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Fusion gene ID: 10529 |
FusionGeneSummary for DPYD_TGFBR3 |
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Fusion gene information | Fusion gene name: DPYD_TGFBR3 | Fusion gene ID: 10529 | Hgene | Tgene | Gene symbol | DPYD | TGFBR3 | Gene ID | 1806 | 7049 |
Gene name | dihydropyrimidine dehydrogenase | transforming growth factor beta receptor 3 | |
Synonyms | DHP|DHPDHASE|DPD | BGCAN|betaglycan | |
Cytomap | 1p21.3 | 1p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | dihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenase | transforming growth factor beta receptor type 3TGF-beta receptor type 3TGF-beta receptor type IIITGFR-3betaglycan proteoglycantransforming growth factor beta receptor III | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q12882 | Q03167 | |
Ensembl transtripts involved in fusion gene | ENST00000370192, ENST00000474241, ENST00000423006, ENST00000306031, | ENST00000212355, ENST00000370399, ENST00000525962, ENST00000468996, | |
Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 6 X 6 X 6=216 |
# samples | 9 | 6 | |
** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DPYD [Title/Abstract] AND TGFBR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DPYD | GO:0006210 | thymine catabolic process | 10410956 |
Hgene | DPYD | GO:0006212 | uracil catabolic process | 1512248|18075467 |
Hgene | DPYD | GO:0006214 | thymidine catabolic process | 1512248 |
Tgene | TGFBR3 | GO:0001837 | epithelial to mesenchymal transition | 18184661 |
Tgene | TGFBR3 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 12958365 |
Tgene | TGFBR3 | GO:0030509 | BMP signaling pathway | 18184661 |
Tgene | TGFBR3 | GO:0032354 | response to follicle-stimulating hormone | 14557487 |
Tgene | TGFBR3 | GO:0034695 | response to prostaglandin E | 14557487 |
Tgene | TGFBR3 | GO:0034699 | response to luteinizing hormone | 14557487 |
Tgene | TGFBR3 | GO:0051271 | negative regulation of cellular component movement | 17999987 |
Tgene | TGFBR3 | GO:0060317 | cardiac epithelial to mesenchymal transition | 18184661 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-95-8494-01A | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000370192 | ENST00000212355 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
Frame-shift | ENST00000370192 | ENST00000370399 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
Frame-shift | ENST00000370192 | ENST00000525962 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
5CDS-intron | ENST00000370192 | ENST00000468996 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000474241 | ENST00000212355 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000474241 | ENST00000370399 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000474241 | ENST00000525962 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-intron | ENST00000474241 | ENST00000468996 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000423006 | ENST00000212355 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000423006 | ENST00000370399 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000423006 | ENST00000525962 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-intron | ENST00000423006 | ENST00000468996 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000306031 | ENST00000212355 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000306031 | ENST00000370399 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-3CDS | ENST00000306031 | ENST00000525962 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
intron-intron | ENST00000306031 | ENST00000468996 | DPYD | chr1 | 98144651 | - | TGFBR3 | chr1 | 92149414 | - |
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FusionProtFeatures for DPYD_TGFBR3 |
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Hgene | Tgene |
DPYD | TGFBR3 |
Binds to TGF-beta. Could be involved in capturing andretaining TGF-beta for presentation to the signaling receptors. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DPYD_TGFBR3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DPYD_TGFBR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DPYD | CHAC2, GOPC, LXN, APOA1BP, C9orf64, GAPDH, TRNT1, RPE, CLK1 | TGFBR3 | TGFBR2, TGFB1, ELAVL1, NRP1, KLK11, ITM2B, ATP1B3, FGF1, GPR183, ATP1B4, PTCH1, SIAE, PIP5K1A, CAMKV, DEFA5, ST8SIA4, FAM19A4, DKKL1, CANT1, DEFA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DPYD_TGFBR3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPYD_TGFBR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DPYD | C0009404 | Colorectal Neoplasms | 5 | CTD_human |
Hgene | DPYD | C1959620 | Dihydropyrimidine Dehydrogenase Deficiency | 4 | CTD_human;HPO;ORPHANET;UNIPROT |
Hgene | DPYD | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Hgene | DPYD | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
Hgene | DPYD | C0034139 | Purine-Pyrimidine Metabolism, Inborn Errors | 2 | CTD_human |
Hgene | DPYD | C0036341 | Schizophrenia | 2 | CTD_human |
Hgene | DPYD | C1510586 | Autism Spectrum Disorders | 2 | CTD_human;HPO |
Hgene | DPYD | C0004352 | Autistic Disorder | 1 | CTD_human;HPO |
Hgene | DPYD | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | DPYD | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
Hgene | DPYD | C0023014 | Language Development Disorders | 1 | CTD_human |
Hgene | DPYD | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | DPYD | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | DPYD | C0027765 | nervous system disorder | 1 | CTD_human |
Hgene | DPYD | C0027947 | Neutropenia | 1 | CTD_human |
Hgene | DPYD | C0028754 | Obesity | 1 | CTD_human;HPO |
Hgene | DPYD | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | DPYD | C0270612 | Leukoencephalopathies | 1 | CTD_human |
Hgene | DPYD | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | DPYD | C2239176 | Liver carcinoma | 1 | CTD_human |