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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10490

FusionGeneSummary for DPP4_PDK1

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP4_PDK1
Fusion gene ID: 10490
HgeneTgene
Gene symbol

DPP4

PDK1

Gene ID

1803

5170

Gene namedipeptidyl peptidase 43-phosphoinositide dependent protein kinase 1
SynonymsADABP|ADCP2|CD26|DPPIV|TP103PDK1|PDPK2|PDPK2P|PRO0461
Cytomap

2q24.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)3-phosphoinositide-dependent protein kinase 13-phosphoinositide-dependent protein kinase 2 pseudogenePkB kinase like gene 1
Modification date2018051920180523
UniProtAcc

P27487

Q15118

Ensembl transtripts involved in fusion geneENST00000360534, ENST00000491591, 
ENST00000543905, ENST00000544863, 
ENST00000282077, ENST00000392571, 
ENST00000410055, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: DPP4 [Title/Abstract] AND PDK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP4

GO:0001666

response to hypoxia

16670267

HgeneDPP4

GO:0006508

proteolysis

27198182

HgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

HgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

HgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

HgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

HgeneDPP4

GO:0042110

T cell activation

7594462

HgeneDPP4

GO:0043542

endothelial cell migration

16651416

TgenePDK1

GO:0006468

protein phosphorylation

14585963

TgenePDK1

GO:0006469

negative regulation of protein kinase activity

9373175

TgenePDK1

GO:0018107

peptidyl-threonine phosphorylation

9368760

TgenePDK1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

17327236

TgenePDK1

GO:0032148

activation of protein kinase B activity

9368760

TgenePDK1

GO:0035556

intracellular signal transduction

14749367

TgenePDK1

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

22454520


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-Q2-A5QZ-01ADPP4chr2

162902042

-PDK1chr2

173451006

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360534ENST00000543905DPP4chr2

162902042

-PDK1chr2

173451006

+
In-frameENST00000360534ENST00000544863DPP4chr2

162902042

-PDK1chr2

173451006

+
In-frameENST00000360534ENST00000282077DPP4chr2

162902042

-PDK1chr2

173451006

+
In-frameENST00000360534ENST00000392571DPP4chr2

162902042

-PDK1chr2

173451006

+
In-frameENST00000360534ENST00000410055DPP4chr2

162902042

-PDK1chr2

173451006

+
intron-3CDSENST00000491591ENST00000543905DPP4chr2

162902042

-PDK1chr2

173451006

+
intron-3CDSENST00000491591ENST00000544863DPP4chr2

162902042

-PDK1chr2

173451006

+
intron-3CDSENST00000491591ENST00000282077DPP4chr2

162902042

-PDK1chr2

173451006

+
intron-3CDSENST00000491591ENST00000392571DPP4chr2

162902042

-PDK1chr2

173451006

+
intron-3CDSENST00000491591ENST00000410055DPP4chr2

162902042

-PDK1chr2

173451006

+

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FusionProtFeatures for DPP4_PDK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP4

P27487

PDK1

Q15118

Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline. {ECO:0000269|PubMed:10570924,ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005,ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392,ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416,ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790,ECO:0000269|PubMed:18708048}. Kinase that plays a key role in regulation of glucoseand fatty acid metabolism and homeostasis via phosphorylation ofthe pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibitspyruvate dehydrogenase activity, and thereby regulates metaboliteflux through the tricarboxylic acid cycle, down-regulates aerobicrespiration and inhibits the formation of acetyl-coenzyme A frompyruvate. Plays an important role in cellular responses to hypoxiaand is important for cell proliferation under hypoxia. Protectscells against apoptosis in response to hypoxia and oxidativestress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534,ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP4chr2:162902042chr2:173451006ENST00000360534-5261_6122767Topological domainCytoplasmic
HgeneDPP4chr2:162902042chr2:173451006ENST00000360534-5267_28122767TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgenePDK1chr2:162902042chr2:173451006ENST00000282077+711337_338315437Nucleotide bindingATP
TgenePDK1chr2:162902042chr2:173451006ENST00000282077+711354_359315437Nucleotide bindingATP
TgenePDK1chr2:162902042chr2:173451006ENST00000410055+712337_338315845Nucleotide bindingATP
TgenePDK1chr2:162902042chr2:173451006ENST00000410055+712354_359315845Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPP4chr2:162902042chr2:173451006ENST00000360534-52629_766122767Topological domainExtracellular
TgenePDK1chr2:162902042chr2:173451006ENST00000282077+711163_393315437DomainHistidine kinase
TgenePDK1chr2:162902042chr2:173451006ENST00000410055+712163_393315845DomainHistidine kinase
TgenePDK1chr2:162902042chr2:173451006ENST00000282077+711279_286315437Nucleotide bindingATP
TgenePDK1chr2:162902042chr2:173451006ENST00000410055+712279_286315845Nucleotide bindingATP


