|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 10490 |
FusionGeneSummary for DPP4_PDK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DPP4_PDK1 | Fusion gene ID: 10490 | Hgene | Tgene | Gene symbol | DPP4 | PDK1 | Gene ID | 1803 | 5170 |
| Gene name | dipeptidyl peptidase 4 | 3-phosphoinositide dependent protein kinase 1 | |
| Synonyms | ADABP|ADCP2|CD26|DPPIV|TP103 | PDK1|PDPK2|PDPK2P|PRO0461 | |
| Cytomap | 2q24.2 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2) | 3-phosphoinositide-dependent protein kinase 13-phosphoinositide-dependent protein kinase 2 pseudogenePkB kinase like gene 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P27487 | Q15118 | |
| Ensembl transtripts involved in fusion gene | ENST00000360534, ENST00000491591, | ENST00000543905, ENST00000544863, ENST00000282077, ENST00000392571, ENST00000410055, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: DPP4 [Title/Abstract] AND PDK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DPP4 | GO:0001666 | response to hypoxia | 16670267 |
| Hgene | DPP4 | GO:0006508 | proteolysis | 27198182 |
| Hgene | DPP4 | GO:0008284 | positive regulation of cell proliferation | 17549790 |
| Hgene | DPP4 | GO:0010716 | negative regulation of extracellular matrix disassembly | 16651416 |
| Hgene | DPP4 | GO:0031295 | T cell costimulation | 10900005|17287217 |
| Hgene | DPP4 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin | 11772392 |
| Hgene | DPP4 | GO:0042110 | T cell activation | 7594462 |
| Hgene | DPP4 | GO:0043542 | endothelial cell migration | 16651416 |
| Tgene | PDK1 | GO:0006468 | protein phosphorylation | 14585963 |
| Tgene | PDK1 | GO:0006469 | negative regulation of protein kinase activity | 9373175 |
| Tgene | PDK1 | GO:0018107 | peptidyl-threonine phosphorylation | 9368760 |
| Tgene | PDK1 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 17327236 |
| Tgene | PDK1 | GO:0032148 | activation of protein kinase B activity | 9368760 |
| Tgene | PDK1 | GO:0035556 | intracellular signal transduction | 14749367 |
| Tgene | PDK1 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol | 22454520 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRP | TCGA-Q2-A5QZ-01A | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000360534 | ENST00000543905 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| In-frame | ENST00000360534 | ENST00000544863 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| In-frame | ENST00000360534 | ENST00000282077 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| In-frame | ENST00000360534 | ENST00000392571 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| In-frame | ENST00000360534 | ENST00000410055 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| intron-3CDS | ENST00000491591 | ENST00000543905 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| intron-3CDS | ENST00000491591 | ENST00000544863 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| intron-3CDS | ENST00000491591 | ENST00000282077 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| intron-3CDS | ENST00000491591 | ENST00000392571 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
