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Fusion gene ID: 10553 |
FusionGeneSummary for DRAM2_TTF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DRAM2_TTF2 | Fusion gene ID: 10553 | Hgene | Tgene | Gene symbol | DRAM2 | TTF2 | Gene ID | 128338 | 8458 |
| Gene name | DNA damage regulated autophagy modulator 2 | transcription termination factor 2 | |
| Synonyms | CORD21|PRO180|TMEM77|WWFQ154 | HuF2|ZGRF6 | |
| Cytomap | 1p13.3 | 1p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA damage-regulated autophagy modulator protein 2damage regulated autophagy modulator 2transmembrane protein 77 | transcription termination factor 2F2RNA polymerase II termination factorhuman factor 2lodestar homologlodestar proteintranscription release factor 2transcription termination factor, RNA polymerase IIzinc finger, GRF-type containing 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6UX65 | Q9UNY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000286692, ENST00000484310, ENST00000539140, | ENST00000369466, ENST00000480701, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 4 X 3=24 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DRAM2 [Title/Abstract] AND TTF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DRAM2 | GO:0010506 | regulation of autophagy | 19895784 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4475-01A | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000286692 | ENST00000369466 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| 5CDS-intron | ENST00000286692 | ENST00000480701 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| 5UTR-3CDS | ENST00000484310 | ENST00000369466 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| 5UTR-intron | ENST00000484310 | ENST00000480701 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| Frame-shift | ENST00000539140 | ENST00000369466 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
| 5CDS-intron | ENST00000539140 | ENST00000480701 | DRAM2 | chr1 | 111674046 | - | TTF2 | chr1 | 117616283 | + |
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FusionProtFeatures for DRAM2_TTF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DRAM2 | TTF2 |
| Plays a role in the initiation of autophagy. In theretina, might be involved in the process of photoreceptor cellsrenewal and recycling to preserve visual function. Inducesapoptotic cell death when coexpressed with DRAM1.{ECO:0000269|PubMed:19895784, ECO:0000269|PubMed:25983245}. | DsDNA-dependent ATPase which acts as a transcriptiontermination factor by coupling ATP hydrolysis with removal of RNApolymerase II from the DNA template. May contribute to mitotictranscription repression. May also be involved in pre-mRNAsplicing. {ECO:0000269|PubMed:10455150,ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840,ECO:0000269|PubMed:9748214}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DRAM2_TTF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DRAM2_TTF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DRAM2 | ELAVL1 | TTF2 | DRAP1, CDC5L, TNIP1, DCP1A, PDCD6IP, PRDX4, CLPB, TACC3, NVL, ZSCAN1, SIRT3, TFAP4, HINFP, ACAT1, SMAD7, SKIL, SMAD1, HDAC11, CDKL3, PPP6R1, HDAC7, PEX19, SKAP1, CBWD1, RABL2A, TOP3A, MYBL2, PCM1, CEP162, CEP120, CEP152, CNTROB, CEP128, CNTRL, NINL, NIN, DCTN1, CETN2, RPGR, XPO1, CREB1, FOXL2, FOXN1, FOXP1, CETN1, IQCF1, RAB2B, PSMC4, COMMD1, HAVCR2, FAM131B, IL17RA, DKK3, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DRAM2_TTF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DRAM2_TTF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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