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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10532

FusionGeneSummary for DPYSL2_FSTL5

check button Fusion gene summary
Fusion gene informationFusion gene name: DPYSL2_FSTL5
Fusion gene ID: 10532
HgeneTgene
Gene symbol

DPYSL2

FSTL5

Gene ID

1808

56884

Gene namedihydropyrimidinase like 2follistatin like 5
SynonymsCRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2-
Cytomap

8p21.2

4q32.2

Type of geneprotein-codingprotein-coding
Descriptiondihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2follistatin-related protein 5follistatin-like protein 5
Modification date2018051920180519
UniProtAcc

Q16555

Q8N475

Ensembl transtripts involved in fusion geneENST00000521913, ENST00000311151, 
ENST00000523027, ENST00000521983, 
ENST00000306100, ENST00000379164, 
ENST00000536695, ENST00000427802, 
ENST00000511170, 
Fusion gene scores* DoF score9 X 7 X 3=1892 X 1 X 1=2
# samples 91
** MAII scorelog2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/2*10)=2.32192809488736
Context

PubMed: DPYSL2 [Title/Abstract] AND FSTL5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2O-01ADPYSL2chr8

26441499

+FSTL5chr4

162508727

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000521913ENST00000306100DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000521913ENST00000379164DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000521913ENST00000536695DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000521913ENST00000427802DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000521913ENST00000511170DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000311151ENST00000306100DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000311151ENST00000379164DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000311151ENST00000536695DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000311151ENST00000427802DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000311151ENST00000511170DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000523027ENST00000306100DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000523027ENST00000379164DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000523027ENST00000536695DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
Frame-shiftENST00000523027ENST00000427802DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
5CDS-5UTRENST00000523027ENST00000511170DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
intron-3CDSENST00000521983ENST00000306100DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
intron-3CDSENST00000521983ENST00000379164DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
intron-3CDSENST00000521983ENST00000536695DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
intron-3CDSENST00000521983ENST00000427802DPYSL2chr8

26441499

+FSTL5chr4

162508727

-
intron-5UTRENST00000521983ENST00000511170DPYSL2chr8

26441499

+FSTL5chr4

162508727

-

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FusionProtFeatures for DPYSL2_FSTL5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPYSL2

Q16555

FSTL5

Q8N475

Plays a role in neuronal development and polarity, aswell as in axon growth and guidance, neuronal growth cone collapseand cell migration. Necessary for signaling by class 3 semaphorinsand subsequent remodeling of the cytoskeleton. May play a role inendocytosis. {ECO:0000269|PubMed:11477421,ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPYSL2_FSTL5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPYSL2_FSTL5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPYSL2AP2A1, NUMB, CRMP1, RHOA, DISC1, TNIK, DPYSL4, ELAVL1, SIRT7, CDK2, IQCB1, LEF1, DNAJB1, EIF3J, XPO7, HSPH1, PDE3A, PUS7, RANBP6, DPYSL2, DPYSL3, GORASP2, DPYSL5, ARMC1, HAX1, NUFIP1, RRP7A, CDCA8, DGUOK, DNAAF2, WDR83, KLHDC3, UNK, ARFIP1, CAP1, CDA, DPH2, LYPLA1, TSG101, UNC13D, NTMT1, VPS28, NTRK1, PPP1CA, PPP1CC, MCM2, DPYS, FAM19A3, LGALS7, TGIF2LY, G3BP1FSTL5PYCARD, WBP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPYSL2_FSTL5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDPYSL2Q16555DB11638ArtenimolDihydropyrimidinase-related protein 2small moleculeapproved|investigational

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RelatedDiseases for DPYSL2_FSTL5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPYSL2C0005586Bipolar Disorder4PSYGENET
HgeneDPYSL2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneDPYSL2C0002395Alzheimer's Disease1CTD_human
HgeneDPYSL2C0011570Mental Depression1PSYGENET
HgeneDPYSL2C0011581Depressive disorder1PSYGENET
HgeneDPYSL2C0029408Degenerative polyarthritis1CTD_human
HgeneDPYSL2C0033937Psychoses, Drug1PSYGENET
HgeneDPYSL2C0036349Paranoid Schizophrenia1CTD_human