| intron-3CDS | ENST00000491591 | ENST00000410055 | DPP4 | chr2 | 162902042 | - | PDK1 | chr2 | 173451006 | + |
Top |
FusionProtFeatures for DPP4_PDK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DPP4 | PDK1 |
| Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline. {ECO:0000269|PubMed:10570924,ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005,ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392,ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416,ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790,ECO:0000269|PubMed:18708048}. | Kinase that plays a key role in regulation of glucoseand fatty acid metabolism and homeostasis via phosphorylation ofthe pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibitspyruvate dehydrogenase activity, and thereby regulates metaboliteflux through the tricarboxylic acid cycle, down-regulates aerobicrespiration and inhibits the formation of acetyl-coenzyme A frompyruvate. Plays an important role in cellular responses to hypoxiaand is important for cell proliferation under hypoxia. Protectscells against apoptosis in response to hypoxia and oxidativestress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534,ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DPP4 | chr2:162902042 | chr2:173451006 | ENST00000360534 | - | 5 | 26 | 1_6 | 122 | 767 | Topological domain | Cytoplasmic |
| Hgene | DPP4 | chr2:162902042 | chr2:173451006 | ENST00000360534 | - | 5 | 26 | 7_28 | 122 | 767 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >PDK1 | chr2:162902042 | chr2:173451006 | ENST00000282077 | + | 7 | 11 | 337_338 | 315 | 437 | Nucleotide binding | ATP |
| Tgene | >PDK1 | chr2:162902042 | chr2:173451006 | ENST00000282077 | + | 7 | 11 | 354_359 | 315 | 437 | Nucleotide binding | ATP |
| Tgene | >PDK1 | chr2:162902042 | chr2:173451006 | ENST00000410055 | + | 7 | 12 | 337_338 | 315 | 845 | Nucleotide binding | ATP |
| Tgene | >PDK1 | chr2:162902042 | chr2:173451006 | ENST00000410055 | + | 7 | 12 | 354_359 | 315 | 845 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DPP4 | chr2:162902042 | chr2:173451006 | ENST00000360534 | - | 5 | 26 | 29_766 | 122 | 767 | Topological domain | Extracellular |
| Tgene | PDK1 | chr2:162902042 | chr2:173451006 | ENST00000282077 | + | 7 | 11 | 163_393 | 315 | 437 | Domain | Histidine kinase |
| Tgene | PDK1 | chr2:162902042 | chr2:173451006 | ENST00000410055 | + | 7 | 12 | 163_393 | 315 | 845 | Domain | Histidine kinase |
| Tgene | PDK1 | chr2:162902042 | chr2:173451006 | ENST00000282077 | + | 7 | 11 | 279_286 | 315 | 437 | Nucleotide binding | ATP |
| Tgene | PDK1 | chr2:162902042 | chr2:173451006 | ENST00000410055 | + | 7 | 12 | 279_286 | 315 | 845 | Nucleotide binding | ATP |
Top |
