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Fusion gene ID: 10513 |
FusionGeneSummary for DPY19L2_MRPL1 |
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Fusion gene information | Fusion gene name: DPY19L2_MRPL1 | Fusion gene ID: 10513 | Hgene | Tgene | Gene symbol | DPY19L2 | MRPL1 | Gene ID | 283417 | 65008 |
Gene name | dpy-19 like 2 | mitochondrial ribosomal protein L1 | |
Synonyms | SPATA34|SPGF9 | BM022|L1MT|MRP-L1 | |
Cytomap | 12q14.2 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | probable C-mannosyltransferase DPY19L2protein dpy-19 homolog 2spermatogenesis associated 34 | 39S ribosomal protein L1, mitochondrialmitochondrial large ribosomal subunit protein uL1m | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6NUT2 | Q9BYD6 | |
Ensembl transtripts involved in fusion gene | ENST00000324472, ENST00000413230, | ENST00000315567, ENST00000506674, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 4=48 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DPY19L2 [Title/Abstract] AND MRPL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-3C-AAAU-01A | DPY19L2 | chr12 | 64061837 | - | MRPL1 | chr4 | 78870951 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000324472 | ENST00000315567 | DPY19L2 | chr12 | 64061837 | - | MRPL1 | chr4 | 78870951 | + |
5CDS-intron | ENST00000324472 | ENST00000506674 | DPY19L2 | chr12 | 64061837 | - | MRPL1 | chr4 | 78870951 | + |
intron-3CDS | ENST00000413230 | ENST00000315567 | DPY19L2 | chr12 | 64061837 | - | MRPL1 | chr4 | 78870951 | + |
intron-intron | ENST00000413230 | ENST00000506674 | DPY19L2 | chr12 | 64061837 | - | MRPL1 | chr4 | 78870951 | + |
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FusionProtFeatures for DPY19L2_MRPL1 |
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Hgene | Tgene |
DPY19L2 | MRPL1 |
Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (Bysimilarity). Required during spermatogenesis for sperm headelongation and acrosome formation. {ECO:0000250,ECO:0000269|PubMed:21397063, ECO:0000269|PubMed:21397064}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 108_128 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 154_174 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 195_215 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 243_265 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 269_286 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 297_317 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 344_364 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 372_392 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 423_443 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 489_509 | 112 | 759 | Transmembrane | Helical |
Hgene | >DPY19L2 | chr12:64061837 | chr4:78870951 | ENST00000324472 | - | 1 | 22 | 534_554 | 112 | 759 | Transmembrane | Helical |