Top

FusionGeneSequence for DPP4_PDK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_244aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_244aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_244aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_244aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_244aa
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL
ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_732nt
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA
GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG
GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT
GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG
AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT
AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_732nt
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA
GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG
GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT
GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG
AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT
AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_732nt
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA
GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG
GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT
GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG
AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT
AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_732nt
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA
GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG
GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT
GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG
AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT
AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_732nt
ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA
GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA
AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG
GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC
GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT
GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG
AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT
AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_1579nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT
AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT
GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT
ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT
TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA
CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA
ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA
CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGATT
CTTCAGTTTTGGGACTTGGACTGGCTTTCCTTGCCCCTCAGCTTGCAGATGGCCTGTTGTGGGACCTTGTGATCATGAACTCCTCCTCCC
ACATCTGATGGAGCTACCAATCATCAGATCTCCTCTGCCTCTGGGGTGCGTCTCAGGCTGGCCAATCACGTTCTTCATCCACGTGGACTA

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_1342nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT
AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT
GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT
ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT
TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA
CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA
ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_13993nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT
AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT
GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT
ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT
TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA
CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA
ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA
CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGGTA
TGGTGTTCAGAACTATATTATACCAAGTACTTTATTTATCGTTTTCACAAAACTATTTGAGTAGAATAAATGGAAACTGAATTCCATTTG
TGCCCGTTAAACCTCCTAAAGGATGAAATTGCACCTATTTTACACTTATATTTTCACAGTTAATTGAACATATTTTTAAACAACTGTAGT
TTTGGGCAACTTTTCACTTTGTGGTAGACTTCAGAAGTGTGGAAATCTTCGGGTTTCTATAGGAAACTAGTTTTTTTTTTTTAAGAAATA
CTTTCATTTATGTTTGCTAGAAACATTTTCTAAATGATAGTGATTAGCTGGTTAGCCATCTTCCTGTTATTTGGAGGAGTTCTGCCATCT
TTTATTCGGTAGTGACAGCTGTAATATGGTCTTCATGTTTATCAGTGACTTGACTACAAGTAAAGCAGAAAACAGTTGGCCTGTAATCAC
AGAACCAGCCACCCTTCGGCGTCTACATGCATTGTCTTAGCTCTGAGGTTAATTTACCATTTTTAAATTTTATTGTAAAGAAGTGTAATG
ACTAGCTCTCTGTGGATCTATGCCAAAATCATGGGCCATCTTTTCTAAGTGTACTTCTGATTAATGCAAGGGGAAATTTTTATACTGAAA
ACAAACAAACAAACTAGCAGCTACTAAAATAGAGAAGAAATTGAGGGCAAAGTAATATGTCTCCAAAACTGAACTGATTGCTTGTTGAGA
TTACCTAGAAAGCTTTTGGAAAAAAATAGAGCTTTTCTGCATCCTACTCCAGATACACTGAATCGGAATCCCTAGGGCTAGAGCCTAGAA
ATCTCACTTTTTAAAATGCTTCCAAGGTAAGTCTGATGCCTACCCTAGGTTGGGAACCACTCTTTCAAAGTAAACAGTGATGACACAGCA
TTTGCTAAAGTAACATCTGTAGGTTTTGGTTTCCACCTATTTAAAGTCAGATTTATAGACTCGAGGAGACAGAAACTGAATCCCACACCT
GGTGCAATTAGAAGCATAATTAGAAGCAGAAGAACAAAATGCCACGTAACCAAAGCATCAGAGCCATCATTGCACGTGTCTTTTTTTCTT
TTTTCTTTTTTTTTTTTCAAGACAGGGTCTCGCTCTTTTGCCCAGGATGGAGTACAGTGGCATGGTCAAGGCTCACTGCAGCTTCAATCT
TCTGGGCTCAAGTAATCCTTCCACCTCAGCCTCCCATATAGCTGGAACTACAGTTGTGCACTACCACACCCAGCTAATTTTTTGATTTCT
TGTGGAGATGAGGTCTCAGTATGTTCCCAGGCTAGTGTTGAACTCCTGAGCTCAAGAAATCCTCCTGCCTGAGTCTCTGAAAGTGCTGGG
ATTACAGGCGTGAGCCACCACACATGGCCTATTGCACAAGTCTTGACAAACAACATATATTTTCTAAAACTATCCAGATTTCATTATCAG
GGAAAAGTTTGCTTAGGTTTATTACAGCAGTCCTTGGCATTTGTATGGTAATTTGTACTTTACAAATACTTTGATATATTATAACTCTAT
TGGTCTTTGAAACAAAGCGATACAGTGTAGGTGGTATCATTCTCTTTCTCACTCAGTGTGGCCCAGAGTTGCTCAGAATTGGAGCAGAGC
CTGAGACGTATCTGCAGATCCTGTCATCAGCTGGCAAGTCCAGGAGACTGTGTCATTTAGAGACTGTGTTGTTAGTTATCCCTCAACATC
TTCTAAGGTGGCAGGAAATAATATTGGAAATAACATTTTAAAGTAAAAATTTTAAAGTTTAAAGAAGAGTTTTGCCACTTAAACAGGGGA
GCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGATGAACAGTTGTGATAAATGTGTAGATTAGAG
GGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAGAGGAGGCATCCTTTGCCCAGAGCTGCTTAGC
TAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGATTTTGTGAAAAACAATAGAACATGTTAATGA
GTAATTTATATTAGTTCGATGTATTACAATTTTTTAGCTTTAAATTACAGTTTTCTTATAATGTTGAAATGTTTTAGAATCCTTTGAATC
TAAGTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACTTATGAAATATTCTCCTCCCCCAAGAAAATTTAAACTTT
TTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTAGCTTATTTTTAAGGTAAAACAGCTTTTTACT
CTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTCCTAGTTGGTTTTAAATCATTGTGCCACCTGA
AAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTAGTTATGAAAATATATTGAAGGACAGGAAGTG
GACACGAAGTGATTTTTGTAACCTGAGCAGTTAATGAATGTGCCAACATTTTCTAGGAAGGGACAGCAAGAATATTCTGCTCTGTAGTTA
AAATACTGGCTGGCTTTTGATGTCTTCATGCTTAATTGTGATCACTTTCTTGCACTGTGATGTTTTTACGTGAATATGTTGAAGTAGAAG
TCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCAACCCTTCTTTTGAAAATAAACTGAGTCAATT
TAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCTCAACATTTTGTAAGCATCCAAAAAATTGGTA
ATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTAGATTTCCAATGTGTATATTCTAATGGAGAAA
GCAAGAGGTAGAGTTTGTATGTTTGACTTACCTTAGATTTTTATTTTCCATACATACTGCAAATGATTGACTTGTTGCATAAATGAAGAT
CTTCTGTTGTGTGCTTTTCAAACACTGTAAATAAATTTGAAATTTGAATAACTTTCCACAGTATAACTGTAAAAAAAAAAAAAAAAAGTC
TTAATTTAACCAGCATTACCCTCTGCTTGTACCAATTGAATGGCAGAACTACTATAGTCAAAAATAAATTCCTATCCTATTTTTAATTGA
TGGGATATAGGCAGCACAATTTCCCTTCATTGTTGAAGCCAACAAGTTCCGTAACAGAACTCCAGAGGTAAATAGCTGGGAAAACTGTTA
GTTTTAAGGTCCCACTGTTGCTCTGTGAATGACTAATCAGAGGAAGCCAAAAATCAGCCAACTAATTTCAGTTTATGTCTTTAATTGTGA
TGTAAGTGTGAAGTTTCTACATATGGGTAATCAGGGTTGAGTTAGGTAGTTTGCAAACATGACTTTTGCTGGAGGAACTTTTAATCATGT
CTTATTAATTTCTGGTCCCAATAATTAATTTTCTTACAGTCAAACCCAATGCACTTGAAAAATAATATAATTAATACTGTGTGAAGAATT
TTTTGCATGTTAAAAAAAGCAAACCACTAGTTTGCTTAGTTCTGGCATTCATAAACTACTGTACCTTCTGTTCTATTGACATGTTTGGAA
AAAAGAATTGAACATATGTACCACCCCCCTCTTTCTAGAGTCTCCACAGTTCTTTAGCAATTGCTAACCATAGGTTTTTAATAGCAAAAG
ACAAGATTGTCAGTTTTTGGTGCAAAACTCTACTCTTTTTGGTTGACTTGGAAAAGCTGTTGTTTATATTGGGAATTGTGACAGCTGTCT
TTTACTTTGTTAAATTAGCAATTATTTAGCAAAAATACAGAGTTTCACCCCAGTAAAATAAACTTCCACGTGAGAGTTGTGTTCATTCAA
GGGTTATTTTTTGAGAGTGGAAGTACATTTCCTGCATTTGTCACAGATAATATCAGAAATTTTGTTGTTTTGATTAAAATGTTGCCATCT
ACTTATAAGTTAAAAATGCTGAGAAGGTTTTTTTTGGAAACAGTTTATGAGGCCAGGACATTTTTAAGTTTGACTCAAATATAAAAAGCC
ACAGTATTCTTGCCATGGTTTTGTACTTAGATGTCTCTCATTATGGAATTCAGAATGTGACAGTTATAGTACTACATGAAAATACTTAAT
ATAGAGTTCTACAGTTACAGTATTGCATGAAAATACAGTATGGTATGAAATTATTTGTCCAAAACTGTACTCCAGAAATGGAGCCCATAT
GATTATATAACTATAAAATAGGATGGGACAGAGAAAAATATGTCTGTATTACAGCATAAACATATCTGGTTTAATATGAACTATTTCTTT
TCATCTCTTTACTCTCAGTATCTCCATAATGGCCAGTATGTAGTAGGCACCTGTAATTGTGAAGCAGCCTCATTGTCTGGGGTAAATACC
AAGGTTCTTGGTCTCATGGCCAAGGAGATCGAGGTCGCAGACACACACAGTTTGGAGCAGGAGTTTAATAGGCAAAAGGAAACAGCTCTG
TTACAGAGAGGGGTTCCGAGCAGGTTGCCAAGTTGTAGTAAAAATGTCAGGGTTTTTATAAATGGGCTAGTGAGGAGGGGGCTCATGAGG
AGGGGATATCTTATCCTCCTAGGGTCCGAGGACGCTTTAGTTGGGACCAGGTGTGCTATCTGTACAGAGCATAGCTTTTTATCAGCTCTT
ATCCCATTCCTTGACCACATAGGCTCTTAGACTCTTATTCTATGTTGTCTTCGTCCAGCTTATCTGGAAGGGAGAGTTTCTCTGTCTGTT
CCCATACATCTTGCAGCTGCAGGCATCCCCCCGGTCTGCTTTTAGCTTCCTTATCTTAGTGCCCCTAAAGGGAAAGGAATGTGCTTATTA
AGGGCCACTGTTTTACTGGGGTTAACTGCATGAGGTCAAAAAGAGCTATATTTGAGCTGCTGTTTGTTAAAAGAAAAGTTTTCTGCCGGG
GACTCGCTTTACCCTGTCTACCTAAATTCTTTCTGCCTTCTATAACAATTGTATGCTCAGTAAATACATAAGGAATAATGAACTTAATAA
CATTTTTTTCCATTCTCAAAATGATACTTAAATGACTCAGTACAACAAAGAAACTGAGTAGTAACCAGTGCAAAACTAGCAAAAGGATGA
AATACACAAGAAAATGAGAGAATTTAAGAGGAGTAGCAAAACAGCACTGCTAAAGTTACGGGTTTATTTTAAAGTTTAAAATAGAAGTAA
ACAAGCAAACATACTGATAATGGTTAGGCTTTCTGTCCCCACCGCACAAATCTCATCTTGAATTATAATCTCAACATGTTAAGGGAGAGA
CCAGATGAAAGTAATTGGATCATGGGGTTGGTTTCTCCCATGCTGTTCTCGTGATAGTTCCCATGAGATCTGATGGTTTTATAAGTATTT
GGTAGTTCCTCCTGCATTCATTCTTCCTGCTGCCCTGTGAAGAGGTGCCTTCCACCATGATTGTGAGTTTCTGGAGGCTTCTGCAGCCTT
GCGGAACTGTGAGTCAATCCTTTTTATTATAAATTACCCCGTCTCAGGCAGTTCTTTATAGCAGTGTGGGGATGGACTAATACTCGCTGG
GTTAGCTGGGGTAGGTAAAGCCACAGCTGTGGCAGCAACCAGCTAGTGGGTGTCCCTTGATGGAGGCTTTGCAGGCTGCAGCAGAAGGGA
CCCTTCAGATAAACCTCCAGTCAGGAAAGGAAAAGGCCCAAATAAACAGTATTTAGATTTTTTTTTAAAGGACATAACTACCAATAGAGA
TTTAAAATAATCATAAGAATACCATTAACTTTATGATAAAAATTTTGTAAGTGGAGAAGAAATGGATATATTTCTAGGAAAACAGTAGAA
GATCCATCTAAGATTTTGACAATTTAAATCAACCACTAAGGAAGTGGAATCAGTAATCACAAGTCCACCTCGCCAAAAGACAATTTTTGA
AAGATGAATGTTACCAAAACATCAAGAAACTGATAATTCCTGTCTTATAGAAACTTTGAAATGAGAGAAAGCTACCCAACCCATTTCAGA
AAGTTAGTAAAATCTCAAAGCTACACTTGAGCAAAGACTGTGAAATATTAATAGACCAATCTTGTTTATGAACATAGATGGAAAAATTGC
TGATGAAATATTGGCACATTGAATGTAGCAGTGCATAAAATATTGTATCATGAGCAAAAGGAGAATCTTTCCCAGGAACAGGAGGATGTT
TTAATAAAAATATGTAATTTACCTCTCTACAGATTAAAGGAGAAAAACTATATGATCACATCAACAGAAACAGGAAATTCAGTTTCTTTG
GGGGATAGTTGTAATTAAAAGTGCTTAACTCACTTATATAAGCCATTAGTGGATGTTACAATAAACCTCGTATAGTGTCAGATGTAAGAC
AGACATACTGGAATTGTCTATGAGGTTGGATCCATGGGCCTGCCATGGAAAATTTGTTGAGTAATACGTCCAAGGCGTCACCATTTGCCA
GGCGTTGCAAGTATCACCATTTGCAAGGTGTTAACAAAAAGTTACCTGCCTATGGATTCTCCTTTCTAACTCTGACCTAATATTTTGGAG
CATAGAGGAAAGAAACATCTTATGTTTCTGTGTTTGGGTAAACATTAGACTTATAAAAGGGCCTAGGGTTTTTTTGTTTGGTAAACCATT
GCCTTTCCTGCTTTGGTGTGGCAAATCTTCCTTTGGAGAAAAAGGTCCCTTTAATCTTAAAACCAACTCTCAGTGACCAACAAAAGCAAC
AAATAGGAACAACCACCCATTAAGAACCATCAGGTGATGCCTCATTTGCTGTGGTGCACAGCTGAACTTGATTGTTACTCTTGGATCAGG
GTTGGCTTGATAAGGACTCACTTAACCAATGGAAAGTAAGGTTAAATCTTTGTAAGCAATGCTCCTGATGCGAATCACCTGGAGATCTTG
AGCAAATGCAGACTGGTTCAGCAGATCTGGAGTGGGGCCTGAGATTCTGCATTTCTAACAAGTTTCCTGGTGATATTAATGCTGCTGGTC
TGTGAGCCATACTTTGAGTAGCAAAGGACTAAAGGTTGTGAGATAAACTGCTTTTAGCAGCCCAAAGGGCCAGCTGGAAAGACGAGACCA
GTTACAGAGCAAATGGCAAGACAGATCTGGTAATCTGATTCTTAGAGTACTTAAAAAAGATAAGAAGGATCTATTCCTGATATACAGGGT
ACTTGGTGGATGTGTCCATGACCTCGAGATCGAAAACCCATTAGTTAATCTTTGTGACATCTGAATTTTAAGGATCTTACCCAGTGAACA
TATAACTAGTGGAAATCCTGATAATTGGCTAATGCAAGGAAGTGATACCCATGTGTAATGCTTATCTTTGTATCCATTTCATGGGGAAGG
TCATGGAAGACGACAGCAAACTTGAGTGGTTAATGAGAGCTTCACTAATGTTGTCTGCTGCAGGCAATAAGTGAAGTCTCTGGCAGTGGG
AAGCATGGACCCAAGACCGAAAGCTCTGGCACTTTATAGCAGTGGTGGGGGGTAGATAGGACTTAGTGTGGCCCCTTAAAGAGCAAGGTC
CAAGTGATTTTCTCTGGTGAATGTCGATGTGGATCTAGTCTCCAGGGTTAGATCCAGGCAGGTAACATCAAAGTCAGTTGATAAGACCTC
TTATGCCTGTGAATGGAAGGCCCTGATAAAACTTCATTATTAATGTTCTGCATTAATTTAGCGGATGACTATAGTCATTTCACATAATCT
AATACATGAATGTCCTGTATGGGTGACTGCTGAGGGTTTAACAAAGGAGAGTCCATTTATATTTGGCTGGTAAGATCGATGCTTCTGTCA
CTACTGATGGGCAAGGATATTAACATCAATATCTAAAAAAATTCTGAGATTTGGATTGTGATGTGTTAAATTTCTAGACCAATTTGAGGA
GAATTTAACAATAGCTTTTCAATTTATGAACATGGCGTATATCTTTTTTGGCGGGGGGTGAGGACAGAGTCTTGCTCTGAGATTACCCAG
GCTGGAGTTTAGTAGCATGATCTTGGCTCACTGCAACCTCTGCCTCCTGAGTTGAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGG
GATTACAGGCGAGCGCCATCATGCCTGACTAATTTTCGTATTTTTAGCAGAGACAGGGTGTCGCCACCTCAAGGGATCCACCTGCCTTGG
CCTCCCAAAGTGCTGGGATTTATAAGCGTGAGTCACCGTACCTGGCCAGACATAGCATATATCTTCCTTTACATAGATTGCCTTTGATTT
CTTTCATTGTTACTTTGTAGTTTTCAGCTTACAGATTCCGCGCATATTTTGTTAGACTTAAATCTAAGTATTTGCTTTTTTTTTAACTTA
CAAATTTTTTTAAAAAAACGTTTTTCCTCTCCAATGTTCATTGCTAATACATTTCACGTTTGAATCTCCAGTTCAGAAAAATCATGGCCT
CTGGAGTTTTACTGAGGACTAGAGATAGCTAAGTAACATAGTTCCACCTTATTCACTTGGTCTTTGATGTGGTGTCCATAATTGAGTAAA
TGGCAGTATGTCCAATGGCAACACCATGAACTTGACTTTGCCCTCTTGTCTAGCCCTCTCCATTTAGACTTGGAAGGGTCAGCAGTAAAA
TTTCACTGGCCCAGTCCAGGGCTGCTTGAGTGTTACTGTTTTGTGCCACAATATGATGTGGCCAGACTACTTTTCTAGTTTCGAGATTAT
TTTGGAGCTTTATATTGGGTATGTTCTTATCCAACTATCATTAGGGGCATTGATCTCTGATGCCCTTTTCTTTCTTATCTTCCAAATGGC
AGGCAGTAAATGGCTTATTAAGCAAGTATAAGATTCAAGATCTCAGCCCCAAAGATACATTTGTAGATGCCAGGCTTAACATTCCTGAGG
CTCTCAGAGAAAACTTTTCCCTCTATAGACTCCCCATTTTAAGAAGGAGGCACAGGGCTTGGTTGGCCCATTTAGTTAGTGACACACCTA
TATTACTCTCCTTGGCATCTTACCCCAGCCCATCCATTGGGTTGTGTCAGTCTTTTATTTCTAAGTGAGGATCCAGTCAACAGGAGGCAC
AAGAGATAGAACCAAATACCATAATGCCTCCTTCTATTCCACTATGAACAGTCAAGGACACTGGAGGCCTCTGGGTGGGACACATAGGCG
TTCAAGAGCCTCTGAGCTTAAAGATATGTGAGTGGAGCTAACTAGACTGTCCAGGTTTGGTCTACACTGTAATTTTTTTTTTTTTTTTTT
TTTTTTGGAAGCAGAGTCTTGCTCTTTTGCCCAGGCCAGAGTGTAGTGGTGTGATCTCAGCTCAGTGCAGCGTCTGCTTCCTGGGTTCAA
GTGATTCTCCTGCCTCAGCCTCCAAGTAGCTGGGACTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGG
GTTTCACCGTGTTGGCCAGGCTGGTCTCGAACTCCTGAGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGATAGCAGGCAT
GAACCACCGTGCTCAGCCTCTCTGTAAATCTTGAGTCGGCACTGAGCTCATGAAAGCTGTGCTGAGTGGGTTTCTTTAGATTTTCATTTT
CATGTTTGCCCCATTTATGCTAATATTAATTATTGGAAAATAATTCACCTACTTTGCTTCTCTCTGACCAACATAGGGGCAGGATCTGTG
GAAAGACATTTACCACCTGTTTGAAAAGGTCAGCGTGCTGATATTCACTAACTACTACCCCCACAACTCCCCCTCCCCCAAACCTGATAG
ATGCTATAATTTCTGCAGTCCAATCACTATTCTTCCCAAACTCCATGAGCCAGATTTTATACATACTTTGCGTGACCATAAAACTCTGTA
CTATTATAGACATAAAACCATTTAATTTCATAGATACCTTCAGTGGTGGCATCACTGGGTCCTCTCTTGGATAGCATAGTCCTATGACCA
AATGGGTCAGTCGTTGATCAGGCTTCATGAGAATATGATCGCTGGGAGAAATATACAGCTAATTTAACAACAAATGACTGTCCTAATTCT
GGAGACCTGGGAAGTATTGATGAGAGTATAGTGATCATAAGCAGACATTGGGTGCTTTAGCAAAGCCAATTTGCCTGCATCCTCTGGAAG
GTAAAGAAGATCTCCTCTCTCTTAGAACTTAATCAAACTCTTGGCATCCACAGAAGGCTAGGAGGATGTAATGAATACTTACCATTTTTG
TGGAAGCCCACAACCTTTTGAATGGCCTTTCTATACTTTAGTGAACCTCCATGTTATGAACCTTACTTCCTCAAGTCTCTTTTGCTGCTA
GGAGGCAGACAGTAACTTCGGTAATTAGAAACATCTGCACTCAGCAACATGAAGCACAAGTTCTGTGCAGTTGTCCATATGCTGTCATGA
GTTTTGCCATATGTATCATCTGGCTTTCAGAGGACCTTTCATGGTTGTCAGGTTAAGTTCCTGATACAGAAGTGGCATCAGTGCTGGTGT
TAATGGCTGCAGTAAAGTCAAATTCCTAGATTTTAGTGCTCTGTGGTAGCAGAGAGAATGGTGGTAGTTTATTTTTTCTTTCCTTTTTTT
TTTAAAAAAAAAAAAAAACCTTTTTCATGTTGAAGTTCACATGACCTACAACTAACCATTTTAAAGTGTAATTCAGTGTCATTCAGTACA
TCCACAATGTGCAATCACCACCTCTGTCTAGTTCCAAAACATTTTTATCACCCTAAAAGGAAACCTTGCACCCATTAAACAGTGGTAGTT
TCTCTATCATGCCACTTTTGTAGCATGCTTTGGGGTCTTATTCCTGGGATCTTTCTCTACAGTGGTATGATTATATAAGGGTGGAAATAT
AAAAGAGTAAGCCTTTAGAAACAGTTTGTGTCTAAATTAGCTCTCAGGCATATTGTCTTCAAAGGAATGTTTTAAACCAGCCAAAGACTA
ACATCAACATGCTTACATTTTGAGTCCAAAATTAAAATCCAAAATAGCCAAGCATGGTGGCTCACGCCTATAATCCCAACTACTCCAGAG
GCTGAGGTGTGATAGAATTTCTTGAACCTAGGCGTTCCAGGCTGCAGTGAGCTATGATTGTGCTGCTGCACTCCAGCCTGGGTGACAGAG
CGAGGTTGCTTCTAAAACAAAAATTTGAAATAGTAAGTGCTTTGATTTTTTTTAATATAGAATCAAACAATTGTGAAAATATAATTGGCT
AAGTTTCATATACAGTTCTTTCTAAAACTCCTTCTGTTCTCTAAGATGTAGTTTGAACCAGCCAAGGATGATGGCTTCAACATGTCTCCA
GTTGTTTTGCCACTCCAGGGCCTGACTCAAACCAAAATAAGACTTGCTGTTACCCTGAGACAAGCCAACTGTCATTGCTTTAGCAACCAC
TACGGCTACAGGTTGTTGCATCATGCCAAGCTCTGTGTTCTTTCTAACTAGTAGAATGGAGTGGGATGGTATCGTGATGGTGAACCCAAA
ACAATGGTACTAGGAAGGAGGTTGGCCAAACTCAGAGTGGAGGCTGACCCTGTATCTGGTTGTAGCAGAGTCGGTCCTAGGGGAACAGGC
TCAGCAGCAGCAAGGATGCAAGGACCAGAAGGCAGCAGGGGAAGGAAAAGGAGCAGGGGATAGGGGAACTTTAGGAGCAGAGTAGTGTTG
ATAACTGGCATCTGGAACCTACAGTTTCCAGTTCAGAGCAGTACACCATACTCAGTGTATACTTACACTCCAAGACATTTCCTGGGCAGT
GATCTAGAAATGATATTTTTAAAAGGAGCTGTGTTTCAGTGTTAGACTGTAGTTATCCAAGCAGTATCAGATAGTGTGCAGTTTTTGTAG
TAAAAGGTAAAAATCTGAATAATAAAGTTTATTAATAACAGTTTTAGTTAATACTTGACTGACATTGAGACCCTTGATGCAAAAAGGTAA
GTAGAAGAGAAGGCTGTAAACACAAGACCATCATACCCTGTGGGGAATTTACAATCTAAATATAACAAACATATAGAGTGAGATAGGAGA
AAAGAAATGGGATGATAATGATATTGCTGTACTAAAGTCTATTTAGGAAATGGAAATATATAGCAAGAGGAGTCAGCTACTTGGGCATTG
ATCAAAGAAAAATAAACATATAGAAGGAAAGAAAGGTCGTTTTAGTTTATAACATTTTCCTTCCGATTCTAGGTGATTATATAGCTAGTT
TACTCTTCCACCCCCAAGATTCTGGGGTATTTTGGCTAATGTTATTTGCAATGTCCATAAACTCAGAAGAAGTTAGTATTAACGGGGATA
TGAAAGAACCTCCAGTTACTATGCAAGAAATTTTAAATTTCCATCATGTTAAATTGTACAACTGTTTATCATTCACTCTGCTGTAAGTCT
ATGTGAAACCAAATCCGTGGATTTACCAATGGCCATTTTATCACCTCCAAACTATCTTTTATTTTTTTGAATTGTATCTCTCTCCTTATT

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_1293nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT
AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT
GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT
ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT
TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA
CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA
ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA

>In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_2869nt
CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG
GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG
CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC
CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC
CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG
CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC
ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG
CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT
AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT
GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT
ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT
TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA
CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA
ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA
CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGTGT
GGCCCAGAGTTGCTCAGAATTGGAGCAGAGCCTGAGACGTATCTGCAGATCCTGTCATCAGCTGGCAAGTCCAGGAGACTGTGTCATTTA
GAGACTGTGTTGTTAGTTATCCCTCAACATCTTCTAAGGTGGCAGGAAATAATATTGGAAATAACATTTTAAAGTAAAAATTTTAAAGTT
TAAAGAAGAGTTTTGCCACTTAAACAGGGGAGCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGA
TGAACAGTTGTGATAAATGTGTAGATTAGAGGGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAG
AGGAGGCATCCTTTGCCCAGAGCTGCTTAGCTAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGA
TTTTGTGAAAAACAATAGAACATGTTAATGAGTAATTTATATTAGTTCGATGTATTACAATTTTTTAGCTTTAAATTACAGTTTTCTTAT
AATGTTGAAATGTTTTAGAATCCTTTGAATCTAAGTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACTTATGAAA
TATTCTCCTCCCCCAAGAAAATTTAAACTTTTTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTA
GCTTATTTTTAAGGTAAAACAGCTTTTTACTCTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTC
CTAGTTGGTTTTAAATCATTGTGCCACCTGAAAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTA
GTTATGAAAATATATTGAAGGACAGGAAGTGGACACGAAGTGATTTTTGTAACCTGAGCAGTTAATGAATGTGCCAACATTTTCTAGGAA
GGGACAGCAAGAATATTCTGCTCTGTAGTTAAAATACTGGCTGGCTTTTGATGTCTTCATGCTTAATTGTGATCACTTTCTTGCACTGTG
ATGTTTTTACGTGAATATGTTGAAGTAGAAGTCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCA
ACCCTTCTTTTGAAAATAAACTGAGTCAATTTAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCT
CAACATTTTGTAAGCATCCAAAAAATTGGTAATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTA
GATTTCCAATGTGTATATTCTAATGGAGAAAGCAAGAGGTAGAGTTTGTATGTTTGACTTACCTTAGATTTTTATTTTCCATACATACTG