FusionGeneSequence for DPP4_PDK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_244aa MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_244aa MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_244aa MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_244aa MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_244aa MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFL ENSTFDEFGHSINDYSISPDGQFILLEYNYVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_732nt ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_732nt ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_732nt ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_732nt ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_732nt ATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTGCCCGTGGTTCTGCTGAACAAA GGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTATAGACTGAAGTTATACTCCTTA AGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATATGGAAACAGCTCAGTTTTCTTG GAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTTATTCTCTTAGAATACAACTAC GTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGT GTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTG AAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCAATAGAAAGACTCCCAGTGTAT AACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAACCCAAAGACATGACGACGTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000543905_chr2_173451006_+_1579nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGATT CTTCAGTTTTGGGACTTGGACTGGCTTTCCTTGCCCCTCAGCTTGCAGATGGCCTGTTGTGGGACCTTGTGATCATGAACTCCTCCTCCC ACATCTGATGGAGCTACCAATCATCAGATCTCCTCTGCCTCTGGGGTGCGTCTCAGGCTGGCCAATCACGTTCTTCATCCACGTGGACTA >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000544863_chr2_173451006_+_1342nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000282077_chr2_173451006_+_13993nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGGTA TGGTGTTCAGAACTATATTATACCAAGTACTTTATTTATCGTTTTCACAAAACTATTTGAGTAGAATAAATGGAAACTGAATTCCATTTG TGCCCGTTAAACCTCCTAAAGGATGAAATTGCACCTATTTTACACTTATATTTTCACAGTTAATTGAACATATTTTTAAACAACTGTAGT TTTGGGCAACTTTTCACTTTGTGGTAGACTTCAGAAGTGTGGAAATCTTCGGGTTTCTATAGGAAACTAGTTTTTTTTTTTTAAGAAATA CTTTCATTTATGTTTGCTAGAAACATTTTCTAAATGATAGTGATTAGCTGGTTAGCCATCTTCCTGTTATTTGGAGGAGTTCTGCCATCT TTTATTCGGTAGTGACAGCTGTAATATGGTCTTCATGTTTATCAGTGACTTGACTACAAGTAAAGCAGAAAACAGTTGGCCTGTAATCAC AGAACCAGCCACCCTTCGGCGTCTACATGCATTGTCTTAGCTCTGAGGTTAATTTACCATTTTTAAATTTTATTGTAAAGAAGTGTAATG ACTAGCTCTCTGTGGATCTATGCCAAAATCATGGGCCATCTTTTCTAAGTGTACTTCTGATTAATGCAAGGGGAAATTTTTATACTGAAA ACAAACAAACAAACTAGCAGCTACTAAAATAGAGAAGAAATTGAGGGCAAAGTAATATGTCTCCAAAACTGAACTGATTGCTTGTTGAGA TTACCTAGAAAGCTTTTGGAAAAAAATAGAGCTTTTCTGCATCCTACTCCAGATACACTGAATCGGAATCCCTAGGGCTAGAGCCTAGAA ATCTCACTTTTTAAAATGCTTCCAAGGTAAGTCTGATGCCTACCCTAGGTTGGGAACCACTCTTTCAAAGTAAACAGTGATGACACAGCA TTTGCTAAAGTAACATCTGTAGGTTTTGGTTTCCACCTATTTAAAGTCAGATTTATAGACTCGAGGAGACAGAAACTGAATCCCACACCT GGTGCAATTAGAAGCATAATTAGAAGCAGAAGAACAAAATGCCACGTAACCAAAGCATCAGAGCCATCATTGCACGTGTCTTTTTTTCTT TTTTCTTTTTTTTTTTTCAAGACAGGGTCTCGCTCTTTTGCCCAGGATGGAGTACAGTGGCATGGTCAAGGCTCACTGCAGCTTCAATCT TCTGGGCTCAAGTAATCCTTCCACCTCAGCCTCCCATATAGCTGGAACTACAGTTGTGCACTACCACACCCAGCTAATTTTTTGATTTCT TGTGGAGATGAGGTCTCAGTATGTTCCCAGGCTAGTGTTGAACTCCTGAGCTCAAGAAATCCTCCTGCCTGAGTCTCTGAAAGTGCTGGG ATTACAGGCGTGAGCCACCACACATGGCCTATTGCACAAGTCTTGACAAACAACATATATTTTCTAAAACTATCCAGATTTCATTATCAG GGAAAAGTTTGCTTAGGTTTATTACAGCAGTCCTTGGCATTTGTATGGTAATTTGTACTTTACAAATACTTTGATATATTATAACTCTAT TGGTCTTTGAAACAAAGCGATACAGTGTAGGTGGTATCATTCTCTTTCTCACTCAGTGTGGCCCAGAGTTGCTCAGAATTGGAGCAGAGC