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FusionGeneSequence for DPY19L2_MRPL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_DPY19L2_ENST00000324472_chr12_64061837_-_MRPL1_ENST00000315567_chr4_78870951_+_179aa MRKQGVSSKRLQSSGRSQSKGRRGASLAREPEVEEEMEKSALGGGKLPRGSWRSSPGRIQSLKERKGLELEVVAKTFLLGPFQFVRNSLA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_DPY19L2_ENST00000324472_chr12_64061837_-_MRPL1_ENST00000315567_chr4_78870951_+_538nt ATGAGAAAACAAGGAGTAAGCTCAAAGCGGCTGCAATCTTCCGGCCGCAGCCAGTCTAAGGGGCGGCGCGGGGCCTCCCTCGCCCGGGAG CCGGAGGTAGAGGAGGAGATGGAAAAGTCGGCCCTAGGCGGCGGGAAACTGCCAAGGGGCTCCTGGAGGTCCTCCCCGGGGAGGATCCAA AGTCTGAAAGAGCGAAAAGGCTTGGAGCTAGAGGTGGTGGCCAAGACCTTTCTTCTCGGCCCCTTCCAGTTCGTCCGTAATTCCCTGGCG CAGCTCCGGGAAAAGGTGCAGGAACTGCAGGCGCGGCGGTTCTCCAGCAGAACCACTCTCGGCATCGTTGGATATGTCAAGTGACCAGAT AGCTGCCAATCTGCAAGCAGTTATTAATGAAGTTTGTAGGCACAGACCGCTGAATTTGGGTCCCTTTGTGGTACGTGCTTTCCTTCGTAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_DPY19L2_ENST00000324472_chr12_64061837_-_MRPL1_ENST00000315567_chr4_78870951_+_905nt GCGAATGGCTTCCAACGCATGCGCCCCACCCCACATTTCACAGTCGCCATGACGACCGGGAGGTCCGCAACGGCTGCGGGGACAAGTCCG TTGAGGCTGCCAGGCGAGTCAGGTCTCTCTGGACCTCGCCTGACTCGGCTGGGCTGTGCCTGAAATTGACCCAGCTCCACCATACTCCTT GATTATGAGAAAACAAGGAGTAAGCTCAAAGCGGCTGCAATCTTCCGGCCGCAGCCAGTCTAAGGGGCGGCGCGGGGCCTCCCTCGCCCG GGAGCCGGAGGTAGAGGAGGAGATGGAAAAGTCGGCCCTAGGCGGCGGGAAACTGCCAAGGGGCTCCTGGAGGTCCTCCCCGGGGAGGAT CCAAAGTCTGAAAGAGCGAAAAGGCTTGGAGCTAGAGGTGGTGGCCAAGACCTTTCTTCTCGGCCCCTTCCAGTTCGTCCGTAATTCCCT GGCGCAGCTCCGGGAAAAGGTGCAGGAACTGCAGGCGCGGCGGTTCTCCAGCAGAACCACTCTCGGCATCGTTGGATATGTCAAGTGACC AGATAGCTGCCAATCTGCAAGCAGTTATTAATGAAGTTTGTAGGCACAGACCGCTGAATTTGGGTCCCTTTGTGGTACGTGCTTTCCTTC GTAGTTCAACAAGTGAAGGTTTATTACTGAAGATTGATCCATTGTTGCCTAAAGAAGTAAAAAATGAAGAAAGTGAAAAAGAAGATGCCT AAATGTGGTGAATTGTGAAATTACTTTCAGTGGTTTAAGAAGCAATGGAGAAAATGATAATACAGCATAATTTTTACATTTGATGTCTTG TTATTGATCATACTTGAAAGTGAACTTTAACATTGAAAAATCGTACAGTCATTTCAAGAATAAGAAAATAAAATTTTCTCTTTGTCTGAA |
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FusionGenePPI for DPY19L2_MRPL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DPY19L2 | GUK1 | MRPL1 | ICT1, CUL3, CAND1, APP, MRPS7, MRPL10, MRPL11, MRPL4, MRPL12, HSPA1L, DLAT, ILF3, SDHA, ACAD9, TUFM, MSLN, MMGT1, SOX2, GOPC, RPL13, MRPL28, ZC3H3, RPS8, HNRNPA1, MRPL39, MRPS30, MRPL47, ATP6V1H, CORO1B, CORO1C, MRTO4, RPS20, RPL12, SETD4, NDUFAF1, APBB2, MRPL49, SLC25A10, PI4KA, SSB, IRS2, PTTG1, MRPL33, MRPL19, MRPL3, MRPL42, MRPL13, MRPL18, MRPL15, MRPL2, MRPL37, MRPL30, MRPL35, MRPL50, MRPL16, PARP16, MRPL20, MRPS18A, PRPF40A, NCKAP5L, MRPL17, MRPL14, MRPL40, MRPL38, MRPL34, MRPL32, MRPL9, MRPL44, MRPL57, BRCC3, MRPL45, MRPL43, GADD45GIP1, MRPL53, MRPL52, SLC30A7, MRPL21, SUGCT, C6orf203, COQ4, MRPL41, CIRBP, RBM3, CYLD |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DPY19L2_MRPL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPY19L2_MRPL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |