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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10484

FusionGeneSummary for DPP3_FEZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP3_FEZ1
Fusion gene ID: 10484
HgeneTgene
Gene symbol

DPP3

FEZ1

Gene ID

10072

9638

Gene namedipeptidyl peptidase 3fasciculation and elongation protein zeta 1
SynonymsDPPIIIUNC-76
Cytomap

11q13.2

11q24.2

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl peptidase 3DPP IIIdipeptidyl aminopeptidase IIIdipeptidyl arylamidase IIIdipeptidyl peptidase IIIenkephalinase Bfasciculation and elongation protein zeta-1zygin Izygin-1
Modification date2018052320180523
UniProtAcc

Q9NY33

Q99689

Ensembl transtripts involved in fusion geneENST00000531863, ENST00000532677, 
ENST00000453114, ENST00000360510, 
ENST00000541961, ENST00000530165, 
ENST00000533799, 		ENST00000527350, 
ENST00000278919, ENST00000366139, 
ENST00000524435, 
Fusion gene scores* DoF score6 X 5 X 4=1206 X 5 X 4=120
# samples 66
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPP3 [Title/Abstract] AND FEZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP3

GO:0006508

proteolysis

9425109|10387075


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-05-4432-01ADPP3chr11

66254148

+FEZ1chr11

125333466

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000531863ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000531863ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000531863ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000531863ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000532677ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000532677ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000532677ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000532677ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000453114ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000453114ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000453114ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000453114ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000360510ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000360510ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000360510ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000360510ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000541961ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000541961ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000541961ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000541961ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000530165ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000530165ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000530165ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
5CDS-intronENST00000530165ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-
intron-intronENST00000533799ENST00000527350DPP3chr11

66254148

+FEZ1chr11

125333466

-
intron-intronENST00000533799ENST00000278919DPP3chr11

66254148

+FEZ1chr11

125333466

-
intron-intronENST00000533799ENST00000366139DPP3chr11

66254148

+FEZ1chr11

125333466

-
intron-intronENST00000533799ENST00000524435DPP3chr11

66254148

+FEZ1chr11

125333466

-

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FusionProtFeatures for DPP3_FEZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP3

Q9NY33

FEZ1

Q99689

Cleaves and degrades bioactive peptides, includingangiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187,PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (invitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758).{ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063,ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109}. May be involved in axonal outgrowth as component of thenetwork of molecules that regulate cellular morphology and axonguidance machinery. Able to restore partial locomotion and axonalfasciculation to C.elegans unc-76 mutants in germlinetransformation experiments. May participate in the transport ofmitochondria and other cargos along microtubules.{ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPP3_FEZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPP3_FEZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPP3ATP5C1, TERF1, TERF2IP, TINF2, POT1, APP, DSTN, LIG4, KEAP1, DLD, ASS1, NHLRC2, PEPD, SGTA, TNFAIP8, TRIP6, NDRG1, SMS, ALDH8A1, UBA1, TANGO2, NTRK1, BBS1FEZ1DISC1, ACTG1, CCL7, DNAAF5, BORA, HTATSF1, SMEK2, PAM16, STAR, COL9A2, GTF2F1, OLFML3, DIS3L2, NDUFB9, P4HB, PDCD7, PTH, PTPRS, TAC3, TTR, TXNDC9, CSTF2, TOMM20, NBR1, PRKCZ, DRAP1, SMARCD1, SAP30L, BRD1, TLK2, ZNF251, SMC3, CLASP2, RAB3GAP1, FEZ1, WWC1, RAI14, SCOC, C16orf59, TBC1D25, FEZ2, TAF1D, MEST, SERPINH1, GEMIN7, C8orf33, HTT, HAP1, BARD1, IMMT, LRIF1, PTN, UBE4B, NEK1, TAF9, ANK3, DGKD, ZYG11A, NELFA, TUBA3C, CEP192, KLHDC2, AURKA, MRS2, SEPN1, LANCL2, IFT140, MED25, MYO5A, ASPM, ATP12A, CREB1, ZNF638, SPECC1L, SCCPDH, PLK1, CKAP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPP3_FEZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DPP3_FEZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFEZ1C0036341Schizophrenia3PSYGENET
TgeneFEZ1C0005586Bipolar Disorder1PSYGENET
TgeneFEZ1C0033975Psychotic Disorders1PSYGENET
TgeneFEZ1C0036337Schizoaffective Disorder1PSYGENET