CTGAGACGTATCTGCAGATCCTGTCATCAGCTGGCAAGTCCAGGAGACTGTGTCATTTAGAGACTGTGTTGTTAGTTATCCCTCAACATC TTCTAAGGTGGCAGGAAATAATATTGGAAATAACATTTTAAAGTAAAAATTTTAAAGTTTAAAGAAGAGTTTTGCCACTTAAACAGGGGA GCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGATGAACAGTTGTGATAAATGTGTAGATTAGAG GGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAGAGGAGGCATCCTTTGCCCAGAGCTGCTTAGC TAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGATTTTGTGAAAAACAATAGAACATGTTAATGA GTAATTTATATTAGTTCGATGTATTACAATTTTTTAGCTTTAAATTACAGTTTTCTTATAATGTTGAAATGTTTTAGAATCCTTTGAATC TAAGTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACTTATGAAATATTCTCCTCCCCCAAGAAAATTTAAACTTT TTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTAGCTTATTTTTAAGGTAAAACAGCTTTTTACT CTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTCCTAGTTGGTTTTAAATCATTGTGCCACCTGA AAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTAGTTATGAAAATATATTGAAGGACAGGAAGTG GACACGAAGTGATTTTTGTAACCTGAGCAGTTAATGAATGTGCCAACATTTTCTAGGAAGGGACAGCAAGAATATTCTGCTCTGTAGTTA AAATACTGGCTGGCTTTTGATGTCTTCATGCTTAATTGTGATCACTTTCTTGCACTGTGATGTTTTTACGTGAATATGTTGAAGTAGAAG TCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCAACCCTTCTTTTGAAAATAAACTGAGTCAATT TAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCTCAACATTTTGTAAGCATCCAAAAAATTGGTA ATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTAGATTTCCAATGTGTATATTCTAATGGAGAAA GCAAGAGGTAGAGTTTGTATGTTTGACTTACCTTAGATTTTTATTTTCCATACATACTGCAAATGATTGACTTGTTGCATAAATGAAGAT CTTCTGTTGTGTGCTTTTCAAACACTGTAAATAAATTTGAAATTTGAATAACTTTCCACAGTATAACTGTAAAAAAAAAAAAAAAAAGTC TTAATTTAACCAGCATTACCCTCTGCTTGTACCAATTGAATGGCAGAACTACTATAGTCAAAAATAAATTCCTATCCTATTTTTAATTGA TGGGATATAGGCAGCACAATTTCCCTTCATTGTTGAAGCCAACAAGTTCCGTAACAGAACTCCAGAGGTAAATAGCTGGGAAAACTGTTA GTTTTAAGGTCCCACTGTTGCTCTGTGAATGACTAATCAGAGGAAGCCAAAAATCAGCCAACTAATTTCAGTTTATGTCTTTAATTGTGA TGTAAGTGTGAAGTTTCTACATATGGGTAATCAGGGTTGAGTTAGGTAGTTTGCAAACATGACTTTTGCTGGAGGAACTTTTAATCATGT CTTATTAATTTCTGGTCCCAATAATTAATTTTCTTACAGTCAAACCCAATGCACTTGAAAAATAATATAATTAATACTGTGTGAAGAATT TTTTGCATGTTAAAAAAAGCAAACCACTAGTTTGCTTAGTTCTGGCATTCATAAACTACTGTACCTTCTGTTCTATTGACATGTTTGGAA AAAAGAATTGAACATATGTACCACCCCCCTCTTTCTAGAGTCTCCACAGTTCTTTAGCAATTGCTAACCATAGGTTTTTAATAGCAAAAG ACAAGATTGTCAGTTTTTGGTGCAAAACTCTACTCTTTTTGGTTGACTTGGAAAAGCTGTTGTTTATATTGGGAATTGTGACAGCTGTCT TTTACTTTGTTAAATTAGCAATTATTTAGCAAAAATACAGAGTTTCACCCCAGTAAAATAAACTTCCACGTGAGAGTTGTGTTCATTCAA GGGTTATTTTTTGAGAGTGGAAGTACATTTCCTGCATTTGTCACAGATAATATCAGAAATTTTGTTGTTTTGATTAAAATGTTGCCATCT ACTTATAAGTTAAAAATGCTGAGAAGGTTTTTTTTGGAAACAGTTTATGAGGCCAGGACATTTTTAAGTTTGACTCAAATATAAAAAGCC ACAGTATTCTTGCCATGGTTTTGTACTTAGATGTCTCTCATTATGGAATTCAGAATGTGACAGTTATAGTACTACATGAAAATACTTAAT ATAGAGTTCTACAGTTACAGTATTGCATGAAAATACAGTATGGTATGAAATTATTTGTCCAAAACTGTACTCCAGAAATGGAGCCCATAT GATTATATAACTATAAAATAGGATGGGACAGAGAAAAATATGTCTGTATTACAGCATAAACATATCTGGTTTAATATGAACTATTTCTTT TCATCTCTTTACTCTCAGTATCTCCATAATGGCCAGTATGTAGTAGGCACCTGTAATTGTGAAGCAGCCTCATTGTCTGGGGTAAATACC AAGGTTCTTGGTCTCATGGCCAAGGAGATCGAGGTCGCAGACACACACAGTTTGGAGCAGGAGTTTAATAGGCAAAAGGAAACAGCTCTG TTACAGAGAGGGGTTCCGAGCAGGTTGCCAAGTTGTAGTAAAAATGTCAGGGTTTTTATAAATGGGCTAGTGAGGAGGGGGCTCATGAGG AGGGGATATCTTATCCTCCTAGGGTCCGAGGACGCTTTAGTTGGGACCAGGTGTGCTATCTGTACAGAGCATAGCTTTTTATCAGCTCTT