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FusionGenePPI for DPP4_PDK1


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPP4CCL22, CARD11, BCL10, IKBKB, DKK1, FAP, ADA, EGFRPDK1PDK2, RALGDS, MTOR, RPS6KB1, RPTOR, PKN2, PKN1, DLAT, SGK1, XRCC6, MYC, USP4, KAT2B, PDK1, EGFR, LAMTOR5, HLA-DPA1, PDHB, HLA-B, PDK3, PDHX, PDHA1, OXLD1, TNK2, COL4A5, HMGN1, MYH1, CCDC93, SPG7, STXBP2, MKNK1, CELF2, SRCAP, RASSF8, RIMS1, VWA8, COG4, PVRL3, PYCR2, NSFL1C, ZNFX1, VKORC1, ILKAP, TRIM47, ATG4A, NRBP2, PIK3CA, FOXD4, PDK4, CRBN, NDUFS7, ACAD9, SLC18A1, APLNR, LAMP3, TRMT61B, NME2P1, DENR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPP4_PDK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDPP4P27487DB01076AtorvastatinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB06203AlogliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB06335SaxagliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB08882LinagliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB01261SitagliptinDipeptidyl peptidase 4small moleculeapproved|investigational
HgeneDPP4P27487DB04876VildagliptinDipeptidyl peptidase 4small moleculeapproved|investigational

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RelatedDiseases for DPP4_PDK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPP4C0011570Mental Depression2PSYGENET
HgeneDPP4C0011581Depressive disorder2PSYGENET
HgeneDPP4C0033687Proteinuria1CTD_human