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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10529

FusionGeneSummary for DPYD_TGFBR3

check button Fusion gene summary
Fusion gene informationFusion gene name: DPYD_TGFBR3
Fusion gene ID: 10529
HgeneTgene
Gene symbol

DPYD

TGFBR3

Gene ID

1806

7049

Gene namedihydropyrimidine dehydrogenasetransforming growth factor beta receptor 3
SynonymsDHP|DHPDHASE|DPDBGCAN|betaglycan
Cytomap

1p21.3

1p22.1

Type of geneprotein-codingprotein-coding
Descriptiondihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenasetransforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III
Modification date2018052320180519
UniProtAcc

Q12882

Q03167

Ensembl transtripts involved in fusion geneENST00000370192, ENST00000474241, 
ENST00000423006, ENST00000306031, 
ENST00000212355, ENST00000370399, 
ENST00000525962, ENST00000468996, 
Fusion gene scores* DoF score9 X 7 X 6=3786 X 6 X 6=216
# samples 96
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPYD [Title/Abstract] AND TGFBR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPYD

GO:0006210

thymine catabolic process

10410956

HgeneDPYD

GO:0006212

uracil catabolic process

1512248|18075467

HgeneDPYD

GO:0006214

thymidine catabolic process

1512248

TgeneTGFBR3

GO:0001837

epithelial to mesenchymal transition

18184661

TgeneTGFBR3

GO:0007179

transforming growth factor beta receptor signaling pathway

12958365

TgeneTGFBR3

GO:0030509

BMP signaling pathway

18184661

TgeneTGFBR3

GO:0032354

response to follicle-stimulating hormone

14557487

TgeneTGFBR3

GO:0034695

response to prostaglandin E

14557487

TgeneTGFBR3

GO:0034699

response to luteinizing hormone

14557487

TgeneTGFBR3

GO:0051271

negative regulation of cellular component movement

17999987

TgeneTGFBR3

GO:0060317

cardiac epithelial to mesenchymal transition

18184661


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-95-8494-01ADPYDchr1

98144651

-TGFBR3chr1

92149414

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000370192ENST00000212355DPYDchr1

98144651

-TGFBR3chr1

92149414

-
Frame-shitENST00000370192ENST00000370399DPYDchr1

98144651

-TGFBR3chr1

92149414

-
Frame-shitENST00000370192ENST00000525962DPYDchr1

98144651

-TGFBR3chr1

92149414

-
5CDS-intronENST00000370192ENST00000468996DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000474241ENST00000212355DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000474241ENST00000370399DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000474241ENST00000525962DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-intronENST00000474241ENST00000468996DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000423006ENST00000212355DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000423006ENST00000370399DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000423006ENST00000525962DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-intronENST00000423006ENST00000468996DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000306031ENST00000212355DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000306031ENST00000370399DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-3CDSENST00000306031ENST00000525962DPYDchr1

98144651

-TGFBR3chr1

92149414

-
intron-intronENST00000306031ENST00000468996DPYDchr1

98144651

-TGFBR3chr1

92149414

-

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FusionProtFeatures for DPYD_TGFBR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPYD

Q12882

TGFBR3

Q03167

Binds to TGF-beta. Could be involved in capturing andretaining TGF-beta for presentation to the signaling receptors.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPYD_TGFBR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPYD_TGFBR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPYDCHAC2, GOPC, LXN, APOA1BP, C9orf64, GAPDH, TRNT1, RPE, CLK1TGFBR3TGFBR2, TGFB1, ELAVL1, NRP1, KLK11, ITM2B, ATP1B3, FGF1, GPR183, ATP1B4, PTCH1, SIAE, PIP5K1A, CAMKV, DEFA5, ST8SIA4, FAM19A4, DKKL1, CANT1, DEFA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPYD_TGFBR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DPYD_TGFBR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPYDC0009404Colorectal Neoplasms5CTD_human
HgeneDPYDC1959620Dihydropyrimidine Dehydrogenase Deficiency4CTD_human;HPO;ORPHANET;UNIPROT
HgeneDPYDC0038356Stomach Neoplasms3CTD_human
HgeneDPYDC0030297Pancreatic Neoplasm2CTD_human
HgeneDPYDC0034139Purine-Pyrimidine Metabolism, Inborn Errors2CTD_human
HgeneDPYDC0036341Schizophrenia2CTD_human
HgeneDPYDC1510586Autism Spectrum Disorders2CTD_human;HPO
HgeneDPYDC0004352Autistic Disorder1CTD_human;HPO
HgeneDPYDC0009375Colonic Neoplasms1CTD_human
HgeneDPYDC0018671Head and Neck Neoplasms1CTD_human
HgeneDPYDC0023014Language Development Disorders1CTD_human
HgeneDPYDC0024121Lung Neoplasms1CTD_human
HgeneDPYDC0027627Neoplasm Metastasis1CTD_human
HgeneDPYDC0027765nervous system disorder1CTD_human
HgeneDPYDC0027947Neutropenia1CTD_human
HgeneDPYDC0028754Obesity1CTD_human;HPO
HgeneDPYDC0031117Peripheral Neuropathy1CTD_human
HgeneDPYDC0270612Leukoencephalopathies1CTD_human
HgeneDPYDC1458155Mammary Neoplasms1CTD_human
HgeneDPYDC2239176Liver carcinoma1CTD_human