ATCCCATTCCTTGACCACATAGGCTCTTAGACTCTTATTCTATGTTGTCTTCGTCCAGCTTATCTGGAAGGGAGAGTTTCTCTGTCTGTT CCCATACATCTTGCAGCTGCAGGCATCCCCCCGGTCTGCTTTTAGCTTCCTTATCTTAGTGCCCCTAAAGGGAAAGGAATGTGCTTATTA AGGGCCACTGTTTTACTGGGGTTAACTGCATGAGGTCAAAAAGAGCTATATTTGAGCTGCTGTTTGTTAAAAGAAAAGTTTTCTGCCGGG GACTCGCTTTACCCTGTCTACCTAAATTCTTTCTGCCTTCTATAACAATTGTATGCTCAGTAAATACATAAGGAATAATGAACTTAATAA CATTTTTTTCCATTCTCAAAATGATACTTAAATGACTCAGTACAACAAAGAAACTGAGTAGTAACCAGTGCAAAACTAGCAAAAGGATGA AATACACAAGAAAATGAGAGAATTTAAGAGGAGTAGCAAAACAGCACTGCTAAAGTTACGGGTTTATTTTAAAGTTTAAAATAGAAGTAA ACAAGCAAACATACTGATAATGGTTAGGCTTTCTGTCCCCACCGCACAAATCTCATCTTGAATTATAATCTCAACATGTTAAGGGAGAGA CCAGATGAAAGTAATTGGATCATGGGGTTGGTTTCTCCCATGCTGTTCTCGTGATAGTTCCCATGAGATCTGATGGTTTTATAAGTATTT GGTAGTTCCTCCTGCATTCATTCTTCCTGCTGCCCTGTGAAGAGGTGCCTTCCACCATGATTGTGAGTTTCTGGAGGCTTCTGCAGCCTT GCGGAACTGTGAGTCAATCCTTTTTATTATAAATTACCCCGTCTCAGGCAGTTCTTTATAGCAGTGTGGGGATGGACTAATACTCGCTGG GTTAGCTGGGGTAGGTAAAGCCACAGCTGTGGCAGCAACCAGCTAGTGGGTGTCCCTTGATGGAGGCTTTGCAGGCTGCAGCAGAAGGGA CCCTTCAGATAAACCTCCAGTCAGGAAAGGAAAAGGCCCAAATAAACAGTATTTAGATTTTTTTTTAAAGGACATAACTACCAATAGAGA TTTAAAATAATCATAAGAATACCATTAACTTTATGATAAAAATTTTGTAAGTGGAGAAGAAATGGATATATTTCTAGGAAAACAGTAGAA GATCCATCTAAGATTTTGACAATTTAAATCAACCACTAAGGAAGTGGAATCAGTAATCACAAGTCCACCTCGCCAAAAGACAATTTTTGA AAGATGAATGTTACCAAAACATCAAGAAACTGATAATTCCTGTCTTATAGAAACTTTGAAATGAGAGAAAGCTACCCAACCCATTTCAGA AAGTTAGTAAAATCTCAAAGCTACACTTGAGCAAAGACTGTGAAATATTAATAGACCAATCTTGTTTATGAACATAGATGGAAAAATTGC TGATGAAATATTGGCACATTGAATGTAGCAGTGCATAAAATATTGTATCATGAGCAAAAGGAGAATCTTTCCCAGGAACAGGAGGATGTT TTAATAAAAATATGTAATTTACCTCTCTACAGATTAAAGGAGAAAAACTATATGATCACATCAACAGAAACAGGAAATTCAGTTTCTTTG GGGGATAGTTGTAATTAAAAGTGCTTAACTCACTTATATAAGCCATTAGTGGATGTTACAATAAACCTCGTATAGTGTCAGATGTAAGAC AGACATACTGGAATTGTCTATGAGGTTGGATCCATGGGCCTGCCATGGAAAATTTGTTGAGTAATACGTCCAAGGCGTCACCATTTGCCA GGCGTTGCAAGTATCACCATTTGCAAGGTGTTAACAAAAAGTTACCTGCCTATGGATTCTCCTTTCTAACTCTGACCTAATATTTTGGAG CATAGAGGAAAGAAACATCTTATGTTTCTGTGTTTGGGTAAACATTAGACTTATAAAAGGGCCTAGGGTTTTTTTGTTTGGTAAACCATT GCCTTTCCTGCTTTGGTGTGGCAAATCTTCCTTTGGAGAAAAAGGTCCCTTTAATCTTAAAACCAACTCTCAGTGACCAACAAAAGCAAC AAATAGGAACAACCACCCATTAAGAACCATCAGGTGATGCCTCATTTGCTGTGGTGCACAGCTGAACTTGATTGTTACTCTTGGATCAGG GTTGGCTTGATAAGGACTCACTTAACCAATGGAAAGTAAGGTTAAATCTTTGTAAGCAATGCTCCTGATGCGAATCACCTGGAGATCTTG AGCAAATGCAGACTGGTTCAGCAGATCTGGAGTGGGGCCTGAGATTCTGCATTTCTAACAAGTTTCCTGGTGATATTAATGCTGCTGGTC TGTGAGCCATACTTTGAGTAGCAAAGGACTAAAGGTTGTGAGATAAACTGCTTTTAGCAGCCCAAAGGGCCAGCTGGAAAGACGAGACCA GTTACAGAGCAAATGGCAAGACAGATCTGGTAATCTGATTCTTAGAGTACTTAAAAAAGATAAGAAGGATCTATTCCTGATATACAGGGT ACTTGGTGGATGTGTCCATGACCTCGAGATCGAAAACCCATTAGTTAATCTTTGTGACATCTGAATTTTAAGGATCTTACCCAGTGAACA TATAACTAGTGGAAATCCTGATAATTGGCTAATGCAAGGAAGTGATACCCATGTGTAATGCTTATCTTTGTATCCATTTCATGGGGAAGG TCATGGAAGACGACAGCAAACTTGAGTGGTTAATGAGAGCTTCACTAATGTTGTCTGCTGCAGGCAATAAGTGAAGTCTCTGGCAGTGGG AAGCATGGACCCAAGACCGAAAGCTCTGGCACTTTATAGCAGTGGTGGGGGGTAGATAGGACTTAGTGTGGCCCCTTAAAGAGCAAGGTC CAAGTGATTTTCTCTGGTGAATGTCGATGTGGATCTAGTCTCCAGGGTTAGATCCAGGCAGGTAACATCAAAGTCAGTTGATAAGACCTC TTATGCCTGTGAATGGAAGGCCCTGATAAAACTTCATTATTAATGTTCTGCATTAATTTAGCGGATGACTATAGTCATTTCACATAATCT AATACATGAATGTCCTGTATGGGTGACTGCTGAGGGTTTAACAAAGGAGAGTCCATTTATATTTGGCTGGTAAGATCGATGCTTCTGTCA