 | 54 | 406 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 78_85 | 54 | 406 | Nucleotide binding | GTP |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 66_276 | 54 | 858 | Region | Note=Small GTPase-like |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 66_276 | 54 | 805 | Region | Note=Small GTPase-like |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 66_276 | 54 | 406 | Region | Note=Small GTPase-like |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 768_797 | 54 | 858 | Repeat | Note=ANK 1 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 801_830 | 54 | 858 | Repeat | Note=ANK 2 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 768_797 | 54 | 805 | Repeat | Note=ANK 1 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 801_830 | 54 | 805 | Repeat | Note=ANK 2 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 768_797 | 54 | 406 | Repeat | Note=ANK 1 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 801_830 | 54 | 406 | Repeat | Note=ANK 2 |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000304032 | + | 1 | 18 | 624_647 | 54 | 858 | Zinc finger | C4-type |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000336665 | + | 1 | 17 | 624_647 | 54 | 805 | Zinc finger | C4-type |
| Hgene | >AGAP1 | chr2:236403493 | chr8:10683754 | ENST00000409457 | + | 1 | 10 | 624_647 | 54 | 406 | Zinc finger | C4-type |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000314787 | - | 3 | 7 | 26_72 | 100 | 329 | Domain | G-patch |
| Tgene | PINX1 | chr2:236403493 | chr8:10683754 | ENST00000519088 | - | 3 | 6 | 26_72 | 100 | 175 | Domain | G-patch |
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FusionGeneSequence for AGAP1_PINX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_283aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLS SRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVES YLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEE >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_283aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLS SRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVES YLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEE >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_283aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLS SRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVES YLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEE >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_129aa MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQNQIREHVIAIEDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGRCQS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_849nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCA TCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAG GAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCA GTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGT TACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCA GCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGC CGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAA >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_849nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCA TCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAG GAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCA GTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGT TACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCA GCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGC CGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAA >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_849nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCA TCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAG GAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCA GTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGT TACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCA GCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGC CGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAA >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_387nt ATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATC TACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAG GAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCC CTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_1867nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGC CAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAA GAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGC CGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTC TGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAG CCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCT GGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAA TGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAAT ACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_1788nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTAT AATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCG >In-frame_AGAP1_ENST00000336665_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_1594nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_1867nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTTTGGGAAAAGACAGAGTAA GAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCCAGGAGTACTTTGC CAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAACGTAAAAGGGGGAA GAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAAAGCCCGAGAGGGC CGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGAGTTCCAAGGCCTC TGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGAAGAAAAAGCTGCA AAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAATGAATCCTTCCCAG CCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCACCCCAGAGCGCCT GGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGGAGGACCTTTTTAA TGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTATAATCATTACAAAT ACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCGTTTGCTCTCGGTT >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_1788nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG AGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTAATTAT AATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCCG >In-frame_AGAP1_ENST00000304032_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_1594nt CGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCCCGGCGCGCCGGGCGGCGC AGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGCCCTCGGCCCCGGCGCTCG GAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGCTCAGGAAGTCACCCGAGC AAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGCTGACCCGGGACGCCGGGG CCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCCGCGCCTTTCTTCTCGCGC CTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCCCCGGGGCGCGGGGCGGCG GCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGCTGCCATCCGGGCCGAGAT CCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGTGCTGCAGAACCAGATCCG GGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTCCAAAATCTCCAAAAACCG TGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCACCATCC AGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGTGGAAC GTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGAGGGAA AGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGACCAGA GTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAGAGGGA AGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTCCAAAT GAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGAGTTCA CCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTCCCAGG >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000314787_chr8_10683754_-_1885nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGAAGGATCTGTCATCTCGGAGCAAAACAGATCTTGACTGCATTTT TGGGAAAAGACAGAGTAAGAAGACTCCCGAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAACCAGCGCCTTCAC CATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTTCTGAGACGCAGGT GGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCAAGAGGCACACGGA GGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAGGCCCCTGCTGGGA CCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGCCCAAAAAGAGGAG AGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGAAGAAGAAAGATTC CAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTGAAGTCACAGCAGA GTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCCCCAAGTTACATTC CCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCAGCAAGAGAGTTTA ATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTAT >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000426190_chr8_10683754_-_1806nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTT CTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCA AGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAG GCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGC CCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTG AAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCC CCAAGTTACATTCCCAGGAGGACCTTTTTAATGTTCTCAATCGTGGCTCTCAGACACAAATAAATTTTTTTGTAAACTCTGAGCCCTTCA GCAAGAGAGTTTAATTATAATCATTACAAATACATGCATTCATGTAAGTGTGCACACGTGTGTGTGCATGTGCGCATCTGTGTGTGTGTG TGTGTGTCACTATCTCCGTTTGCTCTCGGTTCCCTTCAATAACAATGAATGGTGCTTTCTTCTGAAAGACTCAGCCTAATTAAAGGATTA >In-frame_AGAP1_ENST00000409457_chr2_236403493_+_PINX1_ENST00000519088_chr8_10683754_-_1612nt GGCGCTCGGAGCGGGCTCCGCGGCTTGCAAGGCGCCTGCGACTCGGTCCCAGGTCGGCGGGCGGCGCACGGCGGGCTCGCGCGGGGGCCC CGGCGCGCCGGGCGGCGCAGTACGCAGCGCGCGGACCCACGCCACGGCCAGGAGCCCAGAGCAGCGCGGCCACACTGCCCAGGGGTCGGC CCTCGGCCCCGGCGCTCGGAGCGCGGCGGCTGCCTGGGCTTTAATGGCTGCTCCGCGGAGCAGCGCCTAGGGCTGGAAGGCGGCTGCGGC TCAGGAAGTCACCCGAGCAAGCCTCCTTCGGGGCCGGCCGCACCCGCCGCGGCGCGCTCCATGGGGGCGCGCTCCCCCCGGGCGGCCCGC TGACCCGGGACGCCGGGGCCCGCTCGCTCGCCGGCCGCGCGTCCCGGCCATGAACTGAGCCCGCGGGCCAGCCCCGCGCCTGCTCCGCCC GCGCCTTTCTTCTCGCGCCTCCTCCGCCCGCCGCCGGCGGGCCCGGCTCCCCGGGGGCTGCGGCGCCCCGGGCTCGGCGGCCCGCGGGCC CCGGGGCGCGGGGCGGCGGCGGCGGGGGGCGCGCGGCTCCGGGCGCGGCGCCTGCACCATGAACTACCAGCAGCAGCTGGCCAACTCGGC TGCCATCCGGGCCGAGATCCAGCGCTTCGAGTCGGTCCACCCCAACATCTACTCCATCTACGAGCTGCTGGAGCGCGTGGAGGAGCCGGT GCTGCAGAACCAGATCCGGGAGCACGTCATCGCCATCGAAGATTCCTCGGACAAGAAGGAAAAGAAATCTTTTAGCCTTGAGGAAAAGTC CAAAATCTCCAAAAACCGTGTTCACTATATGAAATTCACAAAAGGGCGATGCCAGTCCCTCCACTCCAGAGGAGAACGAAACCACGACAA CCAGCGCCTTCACCATCCAGGAGTACTTTGCCAAGCGGATGGCAGCACTGAAGAACAAGCCCCAGGTTCCAGTTCCAGGGTCTGACATTT CTGAGACGCAGGTGGAACGTAAAAGGGGGAAGAAAAGAAATAAAGAGGCCACAGGTAAAGATGTGGAAAGTTACCTCCAGCCTAAGGCCA AGAGGCACACGGAGGGAAAGCCCGAGAGGGCCGAGGCCCAGGAGCGAGTGGCCAAGAAGAAGAGCGCGCCAGCAGAAGAGCAGCTCAGAG GCCCCTGCTGGGACCAGAGTTCCAAGGCCTCTGCTCAGGATGCAGGGGACCATGTGCAGCCGCCTGAGGGCCGGGACTTCACCCTGAAGC CCAAAAAGAGGAGAGGGAAGAAAAAGCTGCAAAAACCAGTAGAGATAGCAGAGGACGCTACACTAGAAGAAACGCTAGTGAAAAAGAAGA AGAAGAAAGATTCCAAATGAATCCTTCCCAGCCGGGGCCTTCCGACCACTCAGCTGTCAGGGCACTGCGGGGGCAGACACCTCTGGCCTG AAGTCACAGCAGAGTTCACCCCAGAGCGCCTGGGCGCATCTTGTGGCATGCCCATGGGCTGCCGAGTCCTGCCCTCTCGCCACATTTCCC |
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FusionGenePPI for AGAP1_PINX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| AGAP1 | GRB7, TK1, SMN1, APP, SQSTM1, CBWD1, MIER2, XPO1, PRPF4, RHOA, ARF1, ARF6, RAC1, CDC42, P4HA3, PCDHA12, LZTS2, FLCN, PCDH20, PCDHA10, EPHA7, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SH3PXD2A, SRGAP2, EIF4E2, SIPA1L1, LIMA1, MAGI1, TESK2, DCLK1, ZNF638, SRSF12, SYDE1, CDC25B, CDK16, FAM110B, USP21, FAM53C, ANKRD34A, FAM110A, TBC1D25, PPM1H, MAPKAP1, MAST3, RTKN, DENND4C, HDAC4, RAB3IP, TIAM1, PHLDB2, NADK, GAB2, KIAA1804, NF1, CBY1, CGN, RASAL2, MELK, PLEKHA7, MLLT4, DEPDC1B, KIF1C, SH3BP4, CAMSAP2, PLEKHA5, NAV1, EDC3, TRIM25 | PINX1 | MCRS1, PLEKHJ1, PABPC1, TXN, RPS10, HRNR, RPL31, RPS3A, RPS19, RPL23A, GTPBP4, RPS28, CALM3, PABPC4, RPS16, AHCY, CAPRIN1, PAFAH1B2, TERF1, TERT, AIDA, DHX15, CACYBP, GABPA, TP63, EAF1, FBL, ALB, FXR1, FAM98A, PPP2R2D, APP, HIST1H2BG, HIST1H3A, HNRNPD, NOP56, SGTB, CDC14B, CCRN4L, SNRNP70, WDYHV1, DGCR8, RPL8, FOXA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AGAP1_PINX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AGAP1_PINX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AGAP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
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