CTACTGATGGGCAAGGATATTAACATCAATATCTAAAAAAATTCTGAGATTTGGATTGTGATGTGTTAAATTTCTAGACCAATTTGAGGA GAATTTAACAATAGCTTTTCAATTTATGAACATGGCGTATATCTTTTTTGGCGGGGGGTGAGGACAGAGTCTTGCTCTGAGATTACCCAG GCTGGAGTTTAGTAGCATGATCTTGGCTCACTGCAACCTCTGCCTCCTGAGTTGAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGG GATTACAGGCGAGCGCCATCATGCCTGACTAATTTTCGTATTTTTAGCAGAGACAGGGTGTCGCCACCTCAAGGGATCCACCTGCCTTGG CCTCCCAAAGTGCTGGGATTTATAAGCGTGAGTCACCGTACCTGGCCAGACATAGCATATATCTTCCTTTACATAGATTGCCTTTGATTT CTTTCATTGTTACTTTGTAGTTTTCAGCTTACAGATTCCGCGCATATTTTGTTAGACTTAAATCTAAGTATTTGCTTTTTTTTTAACTTA CAAATTTTTTTAAAAAAACGTTTTTCCTCTCCAATGTTCATTGCTAATACATTTCACGTTTGAATCTCCAGTTCAGAAAAATCATGGCCT CTGGAGTTTTACTGAGGACTAGAGATAGCTAAGTAACATAGTTCCACCTTATTCACTTGGTCTTTGATGTGGTGTCCATAATTGAGTAAA TGGCAGTATGTCCAATGGCAACACCATGAACTTGACTTTGCCCTCTTGTCTAGCCCTCTCCATTTAGACTTGGAAGGGTCAGCAGTAAAA TTTCACTGGCCCAGTCCAGGGCTGCTTGAGTGTTACTGTTTTGTGCCACAATATGATGTGGCCAGACTACTTTTCTAGTTTCGAGATTAT TTTGGAGCTTTATATTGGGTATGTTCTTATCCAACTATCATTAGGGGCATTGATCTCTGATGCCCTTTTCTTTCTTATCTTCCAAATGGC AGGCAGTAAATGGCTTATTAAGCAAGTATAAGATTCAAGATCTCAGCCCCAAAGATACATTTGTAGATGCCAGGCTTAACATTCCTGAGG CTCTCAGAGAAAACTTTTCCCTCTATAGACTCCCCATTTTAAGAAGGAGGCACAGGGCTTGGTTGGCCCATTTAGTTAGTGACACACCTA TATTACTCTCCTTGGCATCTTACCCCAGCCCATCCATTGGGTTGTGTCAGTCTTTTATTTCTAAGTGAGGATCCAGTCAACAGGAGGCAC AAGAGATAGAACCAAATACCATAATGCCTCCTTCTATTCCACTATGAACAGTCAAGGACACTGGAGGCCTCTGGGTGGGACACATAGGCG TTCAAGAGCCTCTGAGCTTAAAGATATGTGAGTGGAGCTAACTAGACTGTCCAGGTTTGGTCTACACTGTAATTTTTTTTTTTTTTTTTT TTTTTTGGAAGCAGAGTCTTGCTCTTTTGCCCAGGCCAGAGTGTAGTGGTGTGATCTCAGCTCAGTGCAGCGTCTGCTTCCTGGGTTCAA GTGATTCTCCTGCCTCAGCCTCCAAGTAGCTGGGACTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGGG GTTTCACCGTGTTGGCCAGGCTGGTCTCGAACTCCTGAGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAGTGTTGGGATAGCAGGCAT GAACCACCGTGCTCAGCCTCTCTGTAAATCTTGAGTCGGCACTGAGCTCATGAAAGCTGTGCTGAGTGGGTTTCTTTAGATTTTCATTTT CATGTTTGCCCCATTTATGCTAATATTAATTATTGGAAAATAATTCACCTACTTTGCTTCTCTCTGACCAACATAGGGGCAGGATCTGTG GAAAGACATTTACCACCTGTTTGAAAAGGTCAGCGTGCTGATATTCACTAACTACTACCCCCACAACTCCCCCTCCCCCAAACCTGATAG ATGCTATAATTTCTGCAGTCCAATCACTATTCTTCCCAAACTCCATGAGCCAGATTTTATACATACTTTGCGTGACCATAAAACTCTGTA CTATTATAGACATAAAACCATTTAATTTCATAGATACCTTCAGTGGTGGCATCACTGGGTCCTCTCTTGGATAGCATAGTCCTATGACCA AATGGGTCAGTCGTTGATCAGGCTTCATGAGAATATGATCGCTGGGAGAAATATACAGCTAATTTAACAACAAATGACTGTCCTAATTCT GGAGACCTGGGAAGTATTGATGAGAGTATAGTGATCATAAGCAGACATTGGGTGCTTTAGCAAAGCCAATTTGCCTGCATCCTCTGGAAG GTAAAGAAGATCTCCTCTCTCTTAGAACTTAATCAAACTCTTGGCATCCACAGAAGGCTAGGAGGATGTAATGAATACTTACCATTTTTG TGGAAGCCCACAACCTTTTGAATGGCCTTTCTATACTTTAGTGAACCTCCATGTTATGAACCTTACTTCCTCAAGTCTCTTTTGCTGCTA GGAGGCAGACAGTAACTTCGGTAATTAGAAACATCTGCACTCAGCAACATGAAGCACAAGTTCTGTGCAGTTGTCCATATGCTGTCATGA GTTTTGCCATATGTATCATCTGGCTTTCAGAGGACCTTTCATGGTTGTCAGGTTAAGTTCCTGATACAGAAGTGGCATCAGTGCTGGTGT TAATGGCTGCAGTAAAGTCAAATTCCTAGATTTTAGTGCTCTGTGGTAGCAGAGAGAATGGTGGTAGTTTATTTTTTCTTTCCTTTTTTT TTTAAAAAAAAAAAAAAACCTTTTTCATGTTGAAGTTCACATGACCTACAACTAACCATTTTAAAGTGTAATTCAGTGTCATTCAGTACA TCCACAATGTGCAATCACCACCTCTGTCTAGTTCCAAAACATTTTTATCACCCTAAAAGGAAACCTTGCACCCATTAAACAGTGGTAGTT TCTCTATCATGCCACTTTTGTAGCATGCTTTGGGGTCTTATTCCTGGGATCTTTCTCTACAGTGGTATGATTATATAAGGGTGGAAATAT AAAAGAGTAAGCCTTTAGAAACAGTTTGTGTCTAAATTAGCTCTCAGGCATATTGTCTTCAAAGGAATGTTTTAAACCAGCCAAAGACTA ACATCAACATGCTTACATTTTGAGTCCAAAATTAAAATCCAAAATAGCCAAGCATGGTGGCTCACGCCTATAATCCCAACTACTCCAGAG GCTGAGGTGTGATAGAATTTCTTGAACCTAGGCGTTCCAGGCTGCAGTGAGCTATGATTGTGCTGCTGCACTCCAGCCTGGGTGACAGAG CGAGGTTGCTTCTAAAACAAAAATTTGAAATAGTAAGTGCTTTGATTTTTTTTAATATAGAATCAAACAATTGTGAAAATATAATTGGCT AAGTTTCATATACAGTTCTTTCTAAAACTCCTTCTGTTCTCTAAGATGTAGTTTGAACCAGCCAAGGATGATGGCTTCAACATGTCTCCA GTTGTTTTGCCACTCCAGGGCCTGACTCAAACCAAAATAAGACTTGCTGTTACCCTGAGACAAGCCAACTGTCATTGCTTTAGCAACCAC TACGGCTACAGGTTGTTGCATCATGCCAAGCTCTGTGTTCTTTCTAACTAGTAGAATGGAGTGGGATGGTATCGTGATGGTGAACCCAAA ACAATGGTACTAGGAAGGAGGTTGGCCAAACTCAGAGTGGAGGCTGACCCTGTATCTGGTTGTAGCAGAGTCGGTCCTAGGGGAACAGGC TCAGCAGCAGCAAGGATGCAAGGACCAGAAGGCAGCAGGGGAAGGAAAAGGAGCAGGGGATAGGGGAACTTTAGGAGCAGAGTAGTGTTG ATAACTGGCATCTGGAACCTACAGTTTCCAGTTCAGAGCAGTACACCATACTCAGTGTATACTTACACTCCAAGACATTTCCTGGGCAGT GATCTAGAAATGATATTTTTAAAAGGAGCTGTGTTTCAGTGTTAGACTGTAGTTATCCAAGCAGTATCAGATAGTGTGCAGTTTTTGTAG TAAAAGGTAAAAATCTGAATAATAAAGTTTATTAATAACAGTTTTAGTTAATACTTGACTGACATTGAGACCCTTGATGCAAAAAGGTAA GTAGAAGAGAAGGCTGTAAACACAAGACCATCATACCCTGTGGGGAATTTACAATCTAAATATAACAAACATATAGAGTGAGATAGGAGA AAAGAAATGGGATGATAATGATATTGCTGTACTAAAGTCTATTTAGGAAATGGAAATATATAGCAAGAGGAGTCAGCTACTTGGGCATTG ATCAAAGAAAAATAAACATATAGAAGGAAAGAAAGGTCGTTTTAGTTTATAACATTTTCCTTCCGATTCTAGGTGATTATATAGCTAGTT TACTCTTCCACCCCCAAGATTCTGGGGTATTTTGGCTAATGTTATTTGCAATGTCCATAAACTCAGAAGAAGTTAGTATTAACGGGGATA TGAAAGAACCTCCAGTTACTATGCAAGAAATTTTAAATTTCCATCATGTTAAATTGTACAACTGTTTATCATTCACTCTGCTGTAAGTCT ATGTGAAACCAAATCCGTGGATTTACCAATGGCCATTTTATCACCTCCAAACTATCTTTTATTTTTTTGAATTGTATCTCTCTCCTTATT >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000392571_chr2_173451006_+_1293nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA >In-frame_DPP4_ENST00000360534_chr2_162902042_-_PDK1_ENST00000410055_chr2_173451006_+_2869nt CTTTCACTGGCAAGAGACGGAGTCCTGGGTTTCAGTTCCAGTTGCCTGCGGTGGGCTGTGTGAGTTTGCCAAAGTCCCCTGCCCTCTCTG GGTCTCGGTTCCCTCGCCTGTCCACGTGAGGTTGGAGGAGCTGAACGCCGACGTCATTTTTAGCTAAGAGGGAGCAGGGTCCCCGAGTCG CCGGCCCAGGGTCTGCGCATCCGAGGCCGCGCGCCCTTTCCCCTCCCCCACGGCTCCTCCGGGCCCCGCACTCTGCGCCCCGGCTGCCGC CCAGCGCCCTACACCGCCCTCAGGGGGCCCTCGCGGGCTCCCCCCGGCCGGGATGCCAGTGCCCCGCGCCACGCGCGCCTGCTCCCGCGC CGCCTGCCCTGCAGCCTGCCCGCGGCGCCTTTATACCCAGCGGGCTCGGCGCTCACTAATGTTTAACTCGGGGCCGAAACTTGCCAGCGG CGAGTGACTCCACCGCCCGGAGCAGCGGTGCAGGACGCGCGTCTCCGCCGCCCGCGGTGACTTCTGCCTGCGCTCCTTCTCTGAACGCTC ACTTCCGAGGAGACGCCGACGATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTGGGTGCTGCTGCGCTTGTCACCATCATCACCGTG CCCGTGGTTCTGCTGAACAAAGGCACAGATGATGCTACAGCTGACAGTCGCAAAACTTACACTCTAACTGATTACTTAAAAAATACTTAT AGACTGAAGTTATACTCCTTAAGATGGATTTCAGATCATGAATATCTCTACAAACAAGAAAATAATATCTTGGTATTCAATGCTGAATAT GGAAACAGCTCAGTTTTCTTGGAGAACAGTACATTTGATGAGTTTGGACATTCTATCAATGATTATTCAATATCTCCTGATGGGCAGTTT ATTCTCTTAGAATACAACTACGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTAT TCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCA CAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAGGCTCTGTCAACAGACTCA ATAGAAAGACTCCCAGTGTATAACAAAGCTGCCTGGAAGCATTACAACACCAACCACGAGGCTGATGACTGGTGCGTCCCCAGCAGAGAA CCCAAAGACATGACGACGTTCCGCAGTGCCTAGACACACTTGGGACATCGGAAAATCCAAATGTGGCTTTTGTATTAAATTTGGAAGTGT GGCCCAGAGTTGCTCAGAATTGGAGCAGAGCCTGAGACGTATCTGCAGATCCTGTCATCAGCTGGCAAGTCCAGGAGACTGTGTCATTTA GAGACTGTGTTGTTAGTTATCCCTCAACATCTTCTAAGGTGGCAGGAAATAATATTGGAAATAACATTTTAAAGTAAAAATTTTAAAGTT TAAAGAAGAGTTTTGCCACTTAAACAGGGGAGCTTTGTCTGGAAAATACACTGAGTTGAAACACTTCATCCTTGGAAGGATTATATAAGA TGAACAGTTGTGATAAATGTGTAGATTAGAGGGATGTGAATGGGCAGTTAGTCCAGTGCCCTCATTTAAGAGGCCAAGATCCTGATTCAG AGGAGGCATCCTTTGCCCAGAGCTGCTTAGCTAATCTGACCAAATGTTGGGAAAAATGTCTCACCTAACCCACTATTCCTTAATTATGGA TTTTGTGAAAAACAATAGAACATGTTAATGAGTAATTTATATTAGTTCGATGTATTACAATTTTTTAGCTTTAAATTACAGTTTTCTTAT AATGTTGAAATGTTTTAGAATCCTTTGAATCTAAGTATTTGTTTCCTAAATGAAACATTTGTACAACATTTGATGTTTTTACTTATGAAA TATTCTCCTCCCCCAAGAAAATTTAAACTTTTTCTCTCTATTTAAAAGCTAAGAAATGTTTTAAAGGAAAAATGAAATTATCTTCCTTTA GCTTATTTTTAAGGTAAAACAGCTTTTTACTCTGTTATTGTGGTAATGGACAGAATATTACATACAAAAATATTCTGGGAGAGCTTTTTC CTAGTTGGTTTTAAATCATTGTGCCACCTGAAAGGTTTTTAGATTTTATAGGAGCTAATTTGTCCACCAGCATTAATGTAACACAGTGTA GTTATGAAAATATATTGAAGGACAGGAAGTGGACACGAAGTGATTTTTGTAACCTGAGCAGTTAATGAATGTGCCAACATTTTCTAGGAA GGGACAGCAAGAATATTCTGCTCTGTAGTTAAAATACTGGCTGGCTTTTGATGTCTTCATGCTTAATTGTGATCACTTTCTTGCACTGTG ATGTTTTTACGTGAATATGTTGAAGTAGAAGTCTACCATATTATTTTATAAAATGTTTTCTGTATGGCAATAAACTGAAAACATGGATCA ACCCTTCTTTTGAAAATAAACTGAGTCAATTTAGCCTTTTAAAAATATAGTCATCTCTTTTAAATAGAATCCTCTTCCACCATCAAGGCT CAACATTTTGTAAGCATCCAAAAAATTGGTAATTAGGGGGCTTGCACTAAATTTCACTATCTTCAGTAGAGAGGAACTGTTTGGAACTTA GATTTCCAATGTGTATATTCTAATGGAGAAAGCAAGAGGTAGAGTTTGTATGTTTGACTTACCTTAGATTTTTATTTTCCATACATACTG |
Top |
FusionGenePPI for DPP4_PDK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DPP4 | CCL22, CARD11, BCL10, IKBKB, DKK1, FAP, ADA, EGFR | PDK1 | PDK2, RALGDS, MTOR, RPS6KB1, RPTOR, PKN2, PKN1, DLAT, SGK1, XRCC6, MYC, USP4, KAT2B, PDK1, EGFR, LAMTOR5, HLA-DPA1, PDHB, HLA-B, PDK3, PDHX, PDHA1, OXLD1, TNK2, COL4A5, HMGN1, MYH1, CCDC93, SPG7, STXBP2, MKNK1, CELF2, SRCAP, RASSF8, RIMS1, VWA8, COG4, PVRL3, PYCR2, NSFL1C, ZNFX1, VKORC1, ILKAP, TRIM47, ATG4A, NRBP2, PIK3CA, FOXD4, PDK4, CRBN, NDUFS7, ACAD9, SLC18A1, APLNR, LAMP3, TRMT61B, NME2P1, DENR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for DPP4_PDK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | DPP4 | P27487 | DB01076 | Atorvastatin | Dipeptidyl peptidase 4 | small molecule | approved |
| Hgene | DPP4 | P27487 | DB06203 | Alogliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Hgene | DPP4 | P27487 | DB06335 | Saxagliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Hgene | DPP4 | P27487 | DB08882 | Linagliptin | Dipeptidyl peptidase 4 | small molecule | approved |
| Hgene | DPP4 | P27487 | DB01261 | Sitagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational |
| Hgene | DPP4 | P27487 | DB04876 | Vildagliptin | Dipeptidyl peptidase 4 | small molecule | approved|investigational |
Top |
RelatedDiseases for DPP4_PDK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DPP4 | C0011570 | Mental Depression | 2 | PSYGENET |
| Hgene | DPP4 | C0011581 | Depressive disorder | 2 | PSYGENET |
| Hgene | DPP4 | C0033687 | Proteinuria | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|